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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Studies on Reducing Nitrogen Excretion: Ⅰ. Net Energy Requirement of Finishing Pigs Maximizing Performance and Carcass Quality Fed Low Crude Protein Diets Supplemented with Crystalline Amino Acids显示文摘Two experiments were conducted to investigate the effects of net energy (NE) level on the performance and carcass traits of finishing pigs fed low crude protein (CP) diets supplemented with crystalline amino acids (CAA). A total of 216 (Exp.1) and 360 (Exp.2) barrows (Yorkshire×Landrace×Duroc) were allotted to one of six treatments (n=6). The experimental diets were based on corn and soybean meal, and consisted of a highCP diet that contained approximately 16% CP and 2.50 Mcal/kg of NE as well as five lowCP diets in which the CP level of the diet was reduced by approximately four percentage units but was supplemented with crystalline lysine, methionine, threonine, and tryptophan. The low CP diets provided 2.64, 2.58, 2.50, 2.42, or 2.36 Mcal/kg in Exp.1 as well as 2.45, 2.40, 2.35, 2.30, or 2.25 Mcal/kg in Exp.2. In Exp.1, a linear (P=0.03) increase in weight gain was observed with decreasing NE level while the ratio of gain to feed was unaffected (P>0.05) by NE level. There was a linear increase (P=0.01) in the percentage of fatfree lean and a linear decrease (P=0.03) in the percentage of total fat with decreasing NE levels. In Exp.2, a significant quadratic (P=0.03) effect of NE level was observed for weight gain. The ratio of gain to feed demonstrated a significant (P<0.01) quadratic effect with pigs fed 2.35 and 2.40 Mcal/kg of NE. Pigs fed the diet containing 2.40 Mcal/kg of NE had the lowest percentage of total fat (36.95%) and the highest percentage of fatfree lean (49.36%). The overall results of these experiments indicate that feeding either a surplus or a deficiency of NE is detrimental to both pig performance and carcass composition when low CP diets supplemented with CAA are fed. Our results indicate that when the CP content of the diet is reduced by four percentage units and the diet is properly supplemented with CAA, maximum performance and carcass quality will be obtained if the diet provides approximately 2.42 Mcal/kg of NE. | Hongyu Chen Xuewu Yi Guijie Zhang Ning Lu Licui Chu P. A. Thacker Shiyan Qiao | 2011 | Journal of Animal Science and Biotechnology2011，2，2： | 9 |
| 3 | Electrochemical Hydrogen Storage Performances of the Si Added La-Mg-Ni-based A_2B_7-type Electrode Alloys for Ni/MH Battery Application显示文摘The casting and annealing technologies were applied to fabricate the La0.8Mg0.2Ni3.3Co0.2Six(x = 0-0.2) electrode alloys. The effects of Si content and annealing temperature on the structure and electrochemical performances of the alloys were investigated systematically. The analyses of XRD and SEM show that all the alloys possess a multiphase structure, involving two main phases(La, Mg)2Ni7 and La Ni5 as well as a residual phase La Ni3. The addition of Si brings on an evident increase in the La Ni5 phase and a decrease in the(La, Mg)2Ni7 phase, without altering the main phase component of the alloy, which also makes the lattice constants and cell volumes of the alloy enlarged. Likewise, the annealing treatment engenders the same action on the lattice constants and cell volumes as adding Si. Simultaneously, it gives rise to the variation of the phase abundance and the coarsening of the alloy grains. The electrochemical measurements indicate that the addition of Si ameliorates the cycle stability of the as-cast and annealed alloys significantly, but impairs their discharge capacities clearly. Similarly, the annealing treatment makes a positive contribution to the cycle stability of the alloy evidently, and the discharge capacity of the alloy shows a maximum value with annealing temperature rising. Furthermore, the high rate discharge ability(HRD) first augments and then declines with the rising of Si content and annealing temperature. | 张羊换 YANG Tai CHEN Licui XU Chao REN Huiping ZHAO Dongliang | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 3 |
| 4 | Leucine Supplementation in a Chronically Protein-Restricted Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTOR Pathway in Adult Rats显示文摘 | Bo Zhang Licui Chu Hong Liu Chunyuan Xie Shiyan Qiao Xiangfang Zeng | 2017 | Engineering2017，3，5： | 2 |
| 5 | Systemic action of novel neonicotinoid insecticide IPP‐10 and its effect on the feeding behaviour of Rhopalosiphum padi on wheat显示文摘 | LiCui LinaSun XushengShao YazhongCao DaibinYang ZhongLi HuizhuYuan | 2010 | Pest Manag Sci2010，，7： | 1 |
| 6 | Bioluminescence imaging of caspase-3 activity in mouse liver显示文摘 | Qiuxia Fu Xiangguo Duan Shaoduo Yan Licui Wang Yong Zhou Shuaizheng Jia Juan Du Xiaohui Wang Yuhua Zhang Linsheng Zhan | 2013 | Apoptosis2013，，8： | 1 |
| 7 | Fiber laser GMA hybrid welding of commercially pure titanium显示文摘 | LICUI KUTUSNA MUNEHARUA SIMIZU TAKAO | 2009 | Materials and Design2009，30，1： | 1 |
| 8 | Alanyl-glutamine supplemented parenteral nutrition increases luminal mucus gel and decreaces permeability in the rat small intestine 显示文摘 | Khan J Yasuhiko liboshi LiCui et al | 1999 | J Parenteral Enteral Nutrition1999，23，1： | 1 |
| 9 | 显示文摘 | ZHANGMeng—Xiao(张梦晓) LICui—Can(李璀灿) HUAWei—Ming(华伟明) eta1 | 2014 | 催化学报2014，35，： | 1 |
| 10 | Response of Chinese fir seedlings to low phosphorus stress and analysis of gene expression differences显示文摘Chinese fir(Cunninghamia lanceolata) is an excellent fast-growing timber species occurring in southern China and has significant value in the forestry industry. In order to enhance the phosphorus utilization efficiency in Chinese fir, four clones named X6, S3, S39 and FK were used, and low phosphorus(LP) stress experiments were performed to analyze the response of different clones to phosphorus deficiency. According to the results on seedling height, maximum root length, leaf blade aspect ratio, root ratio, malondialdehyde content, acid phosphates activity,proline content, soluble protein level, and chlorophyll a and b levels of the tested clones, compared to the control groups(CK), the phosphorus high efficiency clone X6 was screen out for transcriptome sequencing experiments. De novo RNA-seq was then used to sequence the root transcriptomes of X6 under LP stress and CK, and we then compared the gene expression differences under the two conditions. A total of 3416 SDEGs were obtained by comparing the LP and CK groups, among which 1742 were up-regulated and 1682 were down-regulated. All SDEGs obtained from the LP and CK treated samples were subjected to KEGG annotation and classification. Through classification statistical analysis using WEGO software,607 SDEGs obtained KEGG pathway annotations, which were related to 206 metabolic pathways. In Chinese fir subjected to LP stress, 53 SDEGs related with phosphorus metabolism, and phosphate uptake and transport were obtained from our transcriptome data. Based on the phosphorus metabolism pathway obtained by KEGG classification, combined with previously report on gene annotation related with phosphorus metabolism, the enzymes encoded by SDEG related with phosphorus metabolism and their expression pattern were mapped onto phosphorus metabolism pathway. | Jianhui Li Dingwei Luo Guifang Ma Licui Jia Jinliang Xu Huahong Huang Zaikang Tong Yong-Quan Lu | 2019 | Journal of Forestry Research2019，30，1： | 1 |
| 11 | BLOSSOMS: Building Lightweight Optimized Sensor Systems on aMassive Scale显示文摘As a joint effort between the Chinese Academy of Sciences and the Hong Kong University of Science and Technology, the BLOSSOMS sensor network project aims to identify research issues at all levels from practical applications down to the design of sensor nodes. In this project, a heterogeneous sensor array including different types of application-dependent sensors as well as monitoring sensors and intruding sensors are being developed. Application-dependent power-aware communication protocols are also being studied for communications among sensor nodes. An ontology-based middleware is built to relieve the burden of application developers from collecting, classifying and processing messy sensing contexts. This project is also developing a set of tools allowing researchers to model, simulate/emulate, analyze, and monitor various functions of sensor networks. | WenGao LionelM.Ni Zhi-WeiXu S.C.Cheung LiCui QiongLuo | 2005 | Journal of Computer Science & Technology2005，20，1： | 1 |
| 12 | GVW ALGORITHM OVER PRINCIPAL IDEAL DOMAINS显示文摘GVW algorithm was given by Gao,Wang,and Volny in computing a Grbner bases for ideal in a polynomial ring,which is much faster and more simple than F5.In this paper,the authors generalize GVW algorithm and present an algorithm to compute a Grbner bases for ideal when the coefficient ring is a principal ideal domain. | LI Dongmei LIU Jinwang LIU Weijun ZHENG Licui | 2013 | Journal of Systems Science & Complexity2013，26，4： | 0 |
| 13 | A New Signature-Based Algorithms for Computing Gr?bner Bases显示文摘Gao,Volny and Wang(2010) gave a simple criterion for signature-based algorithms to compute Grobner bases.It gives a unified frame work for computing Grobner bases for both ideals and syzygies,the latter is very important in free resolutions in homological algebra.Sun and Wang(2011) later generalized the GVW criterion to a more general situation(to include the F5 Algorithm).Signature-based algorithms have become increasingly popular for computing Grobner bases.The current paper introduces a concept of factor pairs that can be used to detect more useless J-pairs than the generalized GVW criterion,thus improving signature-based algorithms. | ZHENG Licui LIU Jinwang LIU Weijun LI Dongmei | 2015 | Journal of Systems Science & Complexity2015，28，1： | 0 |
| 14 | Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets显示文摘Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully elucidated.Previous research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress resistance.Methods In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental procedure.Piglets were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal samples.Results Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ratio.Additionally,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and Oscillospira.Furthermore,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS challenge.This was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and IL-6 in the plasma.Moreover,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented counterparts.Further analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the LPS challenge and stimulated the activation of the Nrf2 signaling pathway.Additionally,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with BAO.Conclusions In summary,our study demonstrates that pre-supplementation of BAO enhances the anti-stress capacity of weaned piglets by improving intestinal microbiota composition,reinforcing the intestinal barrier,and enhancing antioxidative and anti-inflammatory capabilities.These effects are closely associated with the activation of Nrf2 and TLR4/NF-κB/MAPK signaling pathways. | Chang Cui Yulong Wei Yibo Wang Wen Ma Xiaoyu Zheng Jun Wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 15 | How the Antimicrobial Peptides Kill Bacteria:Computational Physics Insights显示文摘In the present article,coarse grained Dissipative Particle Dynamics simulation with implementation of electrostatic interactions is developed in constant pressure and surface tension ensemble to elucidate how the antimicrobial peptidemolecules affect bilayer cellmembrane structure and kill bacteria.We find that peptideswith different chemical-physical properties exhibit differentmembrane obstructing mechanisms.Peptide molecules can destroy vital functions of the affected bacteria by translocating across their membranes via worm-holes,or by associating with membrane lipids to form hydrophilic cores trapped inside the hydrophobic domain of the membranes.In the latter model,the affected membranes are strongly buckled,in accord with very recent experimental observations[G.E.Fantner et al.,Nat.Nanotech.,5(2010),pp.280-285]. | Licui Chen Lianghui Gao Weihai Fang Leonardo Golubovic | 2012 | Communications in Computational Physics2012，11，3： | 0 |
| 16 | An Improvement for GVW显示文摘Gao,et al.(2015)gave a simple algorithm to compute Gr?bner bases named GVW.It can be used to compute Gr?bner bases for both ideals and syzygies at the same time,and the latter plays an important role in free resolutions in homological algebra.In GVW algorithms the authors need to compute all the J-pairs firstly and then use GVW criterion(which refers the criterions used in GVW)to determine which one is useless or which one the authors should do top-reduction.In this paper,based on the study of relations between J-pairs,the authors propose the concept of factor.This concept allows the authors to filter the useless J-pairs in a rather convenient way.Moreover,by using this concept,the authors may easily determine which two pairs’J-pair need not to be computed.Besides,the Gr?bner basis which the authors obtained is relatively simpler than the one in GVW. | ZHENG Licui LI Dongmei LIU Jinwang | 2022 | Journal of Systems Science & Complexity2022，35，1： | 0 |
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