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| 1 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 2 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 3 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 4 | Global chronostratigraphical correlation table for the last 2.7 million years显示文摘 | Philip Gibbard Kim M. Cohen | 2008 | Episodes2008，31，2： | 6 |
| 5 | Split-dose bowel preparation improves adequacy of bowel preparation and gastroenterologists' adherence to National Colorectal Cancer Screening and Surveillance Guidelines显示文摘AIM To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps(< 10 mm).METHODS A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 years old with a normal screening colonoscopy and 1-2 small polyps. Data were abstracted from two time periods, pre and post-split-dose bowel preparation institution. Main outcome measurements were recommendation for timing of repeat colonoscopy and bowel preparation quality. Bivariate analysis by χ~2 tests and Student's t-tests were performed to assess differences between the two cohorts. Multivariable logistic regression was used with guideline consistent recommendations as the dependent variables and an indicator for 2011 cohort as the primary predictor. RESULTS Four thousand two hundred and twenty-five patients were included in the study; 47.0%(1987) prior to the institution of split dose bowel preparation, and 53.0%(2238) after the institution of split dose bowel preparation. Overall, 82.2%(n = 3472) of the colonoscopies were compliant with guideline recommendations, with a small but significantly increased compliance rate in year 2011(83.7%) compared to year 2009(80.4%, P = 0.005), corresponding to an unadjusted odds ratio of 1.25(95%CI: 1.07-1.47; P = 0.005). Colonoscopies with either 'Adequate' or 'Excellent' had increased from 30.6% in year 2009 to 39.6% in year 2011(P < 0.001). However, there was no significant difference in poor/inadequate category of bowel preparation as there was a mild increase from 4.6% in year 2009 to 5.1% in year 2011(P = 0.50). CONCLUSION Split-dose bowel regimen increases endoscopists' compliance to guidelines in average-risk patients with normal colonoscopy or 1-2 small polyps. | Stacy Bartnik Menees H Myra Kim Philip Schoenfeld | 2018 | World Journal of Gastroenterology2018，24，6： | 4 |
| 6 | 腹主动脉瘤病因新探讨显示文摘目的 证实家族性因素和遗传性因素在腹主动脉瘤 ( abdominal aortic aneurysm,AAA)发病中的作用。方法 30 8例澳大利亚欧洲腹主动脉瘤病人和 110例健康对照组以及男女各 4 0例的新生儿对照组。对动脉壁四种重要结构蛋白基因进行等位基因分析。等位基因频率分析采用 Sham and Curtis方法。结果 50例 AAA病人至少有一例直系亲属患有 AAA。在 539例存活的同代亲属中 ,14例查出 AAA,其中 12例已施行了手术治疗。对 74例同代亲属筛选发现 4例患有轻度主动脉扩张 ,6例患有中到重度主动脉扩张。女性病人与对照组之间及女性病人与男性病人之间 ,COL 1A2基因的等位基因频率具有统计学差别。结论 在本组病例中遗传性因素在 AAA发病中起着重要作用。 COL 1A2在男女 AAA发病中作用不同 ,其详细机制有待进一步探讨。 | 徐东 王京生 万峰 M J West Kim Summers Philip Walker | 2000 | 北京医学2000，22，6： | 3 |
| 7 | Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review显示文摘 | Sameer D. Saini Hyungjin Myra Kim Philip Schoenfeld | 2006 | Gastrointestinal Endoscopy2006，，4： | 3 |
| 8 | A survey of ampullectomy practices显示文摘AIM:To investigate the endoscopic ampullectomy practices of expert biliary endoscopists.METHODS:An anonymous survey was mailed to 79 expert biliary endoscopists to assess ampullectomy practices.RESULTS:Forty six(58%) biliary endoscopists returned the questionnaire.Of these, 63% were in academia and in practice for an average of 16.4 years(± 8.6).Endoscopists performed an average of 1.1(± 0.8) ampullectomies per month.Prior to ampullectomy, endoscopic ultrasound was'always'utilized by 67% of respondents vs'sometimes'in 31% of respondents.Empiric biliary sphincterotomy was not utilized uniformly, only 26%'always'and 37%'sometimes'performed it prior to resection.Fifty three percent reported'never'performing empiric pancreatic sphincterotomy prior to ampullectomy.Practitioners with high endoscopic retrograde cholangiopancreatography volumes were the most likely to perform a pancreatic sphincterotomy(OR = 10.9;P = 0.09).Participants overwhelmingly favored'always'placing a prophylactic pancreatic stent, with 86% placing it after ampullectomy rather than prior to resection(23%).Argon plasma coagulation was the favored adjunct modality(83%) for removal of residual adenomatous tissue.Practitioners uniformly(100%) preferred follow-up examination to be within 6 mo post-ampullectomy.CONCLUSION:Among biliary experts, there is less variation in ampullectomy practices than is reflected in the literature. | Stacy B Menees Philip Schoenfeld Hyungjin Myra Kim Grace H Elta | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 9 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 10 | The Effect of Restaging Transurethral Resection on Recurrence and Progression Rates in Patients with Nonmuscle Invasive Bladder Cancer Treated with Intravesical Bacillus Calmette-Guérin显示文摘 | John P. Sfakianos Philip H. Kim A. Ari Hakimi Harry W. Herr | 2014 | The Journal of Urology2014，，2： | 2 |
| 11 | Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA显示文摘AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of Gd-DOTA or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOTA).RESULTS: The normalized SI and ER of the pancreas using Gd-DOTA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P < 0.05). The area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOTA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOTA injection(Gadofluorine P vs Gd-DOTA, 7.37 vs 0.00, P < 0.01). A significant difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-induced diabetes rat model,Gadofluorine P-enhanced MRI of the pancreas showed high accuracy in the diagnosis of diabetes. | Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 12 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9ehkbo0nu599uqq66b6.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 13 | Cervical adjacent segment pathology following fusion:Is it due to fusion?显示文摘Adjacent segment pathology affects 25% of patients within ten years of anterior cervical diskectomy and fusion(ACDF). Laboratory studies demonstrate fused segments increase adjacent level stress including elevated intradiscal pressure and increased range of motion. Radiographic adjacent segment pathology(RASP) has been associated to ACDF in multiple statistically significant studies. Randomized controlled trials(RCTs) comparing anterior cervical discectomy and arthroplasty(ACDA) and ACDF have confirmed ACDF accelerates RASP. The question of greatest clinical interest is whether ACDA, artificial disc surgery, results in fewer adjacent level surgeries than ACDF. Current RCT follow up results reveal only non statistically significant trends favoring ACDA yet the post operative periods are only two to four years. Statistically significant increased RASP in ACDF patients however is already documented. The RCT patients' average ages are in the mid forties with an expected longevity of up to forty more years. Early statistically significant increased RASP in the ACDF patients supports our prediction that given sufficient follow up of ten or more years, fusion will lead to statistically significant higher rate of adjacent level surgery compared to artificial disc surgery. | Philip Rosenthal Kee D Kim | 2013 | World Journal of Orthopedics2013，4，3： | 2 |
| 14 | An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma显示文摘 | George P. Kim Michelle R. Mahoney Daniel Szydlo Tony S. K. Mok Robert Marshke Kyle Holen Joel Picus Michael Boyer Henry C. Pitot Joseph Rubin Philip A. Philip Anna Nowak John J. Wright Charles Erlichman | 2012 | Investigational New Drugs2012，，1： | 2 |
| 15 | Case–case comparison of smoking and alcohol risk associations with Epstein–Barr virus‐positive gastric cancer显示文摘 | M. Constanza Camargo Chihaya Koriyama Keitaro Matsuo Woo‐Ho Kim Roberto Herrera‐Goepfert Linda M. Liao Jun Yu Gabriel Carrasquilla Joseph J.Y. Sung Isabel Alvarado‐Cabrero Jolanta Lissowska Fernando Meneses‐Gonzalez Yashushi Yatabe Ti Ding Nan Hu Philip R | 2014 | Int J Cancer2014，，4： | 1 |
| 16 | Improving source identification of Atlanta aerosol using temperature resolved carbon fractions in positive matrix factorization 显示文摘 | KIM E PHILIP K H ERIC S E | 2004 | Atmospheric Environment2004，38，： | 1 |
| 17 | Incorporation of parametric factors into muhilinear receptor model studies of Atlanta aerosol 显示文摘 | KIM E PHILIP K H PENTTI P | 2003 | Atmospheric Environment2003，37，： | 1 |
| 18 | Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas显示文摘 | Claire M. Mach Jong Kim Benjamin Soibam Chad J. Creighton Shannon M. Hawkins Israel Zighelboim Paul Goodfellow Preethi H. Gunaratne Kunle Odunsi Philip A. Salem Matthew L. Anderson | 2013 | Cancer Letters2013，，2： | 1 |
| 19 | Thermal conductivity of individual silicon nanowires显示文摘 | Li Deyu Wu Yiying Kim Philip | 2003 | Applied Physics Letters2003，83，14： | 1 |
| 20 | The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane显示文摘 | Athar H Chishti Anthony C Kim Shirin M Marfatia Mohini Lutchman Manjit Hanspal Hitesh Jindal Shih-Chun Liu Philip S Low Guy A Rouleau Narla Mohandas Joel A Chasis John G Conboy Phillipe Gascard Yuichi Takakuwa Shu-Ching Huang Edward J Benz Jr Anthony Bret | 1998 | Trends in Biochemical Sciences1998，，8： | 1 |
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