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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Neurohumoral features of myocardial stunning due to sudden emotional stress 显示文摘 | Wittstein I S Thiemann D R Lima J A | 2005 | N Engl J Med2005，352，6： | 1 |
| 3 | The SUMO pathway:emerging mechanisms that shape specificity,conjugation and recognition显示文摘 | Gareau J R Lima C D | | 0，，12： | 1 |
| 4 | The endocannabinoid system in renal cells: regulation of Na+ transport by CB1 receptors through distinct cell signaling pathways显示文摘 | Sampaio L S Taveira Da Silva R Lima D | 2015 | Br J Pharmacol2015，172，19： | 1 |
| 5 | Engineering properties of fiber reinforced cold asphalt mixes显示文摘 | BUENO B D SILVA W R D LIMA D C | 2003 | Journal of Environmental Engineering2003，129，10： | 1 |
| 6 | Neurohumoral features of myocardial stunning due to sudden emotional stress显示文摘 | WITTSTEIN I S THIEMANN D R LIMA J A C | 2005 | N Engl J Med2005，352，： | 1 |
| 7 | Rodlike cellulose microcrystals:structure,properties,and applications显示文摘 | Lima M M D Borsali R | 2004 | Macromolecular Rapid Communications2004，25，7： | 1 |
| 8 | Secondary hyperalgesiain the monoarthritic rat is mediated by GABABand NK 1re-ceptors of spinal dorsal horn neurons:a behavior and c-fosstudy显示文摘 | Castro A R Pinto M Lima D | 2006 | Neuroscience2006，41，4： | 1 |
| 9 | Monitoring program for the first steel catenary riser installed in a moored floating platform in deep water显示文摘 | Machado R Z Mourelle M M Franciss R Silva R M Lima C S Eisemberg R Oliveira D | 1999 | Oceans Conference Record (IEEE)1999，2，： | 1 |
| 10 | Neurohumoral features of myocardial stunning due to sudden emotional stress显示文摘 | Wittstein I S Thiemann D R Lima J A et a1 | | 0，，： | 1 |
| 11 | Integrated control of blue mould using new fungicides and biocontrol yeasts lowers levels of fungicides residues and patulin contamination in apples显示文摘 | LIMA G CASTORIA R CURTIS F D | | 0，，02： | 1 |
| 12 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 13 | 显示文摘 | Abreu F R Lima D G Hamu E H | 2003 | JAOCS2003，80，6： | 1 |
| 14 | The role of depositional setting and diagenesis on the reservoir quality of Devonian sandstones from the Solimoes Basin, Brazil Amazonia显示文摘 | Lima R D De Ros L R | 2002 | Marine and Petroleum Geology2002，19，： | 1 |
| 15 | Beta-p-I, 3-glu- eanase activity of two saprophytic yeasts and possible mode of action as biocontrol agents against postharvest diseases 显示文摘 | EASTORIA R CURRIS F D LIMA G | 1997 | Posthavest Biology and Technology1997，12，： | 1 |
| 16 | Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells显示文摘 | Scolastici C Alves D E Lima R O | 2007 | Toxicology in Vitro2007，21，5： | 1 |
| 17 | Expansion of HAART coverage is associated with sustained decreases in HIV/AIDS morbidity, mortality and HIV transmission: the 'HIV Treatment as Prevention' experience in a Canadian setting 显示文摘 | Montaner J S Lima V D Harrigan P R | 2014 | PLoS One2014，9，87： | 1 |
| 18 | Neurohumoral features of myocardial stunning due to sudden emotional stress显示文摘 | WITTSTEIN I S THIEMANN D R LIMA J A C | 2005 | N Engl J Med2005，352，： | 1 |
| 19 | Thermal degradation of biodegradable edible films based on xanthan and starches from different sources显示文摘 | Soares R M D Lima A M F Oliveira R V B | 2005 | Polym Degrad Stab2005，4，7： | 1 |
| 20 | Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in conscious rats显示文摘 | PAULA R D LIMA C V KHOSLA M C | 1995 | Hypertension1995，26，62： | 1 |
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