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| 1 | QUADRATIC OPTIMIZATION METHOD AND ITS APPLICATION ON OPTIMIZING MECHANISM PARAMETER显示文摘以便设计的机制与最佳的动力学行为满足 kinematics 的要求,一个二次的优化方法基于运动学、动态的优化的不同特征被建议。这个方法包括优化的二步,也就是说运动学、动态的优化。同时,它把运动学的优化的结果用作动态优化的限制方程。这个方法在与显著意义与 high-speedrice 幼苗 transplanter 的椭圆形的行星的齿轮移植机制的参数优化被使用。参数光谱,相遇到运动学的要求,在 kinematics 优化通过设想的人机相互作用被获得,并且最佳的参数在动态优化基于改进基因算法被获得。在动态优化,客观功能作为 theoptimal1 被选动态行为,限制方程从运动学的优化的结果。当两个都运动学、动态的表演充当客观功能时,这个方法对多客观的优化合适。 | ZHAO Yun CHEN Jianneng YU Yaxin YU Gaohong ZHU Jianping | 2006 | Chinese Journal of Mechanical Engineering2006，19，4： | 14 |
| 2 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 3 | miR-330-3p controls cell proliferation by targeting early growth response 2 in non-small-cell lung cancer显示文摘Non-small-cell 肺癌症(NSCLC ) 是最普通的肺癌症之一,并且 microRNAs (miRNAs ) 被报导了在 NSCLC 起必要作用。最近的研究显示了那 miR-330-3p 表情在 NSCLC 样品并且在 NSCLC 大脑转移的纸巾是起来调整的。在这研究, miR-330-3p 表示的起来规定在 NSCLC 和 20 件 NSCLC 耐心的样品被证实。而且, miR-330-3p 在 NSCLC 房间线 A549 和 H23 是过去表示的,并且 miR-330-3p 的提升功能在调整 NSCLC 房间增长和房间周期分发被调查。为了识别潜力,在 NSCLC 指向 miR-330-3p 的基因, miRNA 目标预言数据库被使用。酶活动试金和即时 RT-PCR 分析证实 miR-330-3p 否定地与早生长反应 2 的表示(EGR2 ) 被相关。而且, EGR2 mRNA 为 miR-330-3p 包含二个潜在的有约束力的地点,这也被发现。有 siRNA 的 EGR2 击倒被表明在 NSCLC 房间线作为 miR-330-3p 的在表示上有类似的效果。一起拿,我们的结果证明 EGR2 是 miR-330-3p 的一个目标。 | Xuzhi Liu Hanbing Shi Bo Liu Jianing Li Yaxin Liu Baiquan Yu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 8 |
| 4 | Design and Experimental Research on Seedling Pick-Up Mechanism of Planetary Gear Train with Combined Non-circular Gear Transmission显示文摘Currently, transplanting mechanisms for dryland plug seedlings in China are mainly semiautomatic and have low efficiency. The rotary seedling pick-up mechanism with a planetary gear train for non-uniform intermittent transmission, and a concave and convex locking arc device, has a large rigid impact. To solve these problems, according to the design requirements for a dryland plug seedling transplanting mechanism, a rotary seedling pick-up mechanism of a planetary gear train with combined non-circular gear transmission of incomplete eccentric circular and noncircular gears was proposed. This has the characteristics of two-times greater fluctuation of the transmission ratio in a cycle, and can achieve a non-uniform continuous drive. Through analysis of the working principle of the seedling pick-up mechanism, its kinematics model was established. The human–computer interaction optimization method and self-developed computer-aided analysis and optimization software were used to obtain a set of parameters that satisfy the operation requirements of the seedling pick-up mechanism. According to the optimized parameters, the structure of the seedling pick-up mechanism was designed, a virtual prototype of the mechanism was created, and a physical prototype was manufactured. A virtual motion simulation of the mechanism was performed, high-speed photographic kinematics tests were conducted, and the kinematic properties of the physical prototype were investigated, whereby the correctness of the theoretical model and the optimized design of the mechanism were verified. Further, laboratory seedling pick-up tests were conducted. The success ratio of seedling pick-up was 93.8% when the seedling pick-up efficiency of the mechanism was 60 plants per minute per row, indicating that the mechanism has a high efficiency and success ratio for seedling pick-up and can be applied to a dryland plug seedling transplanter. | Yaxin Yu Jikun Liu Bingliang Ye Gaohong Yu Xuejun Jin Liang Sun Junhua Tong | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 7 |
| 5 | Mining coterie patterns from Instagram photo trajectories for recommending popular travel routes显示文摘 | Yaxin YU Yuhai ZHAO Ge YU Guoren WANG | 2017 | Frontiers of Computer Science2017，11，6： | 5 |
| 6 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 7 | Using Artificial Neural Networks for Energy Regulation Based Variable-speed Electrohydraulic Drive显示文摘In the energy regulation based varibable-speed electrohydraulic drive system, the supply energy and the demanded energy, which will affect the control performance greatly, are crucial. However, they are hard to be obtained via conventional methods for some reasons. This paper tries to a new route: the definitive numerical values of the supply energy and the demanded energy are not required, except for their relationship which is called energy state. A three-layer back propagation(BP) neural network was built up to act as an energy analysis unit to deduce the energy state. The neural network has three inputs: the reference displacement, the actual displacement of cylinder rod and the system flowrate supply. The output of the neural network is energy state. A Chebyshev type II filter was designed to calculate the cylinder speed for the estimation of system flowrate supply. The training and testing samples of neural network were collected by the system accurate simulation model. After off-line training, the neural network was tested by the testing data. And the testing result demonstrates that the designed neural network was successful. Then, the neural network acts as the energy analysis unit in real-time experiments of cylinder position control, where it works efficiently under square-wave and sine-wave reference displacement. The experimental results validate its feasibility and adaptability. Only a position sensor and some pressure sensors, which are cheap and have quick dynamic response, are necessary for the system control. And the neural network plays the role of identifying the energy state. | XU Ming JIN Bo YU Yaxin SHEN Haikuo LI Wei | 2010 | Chinese Journal of Mechanical Engineering2010，23，3： | 3 |
| 8 | Identifi cation of egg protein-derived peptides as xanthine oxidase inhibitors:virtual hydrolysis,molecular docking,and in vitro activity evaluation显示文摘The purpose of this study was to screen the xanthine oxidase(XO)inhibitory peptides from egg white proteins through virtual hydrolysis,in vitro activity validation,and molecular docking.The results demonstrated that tripeptide EEK from ovalbumin exhibited potent XO inhibitory activity with an IC50 value of 141μmol/L.The molecular docking results showed that tripeptide EEK bound with the active center of XO via 3 carbon hydrogen bond interactions,2 salt bridges,5 conventional hydrogen bond interactions,and 4 attractive charge interactions.The residues Glu802,Phe1009,and Arg880 may play key roles in the XO catalytic reaction.Especially,the key intermolecular forces of inhibiting XO activity may be special type of hydrogen bonds including carbon hydrogen bond interactions and attraction charge interactions.The novel tripeptide EEK is potential candidates for controlling hyperuricemia. | Zhipeng Yu Yaxin Cao Ruotong Kan Huizhuo Ji Wenzhu Zhao Sijia Wu Jingbo Liu David Shiuan | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 9 | Electrochemical characterization and microstructure of cold sprayed AA5083/Al_(2)O_(3) composite coatings显示文摘This work focused on the role of Al_(2)O_(3) particles in the corrosion behavior of cold sprayed AA5083 aluminum alloy matrix composite(Al-MMC)coatings.The electrochemical characterization of the coatings was investigated in a 3.5 wt.%NaCl solution as a function of time.The results show that fragmentation of Al_(2)O_(3) particles is not clearly observed in the case of AA5083/20 vol.%Al_(2)O_(3) coating,while the broken Al_(2)O_(3) particles can be seen clearly in AA5083/40 vol.%Al_(2)O_(3) and AA5083/60 vol.%Al_(2)O_(3) coatings.The addition of 20 vol.%Al_(2)O_(3) particles yield the coating with the lowest porosity,and different volume fractions of Al_(2)O_(3)in the feedstock have important effects on the electrochemical behavior of composite coatings.The Al-MMC coating reinforced with 20 vol.%Al_(2)O_(3) particles exhibits the highest Ecorrand the lowest icorrcompared with the other conditions.The order of current density is as follows:AA5083/20vol.%Al_(2)O_(3) | Xiawei Yang Wenya Li Siqi Yu Yaxin Xu Kaiwei Hu Yaobang Zhao | 2020 | Journal of Materials Science & Technology2020，59，24： | 3 |
| 10 | Xuebijing alters tumor necrosis factor-alpha, interleukin-1beta and p38 mitogen activated protein kinase content in a rat model of cardiac arrest following cardiopulmonary resuscitation显示文摘We established a rat model of cardiac arrest by clamping the endotracheal tube of adult rats at expiration. Twenty-four hours after cardiopulmonary resuscitation, nerve cell injury and expression of tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase content were increased. Rats injected with Xuebijing, a Chinese herb compound preparation, exhibited normal cellular structure and morphology, dense neuronal cytoplasm, and decreased tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase expression at 24 hours following cardiopulmonary resuscitation. These data suggest that Xuebijing can attenuate neuronal injury induced by hypoxia and reperfusion during cardiopulmonary resuscitation. | Haifeng Li Mingli Sun Yaxin Yu Xiaoliang Liu | 2011 | Neural Regeneration Research2011，6，33： | 2 |
| 11 | Five Independent Cases of Human Infection with Avian Influenza H5N6—Sichuan Province,China,2021显示文摘Summary What is known about this topic?The emerging H5Ny lineages of the avian influenza virus(AIV)with genomic reassortments have posed a continuous threat to animals and human beings.Since the first case of avian influenza A(H5N6)virus infection in 2014,the World Health Organization has reported a total of 38 cases by August 6,2021. | Chongkun Xiao Jianan Xu Yu Lan Zhongping Huang Lijun Zhou Yaxin Guo Xiyan Li Lei Yang George F.Gao Dayan Wang William J.Liu Xingyu Zhou Huiping Yang | 2021 | China CDC weekly2021，3，36： | 2 |
| 12 | Stimuli-responsive photofunctional materials for green and security printing显示文摘Information recording on paper has always been the most important approach to keep records of human activity and to spread civilization.With the progress of science and technology,paper with different functions should be exploited to conform to the increasing demands in various scenarios.In one aspect,traditional paper can only be used once,and using large amounts of paper causes deforestation,additional solid waste treatment,environmental pollution,and high energy consumption.Consequently,the development of rewritable paper that is environment-friendly,low cost,and can save resources is significant for green printing.In the other aspect,information leakage brings security issues,which may lead to severe consequences,such as war outbreak,economic loss,social problems,and so on.Therefore,the development of security printing has also attracted wide interests.Stimuli-responsive photofunctional materials that have reversible variations in absorption or emission in response to changes in the external environmental have a great potential for the achievement of green and security printing.To date,much progress has been made in these research areas.This paper lists different smart materials that respond to various external stimuli,such as light,water,pH,heat,and metal ions,and summarizes the recent advances towards green and security printing.Also,we discuss the current challenges and future directions in this rapidly growing research field.It is expected that this review article will stimulate and guide future studies for the advanced green and security printing. | Yun Ma Yaxin Yu Jiangang Li Shujuan Liu Wei Huang Qiang Zhao | 2021 | InfoMat2021，3，1： | 2 |
| 13 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 14 | Metal solubility in low temperature electrolysis 显示文摘 | Qiu Zhuxian Tie Jun Yu Yaxin Li Qingfeng | 1997 | Aluminium1997，73，3： | 1 |
| 15 | Highly efficient flexible perovskite solar cells with vacuum-assisted low-temperature annealed SnO2 electron transport layer显示文摘The demand for lightweight, flexible, and high-performance portable power sources urgently requires high-efficiency and stable flexible solar cells. In the case of perovskite solar cells(PSCs), most of the common electron transport layer(ETL) needs to be annealed for improving the optoelectronic properties,while conventional flexible substrates could barely stand the high temperature. Herein, a vacuumassisted annealing SnO_(2) ETL at low temperature(100℃) is utilized in flexible PSCs and achieved high efficiency of 20.14%. Meanwhile, the open-circuit voltage(V_(oc)) increases from 1.07 V to 1.14 V. The flexible PSCs also show robust bending stability with 86.8% of the initial efficiency is retained after 1000 bending cycles at a bending radius of 5 mm. X-ray photoelectron spectroscopy(XPS), atomic force microscopy(AFM), and contact angle measurements show that the density of oxygen vacancies, the surface roughness of the SnO_(2) layer, and film hydrophobicity are significantly increased, respectively. These improvements could be due to the oxygen-deficient environment in a vacuum chamber, and the rapid evaporation of solvents. The proposed vacuum-assisted low-temperature annealing method not only improves the efficiency of flexible PSCs but is also compatible and promising in the large-scale commercialization of flexible PSCs. | Xiaoguo Li Zejiao Shi Fatemeh Behrouznejad Mohammad Hatamvand Xin Zhang Yaxin Wang Fengcai Liu Haoliang Wang Kai Liu Hongliang Dong Farhan Mudasar Jiao Wang Anran Yu Yiqiang Zhan | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 16 | Design of clamping-pot-type planetary gear train transplanting mechanism for rice wide-narrow-row planting显示文摘To design a clamping-pot-type wide-narrow-row pot seedling transplanting(WPST)mechanism with desired spatial beak-shaped trajectory and working posture,a new design method of planetary gear train transplanting mechanism(PGTM)with non-circular gears based on several key spatial poses(position and posture)was proposed.The PGTM was simplified to a spatial open-loop chain with two-revolute(2R)joints.The geometric constraint equations containing only the structural parameters of the chain were then established on the basis of the three key spatial poses,and the homotopy algorithm was used to obtain all the required parameters of the mechanism.In accordance with the parameters obtained,the relative angular displacement relation between the planet carrier and the transplanting arm was optimized,the trajectory of the mechanism was replayed,and the total transmission ratio was determined.The degree of freedom of the spatial 2R mechanism was reduced by attaching to the unequal gear pair,and the transmission ratio was distributed in accordance with the gear type to realize the design of a non-circular gear pitch curve.Lastly,a clamping-pot-type PGTM for rice WPST driven by the combination of planar non-circular and non-conical gears was designed,and virtual simulation and prototype test were conducted.Results showed that the simulation and prototype test trajectories were consistent with the desired trajectory.Under the operating speeds of 50 r/min and 90 r/min,the success rates of seedling picking were 95.32%and 90.15%,respectively,which verified the feasibility of the theoretical method.This method could provide a reference for the design of a spatial PGTM with nonuniform transmission. | Lei Wang Liang Sun Hengmin Huang Yaxin Yu Gaohong Yu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 1 |
| 17 | Synthesis of alumina-nitrogen-doped carbon support for CoMo catalysts in hydrodesulfurization process显示文摘More stringent environmental legislation imposes severe requirements to reduce the sulfur content in diesel to ultra-low levels with high efficient catalysts.In this paper,a series of CoMo/NDC@alumina catalysts were synthesized by combination of the chemical vapor deposition of nitrogen-doped carbon(NDC)using 1,10-phenanthroline and co-impregnation of Mo and Co active components.The optimal catalyst with additive of 25%1,10-phenanthroline was screened by a series of property characterization and the hydrodesulfrization(HDS)active test.The amount of“CoMoS”active phase of the optimal CoMo/C3 catalyst increased 5.3%as compared with the CoMo/c-Al_(2)O_(3).The introduction of NDC improved the sulfidation degree of Mo by 21.8%as compared to the CoMo/c-Al_(2)O_(3) catalyst,which was beneficial to form more active sites.The HDS conversion of the NDC supported catalysts are higher than CoMo/c-Al_(2)O_(3) whether for the dibenzothiophene(DBT)or 4,6-dimethyl dibenzothiophene(4,6-DMDBT).Further hydroprocessing evaluation with Dagang diesel revealed that the CoMo/C3 catalyst possessed higher HDS property and the removal rate of DBTs in the diesel increased by 4%–11%as compared to the CoMo/c-Al_(2)O_(3) catalyst. | Zhentao Chen Yaxin Liu Jian Chen Yang Zhao Tao Jiang Fangyu Zhao Jiahuan Yu Haoxuan Yang Fan Yang Chunming Xu | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 18 | Enhanced photocatalytic activity in anatase/TiO2 (B) core-shell nanofiber 显示文摘 | Li Wei Liu Chang Zhou Yaxin Bai Yang Feng Xin Yang Zhuhong Lu Linghong Lu Xiaohua Chan Kwong- Yu | 2008 | The Journal of Physical Chemistry C2008，112，20： | 1 |
| 19 | Corrosion fatigue behavior of friction stir processed interstitial free steel显示文摘In this study, interstitial free(IF) steel plates were subjected to double-sided friction stir processing(FSP).The fine-grained structure with an average grain size of about 12 m was obtained in the processed zone(PZ) with a thickness of about 2.5 mm. The yield strength(325 MPa) and ultimate tensile strength(451 MPa) of FSP IF steel were significantly higher than those of base material(BM)(192 and 314 MPa),while the elongation(67.5%) almost remained unchanged compared with the BM(66.2%). The average microhardness value of the PZ was about 130 HV, 1.3 times higher than that of the BM. In addition, the FSP IF steel showed a more positive corrosion potential and lower corrosion current density than the BM,exhibiting lower corrosion tendency and corrosion rates in a 3.5 wt% NaCl solution. Furthermore, FSP IF steel exhibited higher fatigue life than the BM both in air and NaCl solution. Corrosion fatigue fracture surfaces of FSP IF steel mainly exhibited a typical transgranular fracture with fatigue striations, while the BM predominantly presented an intergranular fracture. Enhanced corrosion fatigue performance was mainly attributed to the increased resistance of nucleation and growth of fatigue cracks. The corrosion fatigue mechanism was primarily controlled by anodic dissolution under the combined effect of cyclic stress and corrosive solution. | Wen Wang Ruiqi Xu Yaxin Hao Qiang Wang Liangliang Yu Qianying Che Jun Cai Kuaishe Wang Zongyi Ma | 2018 | Journal of Materials Science & Technology2018，34，1： | 1 |
| 20 | Dingxin recipe alleviates atherosclerosis injury in Apo E-knockout mice via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response显示文摘OBJECTIVE:To further elucidate the mechanism underlying the anti-atherosclerotic effect of Dingxin recipe(DXR).METHODS:Fifty 6-week-old male Apo E^-/-mice were randomly divided into the following groups:model,simvastatin(5 mg·kg^-1·d^-1),DXR low-dose(9.30 g·kg^-1·d^-1),DXR middle-dose(18.59 g·kg^-1·d^-1)and DXR high-dose(37.18 g·kg^-1·d^-1)(n=10).Ten male C57BL/6J mice were used as the control group.All Apo E^-/-mice were fed a high-fat diet(HFD)and the control mice received a common diet.After HFD for 12 weeks,the mice were treated with DXR or simvastatin for another 12 weeks.The expression of inflammatory cytokines and visfatin was determined in serum and atherosclerotic lesions by enzyme-linked immunosorbent assay.Visfatin expression was also assessed in aortic atherosclerotic plaques.Cultured vessel endothelial cells(VECs)were pretreated with DXR sera prior to visfatin.The effects of DXR were analyzed to elucidate its protective mechanism against visfatin-induced inflammation in VECs.RESULTS:DXR regulated blood lipids and reduced tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular adhesion molecules-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1)and visfatin expression in Apo E^-/-mice,particularly at the higher doses.The areas of atherosclerotic lesions in the DXR groups were significantly smaller than those in the model group.DXR alleviated visfatin-induced VEC injury via downregulation of TNF-α,IL-6,ICAM-1 and VCAM-1 through mitogen-activated protein kinase pathways.CONCLUSION:DXR alleviated atherosclerosis injury via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response in VECs. | Cui Xiaobing Huang Zhiyong Lou Linjie Cheng Saibo Zhang Yu Zhang Yaxin Jia Yuhua Zhou Fenghua | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 1 |
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