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| 1 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 2 | Cancer:A proteomic disease显示文摘The development of cancer is a pathological process involving multiple environmental carcinogenic factors and genetic alterations.For decades,cancer researchers have focused on genomic and transcriptomic analyses.The completion of the Human Genome Project has opened the door to the post-genome era and oncoproteomics.Proteins play a critical role in tumorigenesis and influence the differences between normal cells and malignant cells.This report proposes the concept that cancer is a proteomic disease.This concept is based on examining protein expression profiles,post-translational modifications,and protein-protein interactions in carcinogenesis using recent advances in comparative,functional and structural proteomics.This approach provides a new way of viewing carcinogenesis,presents new clues in biomarker discovery for cancer diagnosis and therapy,and reveals important scientific findings and their significance to clinical applications. | LI GuoQing XIAO ZheFeng LIU JianPing LI Cui LI Feng CHEN ZhuChu | 2011 | Science China(Life Sciences)2011，54，5： | 8 |
| 3 | A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance显示文摘When facing a sudden danger or aversive condition while engaged in on-going forward motion,animals transiently slow down and make a turn to escape.The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown.Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons(the PET pathway). Inhibiting neurons in the PET pathway led to defects in lightavoidance due to insufficient deceleration and head casting.On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses. | Caixia Gong Zhenhuan Ouyang Weiqiao Zhao Jie Wang Kun Li Peipei Zhou Ting Zhao Nenggan Zheng Zhefeng Gong | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 4 | Twin boundary: Controllable interface to fatigue cracking显示文摘Twin boundaries(TBs) are key factors influencing the mechanical properties of crystalline materials. We have investigated the intrinsic fatigue cracking mechanisms of TBs during the past decade. The effects of TB orientations on the fatigue cracking mechanisms were revealed via cyclic deformation of a series of grown Cu bicrystals with a sole TB. Furthermore, the combined effects of crystallographic orientation and stacking fault energy(SFE) on the fatigue cracking mechanisms were clarified through cyclic deformation of polycrystalline Cu and Cu alloys. Both developments were reviewed in this report which will provide implications to optimize the interfacial design for the improvement of fatigue performance of metallic materials. | Zhefeng Zhang Linlin Li Zhenjun Zhang Peng Zhang | 2017 | Journal of Materials Science & Technology2017，33，7： | 2 |
| 5 | Understanding the mechanism of social tie in the propagation process of social network with communication channel显示文摘The propagation of information in online social networks plays a critical role in modern life,and thus has been studied broadly.Researchers have proposed a series of propagation models,generally,which use a single transition probability or consider factors such as content and time to describe the way how a user activates her/his neighbors.However,the research on the mechanism how social ties between users play roles in propagation process is still limited.Specifically,comprehensive summary of factors which affect user’s decision whether to share neighbor’s content was lacked in existing works,so that the existing models failed to clearly describe the process a user be activated by a neighbor.To this end,in this paper,we analyze the close correspondence between social tie in propagation process and communication channel,thus we propose to exploit the communication channel to describe the information propagation process between users,and design a social tie channel(STC)model.The model can naturally incorporate many factors affecting the information propagation through edges such as content topic and user preference,and thus can effectively capture the user behavior and relationship characteristics which indicate the property of a social tie.Extensive experiments conducted on two real-world datasets demonstrate the effectiveness of our model on content sharing prediction between users. | Kai LI Guangyi LV Zhefeng WANG Qi LIU Enhong CHEN Lisheng QIAO | 2019 | Frontiers of Computer Science2019，13，6： | 2 |
| 6 | Feeling Hot and Cold:Thermal Sensation in Drosophila显示文摘Sensing environmental temperature is crucial for animal life.The model animal,Drosophila melanogaster,can be investigated with a large number of genetic tools,which have greatly facilitated studies of the cellular and molecular mechanisms of thermal sensing.At the molecular level,a group of proteins,including Transient Receptor Potential channels and ionotropic receptors,have been characterized as potential thermal sensors in both larval and adult Drosophila.At the cellular and circuit levels,peripheral and central thermosensory neurons have been identified.More interestingly,thermal information has been found to be specifically encoded by specific central neurons.In this short review,we mainly survey the progress in understanding the molecular mechanisms of thermosensation and the neuronal mechanisms of thermal information processing in the brain of Drosophila.Other recent temperature-related findings such as its impact on neurosecretion and thermotactic behavior in Drosophila are also introduced. | Kun Li Zhefeng Gong | 2017 | Neuroscience Bulletin2017，33，3： | 2 |
| 7 | A simple protocol for bulk synthesis of TiC hollow spheres from carbon nanotubes显示文摘 | Gu Yunle Chen Luyang Li Zhefeng | 2004 | Carbon2004，42，1： | 1 |
| 8 | Identification of stromal differentially expressed proteins in the colon carcinoma by quantitative proteomics显示文摘 | Yibing Mu Yongheng Chen Guiying Zhang Xianquan Zhan Yuanyuan Li Ting Liu Guoqing Li Maoyu Li Zhefeng Xiao Xiaoxiang Gong Zhuchu Chen | 2013 | ELECTROPHORESIS2013，，11： | 1 |
| 9 | On character sums over a short interval显示文摘 | ZHANG Tianping XU Zhefeng LI Zhanhu | 2009 | Journal of Number Theory2009，129，4： | 1 |
| 10 | Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster显示文摘The fruit fly,Drosophila melanogaster,is able to discriminate visual landmarks and form visual long-term memory in a flight simulator.Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis.However,little is known about the molecular mechanisms underlying the visual learning paradigm.The present study demonstrated that both spaced training procedure(STP)and consecutive training procedure(CTP)would induce long-term memory at 12 hour after training,and STP caused significantly higher 12-h memory scores compared with CTP.Labelfree quantification of liquid chromatography-tandem mass spectrometry(LC-MS/MS)and microarray were utilized to analyze proteomic and transcriptomic differences between the STP and CTP groups.Proteomic analysis revealed 30 up-regulated and 27 down-regulated proteins;Transcriptomic analysis revealed 145 up-regulated and 129 down-regulated genes.Among them,five candidate genes were verified by quantitative PCR,which revealed results similar to microarray.These results provide insight into the molecular components influencing visual long-term memory and facilitate further studies on the roles of identified genes in memory formation. | Huoqing Jiang Qinlong Hou Zhefeng Gong Li Liu | 2011 | Protein & Cell2011，2，3： | 1 |
| 11 | Monteggia equivalent lesion in children:a narrative review显示文摘Background Monteggia equivalent lesion represents a group of injury or combined injury patterns that resemble the Monteggia lesion in its presentations and mechanisms.Unlike Monteggia lesions,the equivalent ones,which share vague definitions and mostly occur as sporadic single case reports in the literature,have not been thoroughly reviewed since Bado first proposed the term,especially in the pediatric population.The objective of this review was to elucidate the definition by elaborating on its clinical styles and thus analyzing the mechanism,diagnosis,and management through related literature.Data sources Based on the terms of‘Monteggia equivalent’,‘radial neck fracture’and‘pediatric’,all of the related literature was searched on the PubMed and Google Scholar search engine.Results The advance of the definitions for pediatric Monteggia equivalent lesion(PMEL)was reviewed.The functional roles of the ulnar and the related mechanism theories in this injury were analyzed.The status of the radiocapitellar joint in this injury was emphasized.According to the previous statements,a new classification model was proposed and proper diagnosis and treatment approaches were suggested.Conclusions PMEL should be defined as an ulnar fracture at any level combined with a proximal radial fracture.According to the status of the radiocapitellar joint,it could be divided into three groups.The occult ulnar bowing and delayed radial head dislocation should be a serious concern of orthopedists.Surgical need is usually warranted.Maintaining the ulnar length and securing the radiocapitellar joint are highly recommended. | Lujie Xu Wensong Ye Haibing Li Jingfang Xu Weiwei Zhu Zhefeng Zhen Yi Yang | 2021 | World Journal of Pediatric Surgery2021，4，3： | 0 |
| 12 | Metamagnetic transitions and anomalous magnetoresistance in EuAg4As2 crystals显示文摘In this work,we systematically studied the magnetic and transport properties of EuAg4As2 single crystals.It was found that the two antiferromagnetic transitions(TN1=10 K and TN2=15 K)were driven to lower temperatures by an applied magnetic field.Below TN1,two successive metamagnetic transitions were observed when a magnetic field was applied in the ab plane(H//abplane).For both H//ab and H//c,EuAg4As2 showed a positive,unexpectedly large magnetoresistance(up to 202%)in lower magnetic fields below TN1,and a large negative magnetoresistance(up to-78%)at high fields/intermediate temperatures,thus presenting potential applications in magnetic sensors.Finally,the magnetic phase diagrams of EuAg4As2 were constructed for both H//ab and H//c using the resistivity and magnetisation data. | QinQing Zhu Liang Li ZhiHua Yang ZheFeng Lou JianHua Du JinHu Yang Bin Chen HangDong Wang MingHu Fang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，2： | 0 |
| 13 | 3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution显示文摘Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug delivery.Here we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA nanocage.By placing an RNA three-way junction(3WJ)in the cavity of the nanocage,the conjugated hydrophobic molecules were specifically positioned within the nanocage,preventing their exposure to the biological environment.The assembly of the nanocages was characterized by native polyacrylamide gel electrophoresis(PAGE),atomic force microscopy(AFM),and cryogenic electron microscopy(cryo-EM)imaging.The stealth effect of the nanocage for hydrophobic molecules in vitro was evaluated by gel electrophoresis,flow cytometry,and confocal microscopy.The in vivo sheathing effect of the nanocage for hydrophobic molecules was assessed by biodistribution profiling in mice.The RNA nanocages with hydrophobic biomolecules underwent faster clearance in liver and spleen in comparison to their counterparts.Therefore,this encapsulation strategy holds promise for in vivo delivery of hydrophobic drugs for disease treatment. | Congcong Xu Kaiming Zhang Hongran Yin Zhefeng Li Alexey Krasnoslobodtsev Zhen Zheng Zhouxiang Ji Sijin Guo Shanshan Li Wah Chiu Peixuan Guo | 2020 | Nano Research2020，13，12： | 0 |
| 14 | Identification of neurons responsible for feeding behavior in the Drosophila brain显示文摘Drosophila melanogaster feeds mainly on rotten fruits,which contain many kinds of sugar.Thus,the sense of sweet taste has evolved to serve as a dominant regulator and driver of feeding behavior.Although several sugar receptors have been described,it remains poorly understood how the sensory input is transformed into an appetitive behavior.Here,we used a neural silencing approach to screen brain circuits,and identified neurons labeled by three Gal4 lines that modulate Drosophila feeding behavior.These three Gal4 lines labeled neurons mainly in the suboesophageal ganglia(SOG),which is considered to be the fly’s primary taste center.When we blocked the activity of these neurons,flies decreased their sugar consumption significantly.In contrast,activation of these neurons resulted in enhanced feeding behavior and increased food consumption not only towards sugar,but to an array of food sources.Moreover,upon neuronal activation,the flies demonstrated feeding behavior even in the absence of food,which suggests that neuronal activation can replace food as a stimulus for feeding behavior.These findings indicate that these Gal4-labeled neurons,which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control. | SUN Fei WANG YiJin ZHOU YanQiong VAN SWINDEREN Bruno GONG ZheFeng LIU Li | 2014 | Science China(Life Sciences)2014，57，4： | 0 |
| 15 | Graph-based discovery and analysis of atomic-scale one-dimensional materials显示文摘Recent decades have witnessed an exponential growth in the discovery of low-dimensional materials(LDMs), benefiting from our unprecedented capabilities in characterizing their structure and chemistry with the aid of advanced computational techniques. Recently, the success of two-dimensional compounds has encouraged extensive research into one-dimensional(1 D) atomic chains. Here, we present a methodology for topological classification of structural blocks in bulk crystals based on graph theory,leading to the identification of exfoliable 1 D atomic chains and their categorization into a variety of chemical families. A subtle interplay is revealed between the prototypical 1 D structural motifs and their chemical space. Leveraging the structure graphs, we elucidate the self-passivation mechanism of 1 D compounds imparted by lone electron pairs, and reveal the dependence of the electronic band gap on the cationic percolation network formed by connections between structure units. This graph-theory-based formalism could serve as a source of stimuli for the future design of LDMs. | Shunning Li Zhefeng Chen Zhi Wang Mouyi Weng Jianyuan Li Mingzheng Zhang Jing Lu Kang Xu Feng Pan | 2022 | National Science Review2022，9，6： | 0 |
| 16 | Weathering Characterization and Degradation Analysis of Landscape Wooden Buildings in Semi-Arid and Sandy Area显示文摘Wooden buildings play a very important role in China’s construction and landscape architecture industry.In order to explore the weathering characteristics of the surface layer of landscape wooden buildings,the main causes of weathering were analyzed on the basis of summarizing the common types of weathering characterization.The results showed that the weathering characterization was mainly reflected in the surface defects of wood structures,such as cracking,discoloration,peeling,wind erosion wear,and so on.The coating technology on the surface of constructions was the main artificial factor affecting the surface defects of constructions.In the case of similar surface decoration conditions,sunlight and moisture were the main natural factors affecting the weathering of wooden buildings,which will promote the process of weathering. | Zhefeng Li Huijuan Zhong | 2024 | Journal of Architectural Research and Development2024，8，1： | 0 |
| 17 | Microtubule Assists Actomyosin to Regulate Cell Nuclear Mechanics and Chromatin Accessibility显示文摘Cellular behaviors and functions can be regulated by mechanical cues from microenvironments,which are transmitted to nucleus through the physical connections of cytoskeletons in the cells.How these physical connections determine transcriptional activity were not clearly known.The actomyosin,which generates intracellular traction force,has been recognized to control the nuclear morphology.Here,we have revealed that microtubule,the stiffest cytoskeleton,is also involved in the process of nuclear morphology alteration.The microtubule negatively regulates the actomyosin-induced nuclear invaginations but not the nuclear wrinkles.Moreover,these nuclear shape changes are proven to mediate the chromatin remodeling,which essentially mediates cell gene expression and phenotype determination.The actomyosin disruption leads to the loss of chromatin accessibility,which can be partly recovered by microtubule interference through nuclear shape control.This finding answers the question of how mechanical cues regulate chromatin accessibility and cell behaviors.It also provides new insights into cell mechanotransduction and nuclear mechanics. | Jiwen Geng Zhefeng Kang Qian Sun Man Zhang Peng Wang Yupei Li Jiameng Li Baihai Su Qiang Wei | 2023 | Research2023，，3： | 0 |
| 18 | Drosophila Larval Light-Avoidance is Negatively Regulated by Temperature Through Two Pairs of Central Brain Neurons显示文摘Dear Editor,The innate preference behaviors of animals can be modified by external environmental conditions.In Drosophila for example,the preference for food and temperature are respectively influenced by the hardness of food and environmental light conditions[1,2].Comparatively,environmental modulation of Drosophila light preference has received less investigation.Drosophila avoids light and prefers darkness in the larval stage[3,4].Drosophila larval photoreceptors,Bolwig's organs,and downstream neurons such as the 5th-lateral neurons[4,5]and the posterior ventral lateral-09 neurons[6],are required for the lightavoidance response. | Jie Wang Weiqiao Zhao Qianhui Zhao Jinrun Zhou Xinhang Li Yinhui He Zhefeng Gong | 2022 | Neuroscience Bulletin2022，38，2： | 0 |
| 19 | Bulk superconductivity in the Dirac semimetal TlSb显示文摘A feasible strategy for realizing the Majorana fermions is searching for a simple compound with both bulk superconductivity and Dirac surface states.In this paper,we perform calculations of electronic band structure,the Fermi surface,and the surface states,and measure the resistivity,magnetization,and specific heat of a TlSb compound with a CsCl-type structure.The band structure calculations show that TlSb is a Dirac semimetal when spin-orbit coupling is considered.TlSb is first determined to be a type-Ⅱsuperconductor with T_(c)=4.38 K,Hc1(0)=148 Oe,H_(c2)(0)=1.12 T,andκ_(GL)=10.6.We also confirm that TlSb is a moderately coupled s-wave superconductor.Although we cannot determine the band near the Fermi level EF that is responsible for superconductivity,its coexistence with topological surface states implies that the TlSb compound may be a simple material platform to realize the fault-tolerant quantum computations. | YuXing Zhou Bin Li ZheFeng Lou HuanCheng Chen Qin Chen BinJie Xu ChunXiang Wu JianHua Du JinHu Yang HangDong Wang MingHu Fang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，4： | 0 |
| 20 | Fatigue Life Prediction of Gray Cast Iron for Cylinder Head Based on Microstructure and Machine Learning显示文摘Conventional fatigue tests on complex components are difficult to sample,time-consuming and expensive.To avoid such problems,several popular machine learning(ML)algorithms were used and compared to predict fatigue life of gray cast iron(GCI)with the complex microstructures.The feature analysis shows that the fatigue life of GCI is mainly influenced by the external environment such as the stress amplitude,and the internal microstructure parameters such as the percentage of graphite,graphite length,stress concentration factor at the graphite tip,matrix microhardness and Brinell hardness.For simplicity,collected datasets with some of the above features were used to train ML models including back-propagation neural network(BPNN),random forest(RF)and eXtreme gradient boosting(XGBoost).The comparison results suggest that the three models could predict the fatigue lives of GCI,while the implemented RF algorithm is the best performing model.Moreover,the S–N curves fitted by the Basquin relation in the predicted data have a mean relative error of 15%compared to the measured data.The results have demonstrated the advantages of ML,which provides a generic way to predict the fatigue life of GCI for reducing time and cost. | Xiaoyuan Teng Jianchao Pang Feng Liu Chenglu Zou Xin Bai Shouxin Li Zhefeng Zhang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，9： | 0 |
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