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| 1 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 2 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 3 | A Simulation Model of a Multi-Server EJB System 显示文摘 | DAVID MC GUINNESS LIAM MURPHY | 2005 | ACM SIGSOFT Software Engineering Notes2005，30，4： | 1 |
| 4 | Analysis of a largescale VOD architecture for broadband operators:a P2P-based solution显示文摘 | Nafaa Abdelahmid Murphy Séan Murphy Liam | 2008 | IEEE Communications Magazine2008，46，12： | 1 |
| 5 | An evaluation of the effectiveness and cost effec- tiveness of the National Exercise Referral Scheme in Wales, UK : a randomised controlled trial of a public health policy ini- tiative 显示文摘 | Simon Mark Murphy Rhiannon Tudor Edwards Nefyn Wil- liams | 2012 | J Epidemiol Community Health2012，66，： | 1 |
| 6 | Parallel and distributed state estimation显示文摘 | Falcao D M Felix F Wu Liam Murphy | 1995 | IEEE Trans on Power Systems1995，10，2： | 1 |
| 7 | The Association Between Alcohol and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma显示文摘 | Lesley A. Anderson Marie M. Cantwell R.G. Peter Watson Brian T. Johnston Seamus J. Murphy Heather R. Ferguson Jim McGuigan Harry Comber John V. Reynolds Liam J. Murray | 2009 | Gastroenterology2009，，3： | 1 |
| 8 | The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity显示文摘 | Suresh Mishra Liam J. Murphy | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 9 | HUVEC ICAM-1 and VCAM-1 Synthesis in Response to Potentially Athero-Prone and Athero-Protective Mechanical and Nicotine Chemical Stimuli显示文摘 | Liam T. Breen Peter E. McHugh Bruce P. Murphy | 2010 | Annals of Biomedical Engineering2010，，5： | 1 |
| 10 | Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials显示文摘 | Colum Dunne Lisa Murphy Sarah Flynn Liam O’Mahony Sile O’Halloran Maria Feeney Darrin Morrissey Gerardine Thornton Gerald Fitzgerald Charles Daly Barry Kiely Eamonn M. M. Quigley Gerald C. O’Sullivan Fergus Shanahan J. Kevin Collins | 1999 | Antonie van Leeuwenhoek1999，，1： | 1 |
| 11 | Effects of oral contrast on dose in abdominopelvic computed tomography with pure iterative reconstruction显示文摘AIM To assess the effect of neutral(NC) and positive(PC) oral contrast use on patient dose in low-dose abdominal computed tomography(CT).METHODS Low-dose clinically indicated CTs were performed on 79 Crohn's patients(35 = PC, 1 L 2% gastrografin; 44 = NC, 1.5 L polyethylene glycol). Scanner settings for both acquisitions were identical apart from 25 s difference in intravenous contrast timing. Body mass index(BMI), scan-ranges, dose-length product and size-specific dose estimated were recorded. Data was reconstructed with pure model-based iterative reconstruction. Image quality was objectively and subjectively analysed. Data analysis was performed with Statistical Package for Social Scientists.RESULTS Higher doses were seen in neutral contrast CTs(107.60 ± 78.7 m Gy.cm, 2.47 ± 1.21 m Gy vs 85.65 ± 58.2 m Gy.cm, 2.18 ± 0.96 m Gy). The differencehad both NC and PC investigations. Image-quality assessment yielded 6952 datapoints. NC image quality was significantly superior(P < 0.001)(objective noise, objective signal to noise ratio, subjective spatial resolution, subjective contrast resolution, diagnostic acceptability) at all levels. NC bowel distension was significantly(P < 0.001) superior.CONCLUSION The use of polyethylene glycol as a neutral OC agent leads to higher radiation doses than standard positive contrast studies, in low dose abdominal CT imaging. This is possibly related to the osmotic effect of the agent resulting in larger intraluminal fluid volumes and resultant increased overall beam attenuation. | Kevin P Murphy Liam J Healy Lee Crush Maria Twomey Fiachra Moloney Sylvia Sexton Owen J O'Connor Michael M Maher | 2016 | World Journal of Radiology2016，8，9： | 0 |
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