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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A randomized double blind comparison of the antihypertensive efficacy and safety of once daily losartan compared to twice daily captopril in mild to moderate essential hypertension显示文摘 | Roca Cusachs A Oigman W Lepe L | 1997 | Acta Cardiol1997，52，6： | 1 |
| 3 | A randomized, double-blind comparison of the antihypertensive efficacy and safety of once-daily losartan compared to twice-daily captopril in mild to moderate essential hypertension 显示文摘 | Roca-Cusachs A Oigman W Lepe L | 1997 | Acta Cardiol1997，52，6： | 1 |
| 4 | Constrainedpolymer layers to reduce noise:reality or fiction-anexperimental inquiryintotheir effectiveness显示文摘 | Kari L Lindgren K Feng Leping | 2002 | Polymer Testing2002，，21： | 1 |
| 5 | Constrained polymer layers to reduce noise: reality or fiction--an experimental inquiry into their effectiveness显示文摘 | Leif K Kent L I Feng Leping | 2002 | Polymer Testing2002，21，： | 1 |
| 6 | AMOEBA: robust location privacy scheme for VANET显示文摘 | Sampigethaya K Mingyan L Leping H | 2007 | IEEE Journal on Selected Areas in Communications2007，25，8： | 1 |
| 7 | Antitumor agents, 138 rotenoids and isoflavones as cytotoxic constituents from Amorpha fruticosa 显示文摘 | Leping L Hui-Kang W | 1993 | Journal of Natural Product1993，56，5： | 1 |
| 8 | Synthesis and electrical properties of new rare-earth titaniumperovskites for SOFC anode applications显示文摘 | Lepe F J Fernandez-Urban J Mestres L | 2005 | Journal of Power Sources2005，151，： | 1 |
| 9 | Characteristics of noncarious cervical lesions:a clinical investigation 显示文摘 | Aw TC Lepe X Johnson GH Mancl L | 2002 | J Am Dent Assoc2002，133，6： | 1 |
| 10 | Synthesis and electrical properties of new rare-earth titaniumpervskites for SOFC anode applications显示文摘 | Lepe F J Urban F J Mestres L | 2005 | Journal of Power Sources2005，151，： | 1 |
| 11 | Percutaneous mitral commissurotomy in patients with mitral valve stenosis and thrombosis of the left atrium显示文摘 | MURILLO H AYALA F LEPE L | 1999 | Arch Inst Cardiol Mex1999，69，： | 1 |
| 12 | Worldwide emergence of extensively drug-resistant tuber culosis显示文摘 | Shah NS Wright A Bai GH Barrera L Boulahbal F Martin-Casabona N Drobniewski F Gilpin C Havelkova M Lepe R Lumb R Metchock B Portaels F Rodrigues MF Rusch-Gerdes S Van Deun A Vincent V Laserson K Wells C Cegiels ki JP | 2007 | Emerg Infect Dis2007，13，3： | 1 |
| 13 | Antitumor activity of 9(R)-dihydrotaxane analogs显示文摘 | Li Leping Maring Clarence J | 1995 | J Med Chem1995，38，： | 1 |
| 14 | Synthesis and electrical properties of new rare-earth titanium perovskites for SOFC anode applications显示文摘 | Lepe F J Ferandez-Urbán J Mestres L | 2005 | J Power Sources2005，151，： | 1 |
| 15 | AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development显示文摘 | Sellitto Caterina Li Leping Gao Junyuan Robinson Michael L Lin Richard Z Mathias Richard T White Thomas W | 2013 | Journal of Clinical Investigation2013，，12： | 1 |
| 16 | Percutaneous mitral commissurotomy inpatients with mitralvaive stenosis and thrombosis o f the left atrium显示文摘 | Murillo H Ayala F Lepe L | 1999 | Arch Inst Cardiol Mex1999，69，2： | 1 |
| 17 | Preparation process of microcap- sule containing phase change material for thermal - energy storage 显示文摘 | Yang Z Wei Z Leping L | 2011 | Advanced Science Letters2011，4，3： | 1 |
| 18 | Forkhead box MlBtranscriptional activity requires binding of Cdk-cyclincomplexes for phosphorylation-dependent recruitment ofp300/CBP coactivators 显示文摘 | Major M L Lepe R Costa R H | 2004 | Mol Cell Biol2004，24，7： | 1 |
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