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| 1 | Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms显示文摘Background Alzheimer’s disease is a neurodegenerative disorder.Therapeutically,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s disease.However,the relevant mechanism remains to be fully elucidated.Main body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,etc.The above mechanisms might play different roles at certain stages.It was revealed that the transplantation of BMMSCs could alter some gene levels.Moreover,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific patterns.Conclusions Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD models.Gene expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic effect.The transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease. | Chuan Qin Yalan Lu Kewei Wang Lin Bai Guiying Shi Yiying Huang Yongning Li | 2020 | Translational Neurodegeneration2020，9，2： | 9 |
| 2 | Restoration of rat calvarial defects by poly(lactide-co-glycolide)/hydroxyapatite scaffolds loaded with bone mesenchymal stem cells and DNA complexes显示文摘A composite construct comprising of a bone mesenchymal stem cell (BMSC) sheet, plasmid DNA, encoding human bone morphogenic protein-2 (hBMP-2), and poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) sponge was designed and employed in the restoration of rat calvarial defects. To improve gene transfection efficiency, a cationic chitosan derivative, N,N,N,-trimethyl chitosan chloride (TMC), was employed as the vector. The TMC/DNA complexes had a transfection efficiency of 13% in rat BMSCs, resulting in heterogeneous hBMP-2 expression in a 10-d culture period in vitro. In vivo culture of the composite constructs was performed by implantation into rat full-thickness calvarial defects, using constructs lacking pDNA-hBMP-2 or BMSC sheets as controls. Significantly higher heterogeneous expression of hBMP-2 was detected in vivo at 2 weeks for the cell sheet/DNA complex/scaffold constructs, compared with the constructs lacking pDNA-hBMP-2 or BMSC sheets. New bone formation was evident as early as 4 weeks in the experimental constructs. At 8 weeks, partial bridging of calvarial defects was observed in the experimental constructs, which was significantly better than the constructs lacking pDNA-hBMP-2 or BMSC sheets. Therefore, the combination of the PLGA/HA scaffold with BMSC sheets and gene therapy vectors is effective at enhancing bone formation. | LI Dan WANG Wei GUO Rui QI YiYing GOU ZhongRu GAO ChangYou | 2012 | Chinese Science Bulletin2012，57，5： | 9 |
| 3 | Combustion effects and emission characteristics of SO2, CO, NOx and heavy metals during co-combustion of coal and dewatered sludge显示文摘在易燃的索引(C) 和燃烧特征上在煤混合比率的除去的污泥的影响索引硫二氧化物的(S) 和版本(那么 2), 氮氧化物(没有 x ), 碳一氧化物(公司) 和重金属(Hg,同样 Cd, Pb 和 Cr ) 被学习。如果不到 20% 除去的污泥在煤被增加,燃烧特征上的影响能被忽略。而且,排放模式没有 x , 试验因此 2, 公司和重金属在一个高温度的管状的炉子被执行。结果证明变换没有 x 和全部的排放评价 2 因此随增加比率的污泥的增加减少了,并且当相配的比率到达了 30% 时,修理硫的更好的效果能被获得。在不同残余(底部灰和苍蝇灰) 以及在烟道气体的重金属的五种类型的集中和分布被分析。煤和污泥的特征,以及重金属的挥发在重金属的分发上有大影响,这被显示出。 | Yiying JIN Yangyang LI Fuqiang LIU | 2016 | Frontiers of Environmental Science & Engineering2016，10，1： | 8 |
| 4 | Uric acid lowering effect of Tibetan Medicine RuPeng15 powder in animal models of hyperuricemia显示文摘OBJECTIVE: To evaluate the influence of the Tibetan medicine Ru Peng15 powder(RPP15) on uric acid levels, and explore its possible mechanisms of action in hyperuricemic animal models.METHODS: Hyperuricemic mice were generated by orally administering yeast extract paste twice daily(30 g/kg) for 8 days, to mimic human hyperuricemia induced by high-protein diets. Hyperuricemic rats were generated by intraperitoneal injection of 250 mg/kg potassium oxonate to each animal 1 h before the last oral administration of test compounds, which raised the serum uric acid level by inhibiting the decomposition of uric acid. Levels of uric acid and creatinine in serum and urine were detected by the phosphotungstic acid and picric acid methods respectively, and the activity of xanthine oxidase(XOD) was assayed using a commercial test kit.RESULTS: RPP15(0.4, 0.8, 1.2 g/kg) significantly decreased the level of serum uric acid in healthy rats(P < 0.05). Furthermore, hyperuricemic rats treated with RPP15(0.4, 0.8, 1.2 g/kg) had lower serum uric acid levels(P < 0.05), accompanied by lower urine uric acid(P < 0.05). For the hyperuricemic mice, the levels of uric acid in the serum decreased significantly(P < 0.05) and the activity of XOD in the liver was restored to normal levels after treatment with RPP15(P < 0.05).CONCLUSION: RPP15(0.4, 0.8, 1.2 g/kg) demonstrated an anti-hyperuricemic effect on both healthy and hyperuricemic animals, and the mechanism is most likely associated with inhibiting the activity of XOD. | Kou Yiying Li Yongfang Ma Husai Li Wangyu Li Ruilian Dang Zhancui | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 7 |
| 5 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 6 | Formation of Na_(0.44)MnO_(2) Nanowires via Stress-Induced Splitting of Birnessite Nanosheets显示文摘High aspect ratio Na0.44MnO2 nanowires with a complex one-dimensional(1 D)tunnel structure have been synthesized.We found that the reaction went through layered birnessite nanosheet intermediates,and that their conversion to the final product involved splitting of the nanosheets into nanowires.Based on our observations,a stress-induced splitting mechanism for conversion of birnessite nanosheets to Na0.44MnO2 nanowires is proposed.The final and intermediate phases show topotaxy with〈001〉f//〈020〉b or〈110〉b where frepresents the final Na_(0.44)MnO_(2)phase and b the intermediate birnessite phase.As a result of their high surface areas,the nanowires are efficient catalysts for the oxidation of pinacyanol chloride dye. | Yanguang Li Yiying Wu | 2009 | Nano Research2009，2，1： | 4 |
| 7 | Preparation, Characterization, and Electrocatalytic Performance of Graphene-Methylene Blue Thin Films显示文摘我们向接枝汇报一个一般方法到 graphene 上,通过简单沉浸的薄电影电极处理的芳香的分子。大区域的 electroactive graphene 有甲又蓝色(MB ) 的薄电影 grafted 为菸碱腺嘌 dinucleotide (NADH ) 的氧化作为 electrocatalytic 电极被开发了。NADH 的氧化开始从 ? 0.08 V (对 Ag/AgCl ) 在 graphene-MB 薄电影电极,与一个 Ti 金属电极相比在过电位显示出 530 mV 的减少。薄电影有由于他们支持 NADH 电子转移反应的能力在生物传感器和 biofuel 房间答应应用程序的 graphene-MB。 | Dan wangt Yanguang Li Panitat Hasin Yiying Wu | 2011 | Nano Research2011，4，1： | 2 |
| 8 | Enhanced integrin-mediated human osteoblastic adhesion to porous amorphous calcium phosphate/poly(L-lactic acid) composite显示文摘 | Huang Xin Qi Yiying Li Weixu Shi Zhongli Weng Wenjian Chen Kui He Rongxin | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 9 | First congenital prosopagnosia case reported in China显示文摘先天的 prosopagnosia (CP ) 在没有可报告的大脑损坏,认出脸指缺乏。在这研究,我们报导了一个 CP 病人(X. L。) ,在中国报导,并且与一组脸识别测试了她的第一个 CP 案例和视觉认知探索什么脸处理的方面在 CP 个人被损害的任务。我们的结果给那 X 看。L.possesses 还检测脸的存在的一个正常能力她在单个脸之间区别的能力显著地与正常控制相比被损害。相反,她非检测脸目标的能力极大地被保存,建议她受不了在脸识别的选择缺乏。当时,进一步的脸测试表明她有未经触动的基于特征的分析能力形象、整体的反对处理两个都被损害。我们进一步评估她整体的处理,和显示出的结果的一般能力她在整体的处理的缺陷没被限制为脸,但是到更一般的水平。 | Li Xiaobai Song Yiying | 2007 | Progress in Natural Science:Materials International2007，17，B07： | 2 |
| 10 | Effects of ultrasonic- disintegration on sludge microbial activity and dewate- rability显示文摘 | LI Huan JIN Yiying MAHAR R B | 2009 | Journal of Hazardous Materials2009，161，23： | 1 |
| 11 | Application of alkaline treatment for sludge decrement and humic acid recovery显示文摘 | Li Huan Jin Yiying Nie Yongfeng | 2009 | Bioresource Technology2009，100，24： | 1 |
| 12 | Effects of Germanium on Movement of Dislocations in p-Type Czochralski Silicon显示文摘By indentation at room temperature followed by annealing at high temperatures, the pinning effect of germanium on dislocations in germanium-doped Czochralski silicon was investigated. Experimental results show that the dislocations in germanium-doped Czochralski silicon move shorter and slower than those in Czochralski silicon undoping with germanium when the concentration of germanium is over 1×1018 cm-3. The retarding velocity of dislocations is contributed to the dislocations pinning effect of the strain field introduced by the high concentration germanium, and the Ge4B cluster and the oxygen precipitation those are preferred to form at higher concentration germanium. | Li Dongsheng Zhao Yiying Yang Deren | 2006 | Journal of Rare Earths2006，24，z1： | 1 |
| 13 | Thermal conductivity of individual silicon nanowires显示文摘 | Li Deyu Wu Yiying Kim Philip | 2003 | Applied Physics Letters2003，83，14： | 1 |
| 14 | Radical-scavenging activities of marine-derived xyloketals and related chromanes显示文摘Xyloketals,a new type of antioxidants from a marine mangrove fungus,have potential pharmacological properties.In this paper,the radical-scavenging activities of a series of synthetic xyloketals and related chromanes toward 2,2-diphenyl-1-picrylhydrazyl(DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)were evaluated by absorption spectrometry.One of the compounds(compound 10)displayed significant antioxidative action against DPPH and ABTS.A structure-activity analysis showed that the reactive sites on these compounds correlated with a hydroxygroup and also with ketal or aromatic H substituents.Based in part on a density functional theory(DFT)calculation of compound 10,the antioxidant mechanism of this chromane was deduced as a possible radical-scavenging mechanism by a sequential proton loss electron-transfer(SPLET)process. | Zhongliang Xu Bingtai Lu Qi Xiang Yiying Li Shichang Li Yongcheng Lin Jiyan Pang | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 1 |
| 15 | Texture map- ping subdivision surfaces with hard constraints显示文摘 | WENG Yanlin LI Dongping TONG Yiying | 2013 | Visual Gxomputer2013，29，11： | 1 |
| 16 | Two-Dimensional Supervised Local Similarity and Diversity Projection显示文摘 | Gao Quanxue Xu Hui Li Yiying | | 0，，10： | 1 |
| 17 | Phase noise floor suppression of the output carrier from double sideband-carrier suppressed modulation system显示文摘A theoretical model of all the influencing factors on the phase noise floor of the output carrier from the double sideband-carrier suppressed (DSB-CS) modulation system is presented. Based on the established DSB-CS modulation system with different cases, the phase noise of the input carrier and the output doubled frequency carrier is measured and calculated using the theoretical model, respectively. The calculation results basically agree with the measurement results. It is shown that the phase noise floor of the output carrier is primarily influenced by the signal-spontaneous beat noise and the relative intensity noise (RIN) of the laser. So the phase noise floor of the output carrier can be minimized by choosing the laser with low RIN and the EDFA with low noise factor. | LUO Xin HAN XiuYou GU YiYing LI ShanFeng & ZHAO MingShan | 2011 | Science China(Information Sciences)2011，54，6： | 1 |
| 18 | Key Management Scheme Based on Secret Sharing for Wireless Sensor Networks显示文摘 | Wu Chunying Li Shundong Zhang Yiying | 2015 | International Journal of Information and Communication Technology2015，7，23： | 1 |
| 19 | Two-dimensional Super- vised Local Similarity and Diversity Projection显示文摘 | Gao Quanxue Xu Hui Li Yiying | 2010 | Pattern Recog- nition2010，43，10： | 1 |
| 20 | Thermal conductivity in individual silicon nanowires 显示文摘 | LI Deyu WU Yiying KIM P | 2003 | Appl Phys Lett2003，83，14： | 1 |
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