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| 1 | Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy显示文摘Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated with the wet form. Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%–71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identified AMD associated loci so far. Chronic cigarette smoking is the most proven consistently risk living habits for AMD. Deep learning algorithm has been developed based on image recognition to distinguish wet AMD and normal macula with high accuracy. Currently, anti-vascular endothelial growth factor (VEGF) therapy is highly effective at treating wet AMD. Several new generation AMD drugs and iPSC-derived RPE cell therapy are in the clinical trial stage and are promising to improve AMD treatment in the near future. | Yanhui Deng Lifeng Qiao Mingyan Du Chao Qu Ling Wan Jie Li Lulin Huang | 2022 | Genes & Diseases2022，9，1： | 17 |
| 2 | Application of an analytic hierarchy process to hydrocarbon accumulation coefficient estimation显示文摘The hydrocarbon accumulation coefficient is a key parameter in resources evaluation by genetic techniques. Methods of obtaining its value scientifically have always been an important factor influencing evaluation credibility. In this paper, the hydrocarbon accumulation system is evaluated quantitatively by establishing a hierarchy structure model based on an analytical hierarchy process. The hydrocarbon accumulation system of a higher exploration degree is selected as a calibration area and its hydrocarbon accumulation coefficient can be calculated using methods of hydrocarbon generation potential and reservoir-scale sequence. The hydrocarbon accumulation coefficient of a petroleum accumulation system can be gained by analogy of reservoir forming comprehensive evaluation results with the calibration area. The hydrocarbon accumulation coefficient of each petroleum accumulation system in the upper reservoir-forming combination of the Liaohe Western Sag can be obtained with this method. Practice shows that using the analytical hierarchy process to quantitatively evaluate the hydrocarbon accumulation system and then quantitatively predict the hydrocarbon accumulation coefficient decreases the influence of human factors in resources evaluation, and makes the resources assessment more objective and closer to the actual geological condition. | Gao Yongjin Liu Lifeng Liu Huimin Zheng Feifei Wu Li Zhou Jingjing Qu Dongfang | 2010 | Petroleum Science2010，7，3： | 5 |
| 3 | Fluid Flow Behavior of Liquid in Cylindrical Vessels Stirred by One or Two Air Jets显示文摘Based on the two-phase model (Eulerian-Eulerian model), the three dimensional fluid flow in water and that liquid steel systems stirred by one or two multiple gas jets are simulated. In the Eulerian-Eulerian two-phase model, the gas and the liquid phase are considered to be two different continuous fluids interacting with each other through the finite inter-phase areas. The exchange between the phases is represented by source terms in conversation equations. Turbulence is assumed to be a property of the liquid phase. A new turbulence modification - model is introduced to consider the bubbles movement contribution to and . The dispersion of phases due to turbulence is represented by introducing a diffusion term in mass conservation equation. The mathematical simulation agrees well with the experiment results. The study results indicate that the distance of two nozzles has big effect on fluid flow behavior in the vessel. Using two gas injection nozzles at the half radii of one diameter of the bottom generates a much better mixing than with one nozzle under the condition of the same total gas flow rate. | Lifeng Zhang, Shoji Taniguchi, Kaike Cai, Ying Qu ( Department of Metallurgy Graduate School of Engineering, Tohoku University, Sendai 980-579 Japan Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China) | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，3： | 2 |
| 4 | Influence of Surface Nanocrystallization on Ti Ion Implantation of Pure Iron显示文摘In order to increase the depth or concentration of Ti ion implantation of pure iron, the surface mechanical attrition treatment(SMAT), which can fabricate a nanometer-grained surface layer without porosity and contamination in a pure iron plate, was used before ion implantation. Ti ion was implanted into the SMA treated sample and coarse-grained counterpart by using a metal vapor vacuum arc source implanter. The changing of depth and concentration of Ti was studied in a function of implantation time.By optical microscopy, transmission electron microscopy and X-ray diffraction, the grain size of the nano structured surface was studied. Micro-hardness, friction and wear behavior of nano surface layers were studied. By energy dispersive X-ray spectroscopy and Auger electron spectroscopy, the chemical composition and concentration of Ti ion in the surface implantation layer were studied. Experimental results showed that the concentration of Ti increased dramatically compared with untreated coarsegrained samples, which is attributed to the existence of higher density of defects(supersaturated vacancies, dislocations, non-equilibrium grain boundaries etc.) and compression stress field in the SMA treated nanocrystallined surface layer. The interaction between the defects and the implanted solute atoms leads to the increment of solid solubility. But the implantation depth showed inconspicuous change. It is shown that the ion range is just relevant to the energy and mass of the ion, dose of injection,the mass and density of target material. | Xu Li Yanli An Yinghui Wei Huayun Du Lifeng Hou Chunli Guo Hongbo Qu Yide Wang | 2015 | Journal of Materials Science & Technology2015，31，3： | 2 |
| 5 | Preparation and electrochemical lithium storage features of TiO 2 hollow spheres显示文摘 | Liang Xiao Minglei Cao Daidi Mei Yonglin Guo Lifeng Yao Deyu Qu Bohua Deng | 2013 | Journal of Power Sources2013，，： | 1 |
| 6 | Treatment of Budd-Chiari syndrome with inferior vena cava thrombosis显示文摘 | Ruihua Wang Qingyi Meng Lifeng Qu Xuejun Wu Nianfeng Sun Xing Jin | 2013 | Experimental and Therapeutic Medicine2013，，4： | 1 |
| 7 | Review of Public-Key Cryptosystem Based on the Error Correcting Code显示文摘The paper review the public-key cryptosystems based on the error correcting codes such as Goppa code, BCH code, RS code, rank distance code, algebraic geometric code as well as LDPC code, and made the comparative analyses of the merits and drawbacks of them. The cryptosystem based on Goppa code has high security, but can be achieved poor. The cryptosystems based on other error correcting codes have higher performance than Goppa code. But there are still some disadvantages to solve. At last, the paper produce an assumption of the Niederreiter cascade combination cryptosystem based on double public-keys under complex circumstances, which has higher performance and security than the traditional cryptosystems. | LI Zhongyuan QU Chengqin ZHOU Xueguang ZHUO Lifeng | 2014 | Wuhan University Journal of Natural Sciences2014，19，6： | 1 |
| 8 | Treatment of Budd- Chiari syndrome with inferior vena cava thrombosis显示文摘 | Ruihua Wang Qingyi Meng Lifeng Qu | 2013 | Exp Ther Mede2013，，5： | 1 |
| 9 | Inclusion's Removel Mechanism in Liquid Steel of Continuous Casting Tundish显示文摘Three dimensional velocity distribution and turbulence energy dissipation of the steel in tundish are calculated. Then, the mathematical model of collision removal and flotation removal is established. In this collision mode,the rate constants of all types of collision are concluded, the change rate of inclusion number density is obtained.The quantitative calculation shows that it is violent turbulence at the inlet area of tundish and that collision is the main removal type to those inclusions with radius from 0 to 25μm.The collision of inclusions has two effect: one is to decrease the number of small inclusions, the other is to increase the number of big inclusions.To calculate the removal of inclusions, both collision and flotation should be considered. At last, the result of industrial experiment proves the collisien model is true. | ZHANG Lifeng CAI Kaike QU Ying (Metallurgy Engineering School, USTB, Beijing 100083, China) | 1997 | International Journal of Minerals,Metallurgy and Materials1997，11，2： | 0 |
| 10 | Wet flue gas desulfurization performance of 330 MW coal-fired power unit based on computational fluid dynamics region identification of flow pattern and transfer process显示文摘Wet Flue Gas Desulfurization(WFGD)unit based upon spray scrubber has beenwidely employed to control SO_(2) emissions from flue gas in coal-fired power plant.To clarify the dependence of desulfurization performance on inter-phase transfer behaviors with non-ideal contacting patterns of flue gas and slurry droplets,three regions in spray scrubber are distinguished in terms of gas-slurry flow structures using CFD method in the Eulerian-Lagrangian framework.A comprehensive model is established by involving the transfer process between two phases and chemical reactions in aqueous phase,which is validatedwith the measured data froma WFGD scrubber of 330 MW coal-fired power unit.Numerical results show that the overall uniformity degree of flue gas in whole scrubber is largely determined by the force-balanced droplets in the middle part of scrubber,which is dominated by counter-current mode.Both momentum transfer behavior and SO_(2) chemical absorption process present the synchronicity with the evolution of gas-slurry flow pattern,whilst the heat transfer together with H_(2)O evaporation has little effect on overall absorption process.Three regions are firstly defined as Gas Inlet Region(GIR),Dominant Absorption Region(DAR)and Slurry Dispersed Region(SDR)from the bottom to top of scrubber.SO_(2) is mainly scrubbed in DAR,which provides much more intensive interaction between two phases compared to GIR or SDR.A better understanding of the desulfurization process is obtained from the fundamental relationship between transport phenomena and chemical reactions based upon the complicated hydrodynamics of gas-slurry two-phase flow,which should be useful for designing and optimizing the scrubber in coal-fired power unit. | Jiangyuan Qu Nana Qi Kai Zhang Lifeng Li PengchengWang | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 0 |
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