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| 1 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 2 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 3 | Recent progress in the study of transition in the hypersonic boundary layer显示文摘Turbulence is a universal form of fluid motion. It is the key issue in fluid mechanics. Very recently, it has become a bottleneck in some key engineering research of national importance, such as aeronautics,astronautics and navigation. Developed turbulence and the onset of turbulence, i.e. transition, are two interrelated parts of turbulence. The hypersonic boundary-layer transition is a strategic focus in the fluid mechanics community. This article reviews recent developments in the study of the hypersonic boundary-layer transition, research facilities and experimental techniques. The hypersonic quiet wind tunnel is introduced as a necessary device to obtain real flight data in near space. Near-wall measurement techniques, such as temperature-sensitive paint, near-wall particle image velocimetry and Rayleigh-scattering visualization, are shown. The most important issues in the recent development of the transition in the hypersonic boundary layer are addressed. The instability and nonlinear interaction of different instability modes are discussed. The recent contributions from China, especially at Peking University, are also introduced. | Cunbiao Lee Shiyi Chen | 2019 | National Science Review2019，6，1： | 10 |
| 4 | Teracluster LSSC-II--Its designing principles and applications in large scale numerical simulations显示文摘The teracluster LSSC-II installed at the State Key Laboratory of Scientific and Engineering Computing, Chinese Academy of Sciences is one of the most powerful PC clusters in China. It has a peek performance of 2Tflops. With a Linpack performance of 1.04Tflops, it is ranked at the 43rd place in the 20th TOP500 List (November 2002), 51st place in the 21st TOP500 List (June 2003), and the 82nd place in the 22nd TOP500 List (November 2003) with a new Linpack performance of 1.3Tflops. In this paper, we present some design principles of this cluster, as well as its applications in some large-scale numerical simulations. | ZHANG Linbo, CHEN Shiyi, LI Xinliang, CAO Jianwen, ZHANG Wensheng & GONG XingaoState Key Laboratory of Scientific and Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Department of Mechanical Engineering, The Johns Hopkins University and Center for Computational Science and Engineering, Peking University, Beijing 100875, China Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China Parallel Computing Laboratory, Institute of Software, Chinese Academy of Sciences, Beijing 100080, China Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Surface Physics Laboratory (National Key Laboratory), Fudan University, Shanghai 200433 Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China | 2004 | Science China Mathematics2004，47，z1： | 8 |
| 5 | Correlations for the ignition delay times of hydrogen/air mixtures显示文摘Correlations for the ignition delay times of hydrogen/air mixtures were developed using the method of High Dimensional Model Representation (HDMR).The hydrogen/air ignition delay times for initial conditions over a wide range of temperatures from 800 to 1600 K,pressures from 0.1 to 100 atm,and equivalence ratios from 0.2 to 10 were first calculated utilizing the full chemical mechanism.Correlations were then developed based on these ignition delay times.Two forms of correlations were constructed:the first one is an overall general model covering the whole range of the initial conditions;while the second one is a piecewise correlation model valid for initial conditions within different sub-domains.The performance of these correlations was studied through comparison with results from the full chemical mechanism as well as experimental data.It was shown that these correlations work well over the whole range of initial conditions and that the accuracy can be significantly improved by using different piecewise correlations for different sub-domains.Therefore,piecewise correlations can be used as an effective replacement for the full mechanism when the prediction of chemical time scale is needed in certain combustion modeling. | ZHAO ZhenLong CHEN Zheng CHEN ShiYi | 2011 | Chinese Science Bulletin2011，56，2： | 8 |
| 6 | One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy显示文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery. | Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 7 | Spatial artificial neural network model for subgrid-scale stress and heat flux of compressible turbulence显示文摘The subgrid-scale(SGS)stress and SGS heat flux are modeled by using an artificial neural network(ANN)for large eddy simulation(LES)of compressible turbulence.The input features of ANN model are based on the first-order and second-order derivatives of filtered velocity and temperature at different spatial locations.The proposed spatial artificial neural network(SANN)model gives much larger correlation coefficients and much smaller relative errors than the gradient model in an a priori analysis.In an a posteriori analysis,the SANN model performs better than the dynamic mixed model(DMM)in the prediction of spectra and statistical properties of velocity and temperature,and the instantaneous flow structures. | Chenyue Xie Jianchun Wang Hui Li Minping Wan Shiyi Chen | 2020 | Theoretical & Applied Mechanics Letters2020，10，1： | 5 |
| 8 | Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine显示文摘Background:The clinical features of keloids consist of aberrant proliferation,secretion,differentiation and apoptosis of keloid dermis-derived fibroblasts(KFBs).Notably,the apoptosis rate of KFBs is lower than the proliferation rate.Though the anti-fibrotic effect of adipose-derived stem cells(ADSCs)on keloids has become a hot topic of research,the exact anti-fibrotic mechanism of the paracrine effect remains unclear.This study aimed to find out how the conditioned medium of ADSCs(ADSC-CM)exerts an anti-fibrotic effect in KFBs.Methods:KFBs and ADSCs were extracted and cultured.Then,ADSC-CM was prepared.Whether ADSC-CM could inhibit KFB growth and induce apoptosis was verified by the use of a cell counting kit-8,an 5-Ethynyl-2-deoxyuridine(Edu)kit and flow cytometry.The expressions of cyclooxygenase-1(COX-1),COX-2,caspase 3 and B-cell lymphoma-2(Bcl-2)in ADSC-CM-cultured KFBs were tested by real-time PCR and western blotting.To clarify the role of COX-2 in ADSC-CM-induced KFB apoptosis,a specific COX-2 inhibitor,celecoxib,was applied to KFBs cultured in ADSC-CM.Moreover,we tested the production of arachidonic acid(AA)and prostaglandin E2(PGE2)by ELISA.Then,we established a keloid transplantation model in a nude mouse to validate the therapeutic effect in vivo.Results:The proliferation ability of KFBs cultured in ADSC-CM was found to be weakened and apoptosis was significantly increased.Caspase 3 expression was significantly upregulated and Bcl-2 was downregulated in ADSC-CM-cultured KFBs.Furthermore,ADSC-CM strikingly elevated COX-2 mRNA and protein expressions,but COX-1 expression was unaltered.COX-2 inhibitors reduced ADSC-CM-induced apoptosis.Additionally,COX-2 inhibition blocked the elevation of caspase 3 and reversed the decrease in Bcl-2 expression.ADSC-CM increased PGE2 levels by 1.5-fold and this effect was restrained by COX-2 inhibition.In the nude mouse model,expressions of AA,COX-2 and PGE2 were higher in the translated keloid tissues after ADSC-CM injection than in the controls.Conclusions:We showed activation of the COX-2/PGE2 cascade in KFBs in response to ADSC-CM.By employing a specific COX-2 inhibitor,COX-2/PGE2 cascade activation played a crucial role in mediating the ADSC-CM-induced KFB apoptosis and anti-proliferation effects. | Jinxiu Yang Shiyi Li Leren He Minliang Chen | 2021 | Burns & Trauma2021，9，1： | 4 |
| 9 | Empirical research on fiscal expenditure efficiency of local governments in China: 1978-2005显示文摘利用DEA非参数技术和受限Tobit模型,本文核算了分权财政改革后中国省级地方政府财政支出的相对效率,并对影响该效率变化模式的各种因素进行了解释。 | Chen Shiyi Zhang Jun | 2009 | Social Sciences in China2009，30，2： | 3 |
| 10 | Assessment of Local Public Finance Performance in China When Undesirable Fiscal Phenomena are Taken into Account显示文摘使用数据包封分析(DEA ) 技术和拿的不受欢迎的财政现象进帐号,这份报纸包括地确定在中国的本地政府的公共金融性能在财政分散的功课期间改革。进这个评价的不受欢迎的财政结果的介绍使在中国识别本地公共金融性能的有意义、增进知识的特征可能。当改革首先被实现时,因为不受欢迎的财政现象还没变得太严肃,本地公共金融性能改善。分享系统改革的税没在它的早阶段工作很好,并且否定地影响公共开销效率。改革开始起在 2001 和 2005 之间的一个实质的作用,当本地政府经历了更好公共的金融性能时。相应于最近的年里的金融部门的恶化,本地公共金融性能在 2007 以后变得更坏。财政的水流和税收系统的进一步的改革在中国是必要的,到为国家保证更明亮的未来。 | Shujian Zhang Jun Zhang Shiyi Chen | 2012 | China & World Economy2012，20，6： | 3 |
| 11 | LATTICE BOLTZMANN METHOD FOR FLUID FLOWS显示文摘 | Shiyi Chen Gary D. Doolen | 1998 | Annual Review of Fluid Mechanics1998，，： | 3 |
| 12 | Constraine d large-e ddy simulation of turbulent flow over inhomogeneous rough surfaces显示文摘In this work we extend the method of the constrained large-eddy simulation(CLES)to simulate the tur-bulent flow over inhomogeneous rough walls.In the original concept of CLES,the subgrid-scale(SGS)stress is constrained so that the mean part and the fluctuation part of the SGS stress can be modelled separately to improve the accuracy of the simulation result.Here in the simulation of the rough-wall flows,we propose to interpret the extra stress terms in the CLES formulation as the roughness-induced stress so that the roughness inhomogeneity can be incorporated by modifying the formulation of the constrained SGS stress.This is examined with the simulations of the channel flow with the spanwise alternating high/low roughness strips.Then the CLES method is employed to investigate the temporal response of the turbulence to the change of the wall condition from rough to smooth.We demonstrate that the temporal development of the internal boundary layer is just similar to that in a spatial rough-to-smooth transition process,and the spanwise roughness inhomogeneity has little impact on the transition process. | Wen Zhang Minping Wan Zhenhua Xia Jianchun Wang Xiyun Lu Shiyi Chen | 2021 | Theoretical & Applied Mechanics Letters2021，11，1： | 2 |
| 13 | Factors involved in the success of Castanea henryi stem cuttings in different cutting mediums and cutting selection periods显示文摘Chinquapin(Castanea henryi) is a dual-purpose tree species in China valued for as a source of timber and starch.We investigated the effect of four cutting mediums(pure vermiculite;peat:river sand at 3:1 v/v;peat:krasnozem at 1:1 v/v;and pure krasnozem) and three stem cutting periods(March,May,and July) on rooting performance of C.henryi cuttings.Different cutting periods and cutting mediums greatly influenced the rooting rate of C.henryi,ranging from 3.35 to 77.31%.Principal component analysis indicated that the best combination of cutting period and cutting medium was semi-hardwood cuttings(May cuttings)+krasnozem.Histological evidence indicated that adventitious root initials were present by week 5-6,and that the site of root primordia initiation was observed in the vascular cambium.Stem anatomical structures observed at different periods indicated that a xylem/radius ratio of29.90-37.42% and a fractured phloem fiber ring are indicative of rooting success.The relational model between rooting index and medium properties indicated that nutrient content and porosity significantly influenced callus production.However,pH strongly affected C.henryi root formation,with the Pearson correlation coefficients for May and July cuttings of-0.856 and-0.947,respectively.Our protocol is helpful to achieve mass clone propagation of improved C.henryi genotypes,thus overcoming a common hurdle in chinquapin breeding programs. | Wangzun Chen Libing He Shiyi Tian Joseph Masabni Huan Xiong Feng Zou Deyi Yuan | 2021 | Journal of Forestry Research2021，32，4： | 2 |
| 14 | Numerical investigation of plane Couette flow with weak spanwise rotation显示文摘Direct numerical simulation of rotating plane Couette flow(RPCF) at Re_w= 1300 and Ro = 0.02 was performed with different mesh resolutions and different sizes of computation domain. Our results showed that a grid resolution in wall units with ?x^+=8.51, ?z^+= 4.26, ?y^+|_(min)= 0.0873 and ?y^+|_(max)= 3.89 is fine enough to simulate the problem at the present parameters. The streamwise length Lxand spanwise length Lzof the computational box have different impacts on the flow statistics, where the statistics were converged if Lxis longer than 8πh, while no converged results were obtained for different Lz. More importantly,our results with very long simulation time showed that a state transition would happen if L_x≥ 8πh, from a state with four pairs of roll cells to a state with three pairs of roll cells with L_z= 6πh. Each state could survive for more than 1500 h/U_w, and the flow statistics were different. | YuHan Huang ZhenHua Xia MinPing Wan YiPeng Shi ShiYi Chen | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，4： | 2 |
| 15 | Local Reynolds number and thresholds of transition in shear flows显示文摘Recent experimental and numerical investigations reveal that the onset of turbulence in plane-Poiseuille flow and planeCouette flow has some similar stages separated with different threshold Reynolds numbers.Based on these observations and the energy equation of a disturbed fluid element,a local Reynolds number Re L is derived to represent the maximum ratio of the energy supplement to the energy dissipation in a cross section.It is shown that along the sequence of transition stages,which include transient localized turbulence,'equilibrium' localized turbulence,spatially intermittent but temporally persistent turbulence and uniform turbulence,the corresponding thresholds of Re L for plane-Couette flow,Hagen-Poiseuille flow and plane-Poiseuille flow are consistent,indicating that the critical(threshold) states during the laminar-turbulent transition are determined by the local properties of the base flow and are independent of global features,such as flow geometries(pipe or channel) and types of driving forces(shear driving or pressure driving). | TAO JianJun CHEN ShiYi SU WeiDong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 2 |
| 16 | Glycogen synthase kinase-3: a key kinase in retinal neuron apoptosis in early diabetic retinopathy显示文摘 | Li Zhaohui Ma Ling Chen Xiaodong Li Yonghao Li Shiyi Zhang Jinglin Lu Lin | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 17 | Highly aligned lithiophilic electrospun nanofiber membrane for the multiscale suppression of Li dendrite growth显示文摘Using inorganic fibrous membranes as protective layers has yielded success in suppressing dendrite growth.However,conventional fibrous membranes usually have large voids and low affinity for Li,promoting inhomogeneous charge distribution and allowing some dendrites to grow.Herein,we introduce a highly aligned TiO_(2)/SiO_(2)(A-TS)electrospun nanofiber membrane as a protective layer for the Li metal anode.The A-TS membrane is fabricated by a custom-made electrospinning system with an automatic fiber alignment collector that allows control of the fibers’orientation.At the scale of the individual fibers,their high binding energies with Li can attract more“dead”Li by reacting with the SiO_(2) component of the composite,avoiding uncontrollable deposition on the metal anode.At the membrane scale,these highly ordered structures achieve homogeneous contact and charge distribution on the Li metal surface,leaving no vulnerable areas to nucleate dendrite formation.Additionally,the excellent mechanical and thermal stability properties of the A-TS membrane prevent any potential puncturing by dendrites or thermal runaway in a battery.Hence,an A-TS@Li anode exhibits stable cycling performance when used in both Li-S and Li-NCM811 batteries,highlighting significant reference values for the future design and development of high-energy-density metal-based battery systems. | Jianan Wang Qianyue Ma Shiyi Sun Kai Yang Qiong Cai Emilia Olsson Xin Chen Ze Wang Amr MAbdelkader Yinshi Li Wei Yan Shujiang Ding Kai Xi | 2022 | eScience2022，2，6： | 2 |
| 18 | Structural change, productivity growth and industrial transformation in China 显示文摘 | Chen Shiyi Jefferson G H Zhang Jun | 2011 | China Economic Review2011，22，1： | 1 |
| 19 | Practical framework for data-driven RANSmodeling with data augmentation显示文摘Inspired by the iterative procedure of computing mean fields with known Reynolds stresses(Guo et al.,Theor Appl Mech Lett,2021),we proposed a way to achieve data augmentation by utilizing the intermediate mean fields after proper selections.We also proposed modifications to the Tensor Basis Neural Network(Ling et al.,J Fluid Mech,2016)model.With the modification of the learning targets and the inclusions of wall distance and logarithm of normalized eddy viscosity in the model inputs,the modified version of the model with augmented training datasets shows better performance on Reynolds stress predictions for two dimensional incompressible flow over periodic hills under different geometries.Furthermore,better propagated mean velocity fields can be achieved,showing better agreements with the direct numerical simulations(DNS)results. | Xianwen Guo Zhenhua Xia Shiyi Chen | 2021 | Acta Mechanica Sinica2021，37，12： | 1 |
| 20 | Hydroxyapatite/regenerated silk fibroin scaffold-enhanced osteoinductivity and osteoconductivity of bone marrow-derived mesenchymal stromal cells显示文摘 | Jia Jiang Wei Hao Yuzhuo Li Jinrong Yao Zhengzhong Shao Hong Li Jianjun Yang Shiyi Chen | 2013 | Biotechnology Letters2013，，4： | 1 |
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