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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | C4d complement split product in diagnosis of immnunological activity of chronic allograft nephrovathy显示文摘 | Mroz A Lewandowski Z Cieciura T | 2006 | Transplant Proc2006，38，1： | 1 |
| 4 | Onset of variable-range hopping at ferromagnetic phase nucleation in amorphous paramagnetic LaSrMnO films显示文摘 | OKUNEV V D SAMOILENKO Z A PAFOMOV N N D'YACHENKO T A PLEHOV A L SZYMCZAK R BARAN M SZYMCZAK H LEWANDOWSKI S J | 2005 | Phys Lett A2005，346，： | 1 |
| 5 | Dietary fish oil supplements increase tissue n-3 fatty acid composition and expression of delta-6 desaturase and elongase-2 in Jade Tiger hybrid abalone显示文摘 | Mateos H T Lewandowski P A Su X Q | 2011 | Lipids2011，46，8： | 1 |
| 6 | Evidence for organosulfates in secondary organic aerosol 显示文摘 | Surratt J D Kroll J H Kleindienst T E Edney E O Claeys M Sorooshian A Ng N L Offenberg J H Lewandowski M Jaoui M Flagan R C Seinfeld J H | 2007 | Environ Sci Technol2007，41，2： | 1 |
| 7 | Dietary fish oil supplements increase tissue n-3 fatty acid composition and expression of delta-6 desaturase and elongase-2 in Jade Tiger hybrid abalone显示文摘 | Mateos H T Lewandowski P A Su X | 2011 | Lipids2011，46，8： | 1 |
| 8 | Effects of dietary fish oil replacement with flaxseed oil on tissue fatty acid composition and expression of desaturase and elongase genes显示文摘 | Mateos H T Lewandowski P A Su X | 2012 | Journal of the Science of Food and Agriculture2012，92，2： | 1 |
| 9 | Seasonal variations of total lipid and fatty acid contents in muscle, gonad and digestive glands of farmed Jade Tiger hybrid abalone in Australia 显示文摘 | Mateos H T Lewandowski P A Su X Q | 2010 | Food Chemistry2010，123，： | 1 |
| 10 | The effect of replacing dietary fish oil with canola oil on fatty acid composition and expression of desaturase and elongase genes in Jade Tiger hybrid abalone显示文摘 | Mateos H T Lewandowski P A Su X | 2012 | Food Chemistry2012，131，4： | 1 |
| 11 | Emissions and risks associated with oxyfuel combustion: State of the science and critical data gaps 显示文摘 | Senior C L Morris W Lewandowski T A | 2013 | Journal of the Air & Waste Management Association2013，63，7： | 1 |
| 12 | Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial显示文摘 | Lewandowski C A Frankel M Tomsick T A | 1999 | Stroke1999，30，： | 1 |
| 13 | C4d complement split product in diagnosis of immunological activity of chronic allograft nephropathy显示文摘 | Mroz A Lewandowski Z Cieciura T | 2006 | Transplant Proc2006，38，1： | 1 |
| 14 | Comparison of IEUBK model predictions and actual blood lead values at a former battery recycling site 显示文摘 | Lewandowski T A Forslund B L | 1994 | Environmental Geochemistry and Health1994，16，34： | 1 |
| 15 | SolT race:A raytracing code for complex solar optical systems显示文摘 | Wendelin T Dobos A Lewandowski A | 2013 | Contract2013，30，3： | 1 |
| 16 | Covariance based uncertainty analysis of the NIST electro optic sampling system 显示文摘 | WILLIAMS D F LEWANDOWSKI A CLEMENT T S | 2006 | IEEE Transactions on Microwave Theory and Techniques2006，54，1： | 1 |
| 17 | C4d complement split product in diagnosis of immunological activity of chronic allograft nephropathy显示文摘 | Mroz A Lewandowski Z Cieciura T | 2006 | Transplant Proc2006，38，1： | 1 |
| 18 | Acutemyocardial infarction as the first presentation of thyrotoxicosis in a31-year old woman-case report显示文摘 | Lewandowski KC Rechciński T Krzemińska-Pakua M | 2010 | Thyroid Res2010，3，1： | 1 |
| 19 | Soilmicrobial community response and recovery following groupselection harvest : temporal patterns from an experimental harvestin a US northern hardwood forest 显示文摘 | Lewandowski T E Forrester J A Mladenoff D J | 2015 | Forest Ecology andManagement2015，340，： | 1 |
| 20 | Com- bined intravenous and intra-arterial r-TPA versus intra- arterial therapy of acute ischemic stroke emergency man- agement of stroke (EMS) bridging trial 显示文摘 | Lewandowski C A Frankel M Tomsiek T A | 1999 | Stroke1999，30，12： | 1 |
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