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| 1 | 红树林内生真菌抗细菌和抗真菌活性的初步研究显示文摘目的分离和筛选具有抗细菌和抗真菌活性的红树林内生真菌。方法从红树林植物桐花树、海漆、秋茄、木榄、白骨壤、银叶树中分离到60株内生真菌,对其代谢产物进行抗菌检测,通过滤纸片法来检测内生真菌代谢产物抗细菌和抗真菌活性。结果共有35株内生真菌具有抗细菌活性,占待侧菌株总数的58.3%,其中以不产孢类、青霉属、曲霉属、镰孢属为主,分别占活性菌株总数的51.4%、8.6%、8.6%、8.6%;共有49株内生真菌具有抗真菌活性,占待侧菌株总数的81.7%,其中以不产孢类和盘长孢属为主,分别占活性菌株总数的44.9%、17.1%。结论红树林内生真菌是抗菌活性物质的一个潜在的、丰富的资源库,值得进一步研究和开发。 | 邓祖军 曹理想 谭红铭 Lilian L.P.Vrijmoed 周世宁 | 2007 | 广东药学院学报2007，23，5： | 25 |
| 2 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 3 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 4 | 红树林植物桐花树内生真菌类群分布的研究显示文摘从红树林植物桐花树Aegiceras corniculatum的叶、叶脉、树皮、茎等4个部位,湿季共分离到297株内生真菌,干季共分离到232株内生真菌。叶片内生真菌优势类群为青霉属和盘长孢霉,叶脉为青霉属和枝孢霉属,树皮内生真菌中不产孢类所占比例最高,而茎部的优势类群为枝孢霉属和短梗孢霉,说明内生真菌的分布具有一定的器官和组织特异性。比较各部位内生真菌湿季类群和干季类群发现其优势类群也有一定的变化:叶片内生真菌湿季优势类群是青霉属和盘长孢属,而干季优势类群为不产孢类群B和C;叶脉、树皮、茎的内生真菌的优势菌群在湿季和干季也有差异。这说明不同季节的环境因素(降水量、气温、湿度、光照强度等)的变化对内生真菌的类群及其分布具有较强的影响。 | 邓祖军 曹理想 Vrijmoed Lilian L P 陆勇军 周世宁 | 2010 | 热带海洋学报2010，29，3： | 14 |
| 5 | Genetic Analysis and Fine Mapping of Two Genes for Grain Shape and Weight in Rice显示文摘To identify genetic loci controlling grain weight,an elite indica rice variety,Baodali,with large grains was identified and used in this study.Its derived F2,F3 and BC2F2 with another japonica rice variety Zhonghua 11 were used as mapping populations.Linkage analyses demonstrated that two genes controlling grain weight,designated as GW3 and GW6,were mapped to chromosome 3 and chromosome 6,respectively.Fine mapping delimited GW3 to a 122 kb physical distance between two sequence tagged site markers(WGW16 and WGW19) containing 16 open reading frames annotated by The Institute for Genomic Research(http://gffzzb05470f0357b4fe5h9vpo5b6ux9nw6wbo.ffgz.tsg.suse.edu.cn).GW6 was further mapped between two simple sequence repeat markers(RM7179 and RM3187).These results are useful for both marker assisted selection of grain weight,and for further cloning of GW genes,which will contribute to the dissection of the molecular mechanism underlying grain weight in rice. | Longbiao Guo Lilian Ma Hua Jiang Dali Zeng Jiang Hu Liwen Wu Zhenyu Gao Guangheng Zhang Qian Qian | 2009 | Journal of Integrative Plant Biology2009，51，1： | 13 |
| 6 | Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas显示文摘AIM:To investigate endoscopic ultrasound(EUS) for predicting depth of mucosal invasion and to analyze outcomes following endoscopic and transduodenal resection.METHODS:Records of 111 patients seen at our institution from November 1999 to July 2011 with the postoperative pathological diagnosis of benign ampullary and duodenal adenomas were reviewed.Records of patients who underwent preoperative EUS for diagnostic purposes were identified.The accuracy of EUS in predicting the absence of muscular invasion was assessed by comparing EUS reports to the final surgical pathological results.In addition,the incidence of the post-operative complications over a period of 30 d and the subsequent long-term outcome(recurrence) over a period of 30 mo associated with endoscopic and transduodenal surgical resection was recorded,compared and analyzed.RESULTS:Among 111 patients with benign ampullary and duodenal adenomas,47 underwent preoperative EUS for 29 peri-ampullary lesions and 18 duodenal lesions.In addition,computed tomography was performed in 18 patients,endoscopic retrograde cholangio-pancreatography in 10 patients and esophagogastroduodenoscopy in 22 patients.There were 43 patients with sporadic adenomas and 4 patients with familial adenomatous polyposis(FAP)/other polyposis syndromes.In 38(81%,P < 0.05) patients,EUS reliably identified absence of submucosal and muscularis invasion.In 4 cases,EUS underestimated submucosal invasion that was proven by pathology.In the other 5 patients,EUS predicted muscularis invasion which could not be demonstrated in the resected specimen.EUS predicted tumor muscularis invasion with a specificity of 88% and negative predictive value of 90%(P < 0.05).Types of resection performed included endoscopic resection in 22 cases,partial duodenectomy in 9 cases,transduodenal ampullectomy with sphincteroplasty in 10 cases and pancreaticoduodenectomy in 6 cases.The main post-operative final pathological results included villous adenoma(n = 5),adenoma(n = 8),tubulovillous adenoma(n = 10),tubular adenoma(n = 20) and hyperplastic polyp(n = 2).Among the 47 patients who underwent resection,8(17%,5 of which corresponded to surgical resection) developed post-procedural complications which included retroperitoneal hematoma,intra-abdominal abscess,wound infection,delayed gastric emptying and prolonged ileus.After median followup of 20 mo there were 6 local recurrences(13%,median follow-up = 20 mo) 4 of which were in patients with FAP.CONCLUSION:EUS accurately predicts the depth of mucosal invasion in suspected benign ampullary and duodenal adenomas.These patients can safely undergo endoscopic or local resection. | Lilian C Azih Brett L Broussard Milind A Phadnis Martin J Heslin Mohamad A Eloubeidi Shayam Varadarajulu Juan Pablo Arnoletti | 2013 | World Journal of Gastroenterology2013，19，4： | 13 |
| 7 | Coupling Rice with Fish for Sustainable Yields and Soil Fertility in China显示文摘About 30 million hectares of rice are cultivated annually in China(FAOSTAT,2019).Because most rice fields are wellirrigated and suitable for fish living(‘fish’here refers to various aquatic animals like carps,prawns,crabs,soft shell turtles,etc.)(Fernando,1993),many efforts have been made to determine how well rice farming and aquaculture can be coupled as a rice-fish system(RFS),of which the same land and water produces both rice and aquatic products.With the technological guidance of RFSs and political supports from the Ministry of Agriculture and Rural Affairs of China since 2010(Supplemental Table 1),multiple types of large-scale,high-efficiency and technologically intensive RFSs are now being demonstrated in the main rice-growing areas of China(National Fisheries Technology Extension Centre,2019),and in total about 1.2 million hectares of rice fields are under RFSs. | GUO Liang HU Liangliang ZHAO Lufeng SHI Xiaoyu JI Zijun DING Lilian REN Weizheng ZHANG Jian TANG Jianjun CHEN Xin | 2020 | Rice science2020，27，3： | 11 |
| 8 | NAC Transcription Factor ORE1 and Senescence- Induced BIFUNCTIONAL NUCLEASE1 (BFN1) Constitute a Regulatory Cascade in Arabidopsis显示文摘老朽是包含很多抄写因素的行动的一个高度调整的过程。NAC 抄写因素 ORE1 (ANAC092 ) 最近被显示了在断然在 Arabidopsis thaliana 控制老朽起一个关键作用;然而,它通过施加它的分子的功能的直接目标基因都没以前被识别。这里,我们报导那 BIFUNCTIONAL NUCLEASE1 (BFN1 ) ,著名提高老朽的基因,被 ORE1 直接调整。我们已经检测了 BFN1 的提高的表示在在 estradiol 可诱导的 ORE1 overexpression 线的 ORE1 的正式就职以后的 2 h 和在有 35S:ORE1 的 Arabidopsis 叶肉房间原物的 transfection 以后的 6 h 构造。当在衰老的叶子和成熟的花机关的截去地区的 BFN1 表示在 ore1 异种背景是几乎不在的时, ORE1 和 BFN1 表示模式大部分重叠,由 promoterreporter 显示出基因(GUS ) 熔化。在 vitro 绑定地点试金揭示了一个由两部组成的 ORE1 有约束力的地点,类似于 ORS1 的, ORE1 的 paralog。一个由两部组成的 ORE1 有约束力的地点在 BFN1 倡导者被识别;变异在全身的 BFN1 倡导者的上下文以内的 cis 元素急速地减少了调停 ORE1 的 transactivation 能力在短暂地 transfected Arabidopsis 叶肉房间原物。而且,染色质 immunoprecipitation (薄片) 在 ORE1 有约束力的 vivo 示威到 BFN1 倡导者。我们也在 vivo 表明 ORE1 的绑定到二另外的联系老朽的基因的倡导者,也就是 SAG29/SWEET15 和 SINA1,在老朽期间支持 ORE1 的中央角色。 | Lilian R Matallana-Ramirez Mamoona Rauf Sarit Farage-Barhom Hakan Dortay Gang-Ping Xue Wolfgang Droge-Laser Amnon Lers Salma Balazadeh Bernd Mueller-Roeber | 2013 | Molecular Plant2013，6，5： | 8 |
| 9 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 10 | 批量生产集成调度问题的嵌套式混合遗传算法显示文摘针对多级供应链环境中制造商利用混合流水车间方式生产时如何确定生产、采购及产品运送决策的问题,提出基于混合流水车间调度的批量生产与运送调度模型。考虑双重调度的复杂性,设计了两层嵌套式混合遗传算法,外层针对批量生产与运送调度,限制搜索最优运送频率及生产周期;内层解决混合流水车间调度,特别设计染色体的复式均匀交叉机制,求解产品生产排序及相应的原材料采购批量问题。通过算例验证了算法对解空间的搜索广度、准确度和全局收敛性能,为进一步研究较大规模的复杂供应链调度问题提供了可借鉴的方法。 | 郑永前 董洁 Lilian Forbach | 2014 | 计算机集成制造系统2014，20，1： | 7 |
| 11 | Complete genome analysis of Ketogulonigenium sp. WB0104显示文摘Ketogulonigenium sp. may convert L-sorbose into 2-keto-L-gulonic acid, the vitamin C precursor. The genome of Ketogulonigenium sp. WB0104 consists of a circular 2765030 bp chromo- some with 61.69% G+C content and two circular plasmids of 267968 and 242707 bp. The genome contains 2727 open reading frames (ORFs). The systems of replication, transcription, translation, carbohydrate and energy metabolism are intact, but the repair system is incomplete. About 640 predicted ORFs have been found to encode transporter pro- teins, which account for about one fourth of total predicted ORFs, noticeably higher than other docu- mented bacteria. This may be due to the fact that WB0104 adapts to soil circumstance. | YANG Fan JIA Qian XIONG Zhaohui ZHANG Xiaobing WU Hongtao ZHAO Ying YANG Jian ZHU Junping DONG Jie XUE Ying SUN Lilian SHEN Yan JIN Qi | 2006 | Chinese Science Bulletin2006，51，8： | 6 |
| 12 | Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy显示文摘Hepatitis C virus(HCV)infection represents an important public health problem worldwide.Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.Virus molecular evolution plays an important role in HCV transmission,disease progression and therapy outcome.The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and compartmentalization.These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner.Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV.As a result,superior sustained viral responses have been attained.The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era. | Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 13 | 再生建筑废料铺筑沥青路面结构层力学性能现场试验显示文摘近年来,建筑与拆除废料在许多工程领域得到再生利用,公路与城市道路路面工程只需较少投入就能促进其大量应用,研究前景广阔。该文先简要综述已有相关室内外试验研究现状,着重介绍巴西2003年用再生集料铺筑基层、底基层的某沥青路面试验段,尤其是采用多种现场试验对该路面使用情况进行了8年多跟踪监测及分析评价。研究表明:再生集料能提供天然粒料相同水平的测试参数,类似于普通集料铺筑的路面,其性能可达到满意要求,建议在不同类型路面中更多地研究与应用。 | 杨敏 杨和平 肖杰 童超 Lilian Ribeiro de Rezende Michelle de Oliveira Marques Joo Carlos de Oliveira | 2017 | 中外公路2017，37，3： | 5 |
| 14 | Localization of the Arabidopsis Senescence- and Cell Death-Associated BFN1 Nuclease: From the ER to Fragmented Nuclei显示文摘植物联系老朽或联系 PCD 的核酸酶从不同有机体与核酸酶分享重要相同。然而,他们的功能的知识是有限的。Arabidopsis 联系老朽、联系 PCD 的核酸酶 BFN1 的细胞内部的本地化被调查。在短暂地转变的烟草原物的 BFN1GFP 本地化的分析表明在细丝状的结构的起始的本地化在整个细胞质传播了,它然后在原物开始衰老的原子核附近聚类。这些细丝状的结构作为具有被识别嗯起源。在 BFN1GFP 转基因的 Arabidopsis 植物, BFN1GFP 的类似的本地化在年轻叶子被观察,也就是说,在细丝状的结构,那仅仅在开始衰老在原子核附近重新组织房间。在迟了的老朽, BFN1GFP 与在包膜的泡的碎裂的原子核是局部性的。BFN1 的要求的功能作为 nucleic,在老朽和 PCD 的酸降级的酶被它的本地化模式支持。我们的结果建议在老朽和 PCD 的 nucleic 酸降级处理的调停的奉献分隔空间的存在。 | Sarit Farage-Barhom Shaul Burd Lilian Sonego Ana Mett Eduard Belausov David Gidoni Amnon Lers | 2011 | Molecular Plant2011，4，6： | 5 |
| 15 | Three decades of hepatitis B control with vaccination显示文摘Hepatitis B virus(HBV) continues to represent a major health problem and can lead to acute liver failure, acute hepatitis, chronic carriership, chronic hepatitis of HBV, liver cirrhosis, liver cancer, liver transplantation and death. There is a marked difference in the geographic distribution of carriers. More than 240 million people worldwide are chronic HBV carriers. Mother-to-child transmission remains the most important mechanism of infection in countries with a high prevalence of HBV. Percutaneous/parenteral transmission and unsafe sexual practices are important mode of spread transmission of HBV in other countries. Vaccination against HBV is the gold measure for primary prevention and control of the disease. Currently, 179 countries have added HBV vaccination to their routine vaccination programs with great results. Neonatal immunization with HBV vaccine has been one of the most highly effective measures in public health and the first anti-cancer program to be launched. In this paper we review the achievements for the last three decades. | Liliane C Meireles Rui Tato Marinho Pierre Van Damme | 2015 | World Journal of Hepatology2015，7，18： | 5 |
| 16 | Application of Molecular Distillation Process to Extend the True Boiling Point Curve of Petroleum Residues 400 ℃ +显示文摘 | Erica Roberta Lovo da Rocha Melina Savioli Lopes Maria Regina Wolf Maciel Rubens Maciel Filho Cesar Benedito Batistella Lilian Carmem Medina | 2011 | Journal of Chemistry and Chemical Engineering2011，5，2： | 4 |
| 17 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 18 | Laparoscopic liver resection for living donation: Where do we stand?显示文摘In Western countries, living donor liver transplantation(LDLT) may represent a valuable alternative to deceased donor liver transplantation. Yet, after an initial peak of enthusiasm, reports of high rates of complications and of fatalities have led to a certain degree of reluctance towards this procedure especially in Western countries. As for living donor kidney transplantation, the laparoscopic approach could improve patient's tolerance in order to rehabilitate this strategy and reverse the current trend. In this setting however, initial concerns regarding patient's safety and graft integrity, need for acquiring surgical expertise in both laparoscopic liver surgery and living donor transplantation and lack of evidence supporting the benefits of laparoscopy have delayed the development of this approach. Similarly to what is performed in classical resectional liver surgery, initial experiences of laparoscopy have therefore begunwith left lateral sectionectomy,which is performed for adult to child living donation.In this setting,the laparoscopic technique is now well standardized,is associated with decreased donor blood loss and hospital stays and provides graft of similar quality compared to the open approach.On the other hand laparoscopic major right or left hepatectomies for adult-adult LDLT currently lack standardization and various techniques such as the full laparoscopic approach,the hand assisted approach and the hybrid approach have been reported.Hence,even-though several reports highlight the feasibility of these procedures,the true benefits of laparoscopy over laparotomy remain to be fully assessed.This could be achieved through standardization of the procedures and creation of international registries especially in Eastern countries where LDLT keeps on flourishing. | Fran?ois Cauchy Lilian Schwarz Olivier Scatton Olivier Soubrane | 2014 | World Journal of Gastroenterology2014，20，42： | 4 |
| 19 | PRISMA危害报告清单:改进系统综述中危害的报告(一)显示文摘对于任何一种健康干预的疗法,我们需要同时准确把握其给人们带来的获益和危害。系统综述所纳入的原始研究常常未能对干预措施的危害进行报告或者报告不充分,导致对于危害有关系统综述的报告质量不高。虽然依据系统综述和Meta分析的优先报告条目(PRISMA)声明,可以帮助系统综述的作者撰写一份完整和透明的报告,但它主要关注干预措施的有效性。因此,PRISMA危害报告清单的制定,旨在改进系统综述中对危害的报告,以促进研究者对干预措施的获益和危害更为均衡地评估。在草拟并形成条目清单草案后,采用了改良的德尔菲法对其进行完善。它新增4个必备报告要素以改进系统综述中关于危害的报告,同时确定了在综述不良事件时需要报告的最少条目集。作为PRISMA指南的扩展,本清单旨在提高系统综述中对危害的报告,不论危害是主要结局或是次要结局。 | 胡瑞学(译) 梁宁(译) 柴倩云(译) 杨国彦(译) 韩雪燕(译) 夏如玉(译) 严毓倩(译) 王迪(译) 文玲子(译) 黄娜(译) 杨国彦(校) 李迅(校) 刘建平(校) 费宇彤(校) Zorzela Liliane Loke Yoon K Ioannidis John P | 2018 | 中国药物警戒2018，15，6： | 4 |
| 20 | Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients显示文摘AIM: To study whether alterations in the glycosylation of immunoglobulin G (IgG) specific to the ThomsenFriedenreich glycotope (TF) have diagnostic and prognostic potential in gastric cancer. METHODS: Serum samples were obtained from patients with histologically verified gastric carcinoma (n = 89), healthy blood donors (n = 40), and patients with benign stomach diseases (n = 22). The lectin-enzymelinked immunosorbent assay-based glycoprofiling of TF-specific IgG (anti-TF IgG) was performed using synthetic TF-polyacrylamide conjugate as antigen, total IgG purified by affinity chromatography on protein G sepharose, and lectins of various sugar specificities: mannose-specific concanavalin A (ConA), fucose-specificAleuria aurantia lectin (AAL) and sialic acid-specific Sambucus nigra agglutinin (SNA). The sensitivity and specificity of the differences between cancer patients and controls were evaluated by receiver operator characteristic (ROC) curve analysis. Overall survival was analyzed by the Kaplan-Meier method. Time-dependent ROC curve statistics were applied to determine cut-off values for survival analysis. All calculations and comparisons were performed using the GraphPad Prism 5 and SPSS 15.0 software.RESULTS: The level of TF-specific IgG was significantly increased in cancer patients compared with non-cancer controls (P < 0.001). This increase was pronounced mostly in stage 1 of the disease. Cancer patients showed a higher level of ConA binding to antiTF-IgG (P < 0.05) and a very low level of SNA lectin binding (P = 0.0001). No appreciable stage-dependency of the binding of any lectin to anti-TF IgG was found. A strong positive correlation between the binding of AAL and SNA was found in all groups studied (r = 0.71-0.72; P < 0.0001). The changes in ConA reactivity were not related to those of the fucoseor sialic acid-specific lectin. Changes in the SNA binding index and the ConA/SNA binding ratio demonstrated good sensitivity and specificity for stomach cancer: sensitivity 78.79% (95%CI: 61.09-91.02) and 72.73% (95%CI: 57.21-85.04); specificity 79.17 (95%CI: 65.01-89.53) and 88.64% (95%CI: 71.8-96.6), for the SNA binding index and the ConA/SNA binding ratio, respectively. The other combinations of lectins did not improve the accuracy of the assay. The low level of ConA-positive anti-TF IgG was associated with a survival benefit in cancer patients (HR = 1.56; 95%CI: 0.78-3.09; P = 0.19), especially in stages 3-4 of the disease (HR = 2.17; 95%CI: 0.98-4.79; P = 0.048). A significantly better survival rate was found in all cancer patients with a low reactivity of anti-TF IgG to the fucose-specific AAL lectin (HR = 2.39; 95%CI: 1.0-5.7;P = 0.038).CONCLUSION: The changes in the TF-specific IgG glycosylation pattern can be used as a biomarker for stomach cancer detection, and to predict patient survival. | Kristel Kodar Jelena Izotova Kersti Klaamas Boris Sergeyev Lilian Jrvekülg Oleg Kurtenkov | 2013 | World Journal of Gastroenterology2013，19，23： | 3 |
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