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| 1 | Caking property and active components of coal based on group component separation显示文摘The content and the caking index of the heavy,the dense medium and the loose medium components of coal,obtained by extraction and stripping with CS_2/N-methyl-2-pyrrolidinone mixed solvent(1:1 by volume),were studied and correlated with the caking property of raw coals.Images of the three group components after heat treatment were analyzed.The results show that both caking index(G) and maximum thickness of plastic layer(Y) of coals have a good linear relationship with the content of the medium component;the dense medium and the loose medium components are the two key factors to determine the caking property of raw coals-they are the source materials of fluidity and swelling of coal,respectively;the heavy component without the swelling and fluidity was cohered by the other components;two new indexes,which can extend current understanding of the caking properties,were introduced. | Qin Zhihong Li Xiang Sun Hui Zhao Cuicui Rong Liman | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
| 2 | Profiling of hepatocellular carcinoma neoantigens reveals immune microenvironment and clonal evolution related patterns显示文摘Objective: Neoantigens derived from tumor-specific genomic alterations have demonstrated great potential for immunotherapeutic interventions in cancers. However, the comprehensive profile of hepatocellular carcinoma(HCC) neoantigens and their complex interplay with immune microenvironment and tumor evolution have not been fully addressed.Methods: Here we integrated whole exome sequencing data, transcriptome sequencing data and clinical information of 72 primary HCC patients to characterize the HCC neoantigen profile, and systematically explored its interactions with tumor clonal evolution, driver mutations and immune microenvironments.Results: We observed that higher somatic mutation/neoantigen load was associated with better clinical outcomes and HCC patients could be further divided into two subgroups with distinct prognosis based on their neoantigen expression patterns. HCC subgroup with neoantigen expression probability high(NEP-H) showed more aggressive pathologic features including increased incidence of tumor thrombus(P=0.038), higher recurrence rate(P=0.029),more inclined to lack tumor capsule(P=0.026) and with more microsatellite instability sites(P=0.006). In addition,NEP-H subgroup was also characterized by higher chance to be involved in tumor clonal evolution [odds ratio(OR)=46.7, P<0.001]. Gene set enrichment analysis revealed that upregulation of MYC and its targets could suppress immune responses, leading to elevated neoantigen expression proportion in tumor cells. Furthermore, we discovered an immune escape mechanism that tumors could become more inconspicuous by evolving subclones with less immunogenicity. We observed that smaller clonal mutation clusters with higher immunogenicity in tumor were more likely to involve in clonal evolution. Based on identified neoantigen profiles, we also discovered series of neoantigenic hotspot genes, which could serve as potential actionable targets in future.Conclusions: Our results revealed the landscape of HCC neoantigens and discovered two clinically relevant subgroups with distinct neoantigen expression patterns, suggesting the neoantigen expression should be fully considered in future immunotherapeutic interventions. | Zhenli Li Geng Chen Zhixiong Cai Xiuqing Dong Lei He Liman Qiu Yongyi Zeng Xiaolong Liu Jingfeng Liu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 3 | A novel low pressure-difference fluctuation electro-hydraulic large flowrate control valve for fuel flowrate control of aeroengine afterburner system显示文摘To address the control accuracy of large fuel flowrate during pressure fluctuation,a novel electro-hydraulic fuel metering unit(FMU)is constructed for afterburner fuel system of military aeroengine.Different from the previous FMU,the proposed FMU can achieve the higher precision opening control by a new metering valve with double control chambers(MVDCC),and realize the lower pressure difference fluctuation regulating by a novel two-stage constant pressure difference compensated valve(CPDCV)with dynamic damping orifice and damping piston.The experimental and AMESim simulation results verify the validity and superiority of the novel FMU.Since the temperature-induced variation in fuel properties and device capabilities may degrade or even impair the properties of novel FMU,the discharge flowrate is analyzed by global sensitivity analysis to research the effect proportion of each factor,the temperature effect is explored to ensure the working reliability in long-span temperature variation.Finally,the optimization of structure parameters for novel CPDCV can further reduce pressure difference fluctuation during pressure regulation,and the overshoot,adjust time and the integral of time multiplied by absolute value of error(ITAE)can be reduced by 24%,30%and 26%,respectively.This paper provides a reference for improving the stability of large flowrate during pressure fluctuation. | Jie HANG Yunhua LI Liman YANG | 2022 | Chinese Journal of Aeronautics2022，35，11： | 1 |
| 4 | An in vitro study on the dental caries preventing effect of oligomeric procyanidins in sorghum episperm 显示文摘 | XU Liman LIU Rui LI Duandan | 2011 | Food Chemistry2011，126，3： | 1 |
| 5 | An in vitro study on the dentaJ caries preventing effect of oligomeric procyandins in sorghum episperm显示文摘 | XU LIMAN LIU RUI LI DUANDAN | 2011 | Food Chemistry2011，126，3： | 1 |
| 6 | Tunable light emission from carbon dots by controlling surface defects显示文摘Carbon dots(CDs)are metal-free fluorescent materials that can be used in optical and electronic devices,but few studies have focused on one-step synthesis routes for CDs with tunable color and high photoluminescence quantum yield(PLQY).Herein,CDs with tunable light emission were synthesized using a novel amide-assisted solvothermal approach.The as-prepared CDs were well dispersed and homogeneous,with average diameters of approximately 2.0–4.0 nm,depending on the dopants.Owing to the surface states with different ratios of nitrogen-and oxygen-related species,different CDs can exhibit blue,green,red,or white emission with relatively high PLQYs of 61.6%,41.3%,29.1%and 19.7%,respectively.XPS measurements,in conjunction with DFT calculations,indicate that nitrogen substitution(pyridinic/pyrrolic nitrogen)dominates the blue emission,while introducing oxygen functional groups lowered the LUMO energy level,which resulted in redder emission.In addition,the CDs are demonstrated as a bioimaging probe in both in vitro and in vivo assays,and the white light CDs have been demonstrated to be potential fluorescent materials for white-light-emitting diode(WLED). | Huijun Li Sancan Han Bowen Lyu Ting Hong Shibo Zhi Ling Xu Fengfeng Xue Liman Sai Junhe Yang Xianying Wang Bin He | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 7 | Network-Based Coordinated Motion Control of Large-Scale Transportation Vehicles显示文摘 | Li Yunhua Yang Liman | 2007 | Mechatronics IEEE/ASME Trans On2007，，2： | 1 |
| 8 | Network-based coordinated motion control of large-scale transportation vehicles 显示文摘 | Li Yunhua Yang Liman Yang Guilin | 2007 | Transactions on Mechatronics2007，12，2： | 1 |
| 9 | Preparation and characterization of methacrylate-based monolith for ca- pillary hydrophilic interaction chromatography显示文摘 | Chen Mingluan Li Liman Yuan Bifeng | 2012 | J Chro- matogr A2012，1230，23： | 1 |
| 10 | An in vitro study on the dental caries preventing effect of oligomeric procyanidinsin sorghum episperm 显示文摘 | XU Liman LIU Rui LI Duandan | 2011 | Food Chem2011，126，： | 1 |
| 11 | An in vitro study on the dental caries preventing effect of oligomeric procyanidinsin sorghum episperm显示文摘 | Liman Xu Rui Liu Duandan Li | 2011 | Food Chemistry2011，126，： | 1 |
| 12 | Vote-Based Feature Selection Method for Stratigraphic Recognition in Tunnelling Process of Shield Machine显示文摘Shield machines are currently the main tool for underground tunnel construction. Due to the complexity and variability of the underground construction environment, it is necessary to accurately identify the ground in real-time during the tunnel construction process to match and adjust the tunnel parameters according to the geological conditions to ensure construction safety. Compared with the traditional method of stratum identifcation based on staged drilling sampling, the real-time stratum identifcation method based on construction data has the advantages of low cost and high precision. Due to the huge amount of sensor data of the ultra-large diameter mud-water balance shield machine, in order to balance the identifcation time and recognition accuracy of the formation, it is necessary to screen the multivariate data features collected by hundreds of sensors. In response to this problem, this paper proposes a voting-based feature extraction method (VFS), which integrates multiple feature extraction algorithms FSM, and the frequency of each feature in all feature extraction algorithms is the basis for voting. At the same time, in order to verify the wide applicability of the method, several commonly used classifcation models are used to train and test the obtained efective feature data, and the model accuracy and recognition time are used as evaluation indicators, and the classifcation with the best combination with VFS is obtained. The experimental results of shield machine data of 6 diferent geological structures show that the average accuracy of 13 features obtained by VFS combined with diferent classifcation algorithms is 91%;among them, the random forest model takes less time and has the highest recognition accuracy, reaching 93%, showing best compatibility with VFS. Therefore, the VFS algorithm proposed in this paper has high reliability and wide applicability for stratum identifcation in the process of tunnel construction, and can be matched with a variety of classifer algorithms. By combining 13 features selected from shield machine data features with random forest, the identifcation of the construction stratum environment of shield tunnels can be well realized, and further theoretical guidance for underground engineering construction can be provided. | Liman Yang Xuze Guo Jianfu Chen Yixuan Wang Huaixiang Ma Yunhua Li Zhiguo Yang Yan Shi | 2023 | Chinese Journal of Mechanical Engineering2023，36，5： | 0 |
| 13 | Molecular Cloning, Expression Pattern, and 3D Structural Prediction of the Cold Inducible RNA- Binding Protein(CIRP) in Japanese Flounder(Paralichthys olivaceus)显示文摘Cold-inducible RNA-binding protein(CIRP) is a kind of RNA binding proteins that plays important roles in many physiological processes. The CIRP has been widely studied in mammals and amphibians since it was first cloned from mammals. On the contrary, there are little reports in teleosts. In this study, the Po CIRP gene of the Japanese flounder was cloned and sequenced. The genomic sequence consists of seven exons and six introns. The putative Po CIRP protein of flounder was 198 amino acid residues long containing the RNA recognition motif(RRM). Phylogenetic analysis showed that the flounder Po CIRP is highly conserved with other teleost CIRPs. The 5' flanking sequence was cloned by genome walking and many transcription factor binding sites were identified. There is a Cp Gs region located in promoter and exon I region and the methylation state is low. Quantitative real-time PCR analysis uncovered that Po CIRP gene was widely expressed in adult tissues with the highest expression level in the ovary. The m RNA of the Po CIRP was maternally deposited and the expression level of the gene was regulated up during the gastrula and neurula stages. In order to gain the information how the protein interacts with m RNA, we performed the modeling of the 3D structure of the flounder Po CIRP. The results showed a cleft existing the surface of the molecular. Taken together, the results indicate that the CIRP is a multifunctional molecular in teleosts and the findings about the structure provide valuable information for understanding the basis of this protein's function. | YANG Xiao GAO Jinning MA Liman LI Zan WANG Wenji WANG Zhongkai YU Haiyang QI Jie WANG Xubo WANG Zhigang ZHANG Quanqi | 2015 | Journal of Ocean University of China2015，14，1： | 0 |
| 14 | In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging显示文摘The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage therapy.In this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their administration.The delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)group.Both Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with ICT.Our results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies. | Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen | 2024 | Nano Research2024，17，5： | 0 |
| 15 | MULTITASK SCHEDULING IN NETWORKED CONTROL SYSTEMS WITH APPLICATION TO LARGE SCALE VEHICLE CONTROL显示文摘Aiming at scheduling problems of networked control system (NCS) used to fulfill motion synthesis and cooperation control of the distributed multi-mechatronic systems, the differences of network scheduling and task scheduling are compared, and the mathematic description of task scheduling is presented. A performance index function of task scheduling of NCS according to task balance and traffic load matching principles is defined. According to this index, a static scheduling method is designed and implemented to controlling task set simulation of the DCY100 transportation vehicle. The simulation results are applied successfully to practical engineering in this case so as to validate the effectiveness of the proposed performance index and scheduling algorithm. | YANG Liman LI Yunhua | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 0 |
| 16 | ELECTROCHEMICAL STUDY OF ACTIVITY OF Nb_2O_5 AND MnO IN Nb_(?)O_(?)-MnO-SiO_(?)SYSTEM显示文摘Equilibrium between liquid iron containing Nb with Nb2O5-MnO-SiO2 slag was investigatedat 1828 K,the solid electrolyte oxygen concentration cell being used to measure the activityof oxygen in the metal bath.The activity of NbO5 and MnO in the slag was evaluated,accompanied with an iso-activity diagram of aNb2O5 and aMoO in Nb2O5-MnO-SiO2 slay. | ZHANG Shengbi WEI Shoukun WANG Ruiyin LI Liman University of Science and Technology Beijing,Beijing,China ZHANG Shengbi Professor,Dept.of Metallurgical Physical Chemistry,University of Science and Technology Beijing,Beijing 100083,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，10： | 0 |
| 17 | Multiobjective trajectory optimization of intelligent electro-hydraulic shovel显示文摘Multiobjective trajectory planning is still face challenges due to certain practical requirements and mul-tiple contradicting objectives optimized simultaneously.In this paper,a multiobjective trajectory optimization approach that sets energy consumption,execution time,and excavation volume as the objective functions is presented for the electro-hydraulic shovel(EHS).The proposed cubic polynomial S-curve is employed to plan the crowd and hoist speed of EHS.Then,a novel hybrid constrained multiobjective evolutionary algorithm based on decomposition is proposed to deal with this constrained multiobjective optimization problem.The normalization of objectives is introduced to minimize the unfavorable effect of orders of magnitude.A novel hybrid constraint handling approach based onε-constraint and the adaptive penalty function method is utilized to discover infeasible solution information and improve population diversity.Finally,the entropy weight technique for order preference by similarity to an ideal solution method is used to select the most satisfied solution from the Pareto optimal set.The performance of the proposed strategy is validated and analyzed by a series of simulation and experimental studies.Results show that the proposed approach can provide the high-quality Pareto optimal solutions and outperforms other trajectory optimization schemes investigated in this article. | Rujun FAN Yunhua LI Liman YANG | 2022 | Frontiers of Mechanical Engineering2022，17，4： | 0 |
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