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| 1 | Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis显示文摘Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular components.It has been proven that autophagy could be utilized for cell survival under stresses.Hypoxic-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ischemia-reperfusion.However,it has never been fully understood how leptin was involved in the protective effects conferred by autophagy.In the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome formation.Interestingly,similar effects were also observed when BMSCs were pretreated with rapamycin.The beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/SD.Furthermore,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin expression.Our data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway. | WANG LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan WANG JianAn | 2014 | Science China(Life Sciences)2014，57，2： | 8 |
| 2 | Long-tailed object detection of kitchen waste with class-instance balanced detector显示文摘Intelligent detection and classification of kitchen waste can promote ecological sustainability by replacing inefficient manual processes.However,the presence of non-degradable waste mixed in kitchen waste often follows a long-tailed distribution,making it challenging to train convolutional neural network-based object detectors,which results in the unsatisfactory detection of tailclass waste.To address this challenge,we propose a class-instance balanced detector(CIB-Det) for intelligent detection and classification of kitchen waste.CIB-Det implements two strategies for the loss function:the class-balanced strategy(CBS)and the instance-balanced strategy(IBS).The CBS focuses more on tail classes,and the IBS concentrates on hard-to-classify instances adaptively during training.Consequently,CIB-Det comprehensively and adaptively addresses the long-tailed issue.Our experiments on a real dataset of kitchen waste images support the effectiveness of CIB-Det for kitchen waste detection. | FANG LeYuan TANG Qi OUYANG LiHan YU JunWu LIN JiaXing DING ShuaiYu TANG Lin | 2023 | Science China(Technological Sciences)2023，66，8： | 1 |
| 3 | Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension显示文摘Aortic stenosis(AS)is a progressive heart valve disease occurring predominantly in older patients.According to a survey in a western country,the prevalence of AS is nearly 6.4%in patients over 75 years old(Carabello and Paulus,2009).Transcatheter aortic valve replacement(TAVR)is an alternative method for AS patients.Previous studies have described how up to 66%of TAVR patients have concomitant baseline kidney dysfunction(Ferro et al.,2015;Gargiulo et al.,2015).The majority of patients can benefit from the TAVR procedure with the recovery of kidney function. | Jiaqi FAN Changjie YU Kaida REN Wanbing LIN Stella NG Zexin CHEN Xinping LIN Lihan WANG Qifeng ZHU Yuxin HE Jubo JIANG Xianbao LIU Jian'an WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 1 |
| 4 | Application of Deep Inspiration Breath Hold Technique in Radiotherapy After Breast- Conserving Surgery for Left Breast Cancer and Its Improvement on Cardiac Dose显示文摘Objective:To analyze the application of deep inspiration breath hold technique in radiotherapy after breast-conserving surgery for left breast cancer and the improvement of cardiac dose.Methods:A total of 45 patients with left breast cancer treated in our hospital after breast-conserving surgery were selected,and the selection time was set from January 2020 to August 2022.All patients received radiotherapy.The right breast,heart,and lung volumes,and dose parameters of the heart,lungs,right breast,and left anterior descending coronary artery were compared under free breathing(FB)and deep inspiration breath hold(DIBH)technical modes.Results:The heart volume of the DIBH group was smaller than that of the FB group,and the left and right lung volumes were significantly larger than those of the FB group.In the DIBH group,the heart dose parameters V5,proper lung dose parameters,and left anterior descending coronary artery dose parameters were found lower than that of the FB group,and the differences were statistically significant(P<0.05).Conclusion:Compared with FB,the DIBH technique can reduce the heart’s size and increase the lung volume when used for radiotherapy after breast-conserving surgery for left breast cancer.It also reduces the dose to the heart,right lung,and left anterior descending coronary artery,thus protecting the heart and lungs. | Yu Luo Lihan Huang Qiao Lan Yurui Wu Yin Li Xiaorong Cheng Kunhai Xiong Xiaoyu Wu | 2023 | Proceedings of Anticancer Research2023，7，5： | 0 |
| 5 | Safety analysis of COVID-19 vaccines in liver transplant recipients:a two-center study显示文摘Up to know,product information for COVID-19 mRNA vaccines do not include their use in patients receiving immunosuppressive medication,since they were not included in trials(1).For the BNT162b2 mRNA vaccine,one case of otherwise totally asymptomatic elevations of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)andγ-glutamyl transpeptidase(GGT)serum concentrations in a liver transplant recipient has been reported after the first injection(2).In the present retrospective study,we present safety outcomes of COVID-19 vaccinations in 56 liver transplant patients from two Chinese centers vaccinated with the domestic PiCoVacc,BBIBP-CorV and ZF2001 vaccines.Thirty vaccinated physicians from the Hepatopancreatobiliary Center of Beijing Tsinghua Changgung Hospital served as control,from which 1 participant received an Ad5-nCoV vaccine.The study deadline was 2021-10-31.The observation period for adverse reactions,such as muscle pain and fatigue was 1 week,while for laboratory examinations such as liver function the follow-up period was 1 month. | Rui Tang Chao Li Guangdong Wu Xuan Tong Lihan Yu Huayuan Hao Rui Liao Yucheng Hou Jun Li Wenping Zhao Tieyan Fan Leida Zhang Qian Lu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 0 |
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