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| 1 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 2 | Decomposition reaction kinetics of Baotou RE concentrate with concentrated sulfuric acid at low temperature显示文摘Baotou RE concentrate was decomposed with concentrated sulfuric acid by controlling the roasting temperature below 500°C.Thermogravimetry-differential thermal analysis(TG-DTA) and chemical analytical methods were used to study the thermal decomposition process and the thermal decomposition effect.The Freeman-Carroll method was applied to analyze the TG-DTA curves.The activation energy, reaction order, and reaction frequency factor at different stages were calculated.The Satava method was used to deduce the reaction mechanism and the relative reaction rate during the thermal decomposition process. | WANG Xiuyan LIU Jiemin LI Mei FAN Huili YANG Qishan | 2010 | Rare Metals2010，29，2： | 2 |
| 3 | Technology research on waterworks sludge for ceramsite显示文摘 | Hi Jun Wang Qishan | 2012 | Advanced Materials Research Vols2012，，383390： | 1 |
| 4 | Removal of organic carbon from wastepaper pulp effluent by lab-scale solar photo-Fenten process 显示文摘 | Xu Meijuan Wang Qishan Hao Yueli | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 5 | Degradation of microcystin-RR by UV radiation in the presence of hydrogen peroxide 显示文摘 | Qiao RuiPing Li Nan Wang QiShan et ol | 2005 | Toxieon2005，45，6： | 1 |
| 6 | Coordinated grain boundary deformation governed nanograin annihilation in shear cycling显示文摘Grain growth and shrinkage are essential to the thermal and mechanical stability of nanocrystalline metals,which are assumed to be governed by the coordinated deformation between neighboring grain boundaries(GBs)in the nanosized grains.However,the dynamics of such coordination has rarely been reported,especially in experiments.In this work,we systematically investigate the atomistic mechanism of coordinated GB deformation during grain shrinkage in an Au nanocrystal film through combined stateof-the-art in situ shear testing and atomistic simulations.We demonstrate that an embedded nanograin experiences shrinkage and eventually annihilation during a typical shear loading cycle.The continuous grain shrinkage is accommodated by the coordinated evolution of the surrounding GB network via dislocation-mediated migration,while the final grain annihilation proceeds through the sequential dislocation-annihilation-induced grain rotation and merging of opposite GBs.Both experiments and simulations show that stress distribution and GB structure play important roles in the coordinated deformation of different GBs and control the grain shrinkage/annihilation under shear loading.Our findings establish a mechanistic relation between coordinated GB deformation and grain shrinkage,which reveals a general deformation phenomenon in nanocrystalline metals and enriches our understanding on the atomistic origin of structural stability in nanocrystalline metals under mechanical loading. | Yingbin Chen Qishan Huang Qi Zhu Kexing Song Yanjun Zhou Haofei Zhou Jiangwei Wang | 2021 | Journal of Materials Science & Technology2021，，27： | 1 |
| 7 | G20 Must Look Beyond the Needs Of the Top 20显示文摘After the financial crisis broke out,China was quick to put in place a decisive plan to boost domestic demand,advance eco-nomic restructuring and improve people’s well being.These mea-sures have started to produce results.At present,the Chinese economy still faces severe challenges. | Wang Qishan,Vice Premier of the People’s Republic of China | 2009 | Beijing Review2009，52，14： | 1 |
| 8 | Multi-objective location-routing problem of reverse logistics based on GRA with entropy weight显示文摘 | Hong Liu Wenping Wang Qishan Zhang | 2012 | Grey Systems: Theory and Application2012，，2： | 1 |
| 9 | Removal of organic carbon from wastepaper pulp effluent by lab-scale solar photo-Fenton process 显示文摘 | Xu Meijuan Wang Qishan Hao Yueli | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 10 | Grey Systems 显示文摘 | HongLiu Qishan Zhang Wenping Wang | 2011 | Theory and Ap-plication Volume2011，2334，： | 1 |
| 11 | GAPIT: genome association and prediction integrated tool显示文摘 | Alexander E. Lipka Feng Tian Qishan Wang Jason Peiffer Meng Li Peter J. Bradbury Michael A. Gore Edward S. Buckler Zhiwu Zhang | 2012 | Bioinformatics2012，，18： | 1 |
| 12 | of grey cluster knowledge显示文摘 | Zhang Qishan Wang Haiyan | 2009 | 21(3):259-2682009，21，3： | 1 |
| 13 | 4-stage distribution network optimization of supply chain with grey demands显示文摘 | Qishan Zhang Haiyan Wang Hong Liu | 2012 | Kybernetes2012，，5： | 1 |
| 14 | Knowledge integration of cluster networks based on grey relational analysis knowledge similarities显示文摘 | Liuhong Wang Wenping Zhang Qishan Cai Youhua | 2013 | The Journal of Grey System2013，25，1： | 1 |
| 15 | Knowledge integra- tion of cluster networks based on grey relational analysis knowledge similarities显示文摘 | Liu Hang Wang Wenping Zhang Qishan | 2013 | The Journal of Grey System2013，25，1： | 1 |
| 16 | A full-scale study on preozonation of typical source waters in north China 显示文摘 | Yue Shangchao Wang Qishan Li Sisi | 2012 | Advanced Materials Research2012，，： | 1 |
| 17 | Address at the Opening Session of the 5th China-Africa People’s Forum显示文摘Your Excellency Vincent Meriton,President of the People's Party of Seychelles and Vice President of Seychelles, Your Excellency Clement Mouamba ,Prime Minister of the Republic of the Congo, Ladies and Gentlemen, Dear friends,I feel greatly delighted to have you with us here in Chengdu,the city of Hibiscus,at the 5th China-Africa People's Forum.The forum is especially honoured with the message of congratulations from President Xi Jinping.This adequately reflects the importance the Communist Party of China and the Chinese goyemment have placed on the people-to-people exchanges and cooperation between China and Africa,and points out the way to follow in the proceedings of the Forum. | Wang Qishan | 2018 | International Understanding2018，，3： | 0 |
| 18 | A Novel Algorithm for Generating Optimal Optical Orthogonal Codes with Correlation One显示文摘 | WANG Gang ZHANG Jun Zhang Qishan | 2006 | Chinese Journal of Electronics2006，15，1： | 0 |
| 19 | Maximizing the Role of Inspection Tours to Boost Strict Governance of the CPC (Extract)显示文摘 | Wang Qishan | 2016 | Qiu Shi2016，8，2： | 0 |
| 20 | The novel generating algorithm and properties of hybrid-P-ary generalized bridge functions显示文摘In this paper, we develop novel non-sine functions, named hybrid-P-ary generalized bridge functions, based on the copy and shift methods. The generating algorithm of hybrid-P-ary generalized bridge functions is introduced based on the hybrid-P-ary generalized Walsh function’s copy algorithm. The main property, product property, is also discussed. This function may be viewed as the generalization of the theory of bridge functions. And a lot of non-sine orthogonal functions are the special subset of these novel functions. The hybrid-P-ary generalized bridge functions can be used to search many unknown non-sine functions by defining different parameters. | WANG Gang ZHANG Qishan | 2006 | Science in China(Series F)2006，49，2： | 0 |
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