|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense显示文摘To study the cell proliferation and wound healing activity of polysaccharides from Ganoderma amboinense(GAMPS),the polysaccharide was extracted by water extraction and alcohol precipitation method,and its monosaccharide composition and molecular weight were analyzed.The effects of different concentrations of GAMPS on the cell proliferation were determined by cell survival rate test,and the wound healing ability of GAMPS to NIH/3T3 cells was detected.The preliminary evaluation of the antioxidant ability of GAMPS was conducted by the oxygen radical absorbance capacity(ORAC).The results showed that the GAMPS was composed of glucose,mannose,and galactose at a molar ratio of 67.62:14.07:7.50,and the weightaverage molecular weights were 5.439×10^(6) and 1.704×10^(5) g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter(HPGPC-MALS)analysis.GAMPS(0.2μg/μL)showed the strongest proliferation ability to THP-1 cells,with cell survival rate of 178.7%.The wound healing effect of GAMPS(0.1μg/μL)was obvious on NIH/3T3 and 3.75μg/μL of GAMPS showed the strongest total antioxidant ability.All the results indicate that GAMPS promotes cell proliferation,and has cell wound healing effect and strong antioxidant activity.The results provide theoretical foundation for the development and utilization of GAMPS. | Shuangzhi Zhao Ming Lei Hui Xu Hailun He Alexander Suvorov Junhua Wang Jiying Qiu Qingxin Zhou Jinyu Yang Leilei Chen | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 2 | Expression profiles of seven glutathione S-transferase ( GST ) genes from Venerupis philippinarum exposed to heavy metals and benzopyrene显示文摘 | Linbao Zhang Lihua Qiu Huifeng Wu Xiaoli Liu Liping You Dong Pei Leilei Chen Qing Wang Jianmin Zhao | 2011 | Comparative Biochemistry and Physiology Part C2011，，3： | 1 |
| 3 | Gradual daylength sensing coupled with optimum cropping modes enhances multi-latitude adaptation of rice and maize显示文摘To expand crop planting areas,reestablishment of crop latitude adaptation based on genetic variation in photoperiodic genes can be performed,but it is quite time consuming.By contrast,a crop variety that already exhibits multi-latitude adaptation has the potential to increase its planting areas to be more widely and quickly available.However,the importance and potential of multi-latitude adaptation of crop varieties have not been systematically described.Here,combining daylength-sensing data with the cropping system of elite rice and maize varieties,we found that varieties with gradual daylength sensing coupled with optimum cropping modes have an enhanced capacity for multi-latitude adaptation in China.Furthermore,this multi-latitude adaptation expanded their planting areas and indirectly improved China’s nationwide rice and maize unit yield.Thus,coupling the daylength-sensing process with optimum cropping modes to enhance latitude adaptability of excellent varieties represents an exciting approach for deploying crop varieties with the potential to expand their planting areas and quickly improve nationwide crop unit yield in developing countries. | Xiaoying Wang Jiupan Han Rui Li Leilei Qiu Cheng Zhang Ming Lu Rongyu Huang Xiangfeng Wang Jianfu Zhang Huaan Xie Shigui Li Xi Huang Xinhao Ouyang | 2023 | Plant Communications2023，4，1： | 1 |
| 4 | The origin of ultrasensitive SERS sensing beyond plasmonics显示文摘Plasmon-free surface-enhanced Raman scattering(SERS)substrates have attracted tremendous attention for their abundant sources,excellent chemical stability,superior biocompatibility,good signal uniformity,and unique selectivity to target molecules.Recently,researchers have made great progress in fabricating novel plasmon-free SERS substrates and exploring new enhancement strategies to improve their sensitivity.This review summarizes the recent developments of plasmon-free SERS substrates and specially focuses on the enhancement mechanisms and strategies.Furthermore,the promising applications of plasmon-free SERS substrates in biomedical diagnosis,metal ions and organic pollutants sensing,chemical and biochemical reactions monitoring,and photoelectric characterization are introduced.Finally,current challenges and future research opportunities in plasmon-free SERS substrates are briefly discussed. | Leilei Lan Yimeng Gao Xingce Fan Mingze Li Qi Hao Teng Qiu | 2021 | Frontiers of physics2021，16，4： | 1 |
| 5 | Screening natural antioxidants in peanut shell using DPPH-HPLC-DAD-TOF/MS methods显示文摘 | Qiu Jiying Chen Leilei Zhu Qingjun | | 0，，04： | 1 |
| 6 | Adsorbent for chromium removal based on graphene oxide functionalized with magnetic cyclodextrin–chitosan显示文摘 | Leilei Li Lulu Fan Min Sun Huamin Qiu Xiangjun Li Huimin Duan Chuannan Luo | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 7 | Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice显示文摘This study was performed to determine the effects of bacteriocin-producing and non-bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice.Two P.acidilactici strains with antibacterial activity(P.acidilactici CCFM28 and CCFM18)were obtained based on the inhibition-zone assay.The produced components were identified as bacteriocins through protease treatment,pH adjustment and hydrogen peroxide treatment.Bacteriocin-producing and non-bacteriocin-producing P.acidilactici strains(P.acidilactici CCFM28,CCFM18 and NT17-3)caused significant changes in serum immune factors and intestinal flora of normal mice.After 14 days of intervention,the relative abundance of Firmicutes was significantly decreased,but that of Proteobacteria was significantly increased at the phylum level.At the genus level,the administration of three P.acidilactici strains resulted in the downregulation of Blautia and the upregulation of Ruminococcus and Lactobacillus.Furthermore,there were also different regulations on some probiotic strains,such as Bifidobacterium,Coprococcus and Akkermansia,which were closely related to the antibacterial ability of the bacteriocin and the type of strain.The results indicated that the intervention of different P.acidilactici strains could differently change the structure of intestinal flora in normal mice,which provided theoretical guidance for the selective use of bacteriocin-producing strains for health regulation in the future. | Yiteng Qiao Zhichang Qiu Fengwei Tian Leilei Yu Jianxin Zhao Hao Zhang Qixiao Zhai Wei Chen | 2022 | Food Science and Human Wellness2022，11，2： | 0 |
| 8 | Inspired heat shock protein alleviating prodrug enforces immunogenic photodynamic therapy by eliciting pyroptosis显示文摘Despite immunotherapy involving immune checkpoint inhibitors(ICIs)have revolutionized cancer therapy,the clinical efficacy is limited due to ICI resistance.Pyroptosis is a gasdermin-mediated programmed cell death that enhances responses to ICIs.However,nontargeted elicitation of pyroptosis may induce systemic side effects and toxicity.Therefore,we reasonably design and construct a tumor-specific prodrug that combines the heat shock protein 90 inhibitor tanespimycin(17-AAG)with the photosensitizer chlorin e6(Ce6)to induce pyroptosis,by utilizing the high glutathione level in the tumor microenvironment.The released Ce6 and 17-AAG produce reactive oxygen species by laser triggering,which induces gasdermin E-mediated pyroptosis.Furthermore,17-AAG reduces myeloid-derived suppressor cells and sensitizes tumors to anti-programmed death^(-1)(PD-1)therapy.Thus,our prodrug strategy achieves tumor-targeted pyroptosis to suppress tumor growth,thereby improving the response to anti-PD-1 therapy and extending the survival of 4T1 breast tumor-bearing mice.Consequently,this pyroptosis-based prodrug represents a novel strategy for enforcing immunogenic photodynamic therapy. | Junjie Zhou Xianbin Ma Hao Li Derun Chen Liang Mao Leilei Yang Tian Zhang Wei Qiu Zhigang Xu Zhi-Jun Sun | 2022 | Nano Research2022，15，4： | 0 |
| 9 | Structural engineering of transition-metal nitrides for surfaceenhanced Raman scattering chips显示文摘Noble-metal-free surface-enhanced Raman scattering(SERS)substrates have attracted great attention for their abundant sources,good signal uniformity,superior biocompatibility,and high chemical stability.However,the lack of controllable synthesis and fabrication of noble-metal-free substrates with high SERS activity impedes their practical applications.Herein,we propose a general strategy to fabricate a series of planar transition-metal nitride(TMN)SERS chips via an ambient temperature sputtering deposition route.For the first time,tungsten nitride(WN)and tantalum nitride(TaN)are used as SERS materials.These planar TMN chips show remarkable Raman enhancement factors(EFs)with~105 owing to efficient photoinduced charge transfer process between TMN chips and probe molecules.Further,structural engineering of these TMN chips is used to improve their SERS activity.Benefiting from the synergistic effect of charge transfer process and electric field enhancement by constructing a nanocavity structure,the Raman EF of WN nanocavity chips could be greatly improved to~1.29×10^(7),which is an order of magnitude higher than that of planar chips.Moreover,we also design the WN/monolayer MoS2 heterostructure chips.With the increase of surface electron density on the upper WN and more exciton resonance transitions in the heterostructure,a~1.94×10^(7)level EF and a 5×10^(-10)M level detection limit could be achieved.Our results provide important guidance for the structural design of ultrasensitive noble-metal-free SERS chips. | Leilei Lan Haorun Yao Guoqun Li Xingce Fan Mingze Li Teng Qiu | 2022 | Nano Research2022，15，4： | 0 |
| 10 | Fluorescent Detection of Trace Water in Methanol Based on an AI(III) Chemical Sensor显示文摘 | Liang Hao Qi-ming Qiu Wen-jie Wang Leilei Gu Hui Li | 2016 | Chinese Journal of Chemistry2016，34，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员