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| 1 | Bias-drift-free Mach–Zehnder modulators based on a heterogeneous silicon and lithium niobate platform显示文摘Optical modulators have been and will continue to be essential devices for energy-and cost-efficient optical communication networks.Heterogeneous silicon and lithium niobate modulators have demonstrated promising performances of low optical loss,low drive voltage,and large modulation bandwidth.However,DC bias drift is a major drawback of optical modulators using lithium niobate as the active electro-optic material.Here,we demonstrate high-speed and bias-drift-free Mach–Zehnder modulators based on the heterogeneous silicon and lithium niobate platform.The devices combine stable thermo-optic DC biases in silicon and ultra-fast electro-optic modulation in lithium niobate,and exhibit a low insertion loss of 1.8 d B,a low half-wave voltage of 3 V,an electro-optic modulation bandwidth of at least 70 GHz,and modulation data rates up to 128 Gb/s. | SHIHAO SUN MINGBO HE MENGYUE XU SHENGQIAN GAO ZIYAN CHEN XIAN ZHANG ZILIANG RUAN XIONG WU LIDAN ZHOU LIN LIU CHAO LU CHANGJIAN GUO LIU LIU SIYUAN YU XINLUN CAI | 2020 | Photonics Research2020，8，12： | 5 |
| 2 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 3 | The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells显示文摘 | Xue Zhu Lidan Xue Yong Yao Ke Wang Chengye Tan Miao Zhuang Fanfan Zhou Ling Zhu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 4 |
| 4 | Insight into the interaction between Ni-rich LiNi0.8Co0.1Mn0.1O2 cathode and BF4--introducing electrolyte at 4.5V high voltage显示文摘Owing to the high specific capacity and high voltage,Ni-rich(LiNi0.8Co0.1Mn0.1O2,LNCM811)cathode has been considered as one of the most promising candidate cathode materials for next generation lithium ion batteries,whereas severe capacity fading greatly hinders its practical application.Notably,the compatibility of Ni-rich materials with LiBF4-containing electrolyte has not yet been realized.Herein,1 M LiPF6-based electrolyte with introducing 2 M LiBF4 is proposed to dramatically improve the cyclic stability of high voltage LNCM811/Li half-cell.Addition of high concentrated LiBF4 improves the moisture stability of electrolyte,which hinders the generation of harmful by-product HF,resulting in improved interfacial stability of LNCM811.Lithium plating/stripping reaction of Li/Li symmetric cell confirms that the enhanced cyclic stability is ascribed to the improved interfacial stability of LNCM811 instead of lithium electrode.Morphology and composition characterization results reveal that LiBF4 participates in the CEI film-forming reaction,resulting in suppressed oxidation of electrolyte and interfacial structural destruction of LNCM811. | Guangyuan Lan Hebing Zhou Lidan Xing Jiawei Chen Zifei Li Rude Guo Yanxia Che Weishan Li | 2019 | Journal of Energy Chemistry2019，28，12： | 3 |
| 5 | Surface phase defects induced downstream laser intensity modulation in high-power laser facility显示文摘Optics surface phase defects induced intensity modulation in high-power laser facility for inertial confinement fusion research is studied. Calculations and experiments reveal an exact mapping of the modulation patterns and the optics damage spot distributions from the surface phase defects. Origins are discussed during the processes of optics manufacturing and diagnostics, revealing potential improvements for future optics manufacturing techniques and diagnostic index, which is meaningful for fusion level laser facility construction and its operation safety. | Xin Zhang Wei Zhou Wanjun Dai Dongxia Hu Xuewei Deng Wanqing Huang Lidan Zhou Qiang Yuan Xiaoxia Huang De'en Wang Ying Yang | 2016 | High Power Laser Science and Engineering2016，4，1： | 2 |
| 6 | Revealing the critical effect of solid electrolyte interphase on the deposition and detriment of Co(Ⅱ) ions to graphite anode显示文摘'Dissolution,migration,and deposition'of transition metal ions (TMIs) result in capacity degradation of lithium-ion batteries (LIBs).Understanding such detrimental mechanism of TMIs is critical to the development of LIBs with long cycle life.In most previous works,TMIs were directly introduced into the electrolyte to investigate such a detrimental mechanism.In these cases,the TMIs are deposited directly on the fresh anode surface.However,in the practical battery system,the TMIs are deposited on the anode covered with solid electrolyte interphase (SEI) film.Whether the pre-presence of SEI film on anode surface influences the deposition and detriment of TMIs is unclear.In this work,the deposition of Co element on graphite anode with and without SEI film were systematically studied.The results clearly show that,in comparison with that of fresh graphite (SEI-free),the presence of SEI film aggravates the deposition of Co ions due to the Li^(+)–Co^(2+) ion exchange between the SEI and Co^(2+)-containing electrolyte without the driving of the electric field,leading to faster capacity fading of graphite anode.Therefore,how to regulate electrolytes and film-forming additives to design the components of SEI and prevent its exchange with TMIs,is a crucial way to inhibit the deposition and detriment of TMIs on graphite anode. | Qiming Xie Jiawei Chen Lidan Xing Xianggui Zhou Zekai Ma Binhong Wu Yilong Lin Hebing Zhou Weishan Li | 2022 | Journal of Energy Chemistry2022，31，6： | 2 |
| 7 | Development of planar patch clamp technology and its application in the analysis of cellular electrophysiology显示文摘A patch clamp chip,as a novel cell-based chip for electrophysiological recordings,has many prominent advantages such as high res-olution,accuracy,high throughput and automation. It can be used to perform multivariate and real-time measurements of cell networks in situ. Therefore,this technology will dramatically promote the research on ionic channels,neuronal networks and the application of this technology in drug screening. This paper reviews the development of planar patch clamp technology and its applications in detail. The latest progress in the research of taste cells electrophysiology and taste transduction is also presented. Finally,this paper analyzes the methodology of neural chips. Based on the current research of our laboratory,the prospective applications of a patch clamp chip in the research of taste sensation and transduction mechanisms at molecular and cellular levels are discussed. | Peihua Chen Wei Zhang Jun Zhou Ping Wang Lidan Xiao MO Yang | 2009 | Progress in Natural Science:Materials International2009，19，2： | 2 |
| 8 | Long-term persistence of polychlorinated dibenzo- p -dioxins and dibenzofurans in air, soil and sediment around an abandoned pentachlorophenol factory in China显示文摘 | Cheng Li Minghui Zheng Bing Zhang Lirong Gao Lidan Liu Xin Zhou Xiaodong Ma Ke Xiao | 2011 | Environmental Pollution2011，，： | 1 |
| 9 | Ultra-short term prediction of wind power based on multiples model extreme learning machine显示文摘 | Huang Ting Wang Xin Li Lixue Zhou Lidan Yao Guang | 2011 | Advances in Neural Networks2011，6677，： | 1 |
| 10 | Outstanding performances of graphite||NMC622 pouch cells enabled by a non-inert diluent显示文摘Although high salt concentration electrolyte(HCE)can construct effective Li F-rich interphase film and solve the interphasial instability issue of graphite anode,its high cost,high viscosity and poor wettability with electrode materials limit its large-scale application.Generally,localized high concentration electrolyte(LHCE)is obtained by introducing an electrochemically inert diluent into HCE to avoid the above-mentioned problems while maintaining the high interphasial stability of HCE with graphite anode.Unlike traditional inert diluents,1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluropropyl ether(TTE)with electrochemical activity is introduced into propylene carbonate(PC)-based HCE to obtain LHCE-2(1 M LiPF_(6),PC:DMC:TTE=1:1:6.1)herein.Experimental and theoretical simulation results show that TTE participates in the oxidation decomposition and film-forming reaction at the NCM622 cathode surface,conducting a cathode electrolyte interphase(CEI)rich in organic fluorides with excellent electron insulation ability,high structural stability and low interphasial impedance.Thanks to the outstanding interphasial properties induced by LHCE-2,the graphite||NMC622 pouch cell reaches a capacity retention of 80%after 500 cycles at 1 C under room temperature.While at sub-zero temperatures,the capacity released by the cell with LHCE-2 electrolyte is significantly higher than that of HCE and conventional EC-based electrolytes.Meanwhile,the LHCE-2 electrolyte inherits the advantages of TTE flame-resistant,thus improving the safety of the battery. | Qinqin Cai Hao Jia Guanjie Li Zhangyating Xie Xintao Zhou Zekai Ma Lidan Xing Weishan Li | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 11 | Ultra-short term prediction of wind power based on multiples model extreme learning machine显示文摘 | Huang Ting Wang Xin Li Lixue Zhou Lidan Yao Gang | 2011 | Advances in Neural Networks2011，6677，： | 1 |
| 12 | Long-term persistence of polychlorinated dibenzo- p -dioxins and dibenzofurans in air, soil and sediment around an abandoned pentachlorophenol factory in China显示文摘 | Cheng Li Minghui Zheng Bing Zhang Lirong Gao Lidan Liu Xin Zhou Xiaodong Ma Ke Xiao | 2011 | Environmental Pollution2011，，： | 1 |
| 13 | Identification of a cytochrome P450 from Tripterygium hypoglaucum(Levl.)Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis显示文摘Tripterygium hypoglaucum(Levl.)Hutch,a traditional Chinese medicinal herb with a long history of use,is widely distributed in China.One of its main active components,celastrol,has great potential to be developed into anti-cancer and anti-obesity drugs.Although it exhibits strong pharmacological activities,there is a lack of sustainable sources of celastrol and its derivatives,making it crucial to develop novel sources of these drugs through synthetic biology.The key step in the biosynthesis of celastrol is considered to be the cyclization of 2,3-oxidosqualene into friedelin under the catalysis of 2,3-oxidosqualene cyclases.Friedelin was speculated to be oxidized into celastrol by cytochrome P450 oxidases(CYP450s).Here,we reported a cytochrome P450 ThCYP712K1 from Tripterygium hypoglaucum(Levl.)Hutch that catalyzed the oxidation of friedelin into polpuonic acid when heterologously expressed in yeast.Through substrate supplementation and in vitro enzyme analysis,ThCYP712K1 was further proven to catalyze the oxidation of friedelin at the C-29 position to produce polpunonic acid,which is considered a vital step in the biosynthesis of celastrol,and will lay a foundation for further analysis of its biosynthetic pathway. | CHEN Xiao-Chao LU Yun LIU Yuan ZHOU Jia-Wei ZHANG Yi-Feng GAO Hai-Yun LIDan GAO Wei | 2022 | Chinese Journal of Natural Medicines2022，20，9： | 1 |
| 14 | Bayesian neural network enhancing reliability against conductance drift for memristor neural networks显示文摘The hardware implementation of neural networks based on memristor crossbar array provides a promising paradigm for neuromorphic computing. However, the existence of memristor conductance drift harms the reliability of the deployed neural network, which seriously hinders the practical application of memristor-based neuromorphic computing. In this paper, the impact of different types of conductance drift on the weight realized by memristors is investigated and analyzed. Then, utilizing the weight uncertainty introduced by conductance drift, we propose a weight optimization method based on the Bayesian neural network, which can greatly improve the network performance. Furthermore, an ensemble approach is proposed to enhance network reliability without increasing training cost or crossbar array resources. Finally, the effectiveness of the proposed scheme is verified through a series of experiments. In addition, the proposed scheme can be easily integrated into the implementation of neuromorphic computing, which can provide a better guarantee for its large-scale application. | Yue ZHOU Xiaofang HU Lidan WANG Shukai DUAN | 2021 | Science China(Information Sciences)2021，64，6： | 0 |
| 15 | Measurement of Raman scattering gain coefficient in large-aperture DKDP crystals irradiated by 351 nm pulses显示文摘Transverse stimulated Raman scattering (TSRS) gain coefficient in a large aperture 65% deu terated potassium dihydrogen phosphate (DKDP) is measured at 351 nm. The measurement involves the use of an optical fiber sensor system to detect Raman scattering light in the DKDP crystal. A Raman scattering gain coefficient of 0. 109 cm/GW is obtained and will be used to set upper limit of the DKDP crystals in our laser fa cility to avoid the TSRS induced energy loss and laser damage. The effect of bulk damage on growth behavior of TSRS is also examined and it is found that bulk damage has little impact on the TSRS growth. Thus the influ ence of bulk damage on the measurement of TSRS gain coefficient can be ignored. | Han Wei Xiang Yong Wang Fang Zhou Lidan Feng Bin Li FUCluan Zhao Junpu Zheng Kuixing Zhu Qihua Wei Xiaofeng Zheng Wanguo Gong Mali | 2016 | 强激光与粒子束2016，28，2： | 0 |
| 16 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 17 | Whether and When Superhydrophobic/Superoleophobic Surfaces Are Fingerprint Repellent显示文摘Driven by the ever-increasing demand for fingerprint-resistant techniques in modern society,numerous researches have proposed to develop innovative antifingerprint coatings based on superhydrophobic/superoleophobic surface design.However,whether superhydrophobic/superoleophobic surfaces have favorable repellency to the microscopic fingerprint is in fact an open question.Here,we establish a reliable method that enables evaluating the antifingerprint capability of various surfaces in a quantitative way.We show that superhydrophobicity is irrelevant with fingerprint repellency.Regarding superoleophobic surfaces,two distinct wetting states of microscopic fingerprint residues,i.e.,the'repellent'and the“collapsed”states,are revealed.Only in the'repellent'state,in which the fingerprint residues remain atop surface textures upon being pressed,superoleophobic surfaces can bring about favorable antifingerprint repellency,which correlates positively with their receding contact angles.A finger-deformation-dependent intrusion mechanism is proposed to account for the formation of diferent fingerprint wetting states.Our findings offer important insights into the mechanism of fingerprint repellency and will help the design of high-performance antifingerprint surfaces for diverse applications. | Chengjiao Wu Yue Fan Hongxin Wang Juan Li Yuxi Chen Yingke Wang Lin Liu Lidan Zhou Shilin Huang Xuelin Tian | 2023 | Research2023，，1： | 0 |
| 18 | Broadband photonic structures for quantum light sources显示文摘Quantum light sources serve as one of the key elements in quantum photonic technologies. Such sources made from semiconductor material, e.g., quantum dots (QDs), are particularly appealing because of their great potential of scalability enabled by the modern planar nanofabrication technologies. So far, non-classic light sources based on semiconductor QDs are currently outperforming their counterparts using nonlinear optical process, for instance, parametric down conversion and four-wave mixing. To fully exploring the potential of semiconductor QDs, it is highly desirable to integrate QDs with a variety of photonic nanostructures for better device performance due to the improved light-matter interaction. Among different designs, the photonic nanostructures exhibiting broad operation spectral range is particularly interesting to overcome the QD spectral inhomogeneity and exciton fine structure splitting for the generations of single-photon and entangled photon pair respectively. In this review, we focus on recent progress on high-performance semiconductor quantum light sources that is achieved by integrating single QDs with a variety of broadband photonic nanostructures i.e. waveguide, lens and low-Q cavity. | Zhe He Jiawei Yang Lidan Zhou Yan Chen Tianming Zhao Ying Yu Jin Liu | 2019 | Journal of Semiconductors2019，40，7： | 0 |
| 19 | Suppression of Co(Ⅱ)ion deposition and hazards:Regulation of SEI film composition and structure显示文摘Despite the presence of Li F components in the solid electrolyte interphase(SEI)formed on the graphite anode surface by conventional electrolyte,these Li F components primarily exist in an amorphous state,rendering them incapable of effectively inhibiting the exchange reaction between lithium ions and transition metal ions in the electrolyte.Consequently,nearly all lithium ions within the SEI film are replaced by transition metal ions,resulting in an increase in interphacial impedance and a decrease in stability.Herein,we demonstrate that the SEI film,constructed by fluoroethylene carbonate(FEC)additive rich in crystalline Li F,effectively inhibits the undesired Li^(+)/Co^(2+)ion exchange reaction,thereby suppressing the deposition of cobalt compounds and metallic cobalt.Furthermore,the deposited cobalt compounds exhibit enhanced structural stability and reduced catalytic activity with minimal impact on the interphacial stability of the graphite anode.Our findings reveal the crucial influence of SEI film composition and structure on the deposition and hazards associated with transition metal ions,providing valuable guidance for designing next-generation electrolytes. | Jiaqi Zhan Mingzhu Liu Yutian Xie Jiarong He Hebing Zhou Lidan Xing Weishan Li | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 20 | Large aperture and non-critical phase-matched fourth harmonic generation of Nd:Glass lasers显示文摘A fourth harmonic generation(FHG)scheme in focusing beams is proposed and demonstrated for large aperture Nd:glass laser facilities.By placing the focusing lens before the FHG crystal,the problem of ultraviolet damage can be overcome,largely without affecting FHG conversion efficiency owing to the large angular acceptance of the non-critical phase matching technique.A numerical simulation of the FHG process indicates that angular acceptance can be appropriately increased by lowering the working temperature and jointing the two adjacent compensating angles,so that FHG in focusing beams with relatively small F numbers becomes feasible.With a 170mm3170mm37mmand 65%deuterated potassium dihydrogen phosphate crystal mounted in a high-precision,temperature-controlled system,high-efficiency FHG has been demonstrated in the focusing beam with a full beam convergence angle of 36 mrad.When driven with a 223 J,second harmonic radiation(2ω),1 ns flat-top pulse with a beam area of 130 cm2,corresponding to 1.7 GW/cm22ωinput intensity,182 J of fourth harmonic radiation(4ω)were generated. | Fang Wang Fuquan Li Wei Han Wei Wang Ping Li Lidan Zhou Yong Xiang Bin Feng Xuewei Deng Jingqin Su Qihua Zhu | 2019 | Matter and Radiation at Extremes2019，4，4： | 0 |
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