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| 1 | Design Criterion for Interleaving and Magnetically Integrated Bidirectional DC/DC Converters显示文摘双向DC/DC变换器中大功率储能电感的设计是一件困难而具有挑战性的工作,提出研究双向DC/DC变换器的交错并联磁集成理论以克服这一困难。将三相Buck+Boost双向DC/DC变换器的所有相电感集成为一个耦合电感,对磁集成后变换器运行在Buck模式下的稳态电流纹波和暂态响应速度进行深入研究,给出三相Buck+Boost交错并联磁集成双向DC/DC变换器运行在Buck模式下的设计准则,即在设计这种变换器时,应根据占空比的大小及稳态相电流纹波和暂态总输出电流响应速度的技术要求,利用该文所给出的设计公式和设计区域选择磁集成耦合电感的反向耦合系数。仿真和实验验证了理论分析的正确性。 | YANG Yugang LI Tao FENG Bencheng | 2012 | 中国电机工程学报2012，32，30： | 25 |
| 2 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 3 | Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchange显示文摘Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the human IgG1 CH2 (i.e., Cγ2) and CH3 (i.e., Cγ3) domains with the human IgG1 hinge (i.e. Hγ). Given the relationship between structure and function of protein, the 3-D structures of the two engineered antibody fragments were modeled using computer-aided homology modeling method. Furthermore, the relationship between 3-D conformation and their binding activity was evaluated theoretically. Due to the change of active pocket formed by CDRs, the HL23 (VH-Linker-VL-Hγ-Cγ2-Cγ3) remained its activity because of its preserved conformation, while the binding activity of the LH23 (VL-Linker-VH-Hγ-Cγ2-Cγ3) was impaired severely. Experimental studies by flow cytometry and fluorescence microscopy showed that HL23 possessed significantly superior binding activity to CD20-expressing target cells than LH23. That is to say, the order of variable regions could influence the binding activity of the fusion protein to CD20+ cell lines, which was in accordance with the theoretical results. The study highlights the potential relationship between the antibody binding activity and their 3-D conformation, which appears to be worthwhile in providing direction for future antibody design of recombinant antibody. | Shusheng Geng Jiannan Feng Yan Li Yingxun Sun Xin Gu Ying Huang Yugang Wang Xianjiang Kang Hong Chang Beifen Shen | 2006 | Cellular & Molecular Immunology2006，3，6： | 13 |
| 4 | Aircraft vulnerability modeling and computation methods based on product structure and CATIA显示文摘Survivability strengthening/vulnerability reduction designs have become one of the most important design disciplines of military aircraft now. Due to progressiveness and complexity of modern combat aircraft, the existing vulnerability modeling and computation methods cannot meet the current engineering application requirements. Therefore, a vulnerability modeling and computation method based on product structure and CATIA is proposed in sufficient consideration of the design characteristics of modern combat aircraft. This method directly constructs the aircraft vulnerability model by CATIA or the digital model database, and manages all the product components of the vulnerability model via aircraft product structure. Using CAA second development, the detailed operations and computation methods of vulnerability analysis are integrated into CATIA software environment. Comprehensive assessment data and visual kill probability Iso-contours can also be presented, which meet the vulnerability analysis requirements of modern combat aircraft effectively. The intact vulnerability model of one hypothetical aircraft is constructed, and the effects of redundant technology to the aircraft vulnerability are assessed, which validate the engineering practicality of the method. | Li Jun Yang Wei Zhang Yugang Pei Yang Ren Yunsong Wang Wei | 2013 | Chinese Journal of Aeronautics2013，26，2： | 12 |
| 5 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 6 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 7 | An expression atlas of miRNAs in Arabidopsis thaliana显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate a variety of biological processes. miRNA expression often exhibits spatial and temporal specificity. However, genome-wide miRNA expression patterns in different organs during development of Arabidopsis thaliana have not yet been systemically investigated. In this study, we sequenced small RNA libraries generated from 27 different organ/tissue types, which cover the entire life cycle of Arabidopsis. Analysis of the sequencing data revealed that most miRNAs are ubiquitously expressed, whereas a small set of miRNAs display highly specific expression patterns. In addition, different miRNA members within the same family have distinct spatial and temporal expression patterns. Moreover, we found that some miRNAs are produced from different arms of their hairpin precursors at different developmental stages. This work provides new insights into the regulation of miRNA biogenesis and a rich resource for future investigation of miRNA functions in Arabidopsis. | Le Xu Yugang Hu Ying Cao Jingrui Li Ligeng Ma Yan Li Yijun Qi | 2018 | Science China(Life Sciences)2018，61，2： | 8 |
| 8 | Ultrathin Co(Ni)-doped MoS2 nanosheets as catalytic promoters enabling efficient solar hydrogen production显示文摘收获太阳能经由水减小驾驶氢进化反应的有效人工的光合的系统的设计从两个是很重要的理论、实际的观点。与吸收材料的大光集成适当合作催化剂倡导者代表理想的策略在氢生产提高太阳能的变换效率。此处,第一次,我们报导由 ultrathin 公司(Ni ) 组成的唯一的混合结构的一个班的合成做了瞬间 2 nanosheets (合作催化剂倡导者) 在半导体 CdS nanorods (轻吸收器) 上亲密地成年。同样综合的一个维的 CdS@doped 瞬间 2 heterostructures 展出了很高的 photocatalytic 活动(与 17.3% 的量收益) 并且向从水的光致还原的 H 2 进化的稳定性。理论计算表明做的 Ni 能在瞬间 2 nanosheets 的边地点增加不协调的原子的数字越过 CdS/MoS 2 接口以及氢减小支持电子转移,导致有效 H 2 进化反应。 | Xiaoyan Ma Jinquan Li Changhua An Juan Feng Yuhua Chi Junxue Liu Jun Zhang Yugang Sun | 2016 | Nano Research2016，9，8： | 7 |
| 9 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 10 | Emission characteristics of surface second-order metal grating distributed feedback semiconductor lasers显示文摘To obtain high-power semiconductor lasers with stable operation in a single longitudinal mode and improve the characteristics of the output beam,an end-emitting surface second-order metal grating distributed feedback(DFB) laser emitting at around 940 nm is fabricated.The characteristics of the uncoated devices with and without gratings are tested under room temperature continuous-wave conditions without any temperature-control device and compared.The devices with gratings achieve high powers of up to 385 mW/facet and a small lateral far-field angle of 2.7° at 1.5 A,have only 4.13 nm/A wavelength-shift,and 0.09 nm spectral linewidth at 600 mA,and operate in a stable longitudinal mode.Devices without gratings operate in multimode,with a larger lateral far-field angle(7.3°) and spectral linewidth(1.3 nm),although with higher output powers.Because of the integration of second-order metal gratings and their very high coupling capability,the output beam quality is improved greatly,the lasing wavelength is stable and varies slowly with changes in injection current,while the spectrum is narrowed dramatically,and the far-field angles are greatly reduced.This opens the way for the realization of watt-scale power broad-stripe(>100 μm) surface second-order metal grating end and surface-emitting DFB lasers and arrays with single frequency,single mode operation and high output beam quality. | SHI JunXiu QIN Li LIU Yun ZHANG Nan ZHANG Jian ZHANG LiSen JIA Peng NING YongQiang ZENG YuGang ZHANG JinLong WANG LiJun | 2012 | Chinese Science Bulletin2012，57，17： | 5 |
| 11 | Effects of in-situ TiB_(2)particles on machinability and surface integrity in milling of TiB_(2)/2024 and TiB_(2)/7075 Al composites显示文摘In-situ ceramics particle reinforced aluminum matrix composites are favored in the aerospace industry due to excellent properties.However,the hard ceramic particles as the reinforcement phase bring challenges to machining.To study the effect of in-situ TiB_(2)particles on machinability and surface integrity of TiB_(2)/2024 composite and TiB_(2)/7075 composite,milling experiments were performed,and compared with conventional 2024 and 7075 aluminum alloys.In-situ TiB_(2)particles clustered at the grain boundaries and dispersed inside the matrix alloy grains hinder the dislocation movement of the matrix alloy.Therefore,the milling force and temperature of the composites are higher than those of the aluminum alloys due to the increase of the strength and the decrease of the plasticity.In the milling of composites,abrasive wear is the main wear form of carbide tools,due to the scratching of hard nano-TiB_(2)particles.The composites containing in-situ TiB_(2)particles have machining defects such as smearing,micro-scratches,micro-pits and tail on the machined surface.However,in-situ TiB_(2)particles impede the plastic deformation of the composites,which greatly reduces cutting edge marks on the machined surface.Therefore,under the same milling parameters,the surface roughness of TiB_(2)/2024 composite and TiB_(2)/7075 composite is much less than that of2024 and 7075 aluminum alloy respectively.Under the milling conditions of this experiment,the machined subsurface has no metamorphic layer,and the microhardness of the machined surface is almost the same as that of the material.Besides,compared with 2024 and 7075 aluminum alloy,machined surfaces of TiB_(2)/2024 composite and TiB_(2)/7075 composite both show tensile residual stress or low magnitude of compressive residual stress. | Jie CHEN Weiwei YU Zhenyu ZUO Yugang LI Dong CHEN Qinglong AN Jiwei GENG Ming CHEN Haowei WANG | 2021 | Chinese Journal of Aeronautics2021，34，6： | 5 |
| 12 | Effects of HIV status notification on reducing the risk of sexual transmission of HIV in China显示文摘 | Bao Yugang Jing Jun Zhang Yanhui Li Huasheng Feng Liangui Ning Zhen Tan Hongzhuan | 2014 | Chinese Medical Journal2014，，24： | 4 |
| 13 | Surface-engineering of layered LiNi_(0.815)Co_(0.15)Al_(0.035)O_2 cathode material for high-energy and stable Li-ion batteries显示文摘Surface engineering is an effective strategy to restrain the generation of rocksalt NiO phase on surface of layered LiNi_(0.815)Co_(0.15)Al_(0.035)O_2(NCA) primary nanoparticles, a representative Ni-rich layered oxides cathode materials. Herein, we demonstrate the kilogram-scale synthesis of few-layer reduced graphene oxide(rGO) conformably coated NCA primary nanoparticles cathode materials by a mechanical wet ball-milling strategy. The lightening rGO coating layer effectively avoids the direct contact of electrolyte and NCA with rapid electrons transfer. As a result, the as-obtained NCA@rGO hybrids with only 1.0 wt% rGO content can deliver a high specific capacity(196 mAh g^(-1) at 0.2 C) and fast charge/discharge capability(127 mAh g^(-1) at 5 C), which is much higher than the corresponding NCA nanoparticles(95 mAh g^(-1) at 5 C). Even after100 cycles at 1 C, 91.7% of initial reversible capacity is still maintained. Furthermore, a prismatic pouch cell(240 mAh) is also successfully assembled with the commercial graphite anode. | Yugang Li Haifeng Yu Yanjie Hu Hao Jiang Chunzhong Li | 2018 | Journal of Energy Chemistry2018，27，2： | 4 |
| 14 | Machine learning in nuclear physics at low and intermediate energies显示文摘Machine learning(ML)is becoming a new paradigm for scientific research in various research fields due to its exciting and powerful capability of modeling tools used for big-data processing tasks.In this review,we first briefly introduce the different methodologies used in ML algorithms and techniques.As a snapshot of many applications by ML,some selected applications are presented,especially for low-and intermediate-energy nuclear physics,which include topics on theoretical applications in nuclear structure,nuclear reactions,properties of nuclear matter,and experimental applications in event identification/reconstruction,complex system control,and firmware performance.Finally,we present a summary and outlook on the possible directions of ML use in low-intermediate energy nuclear physics and possible improvements in ML algorithms. | Wanbing He Qingfeng Li Yugang Ma Zhongming Niu Junchen Pei Yingxun Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 3 |
| 15 | Engineering cancer vaccines using stimuli-responsive biomaterials显示文摘 | Yu Zhao Yugang Guo Li Tang | 2018 | Nano Research2018，11，10： | 2 |
| 16 | Novel nanometer scaffolds regulate the biological behaviors of neural stem cells显示文摘Ideal tissue-engineered scaffold materials regulate proliferation, apoptosis and differentiation of cells seeded on them by regulating gene expression. In this study, aligned and randomly oriented collagen nanofiber scaffolds were prepared using electronic spinning technology. Their diameters and appearance reached the standards of tissue-engineered nanometer scaffolds. The nanofiber scaffolds were characterized by a high swelling ratio, high porosity and good mechanical properties. The proliferation of spinal cord-derived neural stem cells on novel nanofiber scaffolds was obviously enhanced. The proportions of cells in the S and G 2 /M phases noticeably increased. Moreover, the proliferation rate of neural stem cells on the aligned collagen nanofiber scaffolds was high. The expression levels of cyclin D1 and cyclin-dependent kinase 2 were increased. Bcl-2 expression was significantly increased, but Bax and caspase-3 gene expressions were obviously decreased. There was no significant difference in the differentiation of neural stem cells into neurons on aligned and randomly oriented collagen nanofiber scaffolds. These results indicate that novel nanofiber scaffolds could promote the proliferation of spinal cord-derived neural stem cells and inhibit apoptosis without inducing differentiation. Nanofiber scaffolds regulate apoptosis and proliferation in neural stem cells by altering gene expression. | Jihui Zhou Fuge Sui Meng Yao Yansong Wang Yugang Liu Feipeng Tian Qiang Li Xiaofeng He Lin Shao Zhiqiang Liu | 2013 | Neural Regeneration Research2013，8，16： | 2 |
| 17 | Effect of heat treatment on microstructures and properties of a novel Al-Zn-Mg-Cu alloy for oil drilling显示文摘In view of the special requirements for strength, heat resistance and corrosion resistance of Al-Zn-Mg-Cu alloy for oil drilling, the Al-6.2 Zn-2.5 Mg-1.6 Cu alloy was prepared by increasing Cu content on basis of Russian Series 1953 alloy. The effect of heat treatment on the microstructures and properties of the alloy was characterized by optical microscope(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM), and investigated by tensile test at room temperature, thermal exposure test and corrosion test. The results show that the strength after T6 aging treatment exhibit a decrease trend as an increase of the solution temperature from465 ℃ to 480 ℃. After the solution treated by the rate of 470 ℃/1 h, second phases dissolve into the matrix very well and the strength property reaches optimum. The alloy has better comprehensive properties treated by a solution treatment of 470 ℃/1 h and then followed by an aging treatment of 120 ℃/24 h + 170 ℃/1 h + 120 ℃/24 h. Under the aging state, the precipitated phases inside the grains are suitable in size, while on the grain boundary distribute discontinuously and the precipitate-free zone is obvious. Besides, the alloy still maintain high tensile properties. The yield strength, tensile strength and elongation are 650 MPa, 686 MPa,12.0%, respectively. The yield strength retention after heat exposure is 92%. The alloy has good corrosion resistance and the exfoliation corrosion degree. The average corrosion rate in the H2S and CO2 environment is 0.0024 mm/a, which is far less than the required 0.12 mm/a. It is insensitive to H2S and CO2 environments. | Yanjun Fu Xiwu Li Kai Wen Shuhui Huang Yang Dong Mao Rao Fubo Yang Yugang Wang Baiqing Xiong Zhihui Li | 2019 | Progress in Natural Science:Materials International2019，29，2： | 2 |
| 18 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 19 | Land exploitation resulting in soil salinization in a desert-oasis ecotone显示文摘 | Yugang Wang Yan Li | | 0，，： | 1 |
| 20 | Maximal modal force rule for optimal placement of point piezoelectric actuators for plates显示文摘 | Li Bin Li Yugang Yin Xuegang | 2000 | Joumal of Intelligent material systems and structures2000，11，7： | 1 |
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