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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project显示文摘 | Kirsi Mustalahti Carlo Catassi Antti Reunanen Elisabetta Fabiani Margit Heier Stan McMillan Liam Murray Marie-Helene Metzger Maurizio Gasparin Enzo Bravi Markku M?ki | 2010 | Annals of Medicine2010，，8： | 1 |
| 3 | Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases显示文摘 | Mübeccel Akdis Simone Burgler Reto Crameri Thomas Eiwegger Hiroyuki Fujita Enrique Gomez Sven Klunker Norbert Meyer Liam O’Mahony Oscar Palomares Claudio Rhyner Nadia Quaked Anna Schaffartzik Willem Van De Veen Sabine Zeller Maya Zimmermann Cezmi A. Akdis | 2011 | The Journal of Allergy and Clinical Immunology2011，，3： | 1 |
| 4 | Multisine with optimal phase-plane uniformity for ADC testing 显示文摘 | ONG M S KUANG Y C LIAM P S | 2012 | IEEE Trans Instru Measur2012，61，3： | 1 |
| 5 | Parallel and distributed state estimation显示文摘 | Falcao D M Felix F Wu Liam Murphy | 1995 | IEEE Trans on Power Systems1995，10，2： | 1 |
| 6 | An attentiondriven model for grouping similar images with image retrieval applications显示文摘 | Oge M Liam M M Gustavo B B | | 0，，： | 1 |
| 7 | Causes of pleural exudates in a region with a high incidence of tuberculosis显示文摘 | Liam C K Lira K H Wong C M | 2000 | Respirology2000，5，1： | 1 |
| 8 | Receptive field optimisation and supervision of a fuzzy spiking neural network显示文摘 | Glackin C Liam M McDaid L | 2011 | Neural Networks2011，24，3： | 1 |
| 9 | Association between tourniquet use and intraoperative blood loss during below-knee amputation显示文摘BACKGROUND Despite over 150000 amputations of lower limbs annually,there remains a wide variation in tourniquet practice patterns and no consensus on their necessity,especially among orthopedic patient populations.The purpose of this study was to determine whether tourniquet use in orthopedic patients undergoing below knee amputation(BKA) was associated with a difference in calculated blood loss relative to no tourniquet use.AIM To determine if tourniquet use in orthopedic patients undergoing BKA was associated with a difference in calculated blood loss relative to no tourniquet use.METHODS We performed a retrospective review of consecutive patients undergoing BKA by orthopedic surgeons at a tertiary care hospital from 2008 through 2018.Blood loss was calculated using a combination of the Nadler equation for preoperative blood volume and a novel formula utilizing preoperative and postoperative hemoglobin levels and transfusions.Univariate and forwards step-wise multivariate linear regressions were performed to determine the association between tourniquet use and blood loss.A Wilcoxon was used to determine the univariate relationship between tourniquet use and blood loss for in the restricted subgroups of patients who underwent BKA for trauma,tumor,and infection.RESULTS Of 97 eligible patients identified,67 underwent surgery with a tourniquet and 30 did not.In multivariate regression,tourniquet use was associated with a 488 mL decrease in calculated blood loss(CI 119-857,P = 0.01).In subgroup analysis,no individual group showed a statistically significant decrease in blood loss with tourniquet use.There was no significant association between tourniquet use and either postoperative transfusions or reoperation at one year.CONCLUSION We found that tourniquet use during BKA is associated with decreased calculated intraoperative blood loss.We recommend that surgeons performing this procedure use a tourniquet to minimize blood loss. | Alden E Wyland Erik Woelber Liam H Wong Jordan Arakawa Zachary M Working James Meeker | 2022 | World Journal of Orthopedics2022，13，7： | 1 |
| 10 | Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases显示文摘 | Mübeccel Akdis Simone Burgler Reto Crameri Thomas Eiwegger Hiroyuki Fujita Enrique Gomez Sven Klunker Norbert Meyer Liam O’Mahony Oscar Palomares Claudio Rhyner Nadia Quaked Anna Schaffartzik Willem Van De Veen Sabine Zeller Maya Zimmermann Cezmi A. Akdis | 2011 | The Journal of Allergy and Clinical Immunology2011，，3： | 1 |
| 11 | Thyroid gland function and growth in IGF binding protein-1transgenic mice显示文摘 | Tomislav M Kadaba R Liam JM | 1999 | Eur J Endocrinol1999，141，： | 1 |
| 12 | Skin prick test reactivity to common aeroallergens in asthmatic patients with and without rhinitis显示文摘 | LIAM C K LOO K L WONG C M | 2002 | Respirology2002，7，： | 1 |
| 13 | Efficient photochemical water splitting by a chemically modified n- TiO2 显示文摘 | Khan Shahed U M A1-Shahry Mofareh Ingler Jr Wil- liam B | 2002 | Science2002，297，5590： | 1 |
| 14 | Confidence Limits for the Indirect Effect: Distribution of the Product and Resampling Methods 显示文摘 | MACKINNON D P LOCKWOOD C M WIL- LIAMS J | 2004 | Multivariate Behavioral Research2004，39，1： | 1 |
| 15 | Causes of pleural exudates in a region with a high incidence of tuberculosis显示文摘 | Liam C K Lim K H Wong C M | 2000 | Respirology2000，5，： | 1 |
| 16 | Tuberculous pleurisy as a manifestation of primary and reactivation disease in a region with a high prevalence of tuberculosis显示文摘 | LIAM C K LIM K H WONG C M | 1999 | Int J Tuberc Lung Dis1999，3，9： | 1 |
| 17 | Dietary carbohydrate intake, glycemic index, and glycemic load and endometrial cancer risk: A prospective cohort study显示文摘 | HELEN G COLEMAN CARl M KITAHARA LIAM J MURRAY | 2014 | Am J Epidemiol2014，179，1： | 1 |
| 18 | Electrical capacitance as a rapid and non-invasive indicator of root length 显示文摘 | Ellis T Murray W Paul K Kavalieris L Brophy J Wil- liams C Maass M | 2013 | Tree Physiol2013，33，1： | 1 |
| 19 | Role of baseline and on-treatment quantitative HBeAg levels in prediciting response to peginterferon a; da-2a (40KD) (pegasys)montherapy in a large, multinational trial of patients with chronic hepatitis B Hepatology显示文摘 | Fried M Liam Y-F Luo k | 2005 | 42:268A2005，42，： | 1 |
| 20 | The effects of nonylphenol on daphnia magna 显示文摘 | COMBER M H I WII LIAMS T D STEWART K M | 1993 | Water Re- search1993，27，2： | 1 |
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