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| 1 | The molecular machinery of regulated cell death显示文摘Cells may die from accidental cell death(ACD)or regulated cell death(RCD).ACD is a biologically uncontrolled process,whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms.A growing number of novel nonapoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies.Here,we critically review the current state of the art regarding non-apoptotic types of RCD,including necroptosis,pyroptosis,ferroptosis,entotic cell death,netotic cell death,parthanatos,lysosome-dependent cell death,autophagy-dependent cell death,alkaliptosis and oxeiptosis.The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidanee of pathogenic cell loss. | Daolin Tang Rui Kang Tom Vanden Berghe Peter Vandenabeele Guido Kroemer | 2019 | Cell Research2019，29，5： | 143 |
| 2 | Ferroptosis:molecular mechanisms and health implications显示文摘Cell death can be executed through different subroutines.Since the description of ferroptosis as an iron-dependent form of nonapoptotic cell death in 2012,there has been mounting interest in the process and function of ferroptosis.Ferroptosis can occur through two major pathways,the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.Ferroptosis is caused by a redox imbalance between the production of oxidants and antioxidants,which is driven by the abnormal expression and activity of multiple redox-active enzymes that produce or detoxify free radicals and lipid oxidation products.Accordingly,ferroptosis is precisely regulated at multiple levels,including epigenetic,transcriptional,posttranscriptional and posttranslational layers.The transcription factor NFE2L2 plays a central role in upregulating anti-ferroptotic defense,whereas selective autophagy may promote ferroptotic death.Here,we review current knowledge on the integrated molecular machinery of ferroptosis and describe how dysregulated ferroptosis is involved in cancer,neurodegeneration,tissue injury,inflammation,and infection. | Daolin Tang Xin Chen Rui Kang Guido Kroemer | 2021 | Cell Research2021，31，2： | 182 |
| 3 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 4 | Augmented reality technology for preoperative planning and intraoperative navigation during hepatobiliary surgery: A review of current methods显示文摘Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes.Data Sources: The keywords 'augmented reality', 'liver', 'laparoscopic' and 'hepatectomy' were used for searching publications in the Pub Med database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key articles.Results: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery,which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR technology.Conclusions: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling,and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods. | Rui Tang Long-Fei Ma Zhi-Xia Rong Mo-Dan Li Jian-Ping Zeng Xue-Dong Wang Hong-En Liao Jia-Hong Dong | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 27 |
| 5 | Precise orbit determination for geostationary satellites with multiple tracking techniques显示文摘A new precise orbit determination (POD) strategy based on the combination of satellite laser ranging (SLR) and C-band transfer ranging for geostationary satellites (GEO) is presented.Two approaches to calibrate ranging biases of the C-band ranging system are proposed,namely the two tracking system co-location comparison and the combined POD method,with calibration accuracies estimated to be 0.5 ns and 1 ns respectively.Using data from a C-band tracking network in China,POD experiments indicate that meter-level POD accuracy is achievable for GEO.Root-mean-square (RMS) of the post-fit C-band ranging data is about 0.205 m.The radial component errors of POD are evaluated with SLR data from a station in Beijing,with residual RMS of 0.133 m.Orbital overlapping experiments show the total orbit error is a few meters.Computations of SLR residuals also suggest that for 2-hour prediction,the predicted radial error is about 0.373 m. | GUO Rui HU XiaoGong TANG Bo HUANG Yong LIU Li CHENG LiuCheng HE Feng | 2010 | Chinese Science Bulletin2010，55，8： | 24 |
| 6 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 7 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 8 | Gut microbiome,liver immunology,and liver diseases显示文摘The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology.The liver is a central immunological organ that is particularly enriched in innate immune cells and constantly exposed to circulating nutrients and endotoxins derived from the gut microbiota.The delicate interaction between the gut and liver prevents accidental immune activation against otherwise harmless antigens.Work on the interplay between the gut microbiota and liver has assisted in understanding the pathophysiology of various liver diseases.Of immense importance is the step from high-throughput sequencing(correlation)to mechanistic studies(causality)and therapeutic intervention.Here,we review the gut microbiota,liver immunology,and the interaction between the gut and liver.In addition,the impairment in the gut-liver axis found in various liver diseases is reviewed here,with an emphasis on alcohol-associated liver disease(ALD),nonalcoholic fatty liver disease(NAFLD),and autoimmune liver disease(AILD).On the basis of growing evidence from these preclinical studies,we propose that the gut-liver axis paves the way for targeted therapeutic modalities for liver diseases. | Rui Wang Ruqi Tang Bo Li Xiong Ma Bernd Schnabl Herbert Tilg | 2021 | Cellular & Molecular Immunology2021，18，1： | 23 |
| 9 | Diagnostic value of tumor marker pro-gastrin-releasing peptide in patients with small cell lung cancer: a systematic review显示文摘背景肺癌症是在世界上的最普通的恶意之一并且导致死亡的领先的癌症之一。这研究的目的是与怀疑的小房间肺癌症( SCLC )作为在病人标准的引用评估并且比较浆液肿瘤标记 pro-gastrin-releasing 肽 31-98 ( ProGRP31-98 )的诊断的值到病理学的诊断直盖住 1978 到 2009 的 .Methods 文学搜索在 Pubmed 被执行,奥维德, MEDLINE , EMbase , Cancerlit ,中国知识基础结构( CNKI ),和用钥匙的 CBM 寻找词;“小房间肺癌症”,“肿瘤标记”,“ ProGRP31-98 ”和“诊断测试”,“ ELISA ”,“ EIA ”和“诊断精确性”。研究被收集,数据分析了与病理相比为 SCLC 的诊断评估浆液 ProGRP31-98 层次的诊断价值。为在分析的包括的资格标准为屏蔽的 Cochrane 和诊断测试方法组(SDTMG ) 出版的诊断研究基于标准。包括的文章的特征被估价,数据用评论经理 4.2 软件为学习异质的进一步统计的分析从原来的文章被提取。基于学习异质分析,合适的“效果”模型被选择由元分析计算分享的敏感和特性。在曲线(AUC ) 下面操作特征(SROC ) 曲线和区域的概括接收装置被产生, 22 篇文章全部的敏感分析 conducted.Results A 被进入这元评论,包括 11 英语有在水平 C 的质量的文章。总共,研究包含了 6759 个题目, 1470 被与 non-SCLC (NSCLC ) 诊断的病理,和 5289 个题目与 SCLC 诊断。元分析证明在研究之中的异质高(P=0.00001,(I2 )=86.8%) 。与 ELISA,分享的敏感是 0.72 (0.70 ~ 0.75 在 95% Cl ) 并且分享的特性是 0.93 (0.92to 0.94 在 95% Cl ) ;SROC 和 AUC 是 0.8817。这些数据建议那 ProGRP31-98 错过的诊断(28%) 的相对高的率,而是错误诊断(7%) 的相对低的率从元分析的 .Conclusion,我们断定浆液 ProGRP31-98 是有为有到病理的类似的诊断精确性的 SCLC 的诊断的高特性的一个珍贵标记。 | TANG Jian-hua ZHANG Xiu-long ZHANG Zhi-hua WANG Rui ZHANG He-ming ZHANG Zhi-lin WANG Jing-hui REN Wei-dong | 2011 | Chinese Medical Journal2011，，10： | 21 |
| 10 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 11 | Bone morphogenetic protein 2 promotes transforming growth factor β3-induced chondrogenesis of human osteoarthritic synovium-derived stem cells显示文摘有更高的 chondrogenic 潜力的背景导出 Synovium 的干细胞(SDSC ) 为软骨新生作为房间来源正在吸引可观的注意。我们调查了骨头的效果形态基因的蛋白质(BMP-2 ) 2 在转变生长因素 beta3 (TGF-3 ) 以后导致了在一个小团文化系统从人的 osteoarthritic synovium 孤立的 SDSC 的 chondrogenesis。clonogenicity,干细胞标记表示和孤立的 SDSC 的多区别潜力被殖民地形成统一试金,流动 cytometry 并且包括分别地染色的茜素红 S,油红 O 和 alcian 蓝色的特定的染色决定的方法。SDSC 小团在与或没有 TGF-3 或 / 并且 BMP-2 中等的 chondrogenic 是有教养的。在白天 21 点,直径和小团的重量被测量。SDSC 的 Chondrogenic 区别被藏红染料 O 染色,骨胶原类型染色的 immunohistochemical, sulfated glycosaminoglycan (sGAG ) 合成和骨胶原类型, aggrecan, SOX9,连接蛋白质,骨胶原类型 X 和 BMP 受体的 mRNA 表示评估。在优化 culturing 密度(104/60 cm2 ) 下面孤立的结果房间显示出 clonogenicity 和多区别潜力。这些房间是积极的(99 ) 为 CD44, CD90, CD105 并且否定(10 ) 为 CD34 和 CD71。在包含 TGF-3 与或没有 BMP-2 的 chondrogenic 媒介区分到 chondrocytic 显型的 SDSC。细胞外的矩阵染色的藏红染料 O 是积极的,骨胶原类型的表示被检测。房间小团独自与 TGF-3 对待, BMP-2 在直径和重量是更大的,生产了更多的 sGAGs,并且表示了骨胶原类型和另外的 chondrogenic 标记的高水平,比有 TGF-3 的媒介,除了 COL10A1。结论 SDSC 能从人的 osteoarthritic synovium 被孤立。有 BMP-2 的补充显著地支持了在里面 SDSC 的 vitro TGF-3-induced chondrogenic 区别。 | RUI Yun-feng DU Lin WANG You WANG Yang LUI Pauline po-yee TANG Ting-ting CHAN Kai-ming DAI Ke-rong | 2010 | Chinese Medical Journal2010，，21： | 19 |
| 12 | Fluxes of CH4 and N_2O from soil under a tropical seasonal rain forest in Xishuangbanna, Southwest China显示文摘从在在 Xishuangbanna 的热带季节的雨林下面的土壤的 CH4 和 N2O 流动,西南中国用关上的静态的房间技术和气体色层法方法被测量一年。三个处理被放在学习的地里:(A) 没有崽,有垃圾的(B) ,和有垃圾和幼苗的(C) 。结果证明在我们的学习的土壤是大气的 CH4 的一个水池和大气的 N2O 的来源。从处理 A, B,和 C 的观察吝啬的 CH4 流动是 50.0 ± 4.0, 35.9 ± 2.8, 31.6 ± 2.8 μ g C/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动是 2.8, 2.6,和 3.7 kgN/hm 2 分别地。在 CH4 和 N2O 流动的季节变化在所有三个处理之中是重要的。垃圾的存在减少了 CH4 举起在湿季节期间(P < 0.05 ) ,然而并非在干旱期期间。调停幼苗的 N2O 排出物有类似的增加在期间湿并且干旱期,显示幼苗在两个季节增加了 N2O 排放。一种强壮的积极关系为处理 B 和处理 C 为所有三个处理,和在 CH4 流动和土壤温度之间的弱关系在 CH4 流动和土壤潮湿之间存在。N2O 流动为所有三个处理与土壤温度相关。 | YAN Yuping SHA Liqing CAO Min ZHENG Zheng TANG Jianwei WANG Yinghong ZHANG Yiping WANG Rui LIU Guangren WANG Yuesi SUN Yang | 2008 | Journal of Environmental Sciences2008，20，2： | 18 |
| 13 | Progress in studies of huperzine A,a natural cholinesterase inhibitor from Chinese herbal medicine显示文摘Huperzine A (HupA ) ,从中国植物 Huperzia serrata 孤立的新奇的碱,是一个有势力,乙酰胆碱酯酶(疼痛) 的高度特定、可逆的禁止者。与 tacrine, donepezil,和 rivastigmine 相比, HupA 通过疼痛的血大脑障碍,更高口头的简历可获得性,和更长的持续时间有更好的穿入禁止的行动。HupA 被发现了在大量动物模型改进认知赤字。HupA 拥有能力保护房间免于过氧化氢,贝它淀粉的蛋白质(或肽) ,充斥使挫折,局部缺血和导致 staurosporine 的细胞毒性和 apoptosis。这些保护的效果与它稀释氧化应力的能力有关,调整 apoptotic 蛋白质 Bcl-2, Bax, P53,和 caspase-3 的表示,保护线粒体,起来调整神经生长因素和它的受体,并且防碍淀粉的先锋蛋白质代谢。在 N-methyl-D-aspartate 受体和钾水流上反对 HupA 的效果可以也也贡献它的 neuroprotection。在啮齿类动物, canines,和健康人的志愿者的 Pharmacokinetic 研究显示 HupA 很快被吸收,在身体广泛地散布了,并且以有在口服以后的慢、延长的版本的性质的中等的率消除了。动物和临床的安全测试证明 HupA 没有意外毒性,特别地,限制剂量的 hepatotoxicity 由 tacrine 导致了。在中国的阶段 IV 临床的试用证明了 HupA 显著地与 Alzheimer 疾病和脉管的痴呆与良性的衰老的健忘,和病人在老人改进了记忆赤字,与最小的外部胆碱能的副作用和没有意外毒性。HupA 能也对 organophosphate 沉醉被用作一个保护的代理人。 | Rui WANG Han YAN Xi-can TANG | 2006 | Acta Pharmacologica Sinica2006，27，1： | 18 |
| 14 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 15 | Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions显示文摘 | Zhen Bian Li-Min Li Rui Tang Dong-Xia Hou Xi Chen Chen-Yu Zhang Ke Zen | 2010 | Cell Research2010，20，9： | 15 |
| 16 | Antipyretic and anti-inflammatory activities of Thais luteostoma extracts and underlying mechanisms显示文摘Thais luteostoma has been utilized as a crude drug whose shell and soft tissue have been widely used for the treatment of heat syndrome in China for thousands of years. The present study was designed to investigate the antipyretic and anti-inflammatory activities of T. luteostoma. T. luteostoma was divided into shell(TLSH) and soft tissue(TLST) samples in the present study. The rat model of yeast-induced fever was used to investigate their antipyretic effects; and the rat model of hind paw edema induced by carrageenan was utilized to study their anti-inflammatory activities, and at the same time, the concentration variations of the central neurotransmitter [prostaglandin E2(PGE2) and cyclic adenosine monophosphate(cA MP)], inflammatory mediators [tumor necrosis factor(TNFα), interleukin-1β(IL-1), interleukin-2(IL-2) and interleukin-6(IL-6)] and ion(Na+ and Ca2+) were also tested. The results showed that TLSH and TLST extracts significantly inhibited yeast-induced pyrexia in rats(P < 0.05), and exhibited more lasting effects as compared to aspirin, and TLSH had the better antipyretic activity than TLST, and that TLSH and TLST could significantly prevent against carrageenan induced paw edema in rats(P < 0.05); and markedly reduced levels of PGE2, cA MP, TNFα, IL-1β, IL-2, IL-6, and Na+/Ca2+. In fever model, TLST could significantly reduce the levels of PGE2(P < 0.01) in rats' homogenate and TNFα(P < 0.05), IL-1β(P < 0.01) in the plasma than TLSH, whereas TLSH could reduce the content of IL-2(P < 0.01) and IL-6(P < 0.01) in plasma and increase the content of Ca2+(P < 0.01) in plasma and homogenate more significantly than TLST. In conclusion, T. luteostoma extract has antipyretic and anti-inflammatory activities, which may be mediated through the suppression of production of PGE2, c AMP, Na+/Ca2+, TNFα, IL-1β, IL-2, and IL-6. | LIU Xin TANG Yu-Ping LIU Rui JIN Yi GUO Jian-Ming ZHAO Jin-Long DING Shao-Xiong LIN Xiang-Zhi LIN Ru-Rong DUAN Jin-Ao | 2015 | Chinese Journal of Natural Medicines2015，13，3： | 15 |
| 17 | Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy显示文摘Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined. | Hao Peng Lei Chen Ling-Long Tang Wen-Fei Li Yan-Ping Mao Rui Guo Yuan Zhang Li-Zhi Liu Li Tian Xu Zhang Xiao-Ping Lin Ying Guo Ying Sun Jun Ma | 2017 | Chinese Journal of Cancer2017，36，12： | 14 |
| 18 | The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy显示文摘在母亲 / 胎儿的接口的 Th2 偏爱的规章的机制仍然保持不清楚。在这研究,我们在蜕膜的 stromal 描绘了 cytokine 生产房间(DSC ) ,蜕膜的有免疫力的房间(DIC ) 和导出胚胎的 trophoblast 房间,并且在早人的怀孕在母亲 / 胎儿的接口在 Th2 偏爱上调查了 CXCL12/CXCR4 相互作用的规定。我们由 trophoblasts, DSC 和 DIC 发现了 Th1 类型和 Th2 类型 cytokines 的微分生产。这些 cytokines 的分泌物在不同房间 cocultures 变化了,导致了到 Th2 偏爱。流动 cytometry 与 DSC 显示出 trophoblasts 的那 coculture, DIC 显著地在 DSC 在 trophoblasts,和 IL-10 生产增加了 IL-4 和 IL-10 生产。然而,有 DSC 和 DIC 的 trophoblasts 的 coculture 显著地增加了干扰素(IFN )-γ在 DSC,和肿瘤坏死因素(TNF )-α 的表示;在 DIC 的表示。没有变化在所有 cocultures 在 DIC 在 trophoblasts,并且在 Th2 类型 cytokine 生产在 Th1 类型 cytokine 生产被看见。而且,有抵销抗体 upregulated 的 anti-CXCR4 的预告的处理 Th1 类型 cytokines IFN-γ 的生产;并且 TNF-α,并且 downregulated Th2 类型 cytokines IL-4 和 IL-10 的生产在 trophoblasts, DSC, DIC 或他们的 cocultures。有趣地, rhCXCL12 禁止了 Th1 类型 cytokine TNF-α 的生产;并且在 DIC 提高了象 IL-4 和 IL-10 那样的 Th2 类型 cytokines 的表示;这效果被 anti-CXCR4 抗体废除。我们的现在的学习阐明了到塑造 Th2 的部件房间的单个贡献偏导,并且揭开经由在在早人的怀孕的母亲 / 胎儿的接口的 CXCL12/CXCR4 信号的复杂串音。 | Hai-Lan Piao Yu Tao Rui Zhu Song-Cun Wang Chuan-Ling Tang Qiang Fu Mei-Rong Du Da-Jin Li | 2012 | Cellular & Molecular Immunology2012，9，5： | 14 |
| 19 | China's provincial CO2 emissions embodied in trade with implications for regional climate policy显示文摘 | Zhangqi ZHONG Rui HUANG Qinneng TANG Xiaonan CONG Zheng WANG | 2015 | Frontiers of Earth Science2015，9，1： | 14 |
| 20 | Prognostic factors for chronic severe hepatitis and construction of a prognostic model显示文摘BACKGROUND: Chronic severe hepatitis is a serious illness with a high mortality rate. Discussion of prognostic judgment criteria for chronic severe hepatitis is of great value in clinical guidance. This study was designed to investigate the clinical and laboratory indices affecting the prognosis of chronic severe hepatitis and construct a prognostic model. METHODS: The clinical and laboratory indices of 213 patients with chronic severe hepatitis within 24 hours after diagnosis were analyzed retrospectively. Death or survival was limited to within 3 months after diagnosis. RESULTS: The mortality of all patients was 47.42%. Compared with the survival group, the age, basis of hepatocirrhosis, infection, degree of hepatic encephalopathy (HE) and the levels of total bilirubin (TBil), total cholesterol (CHO), cholinesterase (CHE), blood urea nitrogen (BUN), blood creatinine (Cr), blood sodium ion (Na), peripheral blood leukocytes (WBC), alpha-fetoprotein (AFP), international normalized ratio (INR) of blood coagulation and prothrombin time (PT) were significantly different in the group who died, but the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB) and hemoglobin (HGB) were not different between the two groups. At the same time, a regression model, Logit (P)=1.573×Age+1.338× HE-1.608×CHO+0.011×Cr-0.109×Na+1.298×INR+11.057, was constructed by logistic regression analysis and the prognostic value of the model was higher than that of the MELD score.CONCLUSIONS: Multivariate analysis excels univariate anlysis in the prognosis of chronic severe hepatitis, and the regression model is of significant value in the prognosis of this disease. | Li, Qian Yuan, Gui-Yu Tang, Ke-Cheng Liu, Guo-Wang Wang, Rui Cao, Wu-Kui | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 13 |
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