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| 1 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 2 | Early diversification of birds: Evidence from a new opposite bird显示文摘A new enantiornithine bird Longipteryx chao-yangensis gen. et sp. nov. is described from the Early Cretaceous Jiufotang Formation in Chaoyang, western Liaoning Province. This new bird is distinguishable from other known enantiornithines in having uncinate processes in ribs, elongate jaws, relatively long wings and short hindlimbs, and metatarsal Ⅳ longer than metatarsals Ⅱ and Ⅲ. This new bird had probably possessed (i) modern bird-like thorax which provides firm attachment for muscles and indicates powerful and active respiratory ability; (ii) powerful flying ability; (iii) special adaptation for feeding on aquatic preys; and (iv) trochleae of metatarsals Ⅰ-Ⅳ almost on the same level, an adaptation for perching. The new bird represents a new ecological type different from all known members of Enantiornithes. It shows that enantiornithines had probably originated earlier than the Early Cretaceous, or this group had experienced a rapid radiation right after it first occurred in the early Early | ZHANG Fucheng ZHOU Zhonghe HOU Lianhai GU Gang | 2001 | Chinese Science Bulletin2001，46，11： | 26 |
| 3 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 4 | Depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis显示文摘Objective:Diagnostic laparoscopy is recommended for the pretherapeutic staging of gastric cancer to detect any unexpected or unconfirmed intra-abdominal metastasis.The aim of this study was to evaluate the role and indications of diagnostic laparoscopy in the detection of intra-abdominal metastasis.Methods:Standard diagnostic laparoscopy with peritoneal cytology examination was performed prospectively on patients who were clinically diagnosed with primary local advanced gastric cancer(c T≥2M0).We calculated the rate of intra-abdominal metastases identified by diagnostic laparoscopy,and examined the relationship between peritoneal dissemination(P)and cytology results(CY).Split-sample method was applied to find clinical risk factors for intra-abdominal metastasis.Multivariate logistic regression analysis and receiver-operator characteristic(ROC)analysis were performed in training set to find out risk factors of intra-abdominal metastasis,and then validate it in testing set.Results:Out of 249 c M0 patients,51(20.5%)patients with intra-abdominal metastasis were identified by diagnostic laparoscopy,including 20(8.0%)P1CY1,17(6.8%)P0CY1 and 14(5.6%)P1CY0 patients.In the training set,multivariate logistic regression analysis and ROC analysis showed that the depth of tumor invasion on computer tomography(CT)scan≥21 mm and tumor-occupied≥2 portions of stomach are predictive factors of metastasis.In the testing set,when diagnostic laparoscopy was performed on patients who had one or two of these risk factors,the sensitivity and positive predictive value for detecting intra-abdominal metastasis were 90.0%and32.1%,respectively.Conclusions:According to our results,depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis. | Ziyu Li Zhemin Li Shuqin Jia Zhaode Bu Lianhai Zhang Xiaojiang Wu Shuangxi Li Fei Shan Xin Ji Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 14 |
| 5 | Prognostic role of lymph node metastasis in early gastric cancer显示文摘Objective: To clarify the relationship between clinicopathological features and lymph node metastasis and to propose the potential indications of lymph node metastasis for prognosis in early gastric cancer(EGC) patients. Methods: We retrospectively observed 226 EGC patients with lymph node resection, and analyzed the associations between lymph node metastasis and clinicopathological parameters using the chi-square test in univariate analysis and logistic regression analysis in multivariate analysis. Overall survival analysis was determined using the Kaplan-Meier and log-rank test. We conducted multivariate prognosis analysis using the Cox proportional hazards model.Results: Of all the EGC patients, 7.5%(17/226) were histologically shown to have lymph node metastasis. The differentiation, lymphovascular invasion and depth of invasion were independent risk factors for lymph node metastasis in EGC. The 5- and 10-year survival rates were significantly lower in patients with lymph node metastasis than in those without and the patients also had shorter progress-free survival time. Lymph node metastasis and tumor size were independent prognostic factors for EGC. The status of the lymph nodes was a significant factor in predicting recurrence or metastasis after surgery. Conclusions: The undifferentiated carcinoma and lymphovascular and/or submucosal invasion were associated with a higher incidence of lymph node metastasis in EGC patients, whom need to perform subsequent D2 lymphadenectomy or laparoscopic lymph node dissection and more rigorous follow-up or additional chemotherapy/radiation after D2 gastrectomy for poor prognosis and high recurrence/metastasis rate. | Zhixue Zheng Yiqiang Liu Zhaode Bu Lianhai Zhang Ziyu Li Hong Du Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，2： | 12 |
| 6 | A New Enantiornitine Bird with Four Long Rectrices from the Early Cretaceous of Northern Hebei,China显示文摘Paraprotopteryx gracilis,从在 Fengning 的早白垩纪 Yixian 形成的一只新 enantiornithine 鸟,北 Hebei 省被树立,基于下列人物:有长 hypocleidum 和大部分的塑造 Y 的叉突狭窄内部胸骨的锁骨的角度,和形态学与另外的 enantiornithines 不同。另外,忍受最大的用手的爪的翼膜的位远侧地延长到专业的远侧的目的掌部;未成年者掌部比专业苗条掌部。仅仅近似地熔化的 Carpometacarpus;部分熔化到对方的距骨和 calcaneum 但是 unfused 到胫骨。这是在有四长消遣瞬间的中生代鸟的第一个记录,它可以词法上代表一个第二等的性人物,从伸长的规模的一个中间的阶段到分叉在补充上升表面补偿不熟练的飞行羽饰,并且拥有功能的优点。 | ZHENG Xiaoting ZHANG Zihui HOU Lianhai | 2007 | Acta Geologica Sinica(English Edition)2007，81，5： | 12 |
| 7 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 8 | A Miocene ostrich fossil from Gansu Province,northwest China显示文摘 | HOU Lianhai ZHOU Zhonghe ZHANG Fucheng WANG Zhao | 2005 | Chinese Science Bulletin2005，50，16： | 8 |
| 9 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 10 | Clinicopathological and prognostic differences between mucinous gastric carcinoma and signet-ring cell carcinoma显示文摘Objective: To analyze the differences in clinicopathologic characteristics and prognosis between mucinous gastric carcinoma (MGC) and signet-ring cell carcinoma (SRCC). Methods: Clinicopathologic and prognostic data of 1,637 patients with histologically confirmed MGC or SRCC who received surgical operations in the Department of Gastroenterological Surgery, Beijing Cancer Hospital between December 2004 and December 2009 were retrospectively collected and analyzed. The clinicopathological features were analyzed statistically using χ 2 test. Survival was analyzed using the Kaplan-Meier method and multivariate analysis of Cox proportional hazards regression model (backward, stepwise). Results: A total of 181 patients with gastric cancer (74 MGC, 107 SRCC) were included. MGC, when compared with SRCC, was featured by senile patients, stage III and IV, upper third stomach, large tumor size, positive lymph node metastasis, and positive lymphatic vascular invasion (P<0.05). The overall 5-year survival rate showed no difference between the two groups (48.8% vs. 44.8%, P>0.05). However, the survival rate for MGC patients was significant lower than that for SRCC patients when compared among the age <60 years, negative distant metastasis, and tumor localized at upper third stomach (P<0.05). Multivariate Cox proportional hazards models revealed that distant metastasis was a significant independent prognostic indicator in MGC group, and lymph node metastasis and distant metastasis was significant independent prognostic indicators in SRCC group. Conclusions: While compared with SRCC, MGC is associated with a more aggressive tumor biologic behavior. There is no statistically significant difference in distant metastasis, an independent prognostic indicator for both MGC and SRCC, which might be the reason for no significant difference of the overall survival rate between the patients with MGC and SRCC. | Zhaode Bu Zhixue Zheng Ziyu Li Xiaojiang Wu Lianhai Zhang Aiwen Wu Xianglong Zong Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 3 |
| 11 | A Method on Extracting Network Connection Information from 64- bit Windows 7 Memory Images显示文摘 | Wang Lianhai Xu Lijuan Zhang Shuhui | 2010 | China Communications2010，7，6： | 3 |
| 12 | Mechanisms discussion of frost heave and test verifications of moisture migration显示文摘Herein we review research on the structure of the frozen fringe and one of its key characteristics(unfrozen water content),and compare its current measurement methods,including pulsed nuclear magnetic resonance(NMR),time-domain reflectometry(TDR),calorimetry,thermometry,the sublimation method,and CT imagery.A freeze-thaw cycle experiment with remolded soil was conducted inside to verify the mechanism of frost heave,measuring such variables as soil-water potential,temperature,water supplement,and the position of the freezing front.Conclusions from the analysis of the experiment data are:(1) The soil-water potential,the water supplement,and the position of the freezing front vary with temperature; and(2) the temperature gradient induces the soil-water potential,which in turn provides a stable driving force for moisture migration. | Chang Yuan ChengSong Yang LianHai Zhang | 2014 | Research in Cold and Arid Regions2014，6，5： | 3 |
| 13 | Ghrelin induces gastric cancer cell proliferation, migration, and invasion through GHS-R/NF-κB signaling pathway显示文摘 | Chuang Tian Lianhai Zhang Daohu Hu Jiafu Ji | 2013 | Molecular and Cellular Biochemistry (-)2013，，1： | 2 |
| 14 | Nomogram for predicting lymph node metastasis rate of submucosal gastric cancer by analyzing clinicopathological characteristics associated with lymph node metastasis显示文摘Background:To combine clinicopathological characteristics associated with lymph node metastasis for submucosal gastric cancer into a nomogram.Methods:We retrospectively analyzed 262 patients with submucosal gastric cancer who underwent D2 gastrectomy between 1996 and 2012.The relationship between lymph node metastasis and clinicopathological features was statistically analyzed.With multivariate logistic regression analysis,we made a nomogram to predict the possibility of lymph node metastasis.Receiver operating characteristic(ROC) analysis was also performed to assess the predictive value of the model.Discrimination and calibration were performed using internal validation.Results:A total number of 48(18.3%) patients with submucosal gastric cancer have pathologically lymph node metastasis.For submucosal gastric carcinoma,lymph node metastasis was associated with age,tumor location,macroscopic type,size,differentiation,histology,the existence of ulcer and lymphovascular invasion in univariate analysis(all P<0.05).The multivariate logistic regression analysis identified that age ≤50 years old,macroscopic type III or mixed,undifferentiated type,and presence of lymphovascular invasion were independent risk factors of lymph node metastasis in submucosal gastric cancer(all P<0.05).We constructed a predicting nomogram with all these factors for lymph node metastasis in submucosal gastric cancer with good discrimination [area under the curve(AUC)=0.844].Internal validation demonstrated a good discrimination power that the actual probability corresponds closely with the predicted probability.Conclusions:We developed a nomogram to predict the rate of lymph node metastasis for submucosal gastric cancer.With good discrimination and internal validation,the nomogram improved individualized predictions for assisting clinicians to make appropriated treatment decision for submucosal gastric cancer patients. | Zhixue Zheng Yinan Zhang Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Yiqiang Liu Zhaode Bu Jiafu Ji | 2015 | Chinese Journal of Cancer Research2015，27，6： | 2 |
| 15 | Live Memory Acquisition through FireWire显示文摘 | Zhang Lei Wang Lianhai Zhang Ruichao Zhang Shubui Zhou Yang | 2010 | China Communications2010，7，6： | 2 |
| 16 | New Early Cretaceous fossil from China documents a novel trophic specialization for Mesozoic birds显示文摘 | Lianhai Hou Luis M. Chiappe Fucheng Zhang Cheng-Ming Chuong | 2004 | Naturwissenschaften2004，，1： | 1 |
| 17 | New Early Cretaceous fossil from China documents a novel trophic specialization for Mesozoic birds显示文摘 | Lianhai Hou Luis M. Chiappe Fucheng Zhang Cheng-Ming Chuong | 2004 | Naturwissenschaften2004，，1： | 1 |
| 18 | 显示文摘 | Zhang Lianhai Zhang Xinsong Li Peipei | 2009 | Reactive & Functional Polymers2009，69，1： | 1 |
| 19 | Effective Cd^2+ chelating fiber based on polyacrylonitrile 显示文摘 | Zhang Lianhai Zhang Xinsong Li Peipei | 2009 | Reactive and Functional Polymers2009，69，1： | 1 |
| 20 | Effective Cd2+ chelating fiber based on polyacrylonitrile 显示文摘 | Zhang Lianhai Zhang Xinsong Li Peipei | 2009 | Reactive and Functional Polymers2009，69，1： | 1 |
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