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| 1 | Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma显示文摘AIM: To evaluate the influence of various clinicopathologicfactors on survival of patients with bile duct carcinoma aftercurative resection.METHODS: A retrospective analysis was made for 86 casesof bile duct carcinoma treated from January 1981 toSeptember 1995. Fifteen clinicopathologic factors possiblyinfluencing survival were selected. Independent variableswere first analyzed by univariate methods. Survival forvariable was estimated by the method of Kaplan and Meier.The variables that were statistically significant by univarlateanalysis were included in a multivariate analysis, which wereconfirmed using the Cox stepwise proportion hazard modelwith the help of SPSS 10.0 for Windows software.RESULTS: The overall cumulative survival rate was 72.6 %at 1 year, 32.4 % at 3 years, and 18.7 % at 5 years. Theresults of univariate analysis showed that the majorsignificant prognostic factors influencing survival of thesepatients were histological type of lesion, lymph nodemetastasis, pancreatic invasion, duodenal invasion, pedneuralinvasion, macroscopic vessel involvement, resected surgicalmargin and depth of cancer invasion (P=0.02, 0.02, 0.004,0.005, 0.01, 0.43, 0.03 and 0.04). Age, sex, location of tumor,size of tumor, macroscopic type of lesions, hepaticmetastasis, and hepatic invasion were not significantlyassociated with prognosis (P>0.05). Pancreatic invasion,perineural invasion and lymph node metastases were thethree most important prognostic factors by multivariateanalysis using the Cox proportional hazards model.CONCLUSION: Pancreatic invasion, pedneural invasion andlymph node metastases are the most important prognosticfactors for bile duct carcinoma after curative resection. | He, P Shi, JS Chen, WK Wang, ZR Ren, H Li, H | 2002 | World Journal of Gastroenterology2002，8，5： | 10 |
| 2 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 3 | Interracial differences in prostate cancer progression among patients from the United States, China and Japan显示文摘 | Haiyen E Zhau Qinlong Li Leland WK Chung | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 4 | EPIMEDOKOREANONE A FROM THE AERIAL PARTS O FEPIMEDIUM KOREANUM NAKAI显示文摘EPIMEDOKOREANONEAFROMTHEAERIALPARTSOFEPIMEDIUMKOREANUMNAKAIWenKuiLI;JunShanYANG;PeiGenXIAO(InstituteofMedicinalPlantDevelopme... | Li, WK Yang, JS Xiao, PG Pan, JQ Lu, MJ Zhang, RY | 1996 | Chinese Chemical Letters1996，7，1： | 2 |
| 5 | Gaps remain in China’s ability to detect emerging infectious diseases despite advances since the onset of SARS and avian flu显示文摘 | Feng ZJ Li WK Varma JK | 2010 | Health Affairs2010，30，1： | 1 |
| 6 | Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice 显示文摘 | Li J Semple K Suh WK | 2011 | Biol Blood Marrow Transplant2011，17，7： | 1 |
| 7 | Specific immunotherapy suppresses Th2 responses via modulating TIM1/ TIM4 interaction on dendritic cells显示文摘 | Zhao CQ Li TL He SH Chen X An YF Wu WK | 2010 | Allergy2010，65，8： | 1 |
| 8 | Model|ing of water mist fire suppression systems by a one-zone model 显示文摘 | Li YF Chow WK | 2004 | Combustion theory and modelling2004，，8： | 1 |
| 9 | Mononuclear histocompatibility leukoeyte antigen-DR expression in the early phase of acute pancreatitis 显示文摘 | Yu WK Li WQ Li N | 2004 | Pancreatology2004，4，34： | 1 |
| 10 | Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury 显示文摘 | Zhang PL Rothblum LI Han WK | 2008 | Kidney International2008，73，5： | 1 |
| 11 | Genetic and cellu- lar evidence of vascular inflammation in neurofibromin- deficient mice and humans显示文摘 | Lasater EA Li F Bessler WK | 2010 | J Clin Invest2010，120，3： | 1 |
| 12 | L5-$1 segment survivorship and clinical outcome analysis after L-L5 isolated fusion 显示文摘 | Ghise|li G Wang JC Hsu WK | 2003 | Spine (Phila Pa 1976)2003，28，12： | 1 |
| 13 | Age at onset in two common neu- rodegenerative diseases is genetically eont rolled 显示文摘 | Li YJ Scott WK Hedges DJ | 2002 | American Journal of Human genetics2002，70，4： | 1 |
| 14 | Sumoylation differentially regulates Spl to control cell differentiation显示文摘 | Gong Li Ji WK Hu XH | 2014 | Proc Natl Aead Sci U S A2014，115，15： | 1 |
| 15 | Therapy and prognosis of intracranial invasive olfactory neuroblastoma显示文摘 | Jiang GY Li FC Chen WK | | 0，，： | 1 |
| 16 | Mononuclear histocompatibility leukocyte an tigen-DR expression in the early phase of acute pancreatitis 显示文摘 | Yu WK Li WQ Li N | 2004 | paneeatology2004，4，3： | 1 |
| 17 | Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class 11 antigens 显示文摘 | Decker WK Xing D Li S | 2009 | Blood2009，113，18： | 1 |
| 18 | Biomechanical and elec- tromyographic evalualion of ankle foot orthosis and dynamic ankle foot orthosis in spastic cerebral palsy显示文摘 | Lain WK Leong JC Li YH | 2005 | Gait Posture2005，22，3： | 1 |
| 19 | Epidural ropivacaine for postoperative analgesia in Taiwanese patients显示文摘 | Lee WK Li CH Lee LS | 2003 | Acta Anaesthesiol Sin2003，41，： | 1 |
| 20 | A prospective randomized study on three different peritoneal dialysis catheters显示文摘 | Lo WK Lui SL Li FK | 2003 | Perit Dial Int2003，23，2： | 1 |
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