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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Fluorodeoxyglucose positron emission tomography as an outcome measure for castrate metastatic prostate cancer treated with antimicrotubule chemotherapy显示文摘 | Morris M J Akhurst T Larson SM | 2005 | Clin- ical cancer research : an official journal of the American Association for Cancer Research2005，11，： | 1 |
| 4 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 5 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 6 | Coalition Structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M Shehory O Tohme F | 1999 | Artificial Intelligence1999，111，12： | 1 |
| 7 | Scaling in the Safety of Next Generation Reactors 显示文摘 | Banerjee S Ortiz M Q Larson T K | 1998 | Nuclear Engineering and Design1998，186，： | 1 |
| 8 | Multiple biomarkers and the risk of inciden hypertension显示文摘 | WANG T J GONA P LARSON M G | 2007 | Hypertension2007，49，： | 1 |
| 9 | Three dimensional atom probe investigation of vanadium nitride precipitates and the role of oxygen and boron in rapidly solidified 316 stainless steel 显示文摘 | Kelly T F Larson D J Miller M K | 1999 | Materials Science and Engineering1999，270，： | 1 |
| 10 | Calcium carbonate saturation index and alkalinity interpretations 显示文摘 | LARSON T E BUSWELL A M | 1942 | Journal of American Water Works Association1942，34，11： | 1 |
| 11 | Leadership style and the discussion of shared and unshared information in decision- making groups显示文摘 | LARSON J R FOSTER-FISHMAN P G FRANZ T M | 1998 | Personality and Social Psychology Bulletin1998，24，5： | 1 |
| 12 | Increased prostatic blood flow in response to microwave ghermal treatment:preliminary findings in two patients with benign prostatic hyperplasia显示文摘 | Larson T R Collins J M | 1995 | Urology1995，46，： | 1 |
| 13 | A numerical model of beach morphological evolution due to waves and currents in thevicinity of coastal structures显示文摘 | Nam P T Larson M Hanson H | 2011 | Coastal Engineering2011，58，： | 1 |
| 14 | An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment显示文摘 | Rubio S Larson T R Gonzalez-Guzman M | | 0，，03： | 1 |
| 15 | Coalition structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M | 1999 | Artif Intell1999，111，12： | 1 |
| 16 | Feeding value of wet distillers byproducts for finishing ruminants显示文摘 | Larson E M Stock R A Klopfenstein T J | 1993 | Journal of Animal Science1993，71，： | 1 |
| 17 | Coalition structure generation with worst case guarantees显示文摘 | Sandholm T W Larson K Andersson M | 1999 | Artificial Intelligence1999，111，12： | 1 |
| 18 | Molecular phylogeneties of Squamata : the position of snakes, am- phisbaenians ,and dibamids ,and the root of the squamate tree显示文摘 | TOWNSEND T M LARSON A LOUIS E | 2004 | Systematic Biology2004，53，5： | 1 |
| 19 | Primary spi nal melanoma显示文摘 | Larson Ⅲ T C Houser O W Onofrio B M | 1987 | Neurosurg1987，66，1： | 1 |
| 20 | Coalition struc- ture generation with worst case guarantees显示文摘 | Sandholm T Larson K Andersson M | 1999 | Artificial Intelligence Journal1999，111，12： | 1 |
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