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| 1 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 2 | TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!显示文摘Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas.This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic.TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed,and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations.Therefore,immunohistochem-istry for TTF-1 in such tumours should be interpreted with caution. | Laurine Verset Marianna Arvanitakis Patricia Loi Jean Closset Myriam Delhaye Myriam Remmelink Pieter Demetter | 2011 | World Journal of Gastrointestinal Oncology2011，3，10： | 2 |
| 3 | Common polymorphism in the PNPLA3 /adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Eric Trépo Thierry Gustot Delphine Degré Arnaud Lemmers Laurine Verset Pieter Demetter Romy Ouziel Eric Quertinmont Vincent Vercruysse Leila Amininejad Pierre Deltenre Olivier Le Moine Jacques Devière Denis Franchimont Christophe Moreno | 2011 | Journal of Hepatology2011，，4： | 2 |
| 4 | Dynamic interactions between HVDC systems connected to AC buses in close proximity 显示文摘 | Bui L X Sood V K Laurin S | 1991 | IEEE Transactions on Power Delivery1991，6，1： | 2 |
| 5 | Liver Transplantation in the Management of Hepatic Epithelioid Hemangioendothelioma: A Single-Center Experience and Review of the Literature显示文摘 | N. Agrawal S. Parajuli P. Zhao R. Satoskar J. Laurin N. Azumi C. Matsumoto K. Shetty | 2011 | Transplantation Proceedings2011，，7： | 2 |
| 6 | Ursdeoxycholic acid or clofibrate in the treatment of non-clcohol-induced steatohepatitis: A pilot study显示文摘 | Laurin KD Crippin JS | 1996 | Hepatoloqy1996，2，： | 1 |
| 7 | Design of an electronically beamscanning reflectarray using aperture-coupled elements显示文摘 | RIEL M LAURIN | 2007 | IEEE Transaction on Antennas and Propagation2007，55，5： | 1 |
| 8 | PAP IB, a new member of the Reg gene family: Cloning, expression, structural properties, and evolution by gene duplication显示文摘 | Emmanuelle Laurine Xavier Manival Claudine Montgelard Chantal Bideau Jean-Louis Bergé-Lefranc Monique érard Jean-Michel Verdier | 2005 | BBA - Gene Structure and Expression2005，，3： | 1 |
| 9 | Rate of mortality for elderly patients after fracture of the hip in the 1980's显示文摘 | White B L Fisher W D Laurin C A | 1987 | J Bone Joint Surg(Am)1987，69，9： | 1 |
| 10 | Ursodcoxycholic acid or clofibrate in the treatment of non - alcohol - induced steatohepatitis:a pilot study显示文摘 | Laurin J Lindor KD Crippin JS | 1996 | Hepatology1996，23，1： | 1 |
| 11 | Risk factors for Alzheimer's disease: a prospective analysis from the Canadian study of health and aging显示文摘 | Lindsay J Laurin D Verreault R | 2002 | Am J Epidemiol2002，156，： | 1 |
| 12 | Development of a fast PCR protocol enabling rapid generation of AmpFLSTRIdentifilerprofiles for genotyping of human DNA显示文摘 | Foster A Laurin N | 2012 | Investig Genet2012，3，1： | 1 |
| 13 | Study of a CPW inductively coupled slot antenna显示文摘 | Santiago S G Jean-Jacques Laurin | 1999 | IEEE Transactions on antennas and propagation1999，47，1： | 1 |
| 14 | Physical restraint use among nursing home residents:A comparison of two data collection methods显示文摘 | Laurin D Voyer P Verreault R | 2004 | BMC Nurs2004，3，1： | 1 |
| 15 | Multiple independent appearances of the cecal appendix in mammalian evolution and an investigation of related ecological and anatomical factors显示文摘 | Heather F. Smith William Parker Sanet H. Kotzé Michel Laurin | 2012 | Comptes rendus - Palevol2012，，： | 1 |
| 16 | Above ground biomass estimation in an African tropical forest with lidar and hyperspectral data显示文摘 | Gaia Vaglio Laurin Qi Chen Jeremy A. Lindsell David A. Coomes Fabio Del Frate Leila Guerriero Francesco Pirotti Riccardo Valentini | 2014 | ISPRS Journal of Photogrammetry and Remote Sensing2014，，： | 1 |
| 17 | Dynamic interactions between HVDC systems connected to AC buses显示文摘 | BUI L X SOOD V K LAURIN S | 1991 | IEEE Trans on Power Delivery1991，6，1： | 1 |
| 18 | Physical activity and risk of cognitive impairment and dementia in elderly persons 显示文摘 | Laurin D Verreault R Lindsay J | 2001 | Arch Neurol2001，58，3： | 1 |
| 19 | The tangential x-ray investigation of the patello-femoraljoint: X-ray technique,diagnostic criteria and their interpretation显示文摘 | Laurin CA Dussault R Levesque HP | 1979 | Clin Orthop Relat Res1979，，144： | 1 |
| 20 | Physical activity and risk of cognitive decline impair-ment and dementia in elderly persons显示文摘 | Laurin d Verreault R Lindsay J | 2001 | Arch Neurol2001，58，： | 1 |
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