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| 1 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 2 | Decreased expression of protease-activated receptor 4 in human gastric cancer显示文摘 | Yong Zhang Guoyu Yu Ping Jiang Yang Xiang Wenliang Li Wenhui Lee Yun Zhang | 2011 | International Journal of Biochemistry and Cell Biology2011，，9： | 2 |
| 3 | Cloning and characterization of a blood coagulation factor Ⅸ-binding protein from the venom of Trimeresurus stejnegeri显示文摘 | Lee Wenhui Zhuang Qingying Zhang Yun | 2003 | Toxicon2003，41，2： | 1 |
| 4 | Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ显示文摘 | Li Qiang Liheng Wang Ning Kon Wenhui Zhao Sangkyu Lee Yiying Zhang Michael Rosenbaum Yingming Zhao Wei Gu Stephen R. Farmer Domenico Accili | 2012 | Cell2012，，3： | 1 |
| 5 | Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ显示文摘 | Li Qiang Liheng Wang Ning Kon Wenhui Zhao Sangkyu Lee Yiying Zhang Michael Rosenbaum Yingming Zhao Wei Gu Stephen R. Farmer Domenico Accili | 2012 | Cell2012，，3： | 1 |
| 6 | Osteoking downregulates Mgp in an osteoporotic fracture rat model显示文摘OBJECTIVE: To investigate the effectiveness of osteoking, a Traditional Chinese Medicine originating from Yi nationality, against osteoporosis(OP) and osteoporotic fracture(OPF), and to elucidate its mechanism of action.METHODS: An osteoporotic fracture rat model was established;animals were divided into three treatment groups: parathyroid hormone, osteoking and0.9%NaCl. After 4, 8 and 12 weeks of treatment, serum and bone tissues were collected. Enzyme-linked immuno sorbent assay, x-ray, histopathological evaluation and proteomics were used.Proteomics and GO annotation were performed based on identified peptides. The relative network was obtained from the STRING database and verified by polymerase chain reaction and Western blotting.RESULTS: After osteoking treatment, the bone mineral density(BMD) increased with time in the osteoking group. At week 12, the BMD and bone mineral salt content of the osteoking group were 4.5%and 20.6% higher than those of the negative control group, respectively. Furthermore, the body weight followed the order of positive control group > osteoking group > negative control group,with significant differences among the groups(P <0.05). Micro-CT analysis of femur sections revealed that the bone surface/volume ratio was significantly higher in the osteoking group than that in the negative control group. X-ray images demonstrated that the osteoking group showed clear callus.Moreover, high-voltage micro-CT demonstrated a massive cortical bone accumulation in the osteoking group. The gray values of callus in the osteoking group were higher than those in the negative group. From week 4 to 12, the serum bone alkaline phosphatase level increased by 49.6% in the osteoking group and the serum propeptide of type procollagen level decreased by 80.6%. Alizarin reⅠd staining demonstrated that the calcium deposition in the osteoking group was higher than that in the negative control group. Notably, the expression of Mgp, a key osteogenesis inhibitor, was lower in the osteoking group compared with the negative control group. Moreover, Sparc, bone morphogenetic protein-2 and Bglap expression was higher in the osteoking group through activation of the transforming growth factor-receptor activator of nuclear factor κB Ligand pathway.CONCLUSION: Osteoking treatment increased bone quality and promoted calcium deposition.The results suggest that osteoking inhibits Mgp through the TGF-β/RANKL pathway to improve OP/OPF. | Sun Yan Wang Xiaoqi Chen Ran Zhu Di Shen Zhiqiang Zhao Hongbin Lee Wenhui | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 1 |
| 7 | A snake venom metalloproteinasc that inhibited cell proliferation and induced morphological changes of ECV304 cells 显示文摘 | Wan Shaogui Jin Yang Lee Wenhui | 2006 | Toxicon2006，47，： | 1 |
| 8 | Obituary:Prof.Yun Zhang(1963-2023)-A scientist focused on toxins and their underlying mechanisms to decipher human diseases显示文摘Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university. | Wenhui Lee Ren Lai | 2024 | Zoological Research2024，45，1： | 0 |
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