|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Expression of the plastid-located lutamine synthetase of medicago truncatula 显示文摘 | PAULA M M LIGIA M L ISABEL M S | 2003 | Plant Physiol2003，132，1： | 1 |
| 3 | Expression of the plastidlocated glutamine synthetase of Medicago truncatula显示文摘 | Paula M M Ligia M L Isabel M S | 2003 | Plant Physiology2003，132，1： | 1 |
| 4 | Aging,ion channel expression and vascular function显示文摘 | Ligia T Jure M Kazuhide N | 2002 | Vase Pharmacol2002，38，1： | 1 |
| 5 | Molecular and Biochemical Characterization of a high Stabile Bacterial Laccase that Occures as a Structural Component of the Bacllussubtilis Endospore Coat显示文摘 | Ligia O Martins Claudio M Soarest ManuelaM | 2002 | The Journal of Biological Chemistry2002，277，18： | 1 |
| 6 | Nonlinear Coherent States for Optimizing Quantum Information显示文摘 | CURADO E M F GAZEAU J P RODRIGUES LIGIA M C S | 2010 | PhysScr2010，82，03： | 1 |
| 7 | Crystal Structure of a Bacterial Endospore Coat Component 显示文摘 | Francisco J Enguita Ligia O M artins Adriano O H Enrique | 2003 | The Journal of Biological Chemistry2003，278，19： | 1 |
| 8 | Expression of the plastid2 located lutamine synthetase of medicago truncatula显示文摘 | Paula M M Ligia M L Isabel M S | 2003 | Plant Physiol2003，132，1： | 1 |
| 9 | Biosurfactant from Lactococcus lactis 53 inhibits microbial adhesion on silicone rubber显示文摘 | Ligia R Henny M Jose AT | 2004 | Applied Microbiology and Biotechnology2004，66，3： | 1 |
| 10 | Crystal structure of a bacterial endospore coat component显示文摘 | Ligia O M Adriano O H | 2003 | J Biolo Chem2003，278，19： | 1 |
| 11 | Improved isolation of murine hepatocytes for in vitro malaria liver stage studies 显示文摘 | Ligia A Goncalves Ana M Vigario Carlos Penha-Goncalves | 2007 | Malaria Journal2007，6，： | 1 |
| 12 | Aging, ion channel expression and vascular function 显示文摘 | Ligia T Jure M Kazuhide N | 2002 | Vasc Pharmacol2002，38，1： | 1 |
| 13 | Agingion channel expression and vascular function显示文摘 | LIGIA M JURE N KAZUHIDE T | 2002 | Vasc Pharmacol2002，38，： | 1 |
| 14 | Spectroscopic methods for the analysis of celadonite and glauconite in Roman green wall paintings 显示文摘 | Ligia M Emilio F O Gian A M | 2011 | J Cult Herit2011，，12： | 1 |
| 15 | Different mutation profiles associated to P53 accumulation in colorectal cancer显示文摘 | Ignacio López Ligia P. Oliveira Paula Tucci Fernando álvarez-Valín Renata A. Coudry Mónica Marín | 2012 | Gene2012，，1： | 1 |
| 16 | Substrate and dioxygen binding to the endospore coat laccase from Bacillus subtilis显示文摘 | David M Ligia O M | 2004 | The Journal of Biological Chemistry2004，22，23： | 1 |
| 17 | Molecular and biochemical characterization of a high stabile bacterial laccase that occures as a structural component of the Bacillus subtilis endospore coat显示文摘 | Claudio M S Manuela M | 2002 | The Journal of Biological Chemistry2002，21，18： | 1 |
| 18 | Fibrodysplasia ossificans progressiva European journal of dermatology 显示文摘 | Maria B Slavomir M Ligia B | 2003 | Genes and Skin2003，13，3： | 1 |
| 19 | Expression of the plastid - located lutamine synthetase of medicago truncatula 显示文摘 | Paula M M Ligia M L Isabel M S | 2003 | Plant Physiol2003，132，1： | 1 |
| 20 | Characterization of hyperbranched polyol polyesters based on 2,2-bis (methylol propionic acid) and pentaerythritol显示文摘 | Edwin A M Pedro P V Ligia S | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员