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| 1 | Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism显示文摘This study analyzed the effects of ecological factors on secondary metabolites of Scutellaria baicalensis using two sources:92individual roots of S.baicalensis from all over China,and secondary metabolites,medicinal materials and inorganic element contents obtained from the testing of 92 S.baicalensis rhizosphere soil samples.The study used environmental data from the Genuine Medicinal Material Spatial Analysis Database.Most of the chemical constituents of S.baicalensis were negatively correlated to latitude and positively correlated to temperature;generally,the contents of 21 chemical constituents were higher at low latitudes than that at high latitudes.By gradual regression analysis,it was found that the content of baicalin in S.baicalensis was negatively correlated to latitude and generally the content of inorganic elements in soil was excessively high(excluding Mg and Ca),which has a negative effect on the accumulation of chemical constituents in S.baicalensis.Based on the cluster analysis of 21 constituents,S.baicalensis from different places of origin was divided into two groups,and S.baicalensis was not genuine only in a specific small region.Within the zone from Chifeng,Inner Mongolia to Taibai,Shaanxi is suitable for accumulation of secondary metabolites of S.baicalensis and such a zone represents a suitable distribution and potential genuine producing area. | GUO LanPing WANG Sheng ZHANG Ji YANG Guang ZHAO ManXi MA WeiFeng ZHANG XiaoBo LI Xuan HAN BangXing CHEN NaiFu HUANG LuQi | 2013 | Science China(Life Sciences)2013，56，11： | 7 |
| 2 | Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer显示文摘Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leading to chromatin condensation and transcriptional repression.HDAC inhibitors are considered a new class of anticancer agents and have been shown to alter gene transcription and exert antitumor effects.This paper describes our work on the structural determination and structure-activity relationship(SAR)optimization of tetrahydroisoquinoline compounds as HDAC inhibitors.These compounds were tested for their ability to inhibit HDAC 1,3,6 and for their ability to inhibit the proliferation of a panel of cancer cell lines.Among these,compound 82 showed the greatest inhibitory activity toward HDAC 1,3,6 and strongly inhibited growth of the cancer cell lines,with results clearly superior to those of the reference compound,vorinostat(SAHA).Compound 82 increased the acetylation of histones H3,H4 and tubulin in a concentration-dependent manner,suggesting that it is a broad inhibitor of HDACs. | Danqi Chen Aijun Shen Guanghua Fang Hongchun Liu Minmin Zhang Shuai Tang Bing Xiong Lanping Ma Meiyu Geng Jingkang Shen | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 3 | Inhibition of free radical induced oxidative hemolysis of red blood cells by green tea polyphenols显示文摘The in vitro oxidative hemolysis of human red blood cells (RBC) was used as a model to study the free radical induced damage of biological membranes and the inhibitory effect of natural antioxidants. The hemolysis was induced by a water-soluble free radical initiator 2,2’-azo(2-asmidinopropane)dihydrochloride (AAPH) and inhibited by the principal polyphenolic components extracted from green tea leaves, i.e. (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicat-echin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and gallic acid (GA). Addition of AAPH at 37℃ caused fast hemolysis after a short period of inhibition period, while addition of the green tea polyphenols efficiently suppressed the hemolysis in the activity sequence of EGCG > EGC> ECG ≈EC>GA, demonstrating that these green tea polyphenols are effective antioxidants which could protect biological membranes from free radical induced oxidative damage. | Lanping Ma Zaiqun Liu Bo Zhou Li Yang Zhongli Liu | 2000 | Chinese Science Bulletin2000，45，22： | 3 |
| 4 | Top-geoherbs of traditional Chinese medicine:common traits,quality characteristics and formation显示文摘Top-geoherbs used in China are always featured with high qualities,and they grow in specified areas with specific environment.Recently,researches on top-geoherbs have attracted increasing attention in China and other countries.In order to have a thorough knowledge of top-geoherbs,this article reviews the concept,historical evolution,common trait and quality characteristics of top-geoherbs,and explains the forming mechanism including genetic mechanism and environmental mechanism.In addition,it introduces the influence of human factors on the quality of top-geoherbs.Finally,it proposes some problems that should be paid attention to in the researches on top-geoherbs. | Luqi Huang Lanping Guo Chaoyi Ma Wei Gao Qingjun Yuan | 2011 | Frontiers of Medicine2011，5，2： | 2 |
| 5 | Inhibition of free radicalinduced peroxidation of rat liver microsomes by resveratrol and its analogues显示文摘 | CAI Yujun FANG Jianguo MA Lanping | 2003 | Biochimica et Biophysica Acta2003，1637，1： | 1 |
| 6 | Antioxidant effects of green tea polyphenols on fxee radical initiated peroxidation of rat liver microsomes显示文摘 | CAI YUJUN MA LANPING HOU LIFEN | 2002 | Chem Phys Lipids2002，120，12： | 1 |
| 7 | Amorphization of Co-Nb Magnetic Alloys by Mechanical Alloying显示文摘Formation of amorphous Co-Nb system by mechanical alloying(MA)in the composition range of Co_(25)Nb_(75)-Co_(70)Nb_(30) was studied by X-ray diffraction.Magnetic properties of the mechanically alloyed Co_(70)Nb_(30) powder were measured.The variation in H_(c) curve with milling time can be explained by two-stage mechanism involved in the milling process.The results show that the amorphous powder prepared by MA is of good soft magnetic properties. | MA Xueming YUE Lanping DONG Yuanda | 1991 | Chinese Physics Letters1991，8，8： | 1 |
| 8 | MECHANICAL REDUCTION OF CuO BY Mg AT ROOM TEMPERATURE显示文摘The mechanical reduction of CuO by pure metallic Mg has been investigated during pulver-izing in ball mill at room temperature.The reduction was towards its completion of an averageparticle size down to 20 nm after milling for 32 h.The mechanism of the mechanical reductionof oxides seems to be the surface activation of nano-metre sized particles driven by mechani-cal force. | MA Xueming YUE Lanping DONG Yuanda Institute of Solid State Physics,Academia Sinica,Hefei,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，3： | 0 |
| 9 | Comment on Two American Writers and Their Works显示文摘Wil1iam Bradford’s of Playmouth PlantationIt has been nearly five hundred years sinca America was discovered. But American litera-ture did not began to develop until the colonial period when the English began to settle on thenorth Amerincan continent in the early part of the seventeenth century. Colonial | Ma Lanping | 1996 | 中州大学学报1996，13，4： | 0 |
| 10 | Gut liver brain axis in diseases:the implications for therapeutic interventions显示文摘Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous systems.In the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment strategies.In this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain axis.Some therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain axis.Besides,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)analogs.Targeting gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related therapies.Targeting liver-brain axis contains epigenetic regulation and Aβmetabolism-related therapies.In the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases. | Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
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