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| 1 | Effect of Simulated Acid Rain on Potential Carbon and Nitrogen Mineralization in Forest Soils显示文摘Acid rain is a serious environmental problem worldwide. In this study, a pot experiment using forest soils planted with the seedlings of four woody species was performed with weekly treatments of pH 4.40, 4.00, 3.52, and 3.05 simulated acid rain (SAR) for 42 months compared to a control of pH 5.00 lake water. The cumulative amounts of C and N mineralization in the five treated soils were determined after incubation at 25 ℃ for 65 d to examine the effects of SAR treatments. For all five treatments, cumulative CO2-C production ranged from 20.24 to 27.81 mg kg-1 dry soil, net production of available N from 17.37 to 48.95 mg kg-1 dry soil, and net production of NO-3 -N from 9.09 to 46.23 mg kg-1 dry soil. SAR treatments generally enhanced the emission of CO2-C from the soils; however, SAR with pH 3.05 inhibited the emission. SAR treatments decreased the net production of available N and NO3-N. The cumulative CH4 and N2O productions from the soils increased with increasing amount of simulated acid rain. The cumulative CO2-C production and the net production of available N of the soil under Acmena acuminatissima were significantly higher (P ≤ 0.05) than those under Schima superba and Cryptocarya concinna. The mineralization of soil organic C was related to the contents of soil organic C and N, but was not related to soil pH. However, the overall effect of acid rain on the storage of soil organic matter and the cycling of important nutrients depended on the amount of acid deposition and the types of forests. | OUYANG Xue-Jun ZHOU Guo-Yi HUANG Zhong-Liang LIU Ju-Xiu ZHANG De-Qiang LI Jiong | 2008 | Pedosphere2008，18，4： | 40 |
| 2 | Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells显示文摘瞄准:调查 rosiglitazone 的效果, peroxisomeproliferator-ac-tivated 受体 gamma ( PPARy )收缩筋在在 hepatocellular carcinomacells 在染色体 10 基因( PTEN )和房间生长上删除的磷酸酶 andtensin 相当或相同事物的表示上,象这些 effects.Methods 的内在的机制一样: RT-PCR 和西方的 blottinganalyses 被执行在 Hep3B 房间 treatedwith rosiglitazone.3-( 4,5-Dimethylthiazol-2-yl )检测抄写和 PTEN 的表示 -2,5-diphenyl | Liang-qi CAO Xi-lin CHEN Qian WANG Xiao-hui HUANG Mao-chuan ZHEN Long-juan ZHANG Wen LI Jiong BI | 2007 | Acta Pharmacologica Sinica2007，28，6： | 32 |
| 3 | Spatial Characteristics of Extreme Rainfall over China with Hourly through 24-Hour Accumulation Periods Based on National-Level Hourly Rain Gauge Data显示文摘Hourly rainfall measurements of 1919 national-level meteorological stations from 1981 through 2012 are used to document,for the first time,the climatology of extreme rainfall in hourly through 24-h accumulation periods in China. Rainfall amounts for 3-,6-,12- and 24-h periods at each station are constructed through running accumulation from hourly rainfall data that have been screened by proper quality control procedures. For each station and for each accumulation period,the historical maximum is found,and the corresponding 50-year return values are estimated using generalized extreme value theory. Based on the percentiles of the two types of extreme rainfall values among all the stations,standard thresholds separating Grade I,Grade II and Grade III extreme rainfall are established,which roughly correspond to the 70th and 90th percentiles for each of the accumulation periods. The spatial characteristics of the two types of extreme rainfall are then examined for different accumulation periods. The spatial distributions of extreme rainfall in hourly through 6-h periods are more similar than those of 12- and 24-h periods. Grade III rainfall is mostly found over South China,the western Sichuan Basin,along the southern and eastern coastlines,and in the large river basins and plains. There are similar numbers of stations with Grade III extreme hourly rainfall north and south of 30°N,but the percentage increases to about 70% south of 30°N as the accumulation period increases to 24 hours,reflecting richer moisture and more prolonged rain events in southern China. Potential applications of the extreme rainfall climatology and classification standards are suggested at the end. | Yongguang ZHENG Ming XUE Bo LI Jiong CHEN Zuyu TAO | 2016 | Advances in Atmospheric Sciences2016，33，11： | 28 |
| 4 | ABF2, ABF3, and ABF4 Promote ABA-Mediated Chlorophyll Degradation and Leaf Senescence by Transcriptional Activation of Chlorophyll Catabolic Genes and Senescence-Associated Genes in Arabidopsis显示文摘叶绿素(Chl ) 降级是叶老朽的一个不可分的过程,并且 NYE1/SGR1 在多样的工厂种类作为 Chl 分解代谢的一个关键管理者被表明了。在这研究,用屏蔽的酵母一个混血儿,我们识别了三 abscisic 酸(骆驼毛的织物) 应答的元素(ABRE ) 绑定抄写因素, ABF2 (AREB1 ) , ABF3,和 ABF4 (AREB2 ) , NYE1 倡导者的通常认为的有约束力的蛋白质。通过 transactivation 分析, electrophoretic 活动性移动试金,和染色质 immunoprecipitation,我们表明了直接跳到并且在 vitro 并且在 vivo 激活 NYE1 倡导者的那 ABF2, ABF3,和 ABF4。骆驼毛的织物是叶老朽的一个积极管理者,并且外长地适用骆驼毛的织物能加速 Chl 降级。ABF, abf2abf3abf4,以及二骆驼毛的织物感觉迟钝的异种, abi1-1 和 snrk2.2/2.3/2.6 的三倍的异种,在骆驼毛的织物处理以后的展出停留绿色显型,与 NYE1 和 NYE2 表示的减少的正式就职一起。相反, ABF4 的 overexpression 在骆驼毛的织物处理之上加速了 Chl 降级。有趣地, ABF2/3/4 能也激活二 Chl 分解代谢的酶基因, PAO 和 NYC1 的表达式,由对他们的倡导者直接有约束力。另外, abf2abf3abf4 展出了功能的停留绿色显型,和联系老朽的基因(下垂) 例如 SAG29 (SWEET15 ) ,可能被 ABF 直接调整。一起拿,我们的结果在调停作为关键管理者建议那 ABF2, ABF3,和 ABF4 可能的行为被触发骆驼毛的织物的 Chl 降级和叶老朽一般来说在 Arabidopsis。 | Shan Gao Jiong Gao Xiaoyu Zhu Yi Song Zhongpeng Li Guodong Ren Xin Zhou Benke Kuai | 2016 | Molecular Plant2016，9，9： | 27 |
| 5 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 6 | Effect of N and P addition on soil organic C potential mineralization in forest soils in South China显示文摘Atmospheric nitrogen deposition is at a high level in some forests of South China. The effects of addition of exogenous N and P on soil organic carbon mineralization were studied to address: (1) if the atmospheric N deposition promotes soil C storage through decreasing mineralization; (2) if the soil available P is a limitation to organic carbon mineralization. Soils (0-10 cm) was sampled from monsoon evergreen broad-leaved forest (MEBF), coniferous and broad-leaved mixed forest (CBMF), and Pinus massoniana forest (PMF) in Dinghushan Biosphere Reserve (located in Guangdong Province, China). The soils were incubated at 25°C for 45 weeks, with addition of N (NH4NO3 solution) or P (KH2PO4 solution). CO2-C emission and the inorganic N (NH4+-N and NO3?-N) of the soils were determined during the incubation. The results showed that CO2-C emission decreased with the N addition. The addition of P led to a short-term sharp increase in CO2 emission after P application, and the responses of CO2-C evolution to P addition in the later period of incubation related to forest types. Strong P inhibition to CO2 emission occurred in both PMF and CBMF soils in the later incubation. The two-pool kinetic model was fitted well to the data for C turnover in this experiment. The model analysis demonstrated that the addition of N and P changed the distribution of soil organic C between the labile and recalcitrant pool, as well as their mineralization rates. In our experiment, soil pH can not completely explain the negative effect of N addition on CO2-C emission. The changes of soil inorganic N during incubation seemed to support the hypothesis that the polymerization of added nitrogen with soil organic compound by abiotic reactions during incubation made the added nitrogen retard the soil organic carbon mineralization. We conclude that atmospheric N deposition contributes to soil C accretion in the three subtropical forest ecosystems, however, the shortage of soil available P in CBMF and PMF may also retard soil organic C mineralization. | OUYANG, Xuejun ZHOU, Guoyi HUANG, Zhongliang ZHOU, Cunyu LI, Jiong SHI, Junhui ZHANG, Deqiang | 2008 | Journal of Environmental Sciences2008，20，9： | 17 |
| 7 | Dependence of Soil Respiration on Soil Temperature and Soil Moisture in Successional Forests in Southern China显示文摘在有癌症的回归线附近的森林里的生物物理的因素的土壤呼吸和它的关系的空间、时间的变化仍然保持高度不明确。为了向实际估计,土壤呼吸率,土壤温度,和土壤潮湿的改进作出贡献,从 2003 年 3 月在南部的中国在 Dinghushan 自然保护区(DNR ) 在三个接连著的副热带的森林里被测量到 2005 年 2 月。现在的学习的全面目的是在这些森林里分析土壤呼吸和它的生物物理的依赖的时间的变化。在生物物理的因素和土壤呼吸率之间的关系在接连著的森林里被比较测试这些森林同样回答了到生物物理的因素的假设。土壤呼吸的 seasonality 与季节的气候模式与一致,与在热潮湿的季节(4 月 9 月) 的高呼吸率并且与在凉爽的干旱期(10 月三月) 的低率。在这些森林测量的土壤呼吸与进步继任显示出一个清楚的增加趋势。DNR 森林里的土壤呼吸率是的累年平均(± SD )(9.0 ± 4.6 ) Mg CO_2-C/hm^2 每年,从(6.1 ± 3.2 ) Mg CO_2-C/hm^2 每早接连著的森林到里的年(10.7 ± 4.9 ) Mg CO^2-C/hm^2 每先进接连著的森林里的年。Soilrespiration 与土壤温度和潮湿被相关。在二个生物物理的变量正在驾驶因素的地方, T/M 模型在 DNRforests 说明了 74%-82%of 土壤呼吸变化。温度敏感沿着进步继任阶段减少了,建议 thatadvanced 接连著的森林有一个好能力适应温度。相反,潮湿与进步继任过程增加了。部分地,这增加被丰富的口罩在进展接连著的森林里引起,在更多的土壤潮湿被需要维持他们的活动的地方。 | Xu-Li Tang Guo-Yi Zhou Shu-Guang Liu De-Qiang Zhang Shi-Zhong Liu Jiong Li Cun-Yu Zhou | 2006 | Journal of Integrative Plant Biology2006，48，6： | 17 |
| 8 | Cytomegalovirus Pneumonia in Patients with Rheumatic Diseases After Immunosuppressive Therapy: A Single Center Study in China显示文摘 | Yu Xue Li Jiang Wei-Guo Wan Yu-Ming Chen Jiong Zhang Zhen-Chun Zhang | 2016 | Chinese Medical Journal2016，，3： | 13 |
| 9 | Moisture vapor transmission rates of various transparent dressings at different temperatures and humidities显示文摘背景透明调味品通常被用来盖住中央静脉的导管地点。然而,他们可能不允许足够的潮湿蒸汽传播,这被建议了,导致支持细菌的生长的本地湿。我们比较了潮湿蒸汽传播率(MVI-Rs ) 不同,当前使用透明、传统的铁纱调味品。我们试图在不同温度和 humidities.Methods 决定 MVTR 调味品被用来封上包含 20 ml deionized 水的 50-ml 塑料离心机试管:在组 1 的试管被平常的铁纱的 12 层盖住,与 IV3000 组织 2,与 OPSITE FLEXIGRID 组织 3,与 3M HP Tegaderm 组织 4,并且与 3M Tegaderm 组织 5。试管笔直地被放在一个人工的气候内阁以便调味品不正在摸水,以便在与皮肤的接触模仿医药调味品的条件。平均 MVTR 在不同条件下面被决定。MVTR 与从在他们的方面上生的组 2-5 的试管也是坚定的,允许调味品摸水因此模仿有出汗的皮肤的调味品的接触,或与流出物伤害了皮肤。当不在与水 surface.Results 组的接触 1 表明了最高的 MVTR 时,我们也由在与那些的与水表面的接触比较他们的 MV-rRs 计算了调味品的自我反应的能力,由组列在后面 2 , 4 , 3 和 5 在下列温度和湿度与正常皮肤调味品在模仿的条件下面联系:20C/30% , 20/60% , 20/90% , 37/30% , 37/60% 和 37/90% 。当相对湿度(RH ) 增加了时, MVTR 减少了。MVTR 在不同调味品和 RH 之中显著地不同:在高温度(37 ) 和高湿度(90%) ,在组 2 的透明调味品的 MVTR 比组 1 的高(P < 0.01 ) 。反应 MVTR 在组 2 是最高的(10.2-16.3 时间 > MVTR ) 当组 4 的最高是第二时(2.6-9.6 时间 > MVTR ).Conclusions RH 和温度在不同调味品的 MVTR 上有重要效果。在组 2 使用的 IV3000 透明调味品象平常的铁纱一样有效。这些结果建议那增加的感染由于低 MVTR 评价可能别是一个问题。为 cathetsr 相关的感染的这些观察的临床的含意需要进一步在 multicenter 研究被调查。 | LIN Yu-shuang CHEN Jiong LI Qiang PAN Ke-ping | 2009 | Chinese Medical Journal2009，，8： | 13 |
| 10 | Population pharmacokinetics of lamotrigine in Chinese children with epilepsy显示文摘目的: 与癫痫在中国孩子为 lamotrigine (LTG ) 当模特儿建立人口 pharmacokinetics (PPK ) 以便提出一个个性化的剂量指南。 | Da-ke HE Li WANG Wei LU Jiong QIN Shen ZHANG Ling LI Jian-ming ZHANG Wei-qun BAO Xiao-qing SONG Hai-tao LIU | 2012 | Acta Pharmacologica Sinica2012，33，11： | 12 |
| 11 | Data mining-aided materials discovery and optimization显示文摘Recent developments in data mining-aided materials discovery and optimization are reviewed in this paper,and an introduction to the materials data mining(MDM)process is provided using case studies.Both qualitative and quantitative methods in machine learning can be adopted in the MDM process to accomplish different tasks in materials discovery,design,and optimization.State-of-the-art techniques in data mining-aided materials discovery and optimization are demonstrated by reviewing the controllable synthesis of dendritic Co_(3)O_(4) superstructures,materials design of layered double hydroxide,battery materials discovery,and thermoelectric materials design.The results of the case studies indicate that MDM is a powerful approach for use in materials discovery and innovation,and will play an important role in the development of the Materials Genome Initiative and Materials Informatics. | Wencong Lu Ruijuan Xiao Jiong Yang Hong Li Wenqing Zhang | 2017 | Journal of Materiomics2017，3，3： | 11 |
| 12 | Mesenchymal stem cells from the human umbilical cord ameliorate fulminant hepatic failure and increase survival in mice显示文摘BACKGROUND:Cell therapy has been promising for various diseases.We investigated whether transplantation of human umbilical cord mesenchymal stem cells(h UCMSCs)has any therapeutic effects on D-galactosamine/lipopolysaccharide(Gal N/LPS)-induced fulminant hepatic failure in mice.METHODS:h UCMSCs isolated from human umbilical cord were cultured and transplanted via the tail vein into severe combined immune deficiency mice with Gal N/LPS-induced fulminant hepatic failure.After transplantation,the localization and differentiation of h UCMSCs in the injured | Jin-Feng Yang Hong-Cui Cao Qiao-Ling Pan Jiong Yu Jun Li Lan-Juan Li | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 11 |
| 13 | Involvement of ayu NOD2 in NF-κB and MAPK signaling pathways: Insights into functional conservation of NOD2 in antibacterial innate immunity显示文摘Nucleotide oligomerization domain 2(NOD2) is a major cytoplasmic sensor for pathogens and is critical for the clearance of cytosolic bacteria in mammals.However, studies regarding NOD2, especially the initiated signaling pathways, are scarce in teleost species. In this study, we identified a NOD2 molecule(PaNOD2) from ayu(Plecoglossus altivelis).Bioinformatics analysis showed the structure of NOD2 to be highly conserved during vertebrate evolution. Dual-luciferase reporter assays examined the activation of NF-κB signaling and Western blotting analysis detected the phosphorylation of three MAP kinases(p-38, Erk1/2, and JNK1/2).Functional study revealed that, like its mammalian counterparts, PaNOD2 was the receptor of the bacterial cell wall component muramyl dipeptide(MDP), and the leucine-rich repeat motif was responsible for the recognition and binding of Pa NOD2 with the ligand. Overexpression of PaNOD2 activated the NF-κB signaling pathway, leading to the upregulation of inflammatory cytokines, including TNF-α and IL-1β in HEK293 T cells and ayu head kidney-derived monocytes/macrophages(MO/MΦ).Particularly, we found that PaNOD2 activated the MAPK signaling pathways, as indicated by the increased phosphorylation of p-38, Erk1/2, and JNK1/2, which have not been characterized in any teleost species previously. Our findings proved that the NOD2 molecule and initiated pathways are conserved between mammals and ayu. Therefore, ayu could be used as an animal model to investigate NOD2-based diseases and therapeutic applications. | Yi Ren Shui-Fang Liu Li Nie Shi-Yu Cai Jiong Chen | 2019 | Zoological Research2019，40，2： | 10 |
| 14 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 15 | A prospective comparison of molecular assay and touch imprint cytology for intraoperative evaluation of sentinel lymph nodes显示文摘哨兵淋巴的背景精确 intraoperative 诊断节点(SLN ) 转移在一样的操作期间为腋的淋巴节点解剖启用病人的选择,为第二操作减少需要。试图有希望地比较 GeneSearchTM 胸淋巴节点(十亿) 的现在的学习有为 SLNs.Methods SLN 的 intraoperative 评估的触摸印记细胞学(TIC ) 的试金是在 1.5-3.0 公里片的 sectioned。TIC 在所有片和十亿试金上被执行,手术后的组织学评估在不同轮流出现节点片上被执行。十亿试金的全面性能与相对 90 个病人的一个总数在学习注册了的手术后的组织学 results.Results 的 TIC 的相比。为十亿试金和 TIC 的完全的 intraoperative 数据在 86 个病人被收集。十亿试金的敏感,特性,和全面精确性是82%,97%,和92%,分别地在一个per 病人基础上与那些相比百分之百,是67%的 TIC 并且十亿试金的90% .Conclusions 性能比 TIC 的优异, TIC 的另外的应用程序没帮助改进 intraoperative 评价的全部的敏感和精确性。宫外的胸织物的存在可能是一个可能的原因假为十亿试金积极。另外,没有增加病理学家的工作量,十亿个试金补充组织病理学说评价和罐头最小化采样错误。 | CHEN Jia-jian YANG Ben-long CHEN Jia-ying ZHANG Jia-xin LI Da-li XU Wei-ping XU Xiao-li YANG Wen-tao SHAO Zhi-min SHEN Zhen-zhou WANG Yong-sheng WU Jiong | 2011 | Chinese Medical Journal2011，，4： | 10 |
| 16 | Molecular characterization of an IL-1β gene from the large yellow croaker(Larimichthys crocea) and its effect on fish defense against Vibrio alginolyticus infection显示文摘Interleukin 1β(IL-1β), the first interleukin to be characterized, plays a key role in regulating the immune response. In this study, we determined the c DNA and genomic DNA sequences of the IL-1β gene from the large yellow croaker, Larimichthys crocea. Phylogenetic analysis indicated that the IL-1β(Lc IL-1β) gene was most closely related to that of European seabass(Dicentrarchus labrax), sharing 67.8% amino acid identity. In healthy large yellow croaker, Lc IL-1β transcription was detected in all tested tissues, with the highest level found in the head kidney. Upon Vibrio alginolyticus infection, Lc IL-1β transcription in all tested tissues was significantly upregulated. Intraperitoneal injection of recombinant Lc IL-1β(r Lc IL-1β) improved the survival rate and reduced the tissue bacterial load after V. alginolyticus infection. In addition, r Lc IL-1β induced monocytes/macrophages(MO/MΦ) chemotaxis and increased phagocytosis and bactericidal activity in vitro. These results suggest that Lc IL-1β plays an important role in the large yellow croaker immune response against V. alginolyticus. | Jun WU Yu-Hong SHI Xue-Heng ZHANG Chang-Hong LI Ming-Yun LI Jiong CHEN | 2015 | Zoological Research2015，36，3： | 8 |
| 17 | Soil Acidification and Heavy Metals in Urban Parks as Affected by Reconstruction Intensity in a Humid Subtropical Environment显示文摘Soil quality is a major concern in the management of urban parks. In this study, the soils at 0–3, 3–13, and 13–23 cm depths were sampled from six urban parks, differing in reconstruction intensity(mainly changes made during conversion of natural forests into parklands), in the Pearl River Delta, China to determine how reconstruction intensity influenced the extent of acidification and heavy metal levels in the soils of urban parks in a humid subtropical environment. High reconstruction intensity(HRI) was practiced in three parks and low reconstruction intensity(LRI) in three other parks. The LRI soils were strongly to extremely acidic(with low exchangeable Ca, Mg, and K concentrations) while the HRI soils were much less acidic. Both total and extractable concentrations of soil heavy metals were related to the specific management practices and age of the park, but did not differ significantly between LRI and HRI parks or among soil depths. Soil p H was significantly related to soil exchangeable cation concentrations and base saturation but was weakly related or unrelated to soil heavy metal levels. Our results suggest that high intensity but not low intensity reconstruction significantly reduces the extent of soil acidification in the urban parks in a humid subtropical environment. | HOU En-Qing XIANG Hui-Min LI Jian-Li LI Jiong WEN Da-Zhi | 2015 | Pedosphere2015，25，1： | 8 |
| 18 | Current understanding on the roles of gut microbiota in fish disease and immunity显示文摘Intensive aquaculture has increased the severity and frequency of fish diseases.Given the functional importance of gut microbiota in various facets of host physiology,modulation of this microbiota is a feasible strategy to mitigate emerging diseases in aquaculture.To achieve this,a fundamental understanding of the interplay among fish health,microbiota, and invading pathogens is required.This commentary focuses on current knowledge regarding the associations between fish diseases,dysbiosis of gut microbiota,and immune responses. Furthermore,updated research on fish disease from an ecological perspective is discussed,including colonization resistance imposed by commensals and strategies used by pathogens to overcome resistance.We also propose several directions for future research,such as exploration of the causal links between fish diseases and specific taxa,and identification of universal gut microbial biomarkers for rapid disease diagnosis. | Jin-Bo Xiong Li Nie Jiong Chen | 2019 | Zoological Research2019，40，2： | 8 |
| 19 | Proteolipidprotein 1 gene mutation in nine patients with Pelizaeus-Merzbacher disease显示文摘背景 Pelizaeus-Merzbacher 疾病( PMD )是有包括眼球震颤的 svmptoms 的稀罕X连接后退的混乱,损害马达开发,混乱,并且进步 spasticity.The proteolipid 蛋白质 1 ( PLPl )基因是 PLP1 基因的 PMD.Duplication 的唯一的病原的基因是为在编码的点变化定序的 500%-70%of PMD cases.whereas 的最经常的基因 defect.accounting 或splice 地点说明 cases.This 学习试图在九个无关的下巴识别 PLP1 变化的 10%-25%of | WANG Jing-min WU Ye WANG Hui-fang DENG Yan-hua YANG Yan-ling QIN Jiong LI Xin-yi WU Xi-ru JIANG Yu-wu | 2008 | Chinese Medical Journal2008，，17： | 7 |
| 20 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
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