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| 1 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 2 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 3 | Viral Metagenomics Analysis of Planktonic Viruses in East Lake,Wuhan,China显示文摘East Lake(Lake Donghu),located in Wuhan,China,is a typical city freshwater lake that has been experiencing eutrophic conditions and algal blooming during recent years.Marine and fresh water are considered to contain a large number of viruses.However,little is known about their genetic diversity because of the limited techniques for culturing viruses.In this study,we conducted a viral metagenomic analysis using a high-throughput sequencing technique with samples collected from East Lake in Spring,Summer,Autumn,and Winter.The libraries from four samples each generated 234,669,71,837,12,820,and 34,236 contigs(>90 bp each),respectively.The genetic structure of the viral community revealed a high genetic diversity covering 23 viral families,with the majority of contigs homologous to DNA viruses,including members of Myoviridae,Podoviridae,Siphoviridae,Phycodnaviridae,and Microviridae,which infect bacteria or algae,and members of Circoviridae,which infect invertebrates and vertebrates.The highest viral genetic diversity occurred in samples collected in August,then December and June,and the least diversity in March.Most contigs have low-sequence identities with known viruses.PCR detection targeting the conserved sequences of genes(g20,psbA,psbD,and DNApol)of cyanophages further confirmed that there are novel cyanophages in the East Lake.Our viral metagenomic data provide the first preliminary understanding of the virome in one freshwater lake in China and would be helpful for novel virus discovery and the control of algal blooming in the future. | Xingyi Ge Yongquan Wu Meiniang Wang Jun Wang Lijun Wu Xinglou Yang Yuji Zhang Zhengli Shi | 2013 | Virologica Sinica2013，28，5： | 8 |
| 4 | Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets显示文摘Dear Editor, Live poultry markets are the major trading system of poultry in China and many other countries, and are also thought to be important for the generation and spread of avian influenza viruses and other avian pathogens (Zhang et al., 2013;Shi et al., 2017;Quan et al., 2018). | Mei Li Xin Yin Lizheng Guan Xia Zhang Guohua Deng Tao Li Pengfei Cui Yong Ma Yujie Hou Jianzhong Shi Hualan Chen | 2019 | Science China(Life Sciences)2019，62，6： | 6 |
| 5 | Contents of soil organic carbon and nitrogen in water-stable aggregates in abandoned agricultural lands in an arid ecosystem of Northwest China显示文摘Soil organic matter content in water-stable aggregates(WSA) in the arid ecosystems(abandoned agricultural lands especially) of China is poorly understood. In this study, we examined the WSA sizes and stability, and soil organic carbon(OC) and nitrogen(N) contents in agricultural lands with abandonment ages of 0, 3, 12, 20, 30 and 40 years, respectively, in the Minqin Oasis of Northwest China. The total soil OC and N contents at depths of 0–20, 20–40 and 40–60 cm in abandoned agricultural lands were compared to those in cultivated land(the control). Agricultural land abandonment significantly(P<0.05) influenced the distribution of MWD(mean weight diameter), and OC and N contents. There were significant increases in MWD and the proportion of macroaggregates(sizes >0.25 mm) as the age of agricultural land abandonment increased. The effect of abandonment ages of agricultural lands on MWD was determined by the changes of OC and N accumulation in WSA sizes >2 mm. The total OC and N contents presented a stratification phenomenon across soil depths in this arid ecosystem. That is, both of them decreased significantly at depths of 0–20 and 40–60 cm while increased at the depth of 20–40 cm. The WSA sizes <0.053 mm had the highest soil OC and N contents(accounting for 51.41%–55.59% and 42.61%–48.94% of their total, respectively). Soil OC and N contents in microaggregates(sizes 0.053–0.25 mm) were the dominant factors that influenced the variations of total OC and N contents in abandoned agricultural lands. The results of this study suggested that agricultural land abandonment may result in the recovery of WSA stability and the shifting of soil organic matter from the silt+clay(<0.053 mm) and microaggregate fractions to the macroaggregate fractions. However, agricultural land abandonment did not increase total soil OC and N contents in the short-term. | WANG Junqiang LIU Lichao QIU Xiaoqing WEI Yujie LI Yanrong SHI Zhiguo | 2016 | Journal of Arid Land2016，8，3： | 6 |
| 6 | Hierarchical three-dimensional flower-like Co3O4 archi- tectures with a mesocrystal structure as high capacity anode materials for long-lived lithium-ion batteries显示文摘 | Wenqiang Cao Wenzhong Wang Honglong Shi Jun Wang Maosheng Cao Yujie Liang Min Zhu | 2018 | Nano Research2018，11，3： | 6 |
| 7 | Contributions of climate, varieties, and agronomic management to rice yield change in the past three decades in China显示文摘和一个庄稼模拟模型,在四个代表性的 agro 气象学的车站的长期的地实验数据被用来在过去的三十年解开大米收益变化的气候变化,变化更新,和授精管理的贡献。我们发现在 1981-2009 变化期间,更新由 16%-52% 增加了米饭产量,管理改进由产量从 16% ~ 10% 改变了的米饭的气候变化的 0-16% ,和贡献增加了产量。变化更新和气候的否定影响在米饭生产上改变的管理改进偏移量。在主要气候变量之中,在太阳的放射的减少到 0.1%per 年平均减少了米饭产量。温度变化的影响有一个明确的空间模式。它在 Tongcheng 车站在 Xinbin 和 Ganyu 车站并且为迟了的米饭为单个米饭每年由 0.04%-0.4% 增加了产量,由在 Tongcheng 在 Mianyang 车站和早米饭为单个米饭每年由 0.2%-0.4% 对比减少的产量车站。在 1981-2009 期间,米饭变化更新被热要求的增加描绘,谷物数字每尖铁和收获索引。新变化比旧的对气候变化不太敏感。高热的要求,高收益潜力和热的发展和农学的管理的改进,容忍的米饭变化应该被鼓励在未来遇见气候变化和增加的食物需求的挑战。 | He ZHANG Fulu TAO Dengpan XIAO Wenjiao SHI Fengshan LIU Shuai ZHANG Yujie LIU Meng WANG Huizi BAI | 2016 | Frontiers of Earth Science2016，10，2： | 5 |
| 8 | Austenite/martensite structure and corresponding ultrahigh strength and high ductility of steels processed by Q&P techniques显示文摘The microstructure of steels treated by Q&P(quenching and partitioning) process was characterized,a method of controlling retained austenite fraction based on inhomogeneous martensitic transformation was proposed,and the mechanical properties of steels treated by Q&P process were measured.The results show that the microstructure of the studied steels is mainly composed of initial martensite,fresh martensite and retained austenite.The initial marteniste formed at the first quenching step is easily etched;the fresh martensite formed at the final quenching step looks like 'blocky' type phase,and the retained austenite is mainly located on the packet boundary and initial austenite grain boundary.The inhomogeneous microstructure causes the experimental optimum quenching temperature corresponding to maximum retained austenite fraction to be higher than the calculation based on CPE(constrained paraequilibrium) model.The product of tensile strength and total tensile elongation is 47.5 GPa%,and tensile strength of 1760 MPa was obtained for the steel with carbon content of 0.51 wt%.The TRIP(transformation induced plasticity) effects of the large fractioned metastable austenite make a main contribution to the high ductility improvement,and the martensitic matrix provides high strength. | WANG CunYu ZHANG YuJie CAO WenQuan SHI Jie WANG MaoQiu DONG Han | 2012 | Science China(Technological Sciences)2012，55，7： | 5 |
| 9 | Interaction between PCC Filler and Cellulosic Fiber in Fiber/Filler Co-refining System显示文摘Mineral fillers are important for conserving raw fiber materials and reducing production costs in the paper industry.However,the increase in filler content will inevitably result in strength reduction,which limits the adding amount of filler in paper production.In this study,we designed a cellulose fiber/filler co-refining approach to improve the strength and optical properties of paper;moreover,the synergistic interaction between fibers and precipitated calcium carbonate(PCC)fillers in the co-refining process was investigated.Results of fiber separation and PCC particle size analysis showed that,compared with conventional refining,the content of fines increased,whereas the PCC particle size decreased.More importantly,composites were formed between the PCC and fines,which promoted strength improvement of paper.Physical tests show that the tensile index of paper with 15%PCC content increased by 22%compared with that of the paper filled by conventional method,whereas the brightness and opacity of paper improved by fiber/filler co-refining for a specified filler content.These findings provide a basis for the further development of co-refining filling technology. | Sheng Qiang Shunxi Song Peiyao Wang Yujie Shi Linhao Li Haitang Liu | 2021 | Paper And Biomaterials2021，6，4： | 5 |
| 10 | Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors显示文摘CDK4/6 inhibitors are the standard treatment in advanced HR+/HER2-breast cancer patients.Nevertheless,the resistance to CDK4/6 inhibitors is inevitable and the strategies to overcome resistance are of great interest.Here,we show that the palbociclibresistant breast cancer cells expressed significantly higher levels of Cyclin D1 and CDK4 proteins because of upregulated protein synthesis.Silencing Cyclin D1 or CDK4 led to cell cycle arrest while silencing Cyclin E1 or CDK2 restored the sensitivity to palbociclib.Furthermore,PI3K/mTOR pathway was hyper-activated in palbociclib-resistant cells,leading to more phosphorylated 4E-BP1 and higher levels of Cyclin D1 and CDK4 translation.Targeting PI3K/mTOR pathway with a specific PI3Kαinhibitor(BYL719)or an mTOR inhibitor(everolimus)reduced the protein levels of Cyclin D1 and CDK4,and restored the sensitivity to palbociclib.The tumor samples expressed significantly higher levels of Cyclin D1,CDK4,p-AKT and p-4E-BP1 after progression on palbociclib treatment.In conclusion,our findings suggest that overexpressed Cyclin D1 and CDK4 proteins lead to the resistance to CDK4/6 inhibitor and PI3K/mTOR inhibitors are able to restore the sensitivity to CDK4/6 inhibitors,which provides the biomarker and rationale for the combinational use of CDK4/6 inhibitors and PI3K/mTOR inhibitors after CDK4/6 inhibitor resistance in breast cancer. | Zijie Cai Jingru Wang Yudong Li Qianfeng Shi Liang Jin Shunying Li Mengdi Zhu Qi Wang Lok Lam Wong Wang Yang Hongna Lai Chang Gong Yandan Yao Yujie Liu Jun Zhang Herui Yao Qiang Liu | 2023 | Science China(Life Sciences)2023，66，1： | 4 |
| 11 | Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis显示文摘Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and naltrexone.Here,we report the de novo assembly and genomic analysis of P.somniferum traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also explored.Among 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 genome.Gene family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)events.The first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease resistance.The more recent species-specific WGD mediated by transposable elements resulted in massive genome expansion.Genes carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new varieties.These genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy. | Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong | 2021 | Horticulture Research2021，8，1： | 4 |
| 12 | The characteristics of the structure, strain and kinematic vorticity of the Wulian detachment fault zone, Shandong Peninsula, China显示文摘As one of the vital tectonic units of the Wulian Metamorphic Core Complex(MCC), the Wulian detachment fault zone(WDFZ), which developed in the Jiaodong peninsula, separates the lower plate of the ultrahigh pressure(UHP) metamorphic rocks in the Sulu orogenic belt from the upper plate of the early Cretaceous Zhucheng basin and the basin basement. The fault zone generally strikes NNE with a dip in the west along the southern portion of the MCC and strikes NE with a dip in the WNWalong the northern portion. The fault zone displays a wavy-tile-shaped extension on the plane, principally composed of the fault breccias and mylonite and transits downward to the mylonitic gneiss. As a whole, the detachment fault zone shows a top-towest or a WNW extension. By calculating the harmonic mean, we obtain a Flynn index K of 0.98–2.0, and the mean value is approximately 1.35 in the fault zone. According to the polar Mohr construction, the extensional crenulation cleavage, the RS/θ,and the quartz C-axial fabric methods, we acquire mean kinematic vorticity values of 0.64–0.97, 0.76–0.93, 0.6–0.92, and 0.63–0.98 with mean values of 0.83, 0.80, 0.78 and 0.86, respectively, for mylonite and promylonite. The strain measurement results and the kinematic vorticity values indicate that the WDFZ is a normal ductile shear zone developed in the extensional setting.The kinematic track shows that the kinematic vorticity value decreases gradually from the NW to the SE as a whole. A simple shear dominates in the middle and upper parts of the shear zone, which is reflected by a higher vorticity value(>0.75, up to 0.98),a low thinning rate and a lower K value. In contrast, toward the footwall, the pure shear is increased significantly, showing a lower vorticity value(<0.70, low to 0.64), a relatively high thinning rate and a higher K value. Combined with the geotectonic background, the development and evolution of the WDFZ should respond to lithospheric thinning and the destruction of the North China Craton(NCC). As a result, the WDFZ can be defined as a thinning normal shear zone developed in the extension tectonic setting and the combined result of the simple shear caused by the crust extension and pure shear led by the rapid uplift of the footwall and magmatic upwelling. | Jinlong NI Junlai LIU Yujie SUN Xiaoxiao SHI Shen LI | 2019 | Science China Earth Sciences2019，62，9： | 4 |
| 13 | Small GTPases:Structure,biological function and its interaction with nanoparticles显示文摘Small GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells.It plays an important role in cytoskeletal reorganization,cell polarity,cell cycle progression,gene expression and many other significant events in cells,such as the interaction with foreign particles.Therefore,it is of great scientific significance to understand the biological properties of small GTPases as well as the GTPase-nano interplay,since more and more nanomedicine are supposed to be used in biomedical field.However,there is no review in this aspect.This review summarizes the small GTPases in terms of the structure,biological function and its interaction with nanoparticles.We briefly introduced the various nanoparticles such as gold/silver nanoparticles,SWCNT,polymeric micelles and other nano delivery systems that interacted with different GTPases.These current nanoparticles exhibited different pharmacological effect modes and various target design concepts in the small GTPases study.This will help to elucidate the conclusion that the therapeutic strategy targeting small GTPases might be a new research direction.It is believed that the in-depth study on the functional mechanism of GTPases can provide insights for the design and study of nanomedicines. | Siyang Song Wenshu Cong Shurong Zhou Yujie Shi Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 3 |
| 14 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 15 | Joint Computation Offloading and Resource Allocation for Mobile-Edge Computing Assisted Ultra-Dense Networks显示文摘Mobile-edge computing(MEC),enabling to offload computing tasks on mobile devices towards edge servers,can reduce the terminals cost.However,a single MEC sever usually has limited computing capabilities,which can not meet a large number of terminals’requirements.In this paper,we consider an ultra-dense networks(UDN)scenario where the macro base stations(MBSs)are assisted by MEC severs.In particular,we first construct system model for MEC assisted UDN,and build the system overhead minimization.Next,in order to solve the problem,we transform the problem into three sub-problems,i.e.,offloading strategies subproblem,channel assignments subproblem,and power allocation subproblem.Then,employing joint offloading and resource allocation algorithms,we obtain the optimal joint strategy for the MEC assisted UDNs.Finally,simulations are conducted to evaluate the performance of our proposed algorithms.Numerical results show that obtained algorithms can effectively reduce the energy consumption of the system and improve the overall performance of the system. | Ya Gao Haoran Zhang Fei Yu Yujie Xia Yongpeng Shi | 2022 | Journal of Communications and Information Networks2022，7，1： | 3 |
| 16 | LIN9 confers paclitaxel resistance in triple negative breast cancer cells by upregulating CCSAP显示文摘LIN9 functions to regulate cell mitotic process.Dysregulation of LIN9 expression is associated with development of human cancers.In this study we assessed the association of LIN9 expression with paclitaxel resistance and clarified the underlying mechanisms for the first time.LIN9 expression in breast cancer tissues was retrieved from publicly available online databases and statistically analyzed.Human TNBC cell lines MDA-MB-231 and MDA-MB-468 and their corresponding paclitaxelresistant sublines 231PTX and 468PTX were used to assess the expression of LIN9 by qRT-PCR and Western blot,cell growth by cell counting,cell viability by MTS assay,and cell apoptosis by flow cytometry.The data showed that high LIN9 expression in breast cancer patients receiving chemotherapy was related to poor overall survival(OS).LIN9 expression was upregulated in paclitaxel-resistant TNBC cells compared to their parental cells.Knockdown of LIN9 or treatment of paclitaxel-resistant TNBC cells with a bromo-and extra-terminal domain inhibitor(BETi)JQ1 which also decreased LIN9 expression enhanced the sensitivity of paclitaxel-resistant TNBC cells to paclitaxel.Mechanistically,decreased LIN9 in resistant cell lines reduced tumor cell viability,promoted multinucleated cells formation and induced tumor cell apoptosis,potentially by directly regulating microtubule-binding protein CCSAP.In conclusion,high LIN9 expression contributed to poor clinical outcomes and paclitaxel resistance in TNBC and BETi,targeting LIN9 expression,could be a reversible drug for PTX-resistant TNBC patients. | Hongna Lai Rui Wang Shunying Li Qianfeng Shi Zijie Cai Yudong Li Yujie Liu | 2020 | Science China(Life Sciences)2020，63，3： | 2 |
| 17 | Study of the Dynamics of Microcystis aeruginosa and its Cyanophage in East Lake using quantitative PCR显示文摘Dear Editor,East Lake,located in the middle and lower reaches of the Yangtze River,is a major source of drinking water for local residents.However,the large increase of population density and the rapid development of industry has resulted in heavy eutrophication of East Lake over the past few decades.Microcystis aeruginosa is a well-known | Han Xia Meiniang Wang Xingyi Ge Yongquan Wu Xinglou Yang Yuji Zhang Tianxian Li Zhengli Shi | 2013 | Virologica Sinica2013，28，5： | 2 |
| 18 | Optical and electrical properties of a spiral LED filament显示文摘This paper introduces a new type of spiral white light-emitting diodes(WLED) filament with high luminous efficiency and uniform optical performance. The optical and thermal properties of the flexible filament were investigated at different stretching heights, namely 0, 1, 2, and 3 cm. The results indicated that the filament showed the best optical characteristics at the stretching height of 2 cm, because of good heat dissipation. In addition, the radiation temperature of the filament was inversely proportional to the output luminous flux. The reliability of the filament at a stretching height of 2 cm was also evaluated after 1000 h of use. The result demonstrated that the luminous flux decay of the bulb was only 0.85%. The flexible spiral WLED filament exhibiting high luminous flux and good reliability could be adapted to promote industrial development in the near future. | Liping Wang Jun Zou Bobo Yang Wenbo Li Yang Li Mingming Shi Wei Zhu Canyun Zhang Fengchao Wang Yujie Lin | 2018 | Journal of Semiconductors2018，39，2： | 2 |
| 19 | Engineering of dendritic dopant-free hole transport molecules:enabling ultrahigh fill factor in perovskite solar cells with optimized dendron construction显示文摘Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial charge carrier kinetics and in turn determining device performance.Here,a novel dendritic engineering strategy is first utilized to design HTMs with a D-A type molecular framework,and diphenylamine and/or carbazole is selected as the building block for constructing dendrons.All HTMs show good thermal stability and excellent film morphology,and the key optoelectronic properties could be fine-tuned by varying the dendron structure.Among them,MPA-Cz-BTI and MCz-Cz-BTI exhibit an improved interfacial contact with the perovskite active layer,and non-radiative recombination loss and charge transport loss can be effectively suppressed.Consequently,high power conversion efficiencies(PCEs)of 20.8%and 21.35%are achieved for MPA-Cz-BTI and MCz-Cz-BTI based devices,respectively,accompanied by excellent long-term storage stability.More encouragingly,ultrahigh fill factors of 85.2%and 83.5%are recorded for both devices,which are among the highest values reported to date.This work demonstrates the great potential of dendritic materials as a new type of dopant-free HTMs for high-performance PVSCs with excellent FF. | Wei Chen Yang Wang Bin Liu Yajun Gao Ziang Wu Yongqiang Shi Yumin Tang Kun Yang Yujie Zhang Weipeng Sun Xiyuan Feng Frédéric Laquai Han Young Woo Aleksandra B.Djurisic Xugang Guo Zhubing He | 2021 | Science China Chemistry2021，64，1： | 2 |
| 20 | Pandemic threat posed by H3N2 avian influenza virus显示文摘Dear Editor,In the last century,H1N1,H2N2,and H3N2 influenza viruses caused pandemics in 1918,1957,and 1968,respectively.In 2009,a novel H1N1 reassortant jumped from pigs to humans and caused a fourth influenza pandemic.Different lineages of H3N2 influenza viruses are commonly found in animal reservoirs.If a different lineage of H3N2 virus jumps to humans,another human influenza pandemic could occur with devastating consequences. | Yaping Zhang Conghui Zhao Yujie Hou Yan Chen Fei Meng Yichao Zhuang Liling Liu Yasuo Suzuki Jianzhong Shi Guohua Deng Hualan Chen | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
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