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| 1 | Fhe roles and functional mechanisms of interleukin-17 amily cytokines in mucosal immunity显示文摘 | Xinyang Song Xiao He Xiaoxia Li Youcun Qian | 2016 | Cellular & Molecular Immunology2016，13，4： | 29 |
| 2 | Semigroup Method for a Mathematical Model in Reliability Analysis显示文摘The system which consists of a reliable machine, an unreliable machine and a storage buffer with infinite many workpieces has been studied. The existence of a unique positive time-dependent solution of the model corresponding to the system has been obtained by using C 0-semigroup theory of linear operators in functional analysis. | Geni Gupur 1,3 , LI Xue-zhi 2,3 1.Department of Mathematics, Xinjiang University, Urumqi 830046,China2. Department of Mathematics, Xinyang Teachers College, Henan 464000, China3. Academy of Mathematics and System Sciences, Chinese Academy of Sci | 2001 | Journal of Systems Science and Systems Engineering2001，13，2： | 12 |
| 3 | The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval显示文摘A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in rodents.Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD. | Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 4 | Effect of hydration on the elasticity of mantle minerals and its geophysical implications显示文摘Recent studies have shown that major nominally anhydrous minerals in the Earth's mantle, such as olivine, pyroxene and garnet, can incorporate considerable amounts of water as structurally bound hydroxyl. Even a small amount of water is present in mantle minerals, it can strongly affect a number of physical properties, including density, sound velocity, melting temperature, and electrical conductivities. The presence of water can also influence the dynamic behavior, lead to lateral velocity heterogeneities, and affect the material circulation of the Earth's deep interior. In particular, seismic studies have reported the existence of low-velocity zones in various locations of the Earth's upper mantle and transition zone, which has been expected to be associated with the presence of water in the region. In the past two decades, the effect of water on the elasticity and sound velocities of minerals at relevant pressure-temperature(P-T) conditions of the Earth's mantle attracted extensive interests. Combining the high P-T experimental and theoretical mineralogical results with seismic observations provides crucial constraints on the distribution of water in the Earth's mantle. In this study, we summarize recent experimental and theoretical mineral physics results on how water affects the elasticity and sound velocity of nominally anhydrous minerals in the Earth's mantle, which aims to provide new insights into the effect of hydration on the density and velocity profile of the Earth's mantle, which are of particular importance in understanding of water distribution in the region. | MAO Zhu LI XinYang | 2016 | Science China Earth Sciences2016，59，5： | 5 |
| 5 | Functionalized periodic Au@MOFs nanoparticle arrays as biosensors for dual-channel detection through the complementary effect of SPR and diffraction peaks显示文摘准备 nanoparticle 穿的周期的 Au@metal 器官的框架(MOF )(MIL-100 (Fe )) 的一个灵巧、便宜的方法被开发。数组用单层在 situ 被制作是的胶体的晶体模板,在底层上由 Au 免职列在后面,并且退火。MIL-100 (Fe ) 涂层用简单溶剂在 nanospheres 上被使用热过程。准备周期的 Au@MIL-100 (Fe ) nanoparticle (NP ) 数组被二座山峰在可见系列描绘。第一座山峰表示 Au nanospheres 的表面电浆子回声(SPR ) ,和另外的山峰,或衍射达到顶点,在 NP 数组从周期的结构发源。在有 3-aminophenylboronic 酸 hemisulfate (PBA ) 的修正以后, Au@MIL-100 (Fe ) NP 数组与好选择展出了敏感回答到不同葡萄糖集中。这些回答能由于在 PBA 和葡萄糖分子之间的强壮的相互作用。衍射山峰在低葡萄糖集中(不到 12 公里) 是敏感的,而 SPR 山峰很快在高集中反应了。山峰因此在不同集中区域为葡萄糖察觉表明了令人满意的互补敏感。这些结果能被用来开发一个双隧道的生物传感器。我们也创造了一张标准图,它能被用来高效地监视血葡萄糖层次。建议策略能被扩大与不同识别代理人用 Au@MIL-100 (Fe ) NP 数组 functionalized 开发不同双隧道的传感器。 | Lifeng Hang Fei Zhou Dandan Men Huilin Li Xinyang Li Honghua Zhang Guangqiang Liu Weiping Cai Cuncheng Li Yue Li | 2017 | Nano Research2017，10，7： | 3 |
| 6 | Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study显示文摘Clinical application of bare metal stents is constrained by the occurrence of instent restenosis,mainly due to the complex biomechanical environment in the body.Numerical simulation method was used to evaluate the effect of plaque composition on stent performance in a carotid artery.CT angiography(CTA)data were used as a reference,and zero-load state of the carotid artery was used to establish a 3D stenotic artery model.Different plaque compositions,calcified and hypo-cellular were defined in Model 1 and Model 2,respectively.Interactions between the stents and arterial tissues within the stent crimping-expansion process were analyzed to explore the effects of plaque composition on the mechanical parameters of carotid stents.Goodman diagram and fatigue safety factor(FSF)were analyzed to explore the effects of plaque composition on fatigue performance of a carotid stent in the stent service process.In the stent crimping-expansion process,the von Mises stress in the stent and the dog-boning ratio in Model 1 were higher than that in Model 2.The calcified plaque prevented the stent from expanding the stenotic vessel to a pre-set diameter.Thus,the risk of rupture in the calcified plaque was higher than that in the hypo-cellular plaque.Plaque also affected the stress/strain in the vessel wall,which was observed to be lower in Model 1 than in Model 2.This indicated that calcified plaque could decrease the stress-induced injury of arterial tissues.Within the stent service process,the stents used in these two models were predicted to not fail under fatigue rupture as calculated by the Goodman diagram.Additionally,the points closer to the fatigue limit were generally observed at the inner bend of the stent crowns.The FSF of the stent in Model 1 was lower than that in Model 2.The stent operating in the presence of calcified plaques suffered high risk of fractures.Reliability and fatigue performance of the stent were found to be associated with plaque composition.Hence,this study may provide stent designers an approach toward enhancing the mechanical reliability of a stent. | Xinyang Cui Qingshuai Ren Zihao Li Kun Peng Gaoyang Li ZhaoyongGu Aike Qiao | 2018 | Computer Modeling in Engineering & Sciences2018，，9： | 3 |
| 7 | Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer显示文摘 | Liu Xinyang Zhang Xiaowei Wang Zhichao Chang Jinjia Wu Zheng Zhang Zhe Wang Shanshan Li Jin | 2014 | Chinese Medical Journal2014，，13： | 3 |
| 8 | Electro-Fenton treatment of concentrates generated in nanofiltration of biologically pretreated landfill leachate显示文摘 | Yujue Wang Xinyang Li Limin Zhen Heqing Zhang Ying Zhang Chengwen Wang | 2012 | Journal of Hazardous Materials2012，，： | 3 |
| 9 | 紊乱的肺部菌群通过分泌外膜囊泡调控白介素-17B的产生促进肺纤维化显示文摘文章简介粘膜微生态一直是当前免疫学领域的研究热点,它已经被证明广泛参与多种粘膜组织免疫稳态的维持以及相关疾病的发生。该团队多年来围绕粘膜微生态与白介素-17家族细胞因子做了一系列研究工作,一方面肠癌发生过程中紊乱的微生态菌群可以通过调控IL-17C的产生促进肠癌的发生,另一方面肠道中微生态菌群也可以通过调控IL-17A的分泌促进肠道损伤修复。尽管如此,目前我们对肺组织中微生态的功能尚知之甚少。 | 杨大平 Xi Chen Jingjing Wang Qi Lou Yunwei Lou Li Li Honglin Wang Jiangye Chen Meng Wu Xinyang Song 钱友存 | 2020 | 科学新闻2020，，2： | 3 |
| 10 | 青海河湟谷地胃癌病理特征及其变化趋势分析(英文)显示文摘Objective: The aim of our study was to discuss changes in the clinicopathological characteristics of gastric cancer in Hehuang Valley of China in recent 10 years. Methods: A retrospective case-control study was performed on 2379 newly-diagnosed gastric cancer patients. All of them came from Hehuang Valley. The patients were divided into two groups [recent 5 years(R5Y) and late 5 years(L5Y)] from February 2003 to February 2013, and the clinicopathological data were surveyed retrospectively. Results: The constituent ratio of upper 1/3 gastric cancer in R5Y and L5Y was 33.5% and 20.7%, respectively, and it showed a significant difference between the two groups(χ2 = 21.28, P = 0.00). The constituent ratio of squamous carcinoma/adenosquamous carcinoma was 2.7% and 1.6%, respectively, and it also showed a significant difference between two groups(χ2 = 50.91, P = 0.00). The constituent ratio of moderately-poorly differentiated/poorly differentiated gastric carcinoma was 84.2% and 50.2%, respectively, and it showed statistically significant difference(χ2 = 30.28, P = 0.00). The detection rate of early gastric cancer(EGC) was 1.47%(35/2379). The constituent ratio of the types of Borrmann II and Borrmann IV of advanced gastric cancer(AGC) among 2379 cases was 47.6% and 40.8%, respectively, and that still showed statistically significant difference(χ2 = 18.80, P = 0.00). The constituent ratio of diffuse-type of gastric cancer in R5Y and L5Y was 36.2% and 30.8%, respectively, even there was a significant difference(χ2 = 7.49, P = 0.01). Furthermore, there were also significant differences in regional lymph nodes metastasis, perineural infiltration and vascular invasion(P < 0.05). The positive detection rate of HER2, ER and PR was 14.88%, 17.23% and 15.93%, respectively. The constituent ratio of HP in two groups was 43.8% and 36.2% respectively, and it also showed a significant difference(χ2 = 13.51, P = 0.00). Conclusion: The pathogenic sites in gastric cancer change to the upper stomach in Hehuang Valley in recent 10 years, and the detection rate of squamous carcinoma/adenosquamous carcinoma reveals a sharp rise. Borrmann III is still one of the main types of advanced gastric cancer, but the detection rates of Borrmann II and IV are increasing. The main type of gastric cancer is the intestinaltype, but the ratio of diffuse-type is also increasing in recent 10 years. The HP detection rate is 40.65%(967/2379), and it has a slight rise in recent 10 years. The detection rate of poorly differentiated adenocarcinoma is increasing despite the fact that the moderately/moderately-poorly differentiated adenocarcinoma is the main histologic types. High detection rates of lymph nodes metastasis, perineural infiltration and vascular invasion indicate poor prognosis in patients with gastric cancer. There is no change in HER2 positive rate, on the contrary, there are a little increase in ER and PR expression in Hehuang Valley. | Su Yan Bin Li Junqi Wu Dawei Xie Yingcai Ma Yuanzhi Xiong Xuxiang Ma Xinjian Guo Man Dai Daquan Zhang Xinyang Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，2： | 2 |
| 11 | Amplification and expression of c-MET correlate with poor prognosis of patients with gastric cancer and upregulate the expression of PDL1显示文摘The prognostic significance of c-MET in gastric cancer(GC)remains uncertain.In the present study,we examined the amplification,expression,and the prognostic value of c-MET,human epidermal growth factor receptor 2(HER2),and programmed cell death 1 ligand 1(PDL1),together with the correlations among them in a large cohort of Chinese samples.A total of 444 patients were included.The immunohistochemistry(IHC)and the dual-color silver in situ hybridization(SISH)were performed to examine their expression and amplification.Univariate and multivariate analyses were performed by the Cox proportional hazard regression model,and survival curves were estimated by the Kaplan-Meier method.The positivity determined by IHC of c-MET was 24.8%,and the MET amplification rate was 2.3%.The positivity rates of HER2 and PDL1 were 8%and 34.7%,respectively.PDL1 expression had a significantly positive association with c-MET expression.c-MET positivity played a significant prognostic role in disease-free survival(DFS)(P=0.032).Patients with mesenchymal-epithelial transition(MET)amplification had significantly poorer prognosis on both DFS and overall survival(OS).Subgroup analysis showed that in HER2-negative patients,but not in HER2-positive patients,MET-positive patients had significantly worse DFS(P=0.000)and OS(P=0.006).c-MET regulated the expression of PDL1 through an AKT-dependent pathway.c-MET inhibitor enhanced the T-cell killing ability and increased the efficacy of PD1 antibody.c-MET was found to be an independent prognostic factor for DFS of GC patients.A combination of c-MET inhibitors and PD1 antibodies could enhance the killing capacity of T cells,providing a preliminary basis for the clinical research on the same combination in GC treatment. | Ya’nan Yang Chenchen Wang Congqi Dai Xinyang Liu Wenhua Li Mingzhu Huang Xiaoying Zhao Dongmei Ji Jin Li Weijian Guo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 2 |
| 12 | Experimental Study on the Heating Effect of a Wind-Energy Stirring Heater显示文摘In this paper,an experiment system of wind-energy stirring heater has been designed and built.Its heating performance under the rotation speed of 300 r/min has been studied through changing stirring rotor’s layer number or using different working fluids.With the help of CFD numerical simulation method,we studied the influence factors including temperature rise,total heat,heating power of each experimental group,and analyzed why these factors have such an effect.The results show:increasing the layer number of the stirring rotors can increase the motion intensity of working fluid and improve the heating effect;the quantity of effective working fluid in the rotor area can be increased significantly with the increasing of liquid level;the working liquid with high density,low viscosity,low specific heat capacity will be the ideal one. | LIU Xingran SUN Xianpeng LI Jianming QIU Xinyang YANG Kang CAO Yanfei | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 13 | Characterizing the rock geological time by terahertz spectrum显示文摘In the field of geology,it is necessary to get the information about the rock geological time,which includes absolute geologic age and relative geologic age .Tracing the evolutionary history of the earth is one of the research tasks of earth science.Time,space,material and motivation are the basic elements for studying geological processes and enviromnental evolution,and time is the basis for studying geological problems.A clear understanding of the interaction between the above elements will be able to clearly make sure the evolution of the earth and the conditions of rock formation.Nowadays,it is urgent to get the geochronological data of rocks for wide range comparison,so as to study the evolution trend and development rule of the earth's crust . | WenXiu Leng QingYan Li RiMa Bao Kun Zhao XinYang Miao YiZhang Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 2 |
| 14 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 15 | Multi-objective microgrid optimal dispatching based on improved bird swarm algorithm显示文摘Multi-objective optimal dispatching schemes with intelligent algorithms are recognized as effective measures to promote the economics and environmental friendliness of microgrid applications.However,the low accuracy and poor convergence of these algorithms have been challenging for system operators.The bird swarm algorithm(BSA),a new bio-heuristic cluster intelligent algorithm,can potentially address these challenges;however,its computational iterative process may fall into a local optimum and result in premature convergence when optimizing small portions of multi-extremum functions.To analyze the impact of a multi-objective economic-environmental dispatching of a microgrid and overcome the aforementioned problems of the BSA,a self-adaptive levy flight strategy-based BSA(LF-BSA)was proposed.It can solve the dispatching problems of microgrid and enhance its dispatching convergence accuracy,stability,and speed,thereby improving its optimization performance.Six typical test functions were used to compare the LF-BSA with three commonly accepted algorithms to verify its excellence.Finally,a typical summer-time daily microgrid scenario under grid-connected operational conditions was simulated.The results proved the feasibility of the proposed LF-BSA,effectiveness of the multi-objective optimization,and necessity of using renewable energy and energy storage in microgrid dispatching optimization. | Xiaoyan Ma Yunfei Mu Yu Zhang Chenxi Zang Shurong Li Xinyang Jiang Meng Cui | 2022 | Global Energy Interconnection2022，5，2： | 2 |
| 16 | Effect of cooked rice with added fructo-oligosaccharide on faecal microorganisms investigated by in vitro digestion and fermentation显示文摘In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation method.The total carbohydrate content,p H,and s hort-chain fatty acids(SCFAs)were determined during in vitro digestion and fermentation.The change in the bacterial phase distribution after the fermentation was also analysed.The results showed that t he total carbohydrate content of the CR with added FOS(FCR)significantly decreased during the simulated digestion.Meanwhile,the p H of the FCR decreased and the SCFAs concentration increased significantly compared to those of the CR during the simulated fermentation.In addition,the FCR showed the advantage of promoting beneficial bacteria,such as Bifidobacterium and Lactobacillus,and inhibiting harmful bacteria,such as Bacteroides and Klebsiella compared to the CR.Therefore,the FOS as a prebiotic could be recommended to produce the high-quality healthy rice food. | Fei Pei Wen Li Xiaolei Ni Xinyang Sun Yijun Yao Yong Fang Wenjian Yang Qiuhui Hu | 2023 | Food Science and Human Wellness2023，12，2： | 2 |
| 17 | Direct fabrication of carbon nanotube-graphene hybrid films by a blown bubble method显示文摘有 graphene 的碳 nanotubes (CNT ) 的杂交提供集成两材料的属性的一个有希望的工具,从而创新的普遍申请。这里,我们在场直接由一个吹的水泡方法装配混合 CNT-graphene 电影的一个方法与选择底层退火结合了。我们把 polymethylmethacrylate (PMMA ) 用作聚合矩阵吹包含自我装配的多围的 CNT 数组的水泡,然后由在 Cu 底层上的热退火把水泡电影转变成一部 CNT-graphene 混合电影;PMMA 为在 CNT 网络之中对很少层 graphene 变得单个直到担任碳来源一连续地, hybridized 结构被形成。比作赤裸(non-hybridized ) CNT 联网,混合电影展览改进了电的电导率和结构的完整。我们的方法也启用一节多围的 CNT-Si 太阳能电池的制造,它有高力量变换效率,通过混合 CNT-graphene 结构的集会。 | Shiting Wu Enzheng Shi Yanbing Yang Wenjing Xu Xinyang Li Anyuan Cao | 2015 | Nano Research2015，8，5： | 2 |
| 18 | Real-time monitoring the formation and decomposition processes of methane hydrate with THz spectroscopy显示文摘Gas hydrates are crystalline clathrate compounds comprised of hydrogen-bonded water cavities,consisting of guest molecules trapped in a lattice of polyhedral water cages under elevated pressures and low temperatures[1].The structures of the gas hydrates are closely related to the types and sizes of the guest species,and three distinct structures,including cubic structure-Ⅰ(sⅠ),cubic structure-Ⅱ(sⅡ),and hexagonal structure-H(sH),are known to form[2].Being expected as a kind of future energy resource,natural | XinYang Miao ShiNing Sun YiZhang Li Wei Wang RiMa Bao Kun Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，1： | 2 |
| 19 | Unsupervised content-preserving transformation for optical microscopy显示文摘The development of deep learning and open access to a substantial collection of imaging data together provide a potential solution for computational image transformation,which is gradually changing the landscape of optical imaging and biomedical research.However,current implementations of deep learning usually operate in a supervised manner,and their reliance on laborious and error-prone data annotation procedures remains a barrier to more general applicability.Here,we propose an unsupervised image transformation to facilitate the utilization of deep learning for optical microscopy,even in some cases in which supervised models cannot be applied.Through the introduction of a saliency constraint,the unsupervised model,named Unsupervised content-preserving Transformation for Optical Microscopy(UTOM);can learn the mapping between two image domains without requiring paired training data while avoiding distortions of the image content.UTOM shows promising performance in a wide range of biomedical image transformation tasks,including in silico histological staining,fluorescence image restoration,and virtual fluorescence labeling.Quantitative evaluations reveal that UTOM achieves stable and high-fidelity image transformations across different imaging conditions and modalities.We anticipate that our framework will encourage a paradigm shift in training neural networks and enable more applications of artificial intelligence in biomedical imaging. | Xinyang Li Guoxun Zhang Hui Qiao Feng Bao Yue Deng Jiamin Wu Yangfan He Jingping Yun Xing Lin Hao Xie Haoqian Wang Qionghai Dai | 2021 | Light(Science & Applications)2021，10，3： | 1 |
| 20 | Etectro-Fenton treatment of concentrates generated in nanofiltration of biolog- ically pretreated landfill leachate显示文摘 | WANG Yujue LI Xinyang ZHEN Limin | 2012 | Journal of Hazardous Ma- terials2012，，： | 1 |
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