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| 1 | BIX-01294-enhanced chemosensitivity in nasopharyngeal carcinoma depends on autophagy-induced pyroptosis显示文摘Nasopharyngeal carcinoma(NPC)is a common cancer in southern China and Southeast Asia.Nowadays,radiotherapy is the therapy of choice for NPC patients,and chemotherapy has been found as an alternative treatment for advanced NPC patients.However,finding novel drugs and pharmacologically therapeutic targets for NPC patients is still urgent and beneficial.Our study showed that BIX-01294(BIX)can induce autophagic vacuoles formation and conversion of LC3B-I to LC3B-II in NPC cells in both dose-and time-dependent manners.Notably,the combination of BIX and chemotherapeutic drugs significantly decreased the cell viability and increased the lactate dehydrogenase release.Meanwhile,BIX plus cis-platinum(Cis)treatment induced pyroptosis in NPC cells as featured by cell swelling and bubble blowing from the plasma membrane,the increased frequency of annexin V and propidium iodide(PI)double-positive cells,as well as the cleavage of gasdermin E(GSDME)and caspase-3.Moreover,the deficiency of GSDME completely shifted pyroptosis to apoptosis.Furthermore,the inhibition of autophagy by chloroquine and the knockout of ATG5 gene significantly blocked the BIX-induced autophagy as well as pyroptosis in both in vitro and in vivo studies.Our data demonstrated that BIX-combined chemotherapeutic drugs could induce the Bax/caspase-3/GSDME-mediated pyroptosis through the activation of autophagy to enhance the chemosensitivity in NPC. | Qian Li Min Wang Yan Zhang Liuqian Wang Wei Yu Xiaomin Bao Biyun Zhang Yanghong Xiang Anchun Deng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 5 |
| 2 | Degradation of trace nitrobenzene in water by microwave-enhanced H2O2-based process显示文摘 | Honghu ZENG Lanjing LU Meina LIANG Jie LIU Yanghong LI | 2012 | Frontiers of Environmental Science & Engineering2012，6，4： | 1 |
| 3 | Formation of photoresponsive uniform colloidal spheres from an amphiphilic azobenzene-containing random copolymer显示文摘 | Li Yaobang Deng Yanghong Tong Xiaolan | 2006 | Macromolecules2006，39，3： | 1 |
| 4 | Distribution of the functional MDR1 C3435T polymorphism in the Han population of China显示文摘 | Li Yanghong Wang Yonghua Sun Jie | 2006 | Swiss Med Wkly2006，136，： | 1 |
| 5 | Efficacy and safety of light therapy for Parkinson disease显示文摘To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disorder associated with significant disability and negative impact on quality of life(QoL),affecting 2%to 3%of the population≥65 years of age.^([1])Although the disorder is defined by motor features including asymmetric tremor,bradykinesia,and rigidity,various non-motor features are typically seen,including cognitive impairment,depression,sensory symptoms,autonomic dysfunction,and sleep disturbances.Due to the complexity,PD is challenging to treat.There are currently no effective treatments to prevent or halt the progression of PD. | Yanghong Li Xiaoxia Zhou Xinyin Wu Beisha Tang | 2022 | Chinese Medical Journal2022，，7： | 1 |
| 6 | Tb￣(3+)as Fluorescent Probe in the Study of the Interaction of Other Lanthanide Ions with Trichosant显示文摘Tb￣(3+)asFluorescentProbeintheStudyoftheInteractionofOtherLanthanideIonswithTrichosanthinHAOQiang;LIWen-lian;ZHANGYan;YUGui;Y... | HAO Qiang LI Wen-lian ZHANG Yan YU Gui YANGHong ZHAO Xu YAO Qi-Zhi and LI Qing-shan(Department of Molecular Biofogy and National Laboratory of enzyme engineering,Jiln University,Changchun, 130023)(Changchun Institute of Physics, Academia Sinica, Cha | 1995 | Chemical Research in Chinese Universities1995，11，4： | 0 |
| 7 | Difference of Visual Information Metric Based on Entropy of Primitive显示文摘Image sparse representation is a method of efficient compression and coding of image signal in the process of digital image processing.Image after sparse representation,to enhance the transmission efficiency of the image signal.Entropy of Primitive(EoP)is a statistical representation of the sparse representation of the image,which indicates the probability of each base element.Based on the EoP,this paper presents an image quality evaluation method-Difference of Visual Information Metric(DVIM).The principle of this method is to evaluate the image quality with the difference between the original image and the distorted image.The comparative experiments between DVIM&PSNR&SSIM are carried out.It was found that there was a great improvement in the image quality evaluation of geometric changes.This method is an effective image quality evaluation method,which overcomes the weakness of other quality evaluation methods for geometrically changing images to a certain extent,and is more consistent with the subjective observation of the human eye. | Yanghong Zhang Feng Sun Liwei Tian Jinfeng Li Longqing Zhang Shengfu Lan | 2020 | Computers, Materials & Continua2020，，2： | 0 |
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