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| 1 | Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6显示文摘应力导致的内脏的超敏性在急躁的肠症候群(IBS ) 是相当普通的病人。Probiotics 玩在在 IBS 病人减少内脏的超敏性的一个重要角色。然而,机制清楚地没被阐明。在这研究,我们调查了像点头的受体 pyrin 的角色包含域的蛋白质(NLRP6 ) 6 由应力在 Clostridium 调整 butyricum 的 IBS 导致了。我们的结果证明 NLRP6 在 IBS 组冒号纸巾是下面调整的。另外, IL-18, IL-1, myeloperoxidase (军邮局) , d 乳的酸(D-LA ) ,和 CD172a 在 IBS 组是起来调整的结肠有粘液。在 NLRP6 基因是 silenced 以后, IL-18 和 IL-1 也被增加。病理学的分数建议了低发炎结肠有粘液而非终端回肠。水回避应力() 显示出内脏的超敏性到结肠的扩张。然而,有 Clostridium butyricum 的治疗颠倒了这些结果,施加有益的效果。在结论, Clostridium butyricum 可以由禁止低等级发炎在 IBS 的内脏的超敏性上施加一个有益的行动结肠通过它 NLRP6 上的行动有粘液。 | Kejia Zhao Leimin Yu Xi Wang Yibo He Bin Lu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 10 |
| 2 | Multi-foci metalens for spectra and polarization ellipticity recognition and reconstruction显示文摘Multispectral and polarized focusing and imaging are key functions that are vitally important for a broad range of optical applications.Conventional techniques generally require multiple shots to unveil desired optical information and are implemented via bulky multi-pass systems or mechanically moving parts that are difficult to integrate into compact and integrated optical systems.Here,a design of ultra-compact transversely dispersive metalens capable of both spectrum and polarization ellipticity recognition and reconstruction in just a single shot is demonstrated with both coherent and incoherent light.Our design is well suited for integrated and high-speed optical information analysis and can significantly reduce the size and weight of conventional devices while simplifying the process of collecting optical information,thereby promising for various applications,including machine vision,minimized spectrometers,material characterization,remote sensing,and other areas which require comprehensive optical analysis. | Hui Gao Xuhao Fan Yuxi Wang Yuncheng Liu Xinger Wang Ke Xu Leimin Deng Cheng Zeng Tingan Li Jinsong Xia Wei Xiong | 2023 | Opto-Electronic Science2023，2，3： | 3 |
| 3 | Recent advances in high-throughput quantitative bioanalysis by LC–MS/MS显示文摘 | Raymond Naxing Xu Leimin Fan Matthew J. Rieser Tawakol A. El-Shourbagy | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，，2： | 1 |
| 4 | EUS elastography for diagnosis of solid pancreatic masses: a meta-analysis显示文摘 | Mei Mei Jingmei Ni Dan Liu Piaopiao Jin Leimin Sun | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 5 | Oscillation results on meromorphic solutions of second order differential equations in the com- plex plane显示文摘 | Cao Tingbin Li Leimin | 2010 | Electron J Qual Theory Differ Equ2010，68，： | 1 |
| 6 | Investigation of a novel catalyst coated membrane method to prepare low-platinum-loading membrane electrode assemblies for PEMFCs显示文摘 | LEIMIN X SHIJUN L LIJUN Y ZHENXING L | 2009 | Fuel Cells2009，9，2： | 1 |
| 7 | A study on dual laser beam separation technology of KDP crystal显示文摘 | Leimin Deng Jun Duan Xiaoyan Zeng Huan Yang Shan Huang | 2013 | International Journal of Machine Tools and Manufacture2013，，： | 1 |
| 8 | Liver-specific deficiency of TMEM30A develops spontaneous hepatocellular carcinoma显示文摘Introduction Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide and mainly originates from chronic liver diseases[1].It is essential to establish a stable and effective model for studying hepatocellular carcinomas.At present,chemical induction is the most common method to establish liver cancer models in mice,in which diethylnitrosamine(DEN)and carbon tetrachloride(CCl4)are the main inducers[2].It simulates well the natural formation process of liver cancer,but the induction time is long.Human primary liver cancer organoids retain livertissue function and genetic stability[3]. | Leiming Liu Zhiqing Xia Yongming Zhang Jingjing Su Leimin Sun Lingling Zhang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 9 | Acousto-optic scanning spatial-switching multiphoton lithography显示文摘Nano-3D printing has obtained widespread attention owing to its capacity to manufacture end-use components with nano-scale features in recent years.Multiphoton lithography(MPL)is one of the most promising 3D nanomanufacturing technologies,which has been widely used in manufacturing micro-optics,photonic crystals,microfluidics,meta-surface,and mechanical metamaterials.Despite of tremendous potential of MPL in laboratorial and industrial applications,simultaneous achievement of high throughput,high accuracy,high design freedom,and a broad range of material structuring capabilities remains a long-pending challenge.To address the issue,we propose an acousto-optic scanning with spatial-switching multispots(AOSS)method.Inertia-free acousto-optic scanning and nonlinear swept techniques have been developed for achieving ultrahigh-speed and aberration-free scanning.Moreover,a spatial optical switch concept has been implemented to significantly boost the lithography throughput while maintaining high resolution and high design freedom.An eight-foci AOSS system has demonstrated a record-high 3D printing rate of 7.6×10^(7)voxel s^(-1),which is nearly one order of magnitude higher than earlier scanning MPL,exhibiting its promise for future scalable 3D nanomanufacturing. | Binzhang Jiao Fayu Chen Yuncheng Liu Xuhao Fan Shaoqun Zeng Qi Dong Leimin Deng Hui Gao Wei Xiong | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 10 | Horizontal platform supported total hip replacement显示文摘Thehorizontalplatformsupported(HPS)femoralcomponent(Dupuy,Warsaw,Indiana)fortotalhipreplacementwasdesignedandintroducedbyTow... | Leimin Chen and Thomas J. Claffey | 1998 | Chinese Medical Journal1998，，12： | 0 |
| 11 | Fixed-time stabilization of discontinuous spatiotemporal neural networks with time-varying coefficients via aperiodically switching control显示文摘This paper focuses on the challenge of fixed-time control for spatiotemporal neural networks(SNNs)with discontinuous activations and time-varying coefficients.A novel fixed-time convergence lemma is proposed,which facilitates the handling of time-varying coefficients of SNNs and relaxes the restriction on the non-positive definiteness of the derivative of the Lyapunov function.Besides,a more flexible and economical aperiodically switching control technique is presented to stabilize SNNs within a fixed time,efectively reducing the amount of information transmission and control costs.Under the newly established fixed-time convergence lemma and aperiodically switching controller,many more general algebraic conditions are deduced to ensure the fixed-time stabilization of SNNs.Numerical examples are provided to manifest the validity of the results. | Xiaofang HU Leimin WANG Chuan-Ke ZHANG Xiongbo WAN Yong HE | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
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