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| 1 | Facilities for Centralized Isolation and Quarantine for the Observation and Treatment of Patients with COVID-19显示文摘The coronavirus disease 2019(COVID-19)pandemic increased the burden on many healthcare systems and in the process,exposed the need for medical resources and physical space.While few studies discussed the efficient utilization of medical resources and physical space so far.Therefore,this study aimed to summarize experiences related to facilities used for centralized isolation for medical observation and treatment during the COVID-19 pandemic in China and to provide suggestions to further improve the management of confirmed cases,suspected cases,and close contacts.In China,three types of facilities for centralized isolation(Fangcang shelter hospitals,refitted non-designated hospitals,and quarantine hotels)underwent retrofitting for the treatment and isolation of confirmed and suspected cases.These facilities mitigated the immediate high demand for space.Moreover,in order to minimize infection risks in these facilities,regulators and governmental agencies implemented new designs,management measures,and precautionary measures to minimize infection risk.Other countries and regions could refer to China’s experience in optimally allocating social resources in response to the COVID-19 pandemic.As a conclusion,government should allocate social resources and construct centralized isolation and quarantine facilities for an emergency response,health authorities should issue regulations for centralized isolation facilities and pay strict attention to the daily management of these facilities,a multidisciplinary administration team is required to support the daily operation of a centralized isolation facility,in-depth studies and international collaboration on the centralized isolation policy are encouraged. | Xianliang Wang Jiao Wang Jin Shen John SJi Lijun Pan Hang Liu Kangfeng Zhao Li Li Bo Ying Lin Fan Liubo Zhang Lin Wang Xiaoming Shi | 2021 | Engineering2021，7，7： | 3 |
| 2 | Secondary hyperparathyroidism associated with multiple brown tumor:a case report显示文摘Brown tumour represents a serious complication of hyperparathyroidism.Definitive diagnosis is based on histological examination,clinical,radiological and laboratory data.Here we report a case of multiple brown tumours localised in collarbone,rib and in the distal ulna due to secondary hyperparathyroidism in a 37-year-old women with chronic renal failure.The clinical management of brown tumour aimed primarily to reduce the elevated parathyroid hormone levels by pharmacological treatment.In our experience,clinicians usually consider brown tumor of hyperparathyroidism is caused by giant cell lesions in maintenance hemodialysis recipients,and multiple brown tumours are rarely seen in these patients. | Li Kangfeng Chen Zhou Zhao Xuezhi Zhou Yukun Zhang Dechang Yang Guanhu Tang Xiaofang | 2011 | Journal of Medical Colleges of PLA(China)2011，26，6： | 0 |
| 3 | Healthy Environment Promotion Campaign in Healthy China Initiative显示文摘On July 15,2019,the State Council of China issued new guidelines for the implementation of the country’s Healthy China Initiative(2019–2030)and for the promotion of population health across the nation.This article interprets Healthy Environment Promotion Campaign(HEPC)in the Healthy China Initiative from four main aspects—background,major indices,strategies,and features.Two outcome indices and four advocacy indices are proposed by the HEPC,and the strategies are mainly embodied at three levels:individual/family,society and government.The strategies have the following features:1)the strategies are developed on the basis of scientific evidence;2)the strategies advocate that citizens must be responsible for their own health;3)the administrative impetus provided by the Chinese government to integrate health into all policies is an important driver for developing and implementing the HEPC;and 4)HEPC is not an isolated campaign,so it is necessary to coordinate all 15 campaigns in order to proactively and properly implement HEPC. | Bo Sun Yibin Cheng Yonghong Li Xianliang Wang Kangfeng Zhao Xiaoyuan Yao Lin Wang Shilu Tong Xiaoming Shi | 2020 | China CDC weekly2020，2，10： | 0 |
| 4 | Biosynthesis and Immunological Evaluation of a Dual-Antigen Nanoconjugate Vaccine Against Brucella melitensis显示文摘Brucellosis,caused by Brucella,is one of the most common zoonosis.However,there is still no vaccine for human use.Although some live attenuated vaccines have been approved for animals,the protection effect is not ideal.In this study,we developed a dual-antigen nanoconjugate vaccine containing both polysaccharide and protein antigens against Brucella.First,the antigenic polysaccharide was covalently coupled to the outer membrane protein Omp19 using protein glycan coupling technology,and then it was successfully loaded on a nano-carrier through the SpyTag/SpyCatcher system.After confirming the efficient immune activation and safety performance of the dual-antigen nanoconjugate vaccine,the potent serum antibody response against the two antigens and remarkable protective effect in non-lethal and lethal Brucella infection models were further demonstrated through different routes of administration.These results indicated that the dual-antigen nanoconjugate vaccine enhanced both T helper 1 cell(Th1)and Th2 immune responses and protected mice from Brucella infection.Furthermore,we found that this protective effect was maintained for at least 18 weeks.To our knowledge,this is the first Brucella vaccine bearing diverse antigens,including a protein and polysaccharide,on a single nanoparticle.Thus,we also present an attractive technology for co-delivery of different types of antigens using a strategy applicable to other vaccines against infectious diseases. | Jing Huang Yufei Wang Kangfeng Wang Shulei Li Peng Sun Yan Guo Jiankai Liu Ruifu Yang Ming Zeng Chao Pan Hengliang Wang Li Zhu | 2023 | Engineering2023，，10： | 0 |
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