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| 1 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 2 | A new type of internal solitary waves with a re-appearance period of 23 h observed in the South China Sea显示文摘The South China Sea (SCS), in particular the northern SCS, is one of ocean areas where energetic internal solitary waves (ISWs)occur most frequently (Cai et al., 2012; Zheng, 2017). Based on the re-appearance period (RP) at an observation station, Ramp et al.(2004) divided the ISWs into two types:Type-a and Type-b. Type-a ISWs arrive regularly at the same time every day, i.e., the RP is about 24 h, and Type-b ISWs arrive about one hour late every day, i.e., the RP is about 25 h. The discovery of the Types-a and b | CHEN Liang ZHENG Quanan XIONG Xuejun YUAN Yeli XIE Huarong | 2018 | Acta Oceanologica Sinica2018，37，9： | 7 |
| 3 | On developing data-driven turbulence model for DG solution of RANS显示文摘High-order Discontinuous Galerkin(DG) methods have been receiving more and more attentions in the area of Computational Fluid Dynamics(CFD) because of their high-accuracy property. However, it is still a challenge to obtain converged solution rapidly when solving the Reynolds Averaged Navier–Stokes(RANS) equations since the turbulence models significantly increase the nonlinearity of discretization system. The overall goal of this research is to develop an Artificial Neural Networks(ANNs) model with low complexity acting as an algebraic turbulence model to estimate the turbulence eddy viscosity for RANS. The ANN turbulence model is off-line trained using the training data generated by the widely used Spalart–Allmaras(SA) turbulence model before the Optimal Brain Surgeon(OBS) is employed to determine the relevancy of input features.Using the selected relevant features, a fully connected ANN model is constructed. The performance of the developed ANN model is numerically tested in the framework of DG for RANS, where the‘‘DG+ANN' method provides robust and steady convergence compared to the ‘‘DG+SA' method. The results demonstrate the promising potential to develop a general turbulence model based on artificial intelligence in the future given the training data covering a large rang of flow conditions. | Liang SUN Wei AN Xuejun LIU Hongqiang LYU | 2019 | Chinese Journal of Aeronautics2019，32，8： | 7 |
| 4 | Progress in research of submesoscale processes in the South China Sea显示文摘This paper overviews research progress in observation, theoretical analysis and numerical modeling of submesoscale dynamic processes in the South China Sea(SCS) particularly during recent five years. The submesoscale processes are defined according to both spatial and dynamic scales, and divided into four subcategories as submesoscale waves, submesoscale vortexes, submesoscale shelf processes, and submesoscale turbulence. The major new findings are as follows.(1) Systematic mooring observations provide new insights into the solitary waves(ISWs) and the typhoon-forced near-inertial waves(NIWs), of which a new type of ISWs with period of 23 h was observed in the northern SCS(NSCS), and the influences of background vorticity, summer monsoon onset, and deep meridional overturning circulation on the NIWs, as well as nonlinear wave-wave interaction between the NIWs and internal tides, are better understood. On the other hand, satellite altimeter sea surface height data are used to reveal the internal tide radiation patterns and provide solid evidence for that the ISWs in the northeastern SCS originate from the Luzon Strait.(2) Submesoscale offshore jets and associated vortex trains off the Vietnam coast in the western boundary of the SCS were observed from satellite chlorophyll concentration images. Spiral trains with the horizontal scale of 15–30 km and the spacing of 50–80 km were identified.(3) 3-D vertical circulation in the upwelling region east of Hainan Island was theoretically analyzed. The results show that distribution patterns of all the dynamic terms are featured by wave-like structures with horizontal wavelength scale of 20–40 km.(4) Numerical models have been used for the research of submesoscale turbulence. Submesoscale vertical pump of an anticyclonic eddy and the spatiotemporal features of submesoscale processes in the northeastern SCS are well modeled. | Quanan Zheng Lingling Xie Xuejun Xiong Xiaomin Hu Liang Chen | 2020 | Acta Oceanologica Sinica2020，39，1： | 7 |
| 5 | Physical design of target station and neutron instruments for China Spallation Neutron Source显示文摘The China Spallation Neutron Source(CSNS)is the first accelerator-based multidiscipline user facility to produce pulsed neutrons by tungsten target under collision of a pulsed proton beam with a beam power of 100 kW at a repetition rate of 25 Hz.In this paper,we focus on the physical design of CSNS target station and neutron instruments.Under optimized design,the flat tungsten target and the compact target-moderator-reflector coupling enhance effective cold and thermal neutron output from moderators.Three wing-type moderators supply four different characteristics of neutrons to 19 beamlines primarily for neutron scattering applications.Layout of neutron instruments are conceptually planned for total 20 beamlines,the configuration and specification have been determined for three day-one neutron instruments.All designs are optimized for the Phase I of 100 kW with a upgradable capacity to 500 kW. | WANG FangWei LIANG TianJiao YIN Wen YU QuanZhi HE LunHua TAO JuZhou ZHU Tao JIA XueJun ZHANG ShaoYing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 7 |
| 6 | Design and Experimental Research on Seedling Pick-Up Mechanism of Planetary Gear Train with Combined Non-circular Gear Transmission显示文摘Currently, transplanting mechanisms for dryland plug seedlings in China are mainly semiautomatic and have low efficiency. The rotary seedling pick-up mechanism with a planetary gear train for non-uniform intermittent transmission, and a concave and convex locking arc device, has a large rigid impact. To solve these problems, according to the design requirements for a dryland plug seedling transplanting mechanism, a rotary seedling pick-up mechanism of a planetary gear train with combined non-circular gear transmission of incomplete eccentric circular and noncircular gears was proposed. This has the characteristics of two-times greater fluctuation of the transmission ratio in a cycle, and can achieve a non-uniform continuous drive. Through analysis of the working principle of the seedling pick-up mechanism, its kinematics model was established. The human–computer interaction optimization method and self-developed computer-aided analysis and optimization software were used to obtain a set of parameters that satisfy the operation requirements of the seedling pick-up mechanism. According to the optimized parameters, the structure of the seedling pick-up mechanism was designed, a virtual prototype of the mechanism was created, and a physical prototype was manufactured. A virtual motion simulation of the mechanism was performed, high-speed photographic kinematics tests were conducted, and the kinematic properties of the physical prototype were investigated, whereby the correctness of the theoretical model and the optimized design of the mechanism were verified. Further, laboratory seedling pick-up tests were conducted. The success ratio of seedling pick-up was 93.8% when the seedling pick-up efficiency of the mechanism was 60 plants per minute per row, indicating that the mechanism has a high efficiency and success ratio for seedling pick-up and can be applied to a dryland plug seedling transplanter. | Yaxin Yu Jikun Liu Bingliang Ye Gaohong Yu Xuejun Jin Liang Sun Junhua Tong | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 7 |
| 7 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 8 | MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP显示文摘MicroRNAs 是从在经由绑定调整蛋白质表示水平到 mRNA 起重要作用的 RNA 发卡结构处理的 22 核苷酸 RNA,也压制它的翻译或加快它的降级。在人,他们调整很编码蛋白质的基因,包括在癌症和另外的疾病重要的基因。在这研究, microRNA-140 (miR-140 ) 的表示被表明显著地在胰腺的管腺癌标本和房间线被压制,与他们的邻近的正常纸巾相比。在生物信息学分析的帮助下, p53 (iASPP ) 的刺激 apoptosis 蛋白质的禁止者被识别是 miR-140 的一个直接目标,并且酶记者实验证实了这发现。miR-140 的 Overexpression 减少 iASPP, Np63, MMP2,和 MMP9 的蛋白质表情。PANC-1 房间的生长和侵略被 miR-140 的 overexpression 在 vitro 稀释。PANC-1 房间线上的 miR-140 的镇压效果能被 iASPP 的用手的 overexpression 部分外面平衡。首先,这些调查结果提供了卓见进 miR-140 的功能的机制,建议 miR-140/iASPP 轴可以防碍 proliferative 和胰腺的管腺癌房间的侵略性质,并且显示 miR-140 能是为胰腺的管腺癌的一个潜在的治疗学的目标。 | Shuai Liang Xuejun Gong Gewen Zhang Gengwen Huang Yebin Lu Yixiong Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 4 |
| 9 | Efficacy of miacalcic in treating a hypercalcemia crisis caused by Williams-Beuren syndrome显示文摘Williams-Beuren syndrome (WBS) is a hereditary disease involving multiple systems due to microdeletion of chromosome 7q11.23.The deleted region in most patients is approximately 1.55 Mb,including 26-28 genes.The incidence of WBS in live-born children is roughly 1/7 500-1/25 000.1 The majority of WBS cases are sporadic;inheritance is autosomal dominant.The clinical manifestations of WBS include aortic valve stenosis alone or combined with other cardiovascular malformations,characteristic facies (full peri-orbital region,flat and short nose,upward pointingnose,long philtrum,wide mouth thick lips,and disorders of the teeth),temporary hypercalcemia,developmental retardation associated with mild-to-moderate dysgnosia,and personality changes.Salmon calcitonin (miacalcic) is widely used in the treatment of adult hypercalcemia crisis. | Gu Yi Gong Chunxiu Shen Ying Wu Di Liang Xuejun Chang Bo Liu Ying Wang Yi | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 10 | A new checkpoint against ferroptosis显示文摘By taking different approaches,two research groups made the same discovery that a CoQ oxidoreductase(renamed as ferroptosis suppressor protein-1,or FSP1)can inhibit ferroptosis,a form of cell death driven by iron-dependent phospholipid peroxidation.As FSP1 is expressed in various cancers and can halt ferroptosis even in the absence of glutathione peroxidase 4(GPX4),which was previously considered indispensable for ferroptosis surveillance,the potential of FSP1 as a new cancer therapeutic target should be explored. | Deguang Liang Liang Deng Xuejun Jiang | 2020 | Cell Research2020，30，1： | 4 |
| 11 | Bottom Currents Observed in and Around a Submarine Valley on the Continental Slope of the Northern South China Sea显示文摘Bottom currents at about 1000 m depth in and around a submarine valley on the continental slope of the northern South China Sea were studied by a 14-month long experiment from July 2013 to September 2014. The observations reveal that bottom currents are strongly influenced by the topography, being along valley axis or isobaths. Power density spectrum analysis shows that all the currents have significant peaks at diurnal and semi-diurnal frequencies. Diurnal energy is dominant at the open slope site, which is consistent with many previous studies. However, at the site inside the valley the semi-diurnal energy dominates, although the distance between the two sites of observation is quite small(11 km) compared to a typical horizontal first-mode internal tide wavelength(200 km). We found this phenomenon is caused by the focusing of internal waves of certain frequencies in the valley. The inertial peak is found only at the open slope site in the first deployment but missing at the inside valley site and the rest of the deployments. Monthly averaged residual currents reveal that the near-bottom currents on the slope flow southwestward throughout the year except in August and September, 2013, from which we speculate that this is a result of the interaction between a mesoscale eddy and the canyon/sag topography. Currents inside the valley within about 10 mab basically flow along slope and in the layers above the 10 mab the currents are northwestward, that is, from the deep ocean to the shelf. The monthly mean current vectors manifest an Ekman layer-like vertical structure at both sites, which rotate counter-clockwise looking from above. | WU Lunyu XIONG Xuejun LI Xiaolong SHI Maochong GUO Yongqing CHEN Liang | 2016 | Journal of Ocean University of China2016，15，6： | 3 |
| 12 | Clinical features and predictors of remission in children under the age of 7 years with Graves’disease显示文摘Importance:Graves’disease(GD)is rare in children under the age of 7 years.Children with this disease exhibit greater thyrotoxicity at diagnosis and require a longer course of medical therapy,compared with pubertal and postpubertal children and adults.Objective:To investigate the clinical features and identify predictors of remission in children under the age of 7 years with GD.Methods:This retrospective study included 77 children who were diagnosed with GD under the age of 7 years and were treated in the Department of Endocrinology,Beijing Children’s Hospital from 2010 to 2018.Clinical manifestations,laboratory data,and follow-up records were collected for all patients.Children who achieved remission of treatment with methimazole were compared with those who had persistent disease to identify which variables were associated with remission;multiple logistic regression and Cox regression analyses were used to evaluate interactions among predictive variables.Results:Sixty-three boys and 14 girls were included;the median age at diagnosis was 4.2 years(interquartile range:3.2-5.3 years).Forty-six(56.7%)patients had no family history of thyroid disease,17 patients had family history of thyroid disease and 14 patients with unknown family history.Of the 77 patients,18(23.4%)patients achieved remission of treatment with methimazole and 59 patients did not;moreover,51(66.2%)had Graves’ophthalmopathy.Univariate analyses revealed no significant differences between the remission group and non-remission group in terms of age at diagnosis,sex,initial goiter size,or initial thyroid hormone concentration.However,there were a trend of correlation between the initial level of thyroid peroxidase antibody(TPOAb)and remission status(univariate analysis OR 1.002,P=0.038;multivariate analysis OR 1.004,P=0.019).Similar results were observed in univariate analysis of the initial thyrotropin receptor antibody(TRAb)level,but this association was not significant in multivariate analysis.Cox regression analyses revealed that children with high TRAb level required longer duration of remission,compared with low TRAb level(OR 0.950,95%CI 0.904-0.997,P=0.037).Interpretation:Initial TRAb level was an independent predictor of remission outcome in young children under the age of 7 years with GD.Initial TRAb level may predict the likelihood of remission in patients with young-age-of-onset GD. | Yi Gu Xuejun Liang Ming Liu Di Wu Wenjing Li Bingyan Cao Yuchuan Li Chang Su Jiajia Chen Chunxiu Gong | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 13 | Mooring observed mode-2 internal solitary waves in the northern South China Sea显示文摘The mode-2 internal solitary waves(ISWs)generated by mode-2 internal tide(IT)are identified by mooring observations in the northern South China Sea(SCS)from 2016 to 2017.Two mode-2 ISWs with a re-appearance period of 24.9 h observed on 29 and 30 July 2016 are characterized by type-b ISWs.They occurred when the isotherms compressed obviously in the vertical direction.Modal decomposition of IT horizontal currents shows that the vertical compression of the isotherms is mainly caused by diurnal mode-2 IT.The analysis of the role of the density stratification reveals that a deeper and thinner pycnocline is favorable for generation of mode-2 ISWs rather than pycnocline intensity.By comparing the mode-2 nonlinear,dispersion coefficients and the Ursell numbers calculated based on the stratification associated with different kinds of ITs with the observation results,it is shown that the diurnal mode-2 IT plays a crucial role in the generation of the mode-2 ISWs.When the diurnal mode-2 IT interacts with the semidiurnal IT and causes a deeper and thinner pycnocline,the mode-2 ISWs are easily excited. | Liang Chen Xuejun Xiong Quanan Zheng Yeli Yuan Long Yu Yanliang Guo Guangbing Yang Xia Ju Jia Sun Zhenli Hui | 2020 | Acta Oceanologica Sinica2020，39，11： | 3 |
| 14 | Impact of warm mesoscale eddy on tropical cyclone intensity显示文摘The spatial-temporal patterns of tropical cyclone(TC) intensity changes caused by the warm ocean mesoscale eddy(WOME) distribution are evaluated using two sets of idealized numerical experiments. The results show that the TC was intensified and weakened when a WOME was close to and far away from the TC center, respectively.The area where the WOME enhanced(weakened) TC intensity is called the inner(outer) area in this study.Amplitudes of the enhancement and weakening caused by the WOME in the inner and outer area decreased and increased over time, while the ranges of the inner and outer area diminished and expanded, respectively. The WOME in the inner area strengthened the secondary circulation of the TC, increased heat fluxes, strengthened the symmetry, and weakened the outer spiral rainband, which enhanced TC intensity. The effect was opposite if the WOME was in the outer area, and it weakened the TC intensity. The idealized simulation employed a stationary TC, and thus the results may only be applied to TCs with slow propagation. These findings can improve our understanding of the interactions between TC and the WOME and are helpful for improving TC intensity forecasting by considering the effect of the WOME in the outer areas. | Jia Sun Guihua Wang Xuejun Xiong Zhenli Hui Xiaomin Hu Zheng Ling Long Yu Guangbing Yang Yanliang Guo Xia Ju Liang Chen | 2020 | Acta Oceanologica Sinica2020，39，8： | 3 |
| 15 | Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice显示文摘Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction or pathogenesis of such diseases still lacks direct evidence. In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice. We found that Olig2 ablation impaired myelin development, which further resulted in severe hypomyelination in the anterior cingulate cortex. Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits. Moreover, Olig2 cKO mice showed increased vulnerability to social avoidance under the mild stress of social isolation. Together,these results indicate that developmental deficits in OL and myelin lead to cognitive impairment and increase the risk of phenotypes reminiscent of mental illnesses. | Xianjun Chen Fei Wang Jingli Gan Zhonghua Zhang Xuejun Liang Tao Li Nanxin Huang Xiaofeng Zhao Feng Mei Lan Xiao | 2020 | Neuroscience Bulletin2020，36，4： | 3 |
| 16 | Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells显示文摘Background and Aims:The safety and efficacy of mesenchymal stem cells(MSCs)in the treatment of acute-onchronic liver failure(ACLF)have been validated.However,the impact of the pathological ACLF microenvironment on MSCs is less well understood.This study was designed to explore the changes in the functional properties of MSCs exposed to ACLF serum.Methods:MSCs were cultured in the presence of 10%,30%and 50%serum concentrations from ACLF patients and healthy volunteers.Then,the cell morphology,phenotype,apoptosis and proliferation of MSCs were evaluated,including the immunosuppressive effects.Subsequently,mRNA sequencing analysis was used to identify the molecules and pathways involved in MSC functional changes in the context of ACLF.Results:In the presence of ACLF serum,MSC morphology significantly changed but phenotype did not.Besides,MSC proliferation activity was weakened,while the apoptosis rate was lightly increased.Most importantly,the immunosuppressive function of MSCs was enhanced in a lowconcentration serum environment but transformed into a proinflammatory response in a high-concentration serum environment.RNA sequencing indicated that 10%serum concentration from ACLF patients mediated the PI3K-Akt pathway to enhance the anti-inflammatory effect of MSCs,while the 50%serum concentration from ACLF patients promoted the conversion of MSCs into a proinflammatory function by affecting the cell cycle.Conclusions:The 50%ACLF serum concentration is more similar to the environment in the human body,which means that direct peripheral blood intravenous infusion of MSCs may reduce the effect of transplantation.Combining treatments of plasma exchange to reduce harmful substances in serum may promote MSCs to exert a stronger anti-inflammatory effect. | Yongyuan Zheng Shu Zhu Xingrong Zheng Wenxiong Xu Xuejun Li Jianguo Li Zhiliang Gao Chan Xie Liang Peng | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 2 |
| 17 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 18 | Existence, morphology and structure of the Yellow Sea Warm Current Branch approaching waters offshore Qingdao, China显示文摘In this study, we focused on full-region cruise survey data, near-bottom continuous mooring observations and sea surface wind products from the western South Yellow Sea in winter; after ensuring the data reliability and accuracy, we processed and analyzed the data. Image resolution experiments were carried out to determine the lowest recognition resolutions for all image types, which represent the resolution characteristics of the data. The existence of a warm water tongue originating from the Yellow Sea Warm Current(YSWC) that approached waters offshore Qingdao was confirmed. For the first time, a high salinity water tongue, corresponding to the warm water tongue, was described and found to be more representative of the YSWC branch path. This warm tongue is a sign of the branch originating from the YSWC, which we defined as the Yellow Sea Warm Current Branch approaching waters offshore Qingdao(YSWC-QDB). The pattern of the warm and salty water tongues showed remarkable rear, branching middle, shrinking neck and expanding top regions. These patterns showed a temporal feature of the tongues, and were the result of multi-temporal branches in front of the YSWC main section as well as the YSWC-QDB crossing the southwestward path of the extension of the North Shandong Coastal Current flowing along the southeast coast of the Shandong Peninsula(NSCC-SESE). Analysis using mooring data at a sensitive and representative station also showed the existence of the YSWC-QDB. It is a probabilistic event that manifests as a northwestward flow that decreases gradually from the bottom to the surface in the early cold air transit stage and consistent in the whole water column profile in the later stage. It varies quasi-periodically with weather processes. It also transports some of the YSWC water stored in the entrance area of the Bohai and Yellow seas under winter wind conditions to the western South Yellow Sea as a compensatory current. This current, caused by northerly winds, especially northwest winds and obstruction of the NSCC-SESE, was present, and strong water reduction and compensation caused significant residual sea level oscillations. The compensatory current, if caused by strong northwest wind,began to appear when its direction was opposite to the wind direction. In addition, confirmation of the YSWC-QDB provides an oceanographic basis for the short cooling time and rapid warming in the Qingdao area in winter. This research provides a basis for further studies of the YSWC-QDB at high spatial and temporal resolutions using large sea surface datasets. For monsoon basin dynamics, this study can also be extended to the whole Bohai and Yellow seas and closed or semi-closed basins on the continental margin. | Xuejun XIONG Xiaomin HU Yanliang GUO Long YU Liang CHEN Yuhuan XUE | 2019 | Science China Earth Sciences2019，62，7： | 2 |
| 19 | Prognostic significance of radical surgical treatment for gastric cancer patients with synchronous liver metastases显示文摘 | Weijia Wang Han Liang Hui Zhang Xuejun Wang Qiang Xue Rupeng Zhang | 2014 | Medical Oncology2014，，11： | 1 |
| 20 | Lack of evolutionary changes identified in SARS-CoV-2 for the re-emerging outbreak of COVID-19 in Beijing,China显示文摘Although significant achievements have shown that the coronavirus disease 2019(COVID‐19)resurgence in Beijing,China,was initiated by contaminated frozen products and transported via cold chain transportation,international travelers with asymptomatic symptoms or false‐negative nucleic acid may have another possible transmission mode that spread the virus to Beijing.One of the key differences between these two assumptions was whether the virus actively replicated since,so far,no reports showed viruses could stop evolution in alive hosts.We studied severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)sequences in this outbreak by a modified leaf‐dating method with the Bayes factor.The numbers of single nucleotide variants(SNVs)found in SARS‐CoV‐2 sequences were significantly lower than those called from B.1.1 records collected at the matching time worldwide(P=0.047).In addition,results of the leaf‐dating method showed ages of viruses sampled from this outbreak were earlier than their recorded dates of collection(Bayes factors>10),while control sequences(selected randomly with ten replicates)showed no differences in their collection dates(Bayes factors<10).Our results which indicated that the re‐emergence of SARS‐CoV‐2 in Beijing in June 2020 was caused by a virus that exhibited a lack of evolutionary changes compared to viruses collected at the corresponding time,provided evolutionary evidence to the contaminated imported frozen food should be responsible for the reappearance of COVID‐19 cases in Beijing.The method developed here might also be helpful to provide the very first clues for potential sources of COVID‐19 cases in the future. | Yang Li Yunjun Zhang Mifang Liang Yi Zhang Xuejun Maa Yong Zhang Xiaohua Zhou | 2022 | Biosafety and Health2022，4，1： | 1 |
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