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| 1 | Control of aliphatic halogenated DBP precursors with multiple drinking water treatment processes: Formation potential and integrated toxicity显示文摘The comprehensive control efficiency for the formation potentials(FPs) of a range of regulated and unregulated halogenated disinfection by-products(DBPs)(including carbonaceous DBPs(C-DBPs), nitrogenous DBPs(N-DBPs), and iodinated DBPs(I-DBPs)) with the multiple drinking water treatment processes, including pre-ozonation, conventional treatment(coagulation–sedimentation, pre-sand filtration), ozone-biological activated carbon(O_3-BAC) advanced treatment, and post-sand filtration, was investigated. The potential toxic risks of DBPs by combing their FPs and toxicity values were also evaluated.The results showed that the multiple drinking water treatment processes had superior performance in removing organic/inorganic precursors and reducing the formation of a range of halogenated DBPs. Therein, ozonation significantly removed bromide and iodide,and thus reduced the formation of brominated and iodinated DBPs. The removal of organic carbon and nitrogen precursors by the conventional treatment processes was substantially improved by O_3-BAC advanced treatment, and thus prevented the formation of chlorinated C-DBPs and N-DBPs. However, BAC filtration leads to the increased formation of brominated C-DBPs and N-DBPs due to the increase of bromide/DOC and bromide/DON.After the whole multiple treatment processes, the rank order for integrated toxic risk values caused by these halogenated DBPs was haloacetonitriles(HANs)》haloacetamides(HAMs) >haloacetic acids(HAAs) > trihalomethanes(THMs) > halonitromethanes(HNMs) 》I-DBPs(I-HAMs and I-THMs). I-DBPs failed to cause high integrated toxic risk because of their very low FPs. The significant higher integrated toxic risk value caused by HANs than other halogenated DBPs cannot be ignored. | Yimeng Zhang Wenhai Chu Dechang Yao Daqiang Yin | 2017 | Journal of Environmental Sciences2017，29，8： | 15 |
| 2 | Preparation and anisotropic properties of textured structural ceramics: A review显示文摘Ceramics are usually composed of randomly oriented grains and intergranular phases, so their properties are the statistical average along each direction and show isotropy corresponding to the uniform microstructures. Some methods have been developed to achieve directional grain arrangement and preferred orientation growth during ceramic preparation, and then textured ceramics with anisotropic properties are obtained. Texture microstructures give particular properties to ceramics along specific directions, which can effectively expand their application fields. In this review, typical texturing techniques suitable for ceramic materials, such as hot working, magnetic alignment, and templated grain growth(TGG), are discussed. Several typical textured structural ceramics including α-Al2O3 and related nacre bioinspired ceramics, Si3N4 and SiAlON, h-BN, MB2 matrix ultra-high temperature ceramics, MAX phases and their anisotropic properties are presented. | Zhuo ZHANG Xiaoming DUAN Baofu QIU Zhihua YANG Delong CAI Peigang HE Dechang JIA Yu ZHOU | 2019 | Journal of Advanced Ceramics2019，8，3： | 14 |
| 3 | Progress of a novel non-oxide Si-B-C-N ceramic and its matrix composites显示文摘In the past twenty years,Si-B-C-N ceramic has attracted wide attention due to its special structure and outstanding properties.The ceramic generally has an amorphous or a nano-crystalline structure,and has excellent structural stability,oxidation resistance,creep resistance and high-temperature mechanical properties,etc.Thus,Si-B-C-N ceramic attracts many researchers and finds potential applications in transportation,aerocraft,energy,information,microelectronics and environment,etc.Much work has been carried out on its raw materials,preparation processes,structural evolution,phase equilibrium and high-temperature properties.In recent years,many researchers focus on its new preparation methods,the preparation of dense ceramic sample with large dimensions,ceramic matrix composites reinforced by carbon fiber or SiC whisker,or components with various applications.Research on Si-B-C-N ceramic will develop our insight into the relationship between structures and properties of ceramics,and will be helpful to the development of novel high-performance ceramics.This paper reviews the preparation processes,general microstructures,mechanical,chemical,electrical and optical properties,and potential applications of Si-B-C-N ceramic,as well as its matrix composites. | Pengfei ZHANG Dechang JIA Zhihua YANG Xiaoming DUAN Yu ZHOU | 2012 | Journal of Advanced Ceramics2012，1，3： | 11 |
| 4 | Effects of heavy metal pollution of highway origin on soil nematode guilds in North Shenyang, China显示文摘Soil samples were collected with distance at 5,20,40,80,160,and 320 m from the Shen-Ha(Shenyang-Harbin) Highway,Northeast China,to investigate the effect of heavy metals of highway origin on soil nematode guilds.The contents of soil Pb,Cu,Zn,and the nematode community structure were analyzed.The results showed that the contents of total and available Pb,Cu,Zn varied significantly with the different distances from the highway.Pb was the main pollutant in the soils in the vicinity of Shen-Ha Highway.The zone from 20 to 40 m away from the highway was the most polluted area.The highest abundance of soil nematodes was found at 5 m while the lowest at 20 m away from the highway.Thirty six genera of nematodes belonging to 23 families were identified.Nematode guilds having different responses to soil heavy metals were classified into four types.Soil nematode guilds may act as a prominent indicator to heavy metal pollution of highway origin. | HAN Dechang ZHANG Xiaoke TOMAR Vijay Vikram Singh LI Qi WEN Dazhong LIANG Wenju | 2009 | Journal of Environmental Sciences2009，21，2： | 10 |
| 5 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 6 | Lipopolysaccharide induced intestinal epithelial injury:a novel organoids-based model for sepsis in vitro显示文摘Background: Advances in organoid culture technology have provided a greater understanding of disease pathogenesis, which has been rarely studied in sepsis before. We aim to establish a suitable organoids-based intestinal injury model for sepsis.Methods: Stable passaged organoids were constructed and pre-treated with lipopolysaccharide (LPS) to mimic sepsis-induced intestinal injury. The LPS-induced sepsis model was used as a reference. We used quantitative real-time polymerase chain reaction to evaluate the RNA levels of inflammatory factors and antimicrobial peptides. Enzyme-linked immunosorbent assay was used to evaluate the protein levels, hematoxylin and eosin staining was used to evaluate the pathology of the small intestine of mice, and immunohistochemistry and immunofluorescence were used to evaluate the intestinal epithelial barrier function. Perkin Elmer OperettaTM was used to obtain high-resolution images of three-dimensional organoids.Results: An LPS concentration >150 μg/mL after 24 h was identified to cause organoid growth restriction. The fluorescence intensity of zonula occludens-1 and occludins at LPS concentrations >100 μg/mL decreased significantly after 24 h. After LPS stimulation for 8 h, the RNA expression levels of interleukin (IL)-1α, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, IL-6, and regenerating islet-derived protein 3 alpha, beta, and gamma increased. These results resembled those of intestinal epithelial layer alterations in a mouse sepsis model. For IL-10, the RNA expression level increased only when the LPS level >200 μg/mL for 24 h.Conclusions: This study provides the primary intestinalin vitro model to study the effects of LPS-induced intestinal injury resembling sepsis. This model provides a platform for immune associated mechanism exploration and effective drug screening. | Sisi Huang Sheng Zhang Limin Chen Xiaojun Pan Zhenliang Wen Yizhu Chen Lidi Zhang Jiao Liu Dechang Chen | 2022 | Chinese Medical Journal2022，135，18： | 3 |
| 7 | Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model显示文摘Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome which afflicts multiple organs and for which there is no cure, such that TSC patients may develop severe mental retardation and succumb to renal or respiratory failure. TSC derives from inactivating mutations of either the TSC1 or TSC2 tumor suppressor gene, and the resulting inactivation of the TSC1/TSC2 protein complex causes hyperactivation of the mammalian target of rapamycin (mTOR), leading to uncontrolled cell growth and proliferation. Recent clinical trials of targeted suppression of mTOR have yielded only modest success in TSC patients. It was proposed that abrogation of a newly identified mTOR-mediated negative feedback regulation on extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway and on the well-documented RTK-PI3K-AKT signaling cascade could limit the efficacy of mTOR inhibitors in the treatment of TSC patients. Therefore, we speculate that dual inhibition of mTOR and ERK/MAPK pathways may overcome the disadvantage of single agent therapies and boost the efficacy of mTOR targeted therapies for TSC patients. Investigation of this hypothesis in a TSC cell model revealed that mTOR suppression with an mTOR inhibitor, rapamycin (sirolimus), led to up-regulation of ERK/MAPK signaling in mouse Tsc2 knockout cells and that this augmented signaling was attenuated by concurrent administration of a MEK1/2 inhibitor, PD98059. When compared with monotherapy, combinatorial application of rapamycin and PD98059 had greater inhibitory effects on Tsc2 deficient cell proliferation, suggesting that combined suppression of mTOR and ERK/MAPK signaling pathways may have advantages over single mTOR inhibition in the treatment of TSC patients. | Ruifang Mi Jianhui Ma Dechang Zhang Limin Li Hongbing Zhang | 2009 | Journal of Genetics and Genomics2009，36，6： | 3 |
| 8 | Structure and magneto-electrical properties of Fe-C films prepared by magnetron sputtering显示文摘Fe-doped amorphous Fe x C 1 x granular films were prepared on n-Si(100) substrates by d.c.magnetron sputtering.The structural properties of Fe x C 1 x films were investigated by X-ray diffraction(XRD),atomic force microscope(AFM) and Raman spectroscopy.The results show that the iron and carbon of as-deposited films are in amorphous state,and the Fe x C 1 x films are diamond-like carbon(DLC) films.After doping iron into the DLC films,a smooth surface morphology of the Fe x C 1 x films has been obtained with the surface roughness Ra of about 0.231 nm for x=18at%.The Fe x C 1 x films have good soft magnetic properties with the coercivity of approximately 20 Oe.A high positive magnetoresistance(MR) up to 93% with x=1at% was observed in a Fe x C 1 x granular film at 300 K.The resistance characteristic of Fe-C films is changed at about 230 K and the positive MR effect can be understood by the p-n heterojunction theory. | MA Lei LIU ZhongWu ZENG DeChang YU HongYa ZHONG XiaPing ZHANG XiaoZhong | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 3 |
| 9 | Target serum concentration of vancomycin may be reached earlier with a loading dose显示文摘Background:Vancomycin treatment failure against vancomycin-susceptible gram-positive cocci is not rare in the intensive care unit(ICU).One of the reasons for this is the substandard drug trough concentration.We aimed to examine the hypothesis that the target serum concentration could be reached earlier with a loading dose of vancomycin.Methods:This retrospective cohort study was conducted at our ICU between June 2018 and June 2020 and involved patients who were suspected of having,or confirmed to have,gram-positive cocci infection and treated with vancomycin.One group of the patients was administered a loading dose of vancomycin(loading group)and compared with the group that did not receive a loading dose(control group).The baseline characteristics,vancomycin serum concentrations,and clinical outcomes were collected and analyzed.Results:Fifty-five patients were finally included,of which 29 received a loading dose of vancomycin.The serum concentration of vancomycin before the second dose was significantly higher for the loading group than for the control group(10.3±6.1 mg/Lvs.5.7±4.4 mg/L,P=0.002).The results for both groups were similar before the fifth dose(12.4±7.3 mg/Lvs.10.3±6.3 mg/L in the loading and the control groups,respectively;P=0.251).The 28-day mortality was lower for the loading group than for the control group(6.7%vs.34.6%in the loading and control groups,respectively;P=0.026).No significant differences were observed in serum creatinine(Cr)concentrations of the two groups.Conclusion:With the loading dose of vancomycin,the target serum concentration of vancomycin may be reached earlier without increasing the risk of acute kidney injury. | Yanxia Huang Le He Yunxin Deng Renjing Zhang Mei Meng Jiao Liu Dechang Chen | 2022 | Chinese Medical Journal2022，，3： | 2 |
| 10 | Pulling out a peptide chain from β-sheet crystallite: Propagation of instability of H-bonds under shear force显示文摘Anti-parallel β-sheet crystallite as the main component of silk fibroin has attracted much attention due to its superior mechanical properties. In this study, we examine the processes of pulling a peptide chain from β-sheet crystallite using steered molecular dynamics simulations to investigate the rupture behavior of the crystallite. We show that the failure of β-sheet crystallite was accompanied by a propagation of instability of hydrogen-bonds(H-bonds) in the crystallite. In addition, we find that there is an optimum size of the crystallite at which the H-bonds can work cooperatively to achieve the highest shear strength. In addition, we find that the stiffness of loading device and the loading rates have significant effects on the rupture behavior of β-sheet crystallite.The stiff loading device facilitates the rebinding of the Hbond network in the stick-slip motion between the chains,while the soft one suppresses it. Moreover, the rupture force of β-sheet crystallites decreases with loading rate. Particularly, when the loading rate decreases to a critical value, the rupture force of the β-sheet crystallite becomes independent of the loading rates. This study provides atomistic details of rupture behaviors of β-sheet crystallite, and, therefore, sheds valuable light on the underlying mechanism of the superior mechanical properties of silk fibroin. | Changjian Xu Dechang Li Yuan Cheng Ming Liu Yongwei Zhang Baohua Ji | 2015 | Acta Mechanica Sinica2015，31，3： | 2 |
| 11 | Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability显示文摘Tumor cells have unique metabolic programming that is biologically distinct from that of corresponding normal cells.Resetting tumor metabolic programming is a promising strategy to ameliorate drug resistance and improve the tumor microenvironment.Here,we show that carboxyamidotriazole(CAI),an anticancer drug,can function as a metabolic modulator that decreases glucose and lipid metabolism and increases the dependency of colon cancer cells on glutamine metabolism.CAI suppressed glucose and lipid metabolism utilization,causing inhibition of mitochondrial respiratory chain complex I,thus producing reactive oxygen species(ROS).In parallel,activation of the aryl hydrocarbon receptor(Ah R)increased glutamine uptake via the transporter SLC1A5,which could activate the ROS-scavenging enzyme glutathione peroxidase.As a result,combined use of inhibitors of GLS/GDH1,CAI could effectively restrict colorectal cancer(CRC)energy metabolism.These data illuminate a new antitumor mechanism of CAI,suggesting a new strategy for CRC metabolic reprogramming treatment. | Jing Shi Rui Ju Hongting Gao Yuqing Huang Lei Guo Dechang Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 12 | Microstructural evolution of h-BN matrix composite ceramics with La-Al-Si-O glass phase during hot-pressed sintering显示文摘BN/La-Al-Si-O composite ceramics were fabricated by hot-pressed sintering using hexagonal boron nitride(h-BN),lanthanum oxide(La_(2)O_(3)),aluminia(Al_(2)O_(3)),and amorphous silica(SiO_(2))as the raw materials.The effects of sintering temperature on microstructural evolution,bulk density,apparent porosity,and mechanical properties of the h-BN composite ceramics were investigated.The results indicated that La-Al-Si-O liquid phase was formed during sintering process,which provided an environment for the growth of h-BN grains.With increasing sintering temperature,the cristobalite phase precipitation and h-BN grain growth occurred at the same time,which had a significant influence on the densification and mechanical properties of h-BN composite ceramics.The best mechanical properties of BN/La-Al-Si-O composite ceramics were obtained under the sintering temperature of 1700℃.The elastic modulus,flexural strength,and fracture toughness were 80.5 GPa,266.4 MPa,and 3.25 MPa·m^(1/2),respectively. | Baofu QIU Xiaoming DUAN Zhuo ZHANG Chen ZHAO Bo NIU Peigang HE Delong CAI Lei CHEN Zhihua YANG Yujin WANG Dechang JIA Yu ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 2 |
| 13 | Solution of the problem of determination of the density of heat flow due to high-pressure gas quenching by the finite-element method显示文摘 | Huang Peng Wie Xingzhao Zhang Weiwen Zeng Dechang | 2006 | Metal Science and Heat Treatment (-)2006，，5： | 1 |
| 14 | Phylogenetic analysis in some Diospyros spp. (Ebenaceae) and Japanese persimmon using chloroplast DNA PCR-RFLP markers显示文摘 | Dechang Hu Qinglin Zhang Zhengrong Luo | 2008 | Scientia Horticulturae2008，，1： | 1 |
| 15 | The genera- tion of XML-based datasets for moving object database 显示文摘 | Jiang Xiajun Zhang Yuping Pi Dechang | 2011 | Adv Inform Sci Serv Sci2011，3，2： | 1 |
| 16 | Sintering mechanism and dielectric properties of LiTaO 3 matrix composites with the addition of Al 2 O 3 particles显示文摘 | Youfeng Zhang Dechang Jia Yu Zhou Qingchang Meng Yangai Liu Hua Ke | 2009 | Ceramics International2009，，： | 1 |
| 17 | Non-180° domains formarion mechanism in LiTaO3grains of an Al2O3/LiTaO3 composite显示文摘 | ZHANG Youfeng ZHOU Yu JIA Dechang | 2009 | Ceramics International2009，35，3： | 1 |
| 18 | Removal of copper from aqueous solution by carbon nanotube/calcium alginate composites显示文摘 | Yanhui Li Fuqiang Liu Bing Xia Qiuju Du Pan Zhang Dechang Wang Zonghua Wang Yanzhi Xia | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 19 | Removal of lead from aqueous solution by activated carbon prepared from Enteromorpha prolifera by zinc chloride activation显示文摘 | Yanhui Li Qiuju Du Xiaodong Wang Pan Zhang Dechang Wang Zonghua Wang Yanzhi Xia | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 20 | Variations of Microstructure and Mechanical Properties of Si-B-O-N Ceramics with Sintering Temperatures显示文摘Si-B-O-N powder without B-O bonds synthesized by polymeric precursor were hot-pressed into ceramics at different temperatures. The variations of microstructure and mechanical properties of Si-B-O-N ceramics have been investigated. Crystallization of Si-B-O-N ceramics occurred at about 1400°C. Density, elastic modulus, and flexural strength of the ceramics increased with the increasing sintering temperatures, and reached to their maximum values at 1600°C. By contrast, hardness and fracture toughness of the ceramics monotonically changed with increasing sintering temperatures. Hardness decreased, while the fracture toughness increased. The principal toughening mechanisms including crack deflection, crack bridging and plate grain pulling-out effects are | Junbao ZHANG, Guangwu WEN, Tingquan LEI, Dechang JIA and Jiancun RAOSchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | 2002 | Journal of Materials Science & Technology2002，18，4： | 1 |
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