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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 3 | SimpleScalar:An Infrastructure for Computer System Modeling显示文摘 | Austin T Larson E Ernst D | 2002 | IEEE Computer2002，35，2： | 1 |
| 4 | Observed microphysical structure of midlevel, mixed-phase ctouds显示文摘 | Fteishauer R P V E Larson T H Vonder Haar | 2002 | J Atmos Sci2002，59，： | 1 |
| 5 | Requirement for 3-Ketoacyl-CoA Thiolase-2 in Peroxisome Development,Fatty Acid Beta-Oxidation and Breakdown of Triacylglycerol in Lipid Bodies of Arabidopsis seedlings显示文摘 | Germain V Rylott E L Larson T R | 2001 | Plant J2001，28，： | 1 |
| 6 | Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly populationfrom Seattle显示文摘 | OLSEN G W CHURCH T R LARSON E B | 2004 | Washington Chemosphere2004，54，： | 1 |
| 7 | SimpleScalar : an infrastructure for computer system modeling显示文摘 | Austin T Larson E Ernst D | 2002 | Computer2002，35，2： | 1 |
| 8 | Calcium carbonate saturation index and alkalinity interpretations 显示文摘 | LARSON T E BUSWELL A M | 1942 | Journal of American Water Works Association1942，34，11： | 1 |
| 9 | A randomized tri- al of high-dose compared with low-dose omegas3 fatty acids in se- vere IgA nephropathy显示文摘 | Donadio J V Jr Larson T S Bergstralh E J | 2001 | J Am Soc Nephrol2001，12，4： | 1 |
| 10 | Skeletal muscle me- tabolism in endurance athletes with near-infrared speetroscopy显示文摘 | Brizendine J T Ryan T E Larson R D | 2013 | Med Sei Sports Exerc2013，45，5： | 1 |
| 11 | Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors显示文摘 | OJO K K LARSON E T KEYLOUN K R | 2010 | Nat Struct Mol Biol2010，17，5： | 1 |
| 12 | Denitrification of wastewater influents with methane显示文摘 | Sollo F W Mueller H F Larson T E | 1976 | Journal of Water Pollution Control Fed1976，48，7： | 1 |
| 13 | Current research on corrosion and tuberculation of cast iron 显示文摘 | LARSON T E SKOLD V | 1958 | Journal of American Water Works Association1958，50，11： | 1 |
| 14 | Simple Scalar:An Infrastructure for Computer System Modeling显示文摘 | Austin T Larson E Dan E | 2002 | Computer2002，35，2： | 1 |
| 15 | Feeding value of wet distillers byproducts for finishing ruminants显示文摘 | Larson E M Stock R A Klopfenstein T J | 1993 | Journal of Animal Science1993，71，： | 1 |
| 16 | Molecular phylogeneties of Squamata : the position of snakes, am- phisbaenians ,and dibamids ,and the root of the squamate tree显示文摘 | TOWNSEND T M LARSON A LOUIS E | 2004 | Systematic Biology2004，53，5： | 1 |
| 17 | Corrosion and tuberculation of cast iron 显示文摘 | Larson T E Skold R V | 1957 | Journal American Water Works Association1957，49，10： | 1 |
| 18 | Gastric evacuation of three food types in the black and yellow rockfish Sebastes chrysomelas 显示文摘 | HOPKINS T E LARSON R J | 1990 | Journal of Fish Biology1990，36，5： | 1 |
| 19 | Foot strike patterns of recreational and sub-elite runners in a long-distance road race显示文摘 | Larson P Higgins E Kaminski J Decker T Preble J Lyons D | | 0，，： | 1 |
| 20 | Nature and origin of hematite in the Moenkopi Formation(Triassic),Colorado Plateau:A contribution to the origin of magnetism in red beds显示文摘 | Walker T R Larson E E Hoblitt R P | 1981 | Journal of Geophysical Research Atmospheres1981，86，1： | 1 |
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