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| 1 | Carbon dioxide emissions from cities in China based on high resolution emission gridded data显示文摘Based on the China high resolution emission gridded data(1 km spatial resolution), this article is aimed to create a Chinese city carbon dioxide(CO_2) emission data set using consolidated data sources as well as normalized and standardized data processing methods. Standard methods were used to calculate city CO_2 emissions, including scope 1 and scope 2. Cities with higher CO_2 emissions are mostly in north, northeast, and eastern coastal areas. Cities with lower CO_2 emissions are in the western region. Cites with higher CO_2 emissions are clustered in the Jing-Jin-Ji Region(such as Beijing, Tianjin, and Tangshan), and the Yangtze River Delta region(such as Shanghai and Suzhou).The city per capita CO_2 emission is larger in the north than the south. There are obvious aggregations of cities with high per capita CO_2 emission in the north. Four cities among the top 10 per capita emissions(Erdos, Wuhai, Shizuishan, and Yinchuan) cluster in the main coal production areas of northern China. This indicates the significant impact of coal resources endowment on city industry and CO_2 emissions. The majority(77%) of cities have annual CO_2 emissions below 50 million tons. The mean annual emission, among all cities, is 37 million tons. Emissions from service-based cities, which include the smallest number of cities, are the highest. Industrial cities are the largest category and the emission distribution from these cities is close to the normal distribution. Emissions and degree of dispersion, in the other cities(excluding industrial cities and service-based cities), are in the lowest level. Per capita C02 emissions in these cities are generally below 20 t/person(89%) with a mean value of 11 t/person. The distribution interval of per capita CO_2 emission within industrial cities is the largest among the three city categories. This indicates greater differences among per capita CO_2 emissions of industrial cities. The distribution interval of per capita CO_2 emission of other cities is the lowest, indicating smaller differences of per capita CO_2 emissions among this city category. Three policy suggestions are proposed: first, city CO_2 emission inventory data in China should be increased,especially for prefecture level cities. Second, city responsibility for emission reduction, and partitioning the national goal should be established, using a bottom-up approach based on specific CO_2emission levels and potential for emission reductions in each city. Third, comparative and benchmarking research on city CO_2 emissions should be conducted, and a Top Runner system of city CO_2emission reduction should be established. | Bofeng Cai Jinnan Wang Shuying Yang Xianqiang Mao Libin Cao | 2017 | Chinese Journal of Population,Resources and Environment2017，15，1： | 10 |
| 2 | Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells显示文摘Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs. | Chao Zhang Jiani Cao Xiaoyan Li Haoyu Xu Weixu Wang Libin Wang Xiaoyang Zhao Wei Li Jianwei Jiao Baoyang Hu Qi Zhou Tongbiao Zhao | 2016 | Science China(Life Sciences)2016，59，9： | 9 |
| 3 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 4 | Model Investigation on Composite Failure Prediction of π-Joint Structures显示文摘This paper was concerned with the tensile mechanics behavior of the composite π-joint under static tensile loading. The numerical strength analysis methodology was presented containing the basis assumption for the analysis, the material modeling, and the selected element type. It was assumed that the composite ply had transverse isotropic material properties and the adhesive had linear elastic properties. With the goal of the strength analysis to determine the onset of the damage initiation and the ultimate failure load, two stiffness degradation models were discussed and a modified maximum stress failure criteria was presented. To verify the numerical model, a pull-off test scheme was performed and the experimental data of five specimens were given. The experimental results indicate that the damage initiation location and the failure load were consistent with numerical predictions and verified the feasibility of the numerical model. | Zhao Libin Qin Tianliang Huanghai Liang Xianzhu Chang Haifeng Cao Zhenghua | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 5 | Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells显示文摘Objective:Effective adjuvant therapeutic strategies are urgently needed to overcome MAPK inhibitor(MAPKi)resistance,which is one of the most common forms of resistance that has emerged in many types of cancers.Here,we aimed to systematically identify the genetic interactions underlying MAPKi resistance,and to further investigate the mechanisms that produce the genetic interactions that generate synergistic MAPKi resistance.Methods:We conducted a comprehensive pair-wise sgRNA-based high-throughput screening assay to identify synergistic interactions that sensitized cancer cells to MAPKi,and validated 3 genetic combinations through competitive growth,cell viability,and spheroid formation assays.We next conducted Kaplan-Meier survival analysis based on The Cancer Genome Atlas database and conducted immunohistochemistry to determine the clinical relevance of these synergistic combinations.We also investigated the MAPKi resistance mechanisms of these validated synergistic combinations by using co-immunoprecipitation,Western blot,qRTPCR,and immunofluorescence assays.Results:We constructed a systematic interaction network of MAPKi resistance and identified 3 novel synergistic combinations that effectively targeted MAPKi resistance(ITGB3+IGF1R,ITGB3+JNK,and HDGF+LGR5).We next analyzed their clinical relevance and the mechanisms by which they sensitized cancer cells to MAPKi exposure.Specifically,we discovered a novel protein complex,HDGF-LGR5,that adaptively responded to MAPKi to enhance cancer cell stemness,which was up-or downregulated by the inhibitors of ITGB3+JNK or ITGB3+IGF1R.Conclusions:Pair-wise sgRNA library screening provided systematic insights into elucidating MAPKi resistance in cancer cells.ITGB3-+IGF1R-targeting drugs(cilengitide+linsitinib)could be used as an effective therapy for suppressing the adaptive formation of the HDGF-LGR5 protein complex,which enhanced cancer stemness during MAPKi stress. | Yu Yu Minzhen Tao Libin Xu Lei Cao Baoyu Le Na An Jilin Dong Yajie Xu Baoxing Yang Wei Li Bing Liu Qiong Wu Yinying Lu Zhen Xie Xiaohua Lian | 2022 | Cancer Biology & Medicine2022，19，2： | 1 |
| 6 | Aging Characteristics of XLPE Insulation of 110 kV Cables in the Initial Stage of Operation显示文摘The aging characteristics of the XLPE insulation of 110 kV power cables in the initial stage of operation are studied in this paper.The XLPE insulation from cables with different running time was tested by using electrical and physicochemical methods,from which the degradation state of XLPE under multiple stresses during operation was derived.The broadband dielectric spectrum test taken from 10–1 to 10^(6) Hz showed that the dielectric constant and dielectric loss of the XLPE insulation first decrease and then increase with the increase of cable running time,which show obvious variation until 10 years of operation.The AC breakdown strengths of the XLPE insulation of operated cables with the service year no longer than 10 years were higher than that of new cables.The mechanical properties of the XLPE insulation showed no dependence with the cable running time.The crystallinity and perfection of the crystallization area were found to be enhanced during operation and the polar functional groups inside the XLPE insulation were found to be determined not only by the cross-linking by-products but also by the oxidation process during cable operation.The experimental results in this paper are important for improving the operation reliability and reducing the maintenance costs of the cables. | Jie Chen Wei Zhang Man Ding Libin Hu Jinpeng Wang Chenying Li Jingying Cao | 2021 | Energy Engineering2021，118，5： | 0 |
| 7 | A new model for China’s CO_(2) emission pathway using the top-down and bottom-up approaches显示文摘Detailed research on China's CO_(2) emission pathway of the 2030 peak and 2060 carbon neutrality goals is fundamental to promote China's climate change action.Previous studies on emission pathways have been based on long-term emission data or model analyses.However,few studies have achieved synergy and pathway optimization at both the micro and macro levels or focused on China's 2060 carbon neutrality goal,making it difficult to support the systematic management of national and regional emission pathways.In this study,we developed an integrated CO_(2) emission pathway model,the Chinese Academy of Environmental Planning Carbon Pathways 1.2 model,under China's climate change goals.Our pathway coupled the top-down and bottom-up approaches and conducted optimization analysis under social fairness and optimal cost conditions.The results provide a clear CO_(2) emission pathway and offer insights for implementing fine management of CO_(2) emissions at the national,regional,sectoral,and spatial gridded levels. | Bofeng Cai Li Zhang Chuyu Xia Lu Yang Hui Liu Lingling Jiang Libin Cao Yu Lei Gang Yan Jinnan Wang | 2021 | Chinese Journal of Population,Resources and Environment2021，19，4： | 0 |
| 8 | NUIST ESM v3 Data Submission to CMIP6显示文摘This paper introduces the experimental designs and outputs of the Diagnostic,Evaluation and Characterization of Klima(DECK),historical,Scenario Model Intercomparison Project(MIP),and Paleoclimate MIP(PMIP)experiments from the Nanjing University of Information Science and Technology Earth System Model version 3(NESM3).Results show that NESM3 reasonably simulates the modern climate and the major internal modes of climate variability.In the Scenario MIP experiment,changes in the projected surface air temperature(SAT)show robust“Northern Hemisphere(NH)warmer than Southern Hemisphere(SH)”and“land warmer than ocean”patterns,as well as an El Niño-like warming over the tropical Pacific.Changes in the projected precipitation exhibit“NH wetter than SH”and“eastern hemisphere gets wetter and western hemisphere gets drier”patterns over the tropics.These precipitation patterns are driven by circulation changes owing to the inhomogeneous warming patterns.Two PMIP experiments show enlarged seasonal cycles of SAT and precipitation over the NH due to the seasonal redistribution of solar radiation.Changes in the climatological mean SAT,precipitation,and ENSO amplitudes are consistent with the results from PMIP4 models.The NESM3 outputs are available on the Earth System Grid Federation nodes for data users. | Jian CAO Libin MA Fei LIU Jing CHAI Haikun ZHAO Qiong HE Bo WANG Yan BAO Juan LI Young-min YANG Hua DENG Bin WANG | 2021 | Advances in Atmospheric Sciences2021，38，2： | 0 |
| 9 | Synergistic effects of plant hormones on spontaneous late-ripening mutant of'Jinghong'peach detected by transcriptome analysis显示文摘Objectives:Peach(Prunus persica L.)is an ancient fruit tree that originated from China.It is the climacteric fruit belonging to genus Prunus in family Rosaceae.Ethylene,which is produced during ripening,accelerates fruit softening,and therefore peaches cannot be stored for a long time.Materials and Methods:To study the mechanism of fruit late ripening,transcriptome analysis of the fruit of a late-ripening mutant of'Jinghong'peach was performed to identify genes and pathways involved in fruit late ripening.Results:A total of 1805,1511,and 2309 genes were found to be differentially expressed in W2_vs_M1,W3_vs_M2,and W3_vs_M3,respectively.Functional enrichment analysis of the differentially expressed genes showed they were related to carotenoid biosynthesis,starch and sucrose metabolism plant hormone signal transduction,flavonoid biosynthesis,and photosynthesis.The expression trends of ripening-related genes that encode transcription factors and plant hormone signal transduction-related genes that encode enzymes were similar.Conclusions:It will help to elucidate the transcriptional regulatory network of fruit development in the spontaneous late-ripening mutant of‘Jinghong’peach and provide a theoretical basis for understanding the molecular regulatory mechanism of fruit ripening. | Man Zhang Tingting Du Yarui Yin Hongyan Cao Zhihua Song Mao Ye Yating Liu Yanhong Shen Libin Zhang Qing Yang Dong Meng Junkai Wu | 2022 | Food Quality and Safety2022，6，1： | 0 |
| 10 | Research and Development of Butterfly Microfluidic Gene Chip for 19 Common Pathogenic Microorganisms of Nosocomial Infection显示文摘Based on butterfly microfluidic gene chip technology,a method for rapid,accurate and efficient detection of 19 common pathogenic microorganisms of nosocomial infection was established,and a butterfly microfluidic gene chip with high-throughput detection was designed and fabricated.Using constant temperature amplification technology,using the polymerase with chain replacement function to react at constant temperature(65℃)and combined with microfluidic chip technology,primers were designed according to the target genes of 19 pathogenic microorganisms,and a butterfly microfluidic gene chip which can detect 19 common pathogenic microorganisms of nosocomial infection was made to simplify the inspection operation process and verify the sensitivity of the chip.The butterfly microfluidic gene chip can be used for the rapid and efficient detection of 19 common pathogenic microorganisms of nosocomial infection,and provides a new idea for the detection and auxiliary diagnosis of pathogenic microorganisms of nosocomial infection. | Jingjing Yu Xu Zhang Jinhai Tian Rong Ma Qi Huang Jia Cao Jia Wang Libin Wang | 2022 | Journal of Clinical and Nursing Research2022，6，1： | 0 |
| 11 | McKay Matrices for Pointed Rank One Hopf Algebras of Nilpotent Type显示文摘Let H be a finite-dimensional pointed rank one Hopf algebra of nilpotent type over a finite group G.In this paper,we investigate the McKay matrix WV of H for tensoring with the 2-dimensional indecomposable H-module V:=M(2,0).It turns out that the characteristic polynomial,eigenvalues and eigenvectors of WV are related to the character table of the finite group G and a kind of generalized Fibonacci polynomial.Moreover,we construct some eigenvectors of each eigenvalue for WV by using the factorization of the generalized Fibonacci polynomial.As an example,we explicitly compute the characteristic polynomial and eigenvalues of WV and give all eigenvectors of each eigenvalue for WV when G is a dihedral group of order 4N+2. | Liufeng Cao Xuejun Xia Libin Li | 2023 | Algebra Colloquium2023，30，3： | 0 |
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