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| 1 | Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma显示文摘 | Tao Liu Gang Chen Dawei Sun Minghui Lei Yongqiang Li Changming Zhou Xiaodong Li Wei Xue Hong Wang Chunjun Liu Jiang Xu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，9： | 22 |
| 2 | Germplasm Diversity of Chinese Kale in China显示文摘Chinese kale is an important vegetable crop in China, especially in South China where the majority of varieties are grown. It originated in South China and spread throughout Southeast Asia thereafter. Chinese kale can be classified into two types according to whether the petals are white or yellow. There are also three main cultivated types based on the edible organs, including the stalk and leaf type, the stalk type,and the leaf type. Two primary types have also been defined based on stalk color, including green stalks and red stalks. They are also cultivated based on the type of stalk, including main stalk and lateral stalk types. Significant differences have also been observed in glucosinolate content among the varieties, and a 40-fold difference in neoindle-3-methyl glucosinolate was detected across the cultivars. | LEI Jianjun CHEN Guoju CHEN Changming CAO Bihao | 2017 | Horticultural Plant Journal2017，3，3： | 11 |
| 3 | Identification and Characterization of a LEA-like Gene, CaMF5,Specifically Expressed in the Anthers of Male-fertile Capsicum annuum显示文摘To improve the understanding of molecular mechanisms of anther and/or pollen development in Chili pepper, in the present study, fulllength cDNA and DNA sequences of the pollen development-related gene CaMF5 were obtained from the anthers of a Capsicum annuum nuclear male-fertile line. Sequence analysis indicated that the full length of CaMF5 was 747 bp, containing a maximum opening reading frame of 447 bp.Amino acid sequence alignment and phylogenetic analysis revealed that CaMF5 shared approximately 37%–77% homology with a series of uncharacterized or hypothetical proteins and late embryogenesis abundant(LEA) proteins from other plants. However, no LEA structural domain was detected in CaMF5, which indicated that it might be a new type of LEA gene. CaMF5 was only expressed in flower buds at stages 7 and 8 and in open flowers of the male-fertile line, whereas it exhibited no expression in any examined organs of the male-sterile line. In addition, CaMF5 showed the highest transcript abundance in the anthers of the male-fertile line, with no expression being detected in any other examined organs, such as the sepals, petals, pistils, roots, stems, or leaves. Taken together, our results suggest that CaMF5 is an anther-specific gene that might encode a new type of LEA protein related to anther and/or pollen development in C. annuum. | Yudan Wang Guoju Chen Jianjun Lei Bihao Cao Changming Chen | 2020 | Horticultural Plant Journal2020，6，1： | 6 |
| 4 | Coexpression network analysis reveals an MYB transcriptional activator involved in capsaicinoid biosynthesis in hot peppers显示文摘Plant biosynthesis involves numerous specialized metabolites with diverse chemical natures and biological activities.The biosynthesis of metabolites often exclusively occurs in response to tissue-specific combinatorial developmental cues that are controlled at the transcriptional level.Capsaicinoids are a group of specialized metabolites that confer a pungent flavor to pepper fruits.Capsaicinoid biosynthesis occurs in the fruit placenta and combines its developmental cues.Although the capsaicinoid biosynthetic pathway has been largely characterized,the regulatory mechanisms that control capsaicinoid metabolism have not been fully elucidated.In this study,we combined fruit placenta transcriptome data with weighted gene coexpression network analysis(WGCNA)to generate coexpression networks.A capsaicinoid-related gene module was identified in which the MYB transcription factor CaMYB48 plays a critical role in regulating capsaicinoid in pepper.Capsaicinoid biosynthetic gene(CBG)and CaMYB48 expression primarily occurs in the placenta and is consistent with capsaicinoid biosynthesis.CaMYB48 encodes a nucleus-localized protein that primarily functions as a transcriptional activator through its C-terminal activation motif.CaMYB48 regulates capsaicinoid biosynthesis by directly regulating the expression of CBGs,including AT3a and KasIa.Taken together,the results of this study indicate ways to generate robust networks optimized for the mining of CBG-related regulators,establishing a foundation for future research elucidating capsaicinoid regulation. | Binmei Sun Xin Zhou Changming Chen Chengjie Chen Kunhao Chen Muxi Chen Shaoqun Liu Guoju Chen Bihao Cao Fanrong Cao Jianjun Lei Zhangsheng Zhu | 2020 | Horticulture Research2020，7，1： | 5 |
| 5 | Analysis of Vitamin P Content and Inheritance Models in Eggplant显示文摘The eggplant(Solanum melongena L.)is rich in vitamin P(also known as rutin),which is beneficial for humans.In this study,the vitamin P contents of 53 eggplant lines were measured via UV spectrophotometry.The results showed that the vitamin P content differed significantly among the eggplant lines and the actual contents of vitamin P in fresh fruit pulp and fresh peel were 0.18–0.82mg·g^−1 and 0.42–2.32mg·g^−1,respectively.Furthermore,themixed major gene and polygene inheritance modelmethod was used for the inheritance analysis of the vitamin P content in F2 populations of three hybridization combinations.Inheritance analysis demonstrated that the vitamin P content of these eggplant lines was a quantitative trait.One or two major genes were the contributor,and the genetic effect was an additive-dominance effect.The high vitamin P content trait was regulated by the main gene and followed an additive effect.The heritability of the major genes controlling the high vitamin P content was low,while the heritability of the major gene that controls the low vitamin P content trait was high.These results provide a theoretical basis for the breeding of eggplants with high vitamin P content. | Riyue Dong Bingwei Yu Shuangshuang Yan Zhengkun Qiu Jianjun Lei Changming Chen Ye Li Bihao Cao | 2020 | Horticultural Plant Journal2020，6，4： | 3 |
| 6 | Grain Refiner for TiAl Intermetallic Compounds显示文摘The effect of BN addition on the grain size and rnechanical properties of Ti-34.1 wt-%Al alloy was investigated. It has been found that BN is an effective grain refiner for TiAl base alloys, The addition of a small arnount of BN to TiAl can change the coarse columnar grains of as-cast rnicrostructure into the fine equiaxed grains. It has been also determined that Ti-34.1 wt-%Al-1.0 wt-%BN alloy has better mechanical properties and | Yuehui HE Yexiang LIU Baiyun HUANG Xuanhui QU and Changming LEI (Powder Metallurgy Research Institute, Central South University of Technology, Changsha, 410083, China) | 1994 | Journal of Materials Science & Technology1994，10，3： | 2 |
| 7 | 基于转录组denovo拼接鉴定辣椒(Capsicum frutescens)中辣椒素生物合成相关基因显示文摘辣椒素是由辣椒果实产生的一组化合物,被广泛应用于许多领域,尤其是医药行业。辣椒素生物合成途径还没有被清楚地确定。为了解更多辣椒素生物合成的知识,我们对辣椒(Capsicum frutescens L.)胎座和果皮的混合材料进行了转录组测序。并使用不同的拼接软件对各拼接参数的影响进行了评估,最终获得了转录组数据de novo拼接的最佳策略之一。我们利用Trinity软件得到共54 045条高质量unigenes(转录物)。约92.65%的unigenes与马铃薯、番茄和辣椒(C.annuum)ESTs数据库公共蛋白序列和基因组有相似性。我们预测到了3个新的结构基因(DHAD,TD,PAT),填补了由Mazourek提出的辣椒素分子合成途径中的空缺,并且以KEGG(京东基因与基因组百科全书)分析为基础,鉴定到了参与辣椒素生物合成新的候选基因。大量的SSR(简单重复序列)和SNP(单核苷酸多态性)标记在C.frutescens和C.annuum序列中被预测到,这些标记可在识别辣椒群体多态性方面提供帮助。这些数据将为辣椒素生物合成途径及相关研究提供新的思路。此外,我们的转录组de novo拼接策略也可用于其他大量类似研究中。 | Liu Shaoqun Li Wanshun Wu Yimin Chen Changming Lei Jianjun 高凌云 孔秋生 | 2014 | 辣椒杂志2014，，1： | 2 |
| 8 | Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy显示文摘We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugsconjugated polydopamine nanoparticles(PDOXCBs),which integrated near infrared(NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle.Upon a mild NIR irradiation(808 nm,1 W/cm^(2),10 min),PDOXCBs gradually heated aqueous solution over 12.8-13.9℃,which accordingly enhanced in vitro dual doxorubicin(DOX) and chlorambucil(CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,L-dithiothreitol(DTT).The combination photothermal-cocktail chemotherapy(PTT-CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration(IC_(50)) of 2.23 μg/mL and a combination index of0.36,displaying a superior synergistic effect between PTT and CCT in vitro. | Lei Zhou Chang Du Rong Zhang Changming Dong | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 9 | Application of a wax-based binder in PIM of WC–TiC–Co cemented carbides显示文摘 | Xuanhui Qu Jianxiang Gao Mingli Qin Changming Lei | 2005 | International Journal of Refractory Metals and Hard Materials2005，，4： | 1 |
| 10 | MICROSTRUCTURE AND MECHANICAL PROPERTIES OF TiAl+Nd ALLOYS显示文摘MICROSTRUCTUREANDMECHANICALPROPERTIESOFTiAl+NdALLOYS￥LeiChangming;HeYuehui;ChenShiqi;QuXuanhui;HuangBaiyun(Researchinstituteo... | Lei Changming He Yuehui Chen Shiqi Qu Xuanhui Huang Baiyun(Research institute of powder MetallurgyCentral South University of Technology, Changsha 410083) | 1996 | 中国有色金属学会会刊:英文版1996，6，3： | 1 |
| 11 | Preparation of konjac glucomannan ester of palmitic acid and its emulsification 显示文摘 | Tian Bingshou Dong Changming Chen Lei | 1998 | J Appl Polym Sci1998，67，： | 1 |
| 12 | Sorption and desorption kinetics of phthalates and phenol on water/sediment interface显示文摘Sorptionanddesorptionkineticsofphthalatesandphenolonwater/sedimentinterfaceYeChangming,ZhaoWushan,LiTie,LeiZhifang,YanHaiRes... | Ye Changming, Zhao Wushan, Li Tie, Lei Zhifang, Yan Hai Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China | 1997 | Journal of Environmental Sciences1997，9，3： | 1 |
| 13 | Preparation of konjac glucomannan ester of palmitic acid and its emulsification显示文摘 | TIAN Bingshou DONG Changming CHEN Lei | 1998 | J Appl Polym Sci1998，67，6： | 1 |
| 14 | Noninvasive Renal Denervation for Resistant Hypertension Using High-Intensity Focused Ultrasound显示文摘 | Shunkang Rong Hui Zhu Dichuan Liu Jun Qian Kun Zhou Que Zhu Yonghong Jiang Gang Yang Changming Deng Dengqing Zhang Qi Zhou Han Lei Tong-Chuan He Zhibiao Wang Jing Huang | 2015 | Hypertension2015，，4： | 1 |
| 15 | Polarisation-insensi-tive strip-loaded waveguide for electro-optic modulators and switches显示文摘 | SUN Jie CHEN Changming GAO Lei | 2009 | Optics Communication2009，282，： | 1 |
| 16 | ROOM-TEMPERATURE MECHANICAL PROPERTIES OF TiAl+Ce ALLOYS显示文摘ROOM-TEMPERATUREMECHANICALPROPERTIESOFTiAl+CeALLOYS￥ChenShiqi;QuXuanhui;HuangBaiyun;LeiChangming(PowderMetallurgyResearchinst... | Chen Shiqi Qu Xuanhui Huang Baiyun Lei Changming(Powder Metallurgy Research institute,Central South University of Technology, Changsha 410083) | 1996 | 中国有色金属学会会刊:英文版1996，6，3： | 0 |
| 17 | Interfacial efects of suspended particles on biodegradation of N-(2,4-dimethyl phenyl)-N’-methylformamidine hydrochloride and dibutyl phthalate in waters显示文摘InterfacialefectsofsuspendedparticlesonbiodegradationofN(2,4dimethylphenyl)N’methylformamidinehydrochlorideanddibutylphth... | Ye Changming, Wang Hong, Lei Zhifang Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China | 1997 | Journal of Environmental Sciences1997，9，2： | 0 |
| 18 | SYNTHESIS OF TiAl+TiB_2 COMPOSITE AND-ITS THERMAL STABILITY显示文摘Synthesis process of a TiAl+TiB2 composite from the elemental powders was studiedby means of differential scanning calorimetry and X-ray diffractometry.TiB2 particlesmay form in TiAl matrix at temperature even below 700℃ owing to the exothermicreactions between Ti and Al powders.TiB2 particles are very thermally stable,and theyalmost did not change in their relative amount,morphology and size after the synthesizedcomposite was remelted.In addition,the existence of TiB2 particles has obvious refiningeffect in the as-cast microstructure of TiAl-base alloys. | QU Xuanhui HUANC Baiyun LEI Changming CHEN Shiqi Central South University of Technology,Changsha,China professor,Powder Metallurgy Research Institute,Central South University of Technology,Changsha 410083,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，12： | 0 |
| 19 | EFFECT OF HOMOGENIZATION PROCESSING ON MICROSTRUCTURE AND PROPERTIES OF Ti-34Al-2Mn ALLOY显示文摘A γ-TiAl base alloy with the composition of Ti-34Al-2Mn(wt--%)was prepared by consum-able electrode arc-melting technique.The effect of homogenization processing following arc-melt-ing on its microstructure and mechanical properties was investigated.The emphases were placedon the microstructural evolution during solidification and homogenization,and the relationship be-tween microstructure and ductility.It has been determined that the samples annealed at 900℃for 20 h exhibit the best ductility compared with those treated at other temperatures up to 1100℃,and they have a mixed structure of equiaxed grain of γ-TiAl single phase and some prima-ry lamellar grains which include three types of interfaces,i.e.,α2/γ,/γ/γS,γ/γT,maintainingspecific orientaion relationships between both sides.The ductility improvement is believed to be as-sociated with existence of suitable amount of α2-Ti3Al phase and the refinement of grains ob-tained at 900℃. | Lei,Changming Qu,Xuanhui Huang,Baiyun Xiong,Xiang Powder Metallurgy Research Institute,Central South University of Technology,Changsha 410083,China | 1993 | 中国有色金属学会会刊:英文版1993，3，4： | 0 |
| 20 | EFFECT OF Sb ADDITION ON MICROSTRUCTURE AND MECHANICAL PROPERTIESOF TiAI INTERMETALLIC COMPOUND显示文摘EFFECTOFSbADDITIONONMICROSTRUCTUREANDMECHANICALPROPERTIESOFTiAIINTERMETALLICCOMPOUNDHeYuehui;QuXuanhui;HuangBaiyun;LeiChangmi... | He Yuehui Qu Xuanhui Huang Baiyun Lei Changming Liu Yexiang(Pouoder Metallurgical Research Institute ,Central South University of Technology ,Changsha 410083) | 1994 | 中国有色金属学会会刊:英文版1994，4，3： | 0 |
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