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| 1 | Promotion by 5-Aminolevulinic Acid of Germination of Pakchoi (Brassica campestris ssp. chinensis var. communis Tsen et Lee) Seeds Under Salt Stress显示文摘The seed germination and seedling growth of pakchoi (Brassica campestris ssp. chinensis var.communis Tsen et Lee cv. Hanxiao) were not significantly inhibited until the concentration of NaCl was increased to150 mmol/L. Treatment of pakchoi seeds with exogenous 5-aminolevulinic acid (ALA), at concentrations ranging from 0.01 to 10.00 mg/L, promoted seed germination when seeds were stressed by salinity, whereas levulinic acid (LA), an inhibitor of ALA dehydrase, significantly inhibited seed germination and seedling growth, suggesting that metabolism of ALA into porphyrin compounds was necessary for seed germination and seedling growth. Determination of respiratory rate during seed germination showed that ALA increased seed respiration under both normal conditions and salt stress. Furthermore, salt stress decreased levels of endogenous ALA, as well as heme, in etiolated seedlings. More salt-tolerant cultivars of pakchoi contained higher relative levels of endogenous ALA and heme under conditions of salt stress.These results indicate that salt stress may inhibit the biosynthesis of endogenous ALA and then heme,which is necessary for seed germination, and treatment of seeds with exogenous ALA prior to germination may be associated with the biosynthesis of heme. | Liang-Ju WANG Wei-Bing JIANG Hui LIU Wei-Qin LIU Lang KANG Xi-Lin HOU | 2005 | Journal of Integrative Plant Biology2005，47，9： | 54 |
| 2 | Differences between CMIP6 and CMIP5 Models in Simulating Climate over China and the East Asian Monsoon显示文摘We compare the ability of coupled global climate models from the phases 5 and 6 of the Coupled Model Intercomparison Project(CMIP5 and CMIP6,respectively)in simulating the temperature and precipitation climatology and interannual variability over China for the period 1961–2005 and the climatological East Asian monsoon for the period 1979–2005.All 92 models are able to simulate the geographical distribution of the above variables reasonably well.Compared with earlier CMIP5 models,current CMIP6 models have nationally weaker cold biases,a similar nationwide overestimation of precipitation and a weaker underestimation of the southeast–northwest precipitation gradient,a comparable overestimation of the spatial variability of the interannual variability,and a similar underestimation of the strength of winter monsoon over northern Asia.Pairwise comparison indicates that models have improved from CMIP5 to CMIP6 for climatological temperature and precipitation and winter monsoon but display little improvement for the interannual temperature and precipitation variability and summer monsoon.The ability of models relates to their horizontal resolutions in certain aspects.Both the multi-model arithmetic mean and median display similar skills and outperform most of the individual models in all considered aspects. | Dabang JIANG Dan HU Zhiping TIAN and Xianmei LANG | 2020 | Advances in Atmospheric Sciences2020，37，10： | 28 |
| 3 | Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death显示文摘 | Jiang H Gomez-Manzano C Aoki H Alonso MM Kondo S McCormick F Xu J Kondo Y Bekele BN Colman H Lang FF Fueyo J | 2007 | 中国神经肿瘤杂志2007，5，3： | 24 |
| 4 | Energy-Efficient Multi-UAV Coverage Deployment in UAV Networks:A Game-Theoretic Framework显示文摘UAV cooperative control has been applied in many complex UAV communication networks. It remains challenging to develop UAV cooperative coverage and UAV energy-efficient communication technology. In this paper, we investigate current works about UAV coverage problem and propose a multi-UAV coverage model based on energy-efficient communication. The proposed model is decomposed into two steps: coverage maximization and power control, both are proved to be exact potential games(EPG) and have Nash equilibrium(NE) points. Then the multi-UAV energy-efficient coverage deployment algorithm based on spatial adaptive play(MUECD-SAP) is adopted to perform coverage maximization and power control, which guarantees optimal energy-efficient coverage deployment. Finally, simulation results show the effectiveness of our proposed approach, and confirm the reliability of proposed model. | Lang Ruan Jinlong Wang Jin Chen Yitao Xu Yang Yang Han Jiang Yuli Zhang Yuhua Xu | 2018 | China Communications2018，15，10： | 24 |
| 5 | The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. | Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma | 2021 | Cancer Communications2021，41，11： | 22 |
| 6 | Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected smal hepatocel ular carcinomas显示文摘BACKGROUND:Hepatocellular carcinoma(HCC)is a highly malignant tumor with a poor prognosis.Because small HCCs possess most of the characteristics of early HCC,we investigated small HCCs to screen potential biomarkers for early diagnosis.METHODS:Proteins were extracted from 10 sets of paired tissue samples from HBV-infected small-HCC patients.The extracted proteins were well resolved by two-dimensional electrophoresis.These HCC-associated proteins were then identified by MALDI-TOF/TOF MS following image analysis.Western blotting and immunohistochemistry were used to assess glutamine synthetase(GS)and phenazine biosynthesislike domain-containing protein(PBLD)expression in liver tissue.Enzyme-linked immunosorbent assays in 152 serum samples(from 49 healthy donors,24 patients with liver cirrhosis,and 79 with HCC)were used to further assess the significance of GS clinically.RESULTS:Fifteen up-regulated and three down-regulated proteins were identified.Western blotting confirmed GS overexpression and decreased PBLD expression in liver tissue.Immunohistochemistry showed that GS was expressed in 70.0%(84/120)of HCCs and 35.8%(43/120)of nontumor tissues;PBLD was expressed in 74.2%(89/120) of nontumor tissues and 40.8%(49/120)of HCCs.The Chi-square test showed significant expression differences between HCCs and adjacent tissues.Consistent with this,serum GS levels in HCC patients were significantly higher than those in liver cirrhosis patients and healthy donors,while the latter two groups were also significantly different.In addition, a diagnostic cutoff value of 2.6 mg/ml was used for GS;it was elevated in 19(76.0%)of 25 HCC patients with AFP≤20 ng/ml and 47(88.7%)of 53 HCC patients with AFP≤200 ng/ml.CONCLUSION:GS and PBLD are abnormally expressed in most HCCs.GS may be a novel serum marker for early HCC, especially for those patients with low AFP levels(≤200 ng/ml). | Jiang Long,Zhen-Wei Lang,Hua-Guang Wang,Tai-Ling Wang,Bao-En Wang and Si-Qi Liu Liver Research Center,Beijing Friendship Hospital, Capital Medical University,Beijing 100050,China Department of Hepatology,Department of Pathology, Beijing Youan Hospital,Capital Medical University,Beijing 100069,China Department of Pharmaceutical Affairs,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China Department of Pathology,China-Japan Friendship Hospital,Beijing 100029,China Beijing Genomics Institute,Chinese Academy of Science,Beijing Airport Industrial Zone B-6,Shunyi,Beijing 101300,China | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 21 |
| 7 | Future extreme climate changes linked to global warming intensity显示文摘Based on the Coupled Model Intercomparison Project Phase 5(CMIP5) daily dataset, we investigate changes of the terrestrial extreme climates given that the global mean temperature increases persistently under the Representative Concentration Pathways 8.5(RCP8.5) scenario. Compared to preindustrial conditions, more statistically significant extreme temperatures, precipitations, and dry spells are expected in the 21 st century. Cold extremes decrease and warm extremes increase in a warmer world, and cold extremes tend to be more sensitive to global warming than the warm ones. When the global mean temperature increases, cold nights, cold days, and warm nights all display nonlinear relationships with it,such as the weakening of the link projected after 3 °C global warming, while the other indices generally exhibit differently, with linear relationships. Additionally, the relative changes in the indices related to extreme precipitation show significantly consistent linear changes with the global warming magnitude.Compared with the precipitation extremes, changes in temperature extremes are more strongly related to the global mean temperature changes. For the projection of the extreme precipitation changes, models show higher uncertainty than that in extreme temperature changes, and the uncertainty for the precipitation extremes becomes more remarkable when the global warming exceeds 5 °C. | Xiaoxin Wang Dabang Jiang Xianmei Lang | 2017 | Science Bulletin2017，62，24： | 20 |
| 8 | Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women显示文摘 | ZHENG Ting-ping SUN Ai-jun XUE Wei WANG Ya-ping JIANG Ying ZHANG Ying LANG Jing-he | 2013 | Chinese Medical Journal2013，，11： | 15 |
| 9 | Extraseasonal ensemble numerical predictions of winter climate over China显示文摘Using the nine-level Atmospheric General Circulation Model developed at the Institute of Atmospheric Physics (IAP9L-AGCM) under the Chinese Academy of Sciences, 30-year extraseasonal short-term ensemble hincast of winter climate is performed, with integrations starting from annual autumn during 1969—1998. Winter climate predictability over China is then evaluated for the first time. It follows that the predictability is higher in tropics than in extratropics. Also, it is higher over ocean compared with land, especially for surface air temperature. With height increasing in troposphere, the predictability of geopotential height slightly changes zonally, but for weakening of band-ship distribution and dropping near the date line. Of all analyzed variables, the prediction skill of air temperature and geopotential height (precipitation) is the highest (smallest). In addition, the predictability of winter climate over China and even East Asia enhances obviously during ENSO cycle, especially during La Nia phase. Simulation comparison against verifying analysis for surface temperature anomaly exhibits the model抯 skill in predicting surface temperature抯 interannual variation trend in winter. | LANG Xianmei, WANG Huijun & JIANG Dabang Nansen-Zhu International Research Center and LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2003 | Chinese Science Bulletin2003，48，19： | 14 |
| 10 | Mushroom Poisoning Outbreaks-China,2020显示文摘What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population.The most notorious lethal mushrooms are the species from genera Amanita,Lepiota,and Galerina that cause acute liver failure,and Russula subnigricans that leads to rhabdomyolysis.What is added by this report?In 2020,the total number of investigations reached 676,involving an estimated 102 species of poisonous mushrooms,24 of which were newly recorded in China.Gyromitra venenata was newly discovered in incidents in Yunnan and Guizhou provinces and were the first reported poisonings due to gyromitrins in China since 2000.The rare poisoning Shiitake mushroom dermatitis was recorded in China.Hemolysis poisoning caused by Paxillus involutus was recorded for the second time since the beginning of the new century,resulting in one death in Inner Mongolia Autonomous Region.What are the implications for public health practice?Promoting knowledge about safe consumption of mushrooms is essential to reduce mushroom poisonings.It is not wise to collect and eat wild mushrooms.For southwestern provinces such as Yunnan,especially,caution must be exercised with unfamiliar mushroom species. | Haijiao Li Hongshun Zhang Yizhe Zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma Yutao Zhang Ke Wen Yuan Yuan Nan Lang Bowen Cheng Junjia Lu Chengye Sun | 2021 | China CDC weekly2021，3，3： | 13 |
| 11 | Arbuscular mycorrhizal fungi ameliorate the chemical properties and enzyme activities of rhizosphere soil in reclaimed mining subsidence in northwestern China显示文摘In semi-arid region of northwestern China, underground mining subsidence often results in decreased vegetation coverage, impoverishment of soil fertility and water stress. In addition, the physical-chemical and biological properties of soil also change, resulting in more susceptible to degradation. In particular, subsidence causes disturbance of the symbioses of plant and microbe that can play a beneficial role in the establishment of vegetation communities in degraded ecosystems. The objective of this study was to evaluate the effects of revegetation with exotic arbuscular mycorrhizal fungi(AMF) inoculum on the chemical and biological properties of soil over time in mining subsidence areas. Soils were sampled at a depth up to 30 cm in the adjacent rhizosphere of Amorpha fruticose Linn. from five reclaimed vegetation communities in northwestern China. In August 2015, a field trial was set up with five historical revegetation experiments established in 2008(7-year), 2011(4-year), 2012(3-year), 2013(2-year) and 2014(1-year), respectively. Each reclamation experiment included two treatments, i.e., revegetation with exotic AMF inoculum(AMF) and non-AMF inoculum(the control). Root mycorrhizal colonization, glomalin-related soil protein(GRSP), soil organic carbon(SOC), soil nutrients, and enzyme activities were also assessed. The results showed that mycorrhizal colonization of inoculated plants increased by 33.3%–163.0% compared to that of non-inoculated plants(P<0.05). Revegetation with exotic AMF inoculum also significantly improved total GRSR(T-GRSP) and easily extracted GRSP(EE-GRSP) concentrations compared to control, besides the T-GRSP in 1-year experiment and the EE-GRSP in 2-year experiment. A significant increase in SOC content was only observed in 7-year AMF reclaimed soils compared to non-AMF reclaimed soils. Soil total N(TN), Olsen phosphorus(P) and available potassium(K) were significantly higher in inoculated soil after 1–7 years of reclamation(except for individual cases), and increased with reclamation time(besides soil Olsen P). The exotic AMF inoculum markedly increased the average soil invertase, catalase, urease and alkaline phosphatase by 23.8%, 21.3%, 18.8% and 8.6%, respectively(P<0.01), compared with the control. Root mycorrhizal colonization was positively correlated with soil parameters(SOC, TN and soil available K) and soil enzyme activities(soil invertase, catalase, urease and alkaline phosphatase) in both AMF and non-AMF reclaimed soils(P<0.05), excluding availableK in non-AMF reclaimed soils. T-GRSP(P<0.01) and EE-GRSP(P<0.05) were significantly correlated with the majority of edaphic factors, except for soil Olsen P. The positive correlation between root mycorrhizal colonization and available K was observed in AMF reclaimed soils, indicating that the AMF reclaimed soil with a high root mycorrhizal colonization could potentially accumulate available K in soils. Our findings concluded that revegetation with exotic AMF inoculum influenced soil nutrient availability and enzyme activities in the semi-arid ecosystem, suggesting that inoculating AMF can be an effective method to improve soil fertility and support restoration of vegetation communities under poor conditions like soil nutrient deficiency and drought. | QIU Lang BI Yinli JIANG Bin WANG Zhigang ZHANG Yanxu Yryszhan ZHAKYPBEK | 2019 | Journal of Arid Land2019，11，1： | 11 |
| 12 | Mushroom Poisoning Outbreaks--China,2019显示文摘What is already known about this topic?Mushroom poisoning is becoming one of the most serious food safety issues in China,which is responsible for nearly a half of all oral poisoning deaths.What is added by this report?In China,many mushrooms were previously“recorded”as poisonous.In this study,about 70 species obtained from mushroom poisoning incidents including several new records were confirmed accurately by morphological and molecular evidence in 2019,and spatial and temporal distribution characters of 13 lethal mushrooms were summarized systematically.What are the implications for public health practice?Precise and timely species identification is of pivotal importance in mushroom incidents.More efforts and cooperation are continued to be needed urgently for the governments,CDC staff,doctors and mycologists in future. | Haijiao Li Hongshun Zhang Yizhe Zhang Kaiping Zhang Jing Zhou Yu Yin Shaofeng Jiang Peibin Ma Qian He Yutao Zhang Ke Wen Yuan Yuan Nan Lang Junjia Lu Chengye Sun | 2020 | China CDC weekly2020，2，2： | 11 |
| 13 | Monolayer organic field-effect transistors显示文摘Monolayer organic field-effect transistors(OFETs) are attracting worldwide interest in device physics and novel applications due to their ultrathin active layer for two-dimensional charge transport. The monolayer films are generally prepared by thermal evaporation, the Langmuir technique or self-assembly process, etc., but their electrical performance is relatively lower than corresponding thick films. From 2011, the performance of monolayer OFETs has been boosted by using the monolayer molecular crystals(MMCs) as active channels, which opened up a new era for monolayer OFETs. In this review, recent progress of monolayer OFETs, including the preparation of monolayer films, their OFET performance and applications are summarized.Finally, perspectives of monolayer OFETs in the near future are also discussed. | Jie Liu Lang Jiang Wenping Hu Yunqi Liu Daoben Zhu | 2019 | Science China Chemistry2019，62，3： | 7 |
| 14 | Synthesis of Large-Area, Few-Layer Graphene on Iron Foil by Chemical Vapor Deposition显示文摘我们表明一个简单、可控制的方法综合大区域,由优化化学蒸汽免职(CVD ) 的铁底层上的很少层 graphene 用甲烷和氢的混合物的方法。基于 Fe-C 阶段图的分析,为 Fe 表面上的 graphene 的成功的合成的一个合适的过程被设计。适当温度和冷却过程被发现在高度水晶的很少层 graphene 的合成很重要。基于 Graphene 的地效果晶体管(联邦货物税) 设备用产生很少层 graphene 被制作,并且与 3001150 cm2/ 的提取活动性显示出好质量(V 敢椠 ?? 敤瑢吗? | Yunzhou Xue Bin Wu Yunlong Guo Liping Huang Lang Jiang Jianyi Chen Dechao Geng Yunqi Liu Wenping Hu Gui Yu | 2011 | Nano Research2011，4，12： | 7 |
| 15 | 雷帕霉素对小鼠百草枯中毒导致肺纤维化的治疗作用(英文)显示文摘目的:评估雷帕霉素(RAPA)对小鼠百草枯(PQ)中毒导致肺纤维化的治疗作用,并初步探讨其作用机制。创新点:首次在小鼠PQ中毒的模型中证明RAPA可明显抑制肺纤维化,且此作用与转化生长因子-β1(TGF-β1)的抑制相关。方法:将C57BL/6J雄鼠分为对照组(腹腔注射生理盐水)和实验组(腹腔注射10 mg/kg PQ)。实验组根据采用的治疗不同,可分为以下四组:PQ组、PQ+RAPA组、PQ+MP(甲强龙)组和PQ+MP+RAPA组。用苏木精-伊红染色法(H&E)和马松(Masson)三色染色法观察肺组织病理结构变化,用酶联免疫吸附测定(ELISA)试剂盒检测肺组织中的羟脯氨酸(HYP)含量,用免疫组化和免疫印迹的方法检测TGF-β1和α-平滑肌肌动蛋白(α-SMA)的表达水平。结论:本实验中小鼠的肺组织病理染色结果显示,RAPA治疗能缓解肺纤维化导致的病理改变(图3)。ELISA实验结果显示,RAPA治疗28天后可显著降低肺组织中HYP的含量(图4)。免疫组化和免疫印迹实验结果显示,RAPA治疗能明显下调肺组织中TGF-β1和α-SMA的高表达(图5和6)。综上所述,RAPA在治疗PQ中毒导致的肺纤维化中有重要价值。 | Xue SHAO Meng LI Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG Jiang-hua CHEN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 7 |
| 16 | Mushroom Poisoning Outbreaks — China, 2021显示文摘Summary What is already known about this topic?Mushroom poisoning is one of the most serious food safety issues in China.Most poisoning incidents resulted from eating mushrooms causing gastroenteritis and psycho-neurological disorder from which patients usually could fully recover.Most deaths resulted from species causing acute liver failure and rhabdomyolysis,and the remaining deaths were attributed to acute renal failure and hemolysis.What is added by this report?In 2021,the total number of investigations was 327 from 25 provincial-level administrative divisions,involving 923 patients and 20 deaths,and the overall mortality was 2.17%.Overall,74 poisonous mushrooms causing 6 different clinical syndromes were successfully identified,15 of which were newly recorded in China as poisonous mushrooms.What are the implications for public health practice?Considering the potential huge risks for collecting and eating wild mushrooms,we strongly advise not collecting and eating unfamiliar wild mushrooms.Promoting knowledge about poisonous mushrooms is essential and urgent to reduce mushroom poisonings.Precise species identification timely after mushroom poisoning is important for appropriate diagnosis and treatment.Many deaths were ascribed to delayed hospitalization. | Haijiao Li Hongshun Zhang Yizhe Zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma Yutao Zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun | 2022 | China CDC weekly2022，4，3： | 7 |
| 17 | Climate Change of 4℃ Global Warming above Pre-industrial Levels显示文摘Using a set of numerical experiments from 39 CMIP5 climate models, we project the emergence time for 4?C global warming with respect to pre-industrial levels and associated climate changes under the RCP8.5 greenhouse gas concentration scenario. Results show that, according to the 39 models, the median year in which 4?C global warming will occur is 2084.Based on the median results of models that project a 4?C global warming by 2100, land areas will generally exhibit stronger warming than the oceans annually and seasonally, and the strongest enhancement occurs in the Arctic, with the exception of the summer season. Change signals for temperature go outside its natural internal variabilities globally, and the signal-tonoise ratio averages 9.6 for the annual mean and ranges from 6.3 to 7.2 for the seasonal mean over the globe, with the greatest values appearing at low latitudes because of low noise. Decreased precipitation generally occurs in the subtropics, whilst increased precipitation mainly appears at high latitudes. The precipitation changes in most of the high latitudes are greater than the background variability, and the global mean signal-to-noise ratio is 0.5 and ranges from 0.2 to 0.4 for the annual and seasonal means, respectively. Attention should be paid to limiting global warming to 1.5?C, in which case temperature and precipitation will experience a far more moderate change than the natural internal variability. Large inter-model disagreement appears at high latitudes for temperature changes and at mid and low latitudes for precipitation changes. Overall, the intermodel consistency is better for temperature than for precipitation. | Xiaoxin WANG Dabang JIANG Xianmei LANG | 2018 | Advances in Atmospheric Sciences2018，35，7： | 6 |
| 18 | Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences显示文摘AIM:To evaluate the efficacy of centralized culture and possible influencing factors.METHODS:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(H.pylori) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal endoscopy.Gastric mucosal biopsies were taken from the antrum for culture.These biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 h.The culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 test.An additional 5736 biopsies from H.pylori-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory setting.RESULTS:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the H.pylori-positive quality control specimens.In the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport group.In contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter H.pylori samples. | Ya-Nan Gong You-Ming Li Ning-Min Yang Hong-Zhang Li Feng Guo Lang Lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-Chao Shi Wu-Heng Tang Xin-Jian Zhu Wei Shao Xiao-Feng Zhang Xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng Wu Xu-Peng Chen Qiu-Long Ding Hong Ouyang Feng-Zhe Jin Yan-Li Xu Jian-Zhong Zhang | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 19 | Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor显示文摘Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers.Discovery of new multi-target scaffolds are important for developing such agents. A series of five novel acridine analogues,LXL 1-5,were synthesized and their antiproliferative activity against HepC-2 cell lines were evaluated,among which the 9-benzyloxyacridine analogue,LXL-5, showed inhibitory activity against tyrosine kinases,VEGFR-2 and Src.The results of UV-visible absorption spectra and fluorescence emission spectra,as well as DNA topoisomerase I inhibition assay, indicated topoisomerase I inhibitory activity.Our study suggested that acridine scaffold,previously shown to have no multi-target kinase and topoisomerase inhibitory activity,might be potentially developed as a multi-target inhibitor of tyrosine kinases and topoisomerase I. | Xu-Liang Lang Qin-Sheng Sun Yu-Zong Chen Lu-Lu Li Chun-Yan Tan Hong-Xia Liu Chun-Mei Gao Yu-Yang Jiang | 2013 | Chinese Chemical Letters2013，24，8： | 5 |
| 20 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
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