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| 1 | New reference trajectory optimization algorithm for a flight management system inspired in beam search显示文摘With the objective of reducing the flight cost and the amount of polluting emissions released in the atmosphere, a new optimization algorithm considering the climb, cruise and descent phases is presented for the reference vertical flight trajectory. The selection of the reference vertical navigation speeds and altitudes was solved as a discrete combinatory problem by means of a graphtree passing through nodes using the beam search optimization technique. To achieve a compromise between the execution time and the algorithm's ability to find the global optimal solution, a heuristic methodology introducing a parameter called ‘‘optimism coefficient was used in order to estimate the trajectory's flight cost at every node. The optimal trajectory cost obtained with the developed algorithm was compared with the cost of the optimal trajectory provided by a commercial flight management system(FMS). The global optimal solution was validated against an exhaustive search algorithm(ESA), other than the proposed algorithm. The developed algorithm takes into account weather effects, step climbs during cruise and air traffic management constraints such as constant altitude segments, constant cruise Mach, and a pre-defined reference lateral navigation route. The aircraft fuel burn was computed using a numerical performance model which was created and validated using flight test experimental data. | Alejandro MURRIETA-MENDOZA Bruce BEUZE Laurane TERNISIEN Ruxandra Mihaela BOTEZ | 2017 | Chinese Journal of Aeronautics2017，30，4： | 4 |
| 2 | 树突状细胞自然杀伤细胞凝集素群受体1促进小鼠动脉粥样硬化的发展显示文摘动脉粥样硬化发展过程中的坏死核心形成与慢性炎症反应有关,其促进斑块发展加快和不稳定。然而,坏死与动脉粥样硬化发展之间的分子生物学联系机制尚未完全清楚。 | 刘莉 叶鹏 Haddad Y Lahoute C Clément M Laurans L Metghalchi S Lynda Z Giraud A Loyer X Vandestienne M Wain-Hobson J Esposito B Potteaux S Ait-Oufella H Tedgui A Mallat Z Taleb S | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 3 | Diagnostic value of a new procalcitonin cord sample-guided algorithm to manage newborns suspected of early-onset infection显示文摘 | Cabaret B Laurans C Launay E | 2013 | Arch Pediatr2013，20，9： | 1 |
| 4 | Coexistence of SHV-4-and TEM-24-producing enterobacter aerogenes strains before a large outbreak of TEM-24-producing strians in a French hospial 显示文摘 | Mammeri H Laurans G Eveillard M | 2001 | J Clin Microbiol2001，39，6： | 1 |
| 5 | Oc026—Impact Of Circulating Levels Of Interleukin-17 And Cardiovascular Outcomes In Patients With Acute Myocardial Infarction显示文摘 | T. Simon S. Taleb N. Danchin L. Laurans B. Rousseau S. Simon Cattan J.-M. Montely O. Dubourg A. Tedgui S. Kotti Z. Mallat | 2013 | Clinical Therapeutics2013，，8： | 1 |
| 6 | Histological aspects of a hypersensitive response in poplar to Melampsora lari-populina显示文摘 | PILATE G | 1999 | Biochemistry and Cell Biology1999，89，3： | 1 |
| 7 | Normalisation in product life cycle assessment: An LCA of the global and European economic systems in the year 2000显示文摘 | Anneke Wegener Sleeswijk Lauran F.C.M. van Oers Jeroen B. Guinée Jaap Struijs Mark A.J. Huijbregts | 2007 | Science of the Total Environment2007，，1： | 1 |
| 8 | Molecular characterization and mechanisms of resistance of multidrug-resistant human Salmonella enterica serovar typhimurium isolated in Amiens(France)显示文摘 | Biendo M Laurans G Thomas D | 2005 | Int J Antimicrob Agents2005，26，3： | 1 |
| 9 | Histological aspects of a hypersensitive response in poplar to Melampsora larici-populina显示文摘 | Laurans F Pilate G | 1999 | Phytopathology1999，89，： | 1 |
| 10 | Normalisation in product life cycle assessment: An LCA of the global and European economic systems in the year 2000显示文摘 | Anneke Wegener Sleeswijk Lauran F.C.M. van Oers Jeroen B. Guinée Jaap Struijs Mark A.J. Huijbregts | 2007 | Science of the Total Environment2007，，1： | 1 |
| 11 | Rotordynamic evaluation of a near-tangential-injection hybrid bearing显示文摘 | Lauran F T Childs D W | | 0，，04： | 1 |
| 12 | Chromsomal location,exon structure and vascular expression patterns of the human PDGF-C and PDGF-D genes显示文摘 | Uutela M Lauran J Bergsten E | 2001 | Circulation2001，103，18： | 1 |
| 13 | Distribution of macrophage polarization markers in human atherosclerosis 显示文摘 | Lauran S J Marion JG Saskiavan der Velden | 2012 | Atherosclerosis2012，225，2： | 1 |
| 14 | Normalisation in product life cycle assessment:an LCA of the global and European economic systems in the year 2000显示文摘 | Anneke W S Lauran F C M Jeroen B | | 0，，01： | 1 |
| 15 | Diagnostic val- ue of a new procalcitonin cord sample-guided algorithm to man- age newbornssuspected of early-onset infection 显示文摘 | CABARET B LAURANS C LAUNA E | 2013 | Arch Pedi- atr2013，20，9： | 1 |
| 16 | Molecular diversity of Proteus mirabilis isolates producing extended - spectrum beta - lactamases in a French university hospital显示文摘 | Biendo M Thomas D Laurans G | 2005 | Clin Microbiol Infect2005，11，5： | 1 |
| 17 | Diagnostic value of a new procalcitonin cord sample-guided algorithm to manage newborns suspected of early-onset infection显示文摘 | Cabaret B Laurans C Launay E | 2013 | Arch Pediatr2013，20，9： | 1 |
| 18 | KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule associated protein 显示文摘 | GUNEL M LAURANS M S SHIN D | 2002 | Proc Natl Acad Sci USA2002，99，10： | 1 |
| 19 | Long-term survival for patients with non-small-cell lung cancer with intratu- moral lymphoid structures显示文摘 | Dieu-Nosjean MC Antoine M Danel C Heudes D Wislez M Poulot V Rabbe N Laurans L Tartour E de Chaisemartin L | 2008 | J Clin Oncol2008，26，： | 1 |
| 20 | Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance显示文摘 | Cherfils-Vicini Julien Platonova Sophia Gillard Mélanie Laurans Ludivine Validire Pierre Caliandro Rafaele Magdeleinat Pierre Mami-Chouaib Fathia Dieu-Nosjean Marie-Caroline Fridman Wolf-Herman Damotte Diane Sautès-Fridman Catherine Cremer Is | 2010 | Journal of Clinical Investigation2010，，4： | 1 |
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