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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Vertical Distribution Characteristics of PM2.5 Observed by a Mobile Vehicle Lidar in Tianjin, China in 2016显示文摘We present mobile vehicle lidar observations in Tianjin, China during the spring, summer, and winter of 2016. Mobile observations were carried out along the city border road of Tianjin to obtain the vertical distribution characteristics of PM_(2.5). Hygroscopic growth was not considered since relative humidity was less than 60% during the observation experiments. PM_(2.5) profile was obtained with the linear regression equation between the particle extinction coefficient and PM_(2.5) mass concentration. In spring, the vertical distribution of PM_(2.5) exhibited a hierarchical structure. In addition to a layer of particles that gathered near the ground, a portion of particles floated at 0.6–2.5-km height. In summer and winter, the fine particles basically gathered below 1 km near the ground. In spring and summer, the concentration of fine particles in the south was higher than that in the north because of the influence of south wind. In winter, the distribution of fine particles was opposite to that measured during spring and summer. High concentrations of PM_(2.5) were observed in the rural areas of North Tianjin with a maximum of 350 μg m–3 on 13 December2016. It is shown that industrial and ship emissions in spring and summer and coal combustion in winter were the major sources of fine particles that polluted Tianjin. The results provide insights into the mechanisms of haze formation and the effects of meteorological conditions during haze–fog pollution episodes in the Tianjin area. | Lihui LYU Yunsheng DONG Tianshu ZHANG Cheng LIU Wenqing LIU Zhouqing XIE Yan XIANG Yi ZHANG Zhenyi CHEN Guangqiang FAN Leibo ZHANG Yang LIU Yuchen SHI Xiaowen SHU | 2018 | Journal of Meteorological Research2018，32，1： | 5 |
| 4 | Comparison of mixing layer height inversion algorithms using lidar and a pollution case study in Baoding, China显示文摘Beijing–Tianjin–Hebei area is suffering from atmospheric pollution from a long time. The understanding of the air pollution mechanism is of great importance for officials to design strategies for the environmental governance. Mixing layer height(MLH) is a key factor influencing the diffusion of air pollutants. It plays an important role on the evolution of heavy pollution events. Light detection and ranging(lidar), is an effective remote-sensing tool, which can retrieve high spatial and temporal evolution process within mixing layer(ML), especially the variation of MLH. There are many methods to retrieve MLH, but each method has its own applicable limitations. The Mie-lidar data in Beijing was firstly used to compare three different algorithms which are widely used under different pollution levels.We find that the multi-layer structure near surface may cause errors in the detection of mixing layer. The MLH retrieved based on image edge detection was better than another two methods especially under heavy polluted episode. Then we applied this method to investigate the evolution of the mixing layer height during a pollution episode in December2016. MLH at Gucheng county showed the positive correlation with the concentration of particulate matters during the start of this pollution episode. The elevated pollution level in Gucheng was not associated with MLH's decrease, and the significantly increased particulate matters raised the boundary layer, which trapped the pollutants near the surface. | Xiangguang Ji Cheng Liu Zhouqing Xie Qihou Hu Yunsheng Dong Guangqiang Fan Tianshu Zhang Chengzhi Xing Zhuang Wang Zeeshan Javed Jianguo Liu | 2019 | Journal of Environmental Sciences2019，31，5： | 5 |
| 5 | Regulation of REGγ cellular distribution and function by SUMO modification显示文摘新兴的调整 REG 的蛋白质的发现在多重生物过程作为一条重要小径加重了 REG-proteasome,包括细胞生长,细胞周期规定,和 apoptosis。然而,很少对 REG-proteasome 小径的规定被知道。这里,我们证明 REG 能是在 vitro 并且在由 SUMO-1, SUMO-2,和 SUMO-3 的 vivo 的 SUMOylated。激活的 STAT (PIAS ) 的 SUMO-E3 蛋白质禁止者 1 身体上与 REG 联系并且支持 REG 的 SUMOylation。REG 的 SUMOylation 被发现发生在多重地点,包括 K6, K14,和 K12。变化分析显示这些相扑地点同时在房间贡献了 REG 的 SUMOylation 地位。由相扑变化形式的 REG 的 Posttranslational 修正被揭示调停 REG 并且到原因的 cytosolic translocation 增加了这 proteasome 使活跃之物的稳定性。显示的 SUMOylation 缺乏的 REG 稀释了能力降级 p21Waf//Cip1 由于为 p21 的 REG SUMOylation 有缺点的异种的减少的亲密关系。一起拿,我们报导调整 proteasome 使活跃之物 REG 的活动的以前未被认出的机制。这规章的机制可以使 REG 能与一个更宽广的底层系列在蛋白质降级作为一个更多的有势力因素工作。 | Yan Wu Lu Wang Ping Zhou Guangqiang Wang Yu Zeng Ying Wang Jian Liu Bianhong Zhang Shuang Liu Honglin Luo Xiaotao Li | 2011 | Cell Research2011，21，5： | 4 |
| 6 | Functionalized periodic Au@MOFs nanoparticle arrays as biosensors for dual-channel detection through the complementary effect of SPR and diffraction peaks显示文摘准备 nanoparticle 穿的周期的 Au@metal 器官的框架(MOF )(MIL-100 (Fe )) 的一个灵巧、便宜的方法被开发。数组用单层在 situ 被制作是的胶体的晶体模板,在底层上由 Au 免职列在后面,并且退火。MIL-100 (Fe ) 涂层用简单溶剂在 nanospheres 上被使用热过程。准备周期的 Au@MIL-100 (Fe ) nanoparticle (NP ) 数组被二座山峰在可见系列描绘。第一座山峰表示 Au nanospheres 的表面电浆子回声(SPR ) ,和另外的山峰,或衍射达到顶点,在 NP 数组从周期的结构发源。在有 3-aminophenylboronic 酸 hemisulfate (PBA ) 的修正以后, Au@MIL-100 (Fe ) NP 数组与好选择展出了敏感回答到不同葡萄糖集中。这些回答能由于在 PBA 和葡萄糖分子之间的强壮的相互作用。衍射山峰在低葡萄糖集中(不到 12 公里) 是敏感的,而 SPR 山峰很快在高集中反应了。山峰因此在不同集中区域为葡萄糖察觉表明了令人满意的互补敏感。这些结果能被用来开发一个双隧道的生物传感器。我们也创造了一张标准图,它能被用来高效地监视血葡萄糖层次。建议策略能被扩大与不同识别代理人用 Au@MIL-100 (Fe ) NP 数组 functionalized 开发不同双隧道的传感器。 | Lifeng Hang Fei Zhou Dandan Men Huilin Li Xinyang Li Honghua Zhang Guangqiang Liu Weiping Cai Cuncheng Li Yue Li | 2017 | Nano Research2017，10，7： | 3 |
| 7 | High efficient catalytic oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid under benign conditions with nitrogen-doped graphene encapsulated Cu nanoparticles显示文摘Selective oxidation of 5-hydroxymethylfurfual(HMF) to 2,5-furandicarboxylic acid(FDCA) as a bioplastics monomer is efficiently promoted by a simple system without noble-metal and base additives. In this work, graphene oxide(GO) was first synthesised by an electrochemical method with flexible graphite paper(FGP) as start carbon material, then, nitrogen-doped graphene(NG) layers encapsulated Cu nanoparticles(NPs) was prepared by one-step thermal treatment of GO supported Cu2+ in flowing NH3 atmosphere. Compared with NG supported Cu NPs prepared by the traditional impregnation method, enhanced catalytic activity was achieved over Cu/NG and an FDCA yield of 95.2% was achieved under mild reaction conditions with tert-butylhydroperoxide(t-BuOOH) as the oxidant. Control experiments with different catalysts and different addition procedure of t-BuOOH showed the yield of HMF and various intermediates during reaction. From the changing of intermediates concentrations and reaction rates, a reaction pathway through HMF-DFF-FFCA-FDCA was proposed. This work gives a more convenient, more green,more economical and effective method in encapsulated metal NPs preparation and high selectivity in HMF oxidation to FDCA under mild conditions. | Chaoxin Yang Xiao Li Zhenzhou Zhang Bohan Lv Jiachun Li Zhenjian Liu Wanzhen Zhu Furong Tao Guangqiang Lv Yongxing Yang | 2020 | Journal of Energy Chemistry2020，29，11： | 3 |
| 8 | Trapeziform Ag nanosheet arrays induced by electrochemical deposition on Au-coated substrate显示文摘 | LIU Guangqiang CAI Weiping LIANG Changhao | 2008 | Cryst Growth Des2008，8，8： | 1 |
| 9 | Numerical simulation of wind flow over transverse and pyramid dunes显示文摘 | Benli Liu Jianjun Qu Weimin Zhang Guangqiang Qian | 2011 | Journal of Wind Engineering & Industrial Aerodynamics2011，，8： | 1 |
| 10 | Preparation of DyFe_2 by the Reduction-Diffusion Process显示文摘The free energy change for the reduction-diffusion reaction which was used to prepare the DyFe2 Dy2 O3(s) + 3Ca(g) + 4Fe(s) = 3CaO(s) + 2DyFe2(s) intermetallic compound powder was calculated. The reduction-diffusion experiments were carried out at 1073, 1123. 1273 and 1373 K respectively using powders of Dy2O3, iron, and calcium grains as raw materials. XRD and EDX analysis confirmed that DyFe2 was formed by the diffusion of Dy into Fe. | Guangsi GUO, Guangqiang LI, Zhenqi HUANG, Zhitong SUI and Liang LIU (School of Materials and Metallurgy, Northeastern University, Shenyang 110006, China) Thlin ZHOU (Baotou Research Institute of Rare Earth, Baotou 014010, China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 1 |
| 11 | Numerical simulation of wind flow over transverse and pyramid dunes显示文摘 | Benli Liu Jianjun Qu Weimin Zhang Guangqiang Qian | 2011 | Journal of Wind Engineering & Industrial Aerodynamics2011，，8： | 1 |
| 12 | Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy显示文摘Sonodynamic therapy(SDT)has attracted widespread interest in biomedicine,owing to its novel and noninvasive therapeutic method triggered by ultrasound(US).Herein,the Ti_(3)C_(2) MXene nanosheets(Ti_(3)C_(2) NSs)are developed as good sonosensitizers via a two-step method of chemical exfoliation and high-temperature treatment.With the high-temperature treatment,the oxygen defect of Ti_(3)C_(2) MXene nanosheets(H-Ti_(3)C_(2) NSs)is greatly increased.Therefore,the electron(e^(-))and hole(h^(+))generated by US can be separated faster due to the improved degree of oxidation,and then the recombination of e^(-)-h^(+)can be prevented with the abundant oxygen defect under US irradiation,which induced the sonodynamic efficiency greatly to improve around 3.7-fold compared with Ti_(3)C_(2) NSs without high-temperature treatment.After PEGylation,the H-Ti_(3)C_(2)-PEG NSs show good stability and biocompatibility.In vitro studies exhibit that the inherent property of mild photothermal effect can promote the endocytosis of H-Ti_(3)C_(2)-PEG NSs,which can improve the SDT efficacy.In vivo studies further display that the increased blood supply by the mild photothermal effect can significantly relieve hypoxia in the tumor microenvironment,showing photothermal therapy(PTT)enhanced SDT.Most importantly,the H-Ti_(3)C_(2)-PEG NSs can be biodegraded and excreted out of the body,showing no significant long-term toxicity.Our work develops the defective H-Ti_(3)C_(2) NSs as high-efficiency and safe sonosensitizers for photothermal-enhanced SDT of cancer,extending the biomedical application of MXene-based nanoplatforms. | Guangqiang Li Xiaoyan Zhong Xianwen Wang Fei Gong Huali Lei Yangkai Zhou Chengfei Li Zhidong Xiao Guoxi Ren Liang Zhang Zhiqiang Dong Zhuang Liu Liang Cheng | 2022 | Bioactive Materials2022，7，2： | 1 |
| 13 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 14 | Immobilizing haemoglobin on gold/gra- phene-chitosan nanoeomposite as efficient hy- drogen peroxide biosensor 显示文摘 | Lingling Zhang Guangqiang Han Yun Liu | 2014 | Sensors and Actuators B : Chemical2014，197，： | 1 |
| 15 | Constructing the latest Neoproterozoic to Early Paleozoic multiple crust-mantle interactions in western Bainaimiao arc terrane,southeastern Central Asian Orogenic Belt显示文摘Identifying the crust-mantle interactions in association with the evolution of the Precambrian microcontinents provides critical constraints on the accretionary evolution in the Central Asian Orogenic Belt(CAOB).The Bainaimiao arc terrane(BAT)is one of the most important Precambrian microcontinents in southeastern CAOB,however,few studies have paid attention to the types and the evolving processes of the crust-mantle interactions that occurred before its final accretion onto the northern North China Craton.This study presents an integrated study of geochronology,zircon Hf isotope and whole-rock geochemistry on the latest Neoproterozoic diabases and the Early Paleozoic arc intrusions in the western BAT.The latest Neoproterozoic(ca.546 Ma)diabases display low SiO2(46.52-49.24 wt.%)with high MgO(8.23-14.41 wt.%),Cr(66-542 ppm)and Ni(50-129 ppm),consisting with mantle origin.Their highly negative zirconεHf(t)(-12.0 to-24.7)and high Fe/Mn ratios(62.1-81.7)further indicate a significantly enriched mantle source.Considering that the BAT maybe initially separated from the Tarim Craton with a thickened crustal root,we propose that these diabases were generated through partial melting of an enriched lithospheric mantle source that had been hybridized by lower-crustal eclogites during foundering of the BAT lower crust.The Early Paleozoic(ca.475-417 Ma)arc intrusions in western BAT can be divided into PeriodsⅠandⅡat approximately 450 Ma.The PeriodⅠ(>450 Ma)intrusions contain abundant mafic minerals like hornblende and pyroxene,and show positive zirconεHf(t)(+1.5 to+10.9).They are predominantly medium-K calc-alkaline with broad correlations of SiO2 versus various major and trace elements,which correlate well with the experimental melts produced by the fractional crystallization of primitive hydrous arc magmas at 7 kbar.We assume they were formed through mid-crustal differentiation of the mantle wedge-derived hydrous basaltic melts.By contrast,the PeriodⅡ(≤450 Ma)intrusions are characterized by variable zircon eHf(t)(-15.0 to+11.5)with irregular variations in most major and trace elements,which are more akin to the arc magmas generated in an open system.The general occurrence of elder inherited zircons,along with the relatively high Mg#(>45)of some samples,call upon a derivation from the reworking of the previously subduction-modified BAT lower crust with the input of mantle-derived mafic components.In combination with the Early Paleozoic tectonic melanges flanking western BAT,we infer that the compositional transition from PeriodⅠtoⅡcan be attributed to the tectonic transition from south-dipping subduction of Solonker ocean to north-dipping subduction of South Bainaimiao ocean in southeastern CAOB.The above results shed light not only on the latest Neoproterozoic to Early Paleozoic multiple crust-mantle interactions in western BAT,but also on the associated crustal construction processes before the final arc-continent accretion. | Min Liu Shaocong Lai Da Zhang Renzhi Zhu Jiangfeng Qin Guangqiang Xiong Haoran Wang | 2020 | Geoscience Frontiers2020，11，5： | 1 |
| 16 | Effect of Tundish Lining on Steel Cleanliness显示文摘To clarify the effect of the tundish lining on the steel cleanliness,the MgO based and Al2 O3 based gunning materials( GM) were used as the lining of the alumina crucibles,respectively,in which about 200 g of ultra-low carbon steel was charged at 1 823 K for 2 h in pure argon atmosphere. The chemical analysis was carried out to investigate the change of chemical composition of steel in contact with GM after high temperatures holding experiments. The steel cleanliness in terms of inclusion number density,inclusion size and inclusion size distribution was evaluated by SEM and EDS. It was found that the MgO GM provided more oxygen and showed a stronger oxidizing capacity due to its higher content of reducible oxides( 10. 5 mass% SiO2+ 2 mass%Fe2 O3). The use of Al2 O3 GM resulted in an improved steel cleanliness and consequently Al2 O3 GM could be a promising refractory material in the tundish lining. | LIU Yu LI Guangqiang ZHANG Zhao WANG Li | 2018 | China's Refractories2018，27，3： | 0 |
| 17 | Defect engineering on BiFeO_(3) through Na and V codoping for aqueous Na-ion capacitors显示文摘Sodium with low cost and high abundance is considered as a substitute element of lithium for batteries and supercapacitors,which need the appropriate host materials to accommodate the relatively large Na^(+) ions.Compared to Li^(+) storage,Na^(+) storage makes higher demands on the structural optimization of perovskite bismuth ferrite(BiFeO_(3)).We propose a novel strategy of defect engineering on BiFeO_(3) through Na and V codoping for high-efficiency Na^(+) storage,to reveal the roles of oxygen vacancies and V ions played in the enhanced electrochemical energy storage performances of Na-ion capacitors.The formation of the oxygen vacancies in the Na and V codoped BiFeO_(3)(denoted as NV-BFO),is promoted by Na doping and suppressed by V doping,which can be demonstrated by XPS and EPR spectra.By the first-principles calculations,the oxygen vacancies and V ions in NV-BFO are confirmed to substantially lower the Na^(+)migration energy barriers through the space and electric field effects,to effectively promote the Na^(+) transport in the crystals.Electrochemical kinetic analysis of the NV-BFO//NV-BFO capacitors indicates the dominant capacitive-controlled capacity,which depends on fast Na^(+) deintercalation-intercalation process in the NV-BFO electrode.The NV-BFO//NV-BFO capacitors open up a new avenue for developing highperformance Na-ion capacitors. | Wenyun Wang Chao Yang Shangjing Yu Daotong Han Wentao Qi Rui Ling Guangqiang Liu | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 18 | Experiment Research on the Enrichment of Precious Metals from Nickel-copper-iron Matte显示文摘According to the chemical and phase composition of the nickel-copper-iron matte containing precious metals and the progress in enrichment of precious metals from the nickel-copper-iron matte containing precious metals at home and abroad, this paper put forward the process route of enrichment of precious metals and selectively leaching of base metals from the nickel-copper-iron matte by sulfuric acid and sodium hypochlorite. The effects of particle size, leaching temperature, leaching time, amount of sulfuric acid and sodium hypochlorite on the leaching rate of nickel, cobalt, copper and iron are mainly discussed. The results show that raw material particle size has significantly effects on the leaching rate of base metals, high leaching rate of base metals and enrichment of precious metals are obtained with the suitable particle size. Through the experiments, the reasonable experiment parameters and conditions were determined as fellows: particle size of-200 to +250 mesh, leaching temperature 95℃ , leaching time 5 h, sulfuric acid concentration 30%, adding amount of sodium hypochlorite 3 times of matte weight. Under these experiment parameters and conditions, the leaching rate of nickel, cobalt, copper and iron were 97.39%, 96.24%, 98.30% and 99.01%, respectively. The content of nickel, cobalt, copper, iron in the leaching residues was 8.15%, 0.23%, 1.40% and 0.24%, respectively. The content of Pt, Pd, Au, Ag and Rh in the leaching residues was 247 g/t, 521 g/t, 112 g/t, 494 g/t and 24 g/t, respectively. The content of Pt, Pd, Au, Ag and Rh in the leaching solution was <0.0005 g/L, 0.0023 g/L, 0.0007 g/L, <0.0005 g/L and 0.00017 g/L, respectively. This process has advantages as follows: a small investment, simple technology, high enrichment efficiency. | FAN Xingxiang LIU Yang DONG Haigang FU Guangqiang WU Yuedong ZHAO Jiachun WU Xiaofeng | 2012 | 贵金属2012，33，A01： | 0 |
| 19 | Research on Experimental and Application for the High Efficient Enrichment of the Low-grade Precious Metal Materials显示文摘On the basis of reviewing the progress in the high efficient enrichment from secondary resources of low grade precious metals at home and abroad, a process route of the high efficient enrichment precious metals from secondary resources of low-grade metals by adding iron oxide as the trapping agent, reducing agent, additive, mixing uniformly and grinding, pelletizing, reduction, grinding and separation, and selectively acid leaching iron has been put forward in this paper. The experiments of reduction, grinding and separation, and selectively acid leaching iron were carried out mainly. Under the decided experiment parameters and conditions, iron generated during the reduction can trap precious metals during reduction, high active alloy powders were obtained from the reduced products by grinding and separation, the concentration of precious metals was obtained by acid leaching high active alloy powders. The better enrichment effect was obtained by adopting the technical route of processing. Other low grade noble metal materials and enrichment ratio of precious metals from the materials to acid products was high through acid leaching. This process has the advantages of simple process, environmental-friendly, strong adaptability of raw materials, high concentration ratio, which was regarded as a kind of the general efficient enrichment technology of low grade precious metal materials. | FAN Xingxiang FU Guangqiang DONG Haigang WU Yuedong LIU Yang ZHAO Jiachun WU Xiaofeng LI Bojie TONG Weifeng | 2012 | 贵金属2012，33，A01： | 0 |
| 20 | CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity显示文摘CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer development.However,little is known about the effects of CFTR on the differentiation and function ofγδT cells.In this study,we observed that CFTR was functionally expressed on the cell surface ofγδT cells.Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.Interestingly,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)influx.CFTR was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun signaling.In addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT cells.Thus,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor immunity.Our investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer. | Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei Lei Yi Hu Zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo Huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，8： | 0 |
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