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| 1 | Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma显示文摘Objective: To investigate the frequency of parasympathetic neurogenesis and determine its association with tumor budding and prognosis in pancreatic ductal adenocarcinoma(PDAC).Methods: Parasympathetic neurogenesis was defined as the distribution of abnormal parasympathetic nerves in the stroma tissue. Staining of vesicular acetylcholine transporter(VACh T), as a marker for parasympathetic neurogenesis, was performed on a representative specimen of the tumor for 59 PDAC patients with available clinical, pathologic, and follow-up information. Three specimens containing normal pancreatic tissues were stained in parallel. The number of parasympathetic nerve fibers was counted in five high-power microscopic fields(5×0.785 mm^2). Cut-off values were calculated by receiver operating characteristic curve analysis.Results: VACh T-positive parasympathetic nerve fibers were not seen in the stroma of 3 cases of normal pancreatic tissues. In 59 PDAC cases, the range of parasympathetic neurogenesis was 4-38 fibers/(5×0.785) mm^2, with a median of 18 fibers/(5×0.785) mm^2. Patients with parasympathetic neurogenesis >15 fibers/(5×0.785) mm^2 were defined as the high-density group(39 patients, 66.1%), and those with parasympathetic neurogenesis ≤15 fibers/(5×0.785) mm^2 as the low-density group(20 patients, 33.9%). The high-density group had a higher occurrence of tumor budding(P=0.001) and a higher rate of early recurrence(P=0.035). Parasympathetic neurogenesis appeared to be an independent adverse prognostic factor [hazard ratio(HR)=2.45, 95% confidence interval(95% CI): 1.25-4.81, P=0.009], in addition to American Joint Committee on Cancer(AJCC) stage(P=0.010) and tumor budding(P=0.009).Conclusions: Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in PDAC. | Lingfu Zhang Limei Guo Ming Tao Wei Fu Dianrong Xiu | 2016 | Chinese Journal of Cancer Research2016，28，2： | 8 |
| 2 | Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering显示文摘Vascular grafts must avoid negative inflammatory responses and thrombogenesis to prohibit fibrotic deposition immediately upon implantation and promote the regeneration of small diameter blood vessels(<6 mm inner diameter).Here,polyurethane(PU)elastomers incorporating anti-coagulative and anti-inflammatory Gastrodin were fabricated.The films had inter-connected pores with porosities equal to or greater than 86%and pore sizes ranging from 250 to 400μm.Incorporation of Gastrodin into PU films resulted in desirable mechanical properties,hydrophilicity,swelling ratios and degradation rates without collapse.The released Gastrodin maintained bioactivity over 21 days as assessed by its anti-oxidative capability.The Gastrodin/PU had better anti-coagulation response(less observable BSA,fibrinogen and platelet adhesion/activation and suppressed clotting in whole blood).Red blood cell compatibility,measured by hemolysis,was greatly improved with 2Gastrodin/PU compared to other Gastrodin/PU groups.Notably,Gastrodin/PU upregulated anti-oxidant factors Nrf2 and HO-1 expression in H2O2 treated HUVECs,correlated with decreasing pro-inflammatory cytokines TNF-αand IL-1β in RAW 264.7 cells.Upon implantation in a subcutaneous pocket,PU was encapsulated by an obvious fibrous capsule,concurrent with a large amount of inflammatory cell infiltration,while Gastrodin/PU induced a thinner fibrous capsule,especially 2Gastrodin/PU.Further,enhanced adhesion and proliferation of HUVECs seeded onto films in vitro demonstrated that 2Gastrodin/PU could help cell recruitment,as evidenced by rapid host cell infiltration and substantial blood vessel formation in vivo.These results indicate that 2Gastrodin/PU has the potential to facilitate blood vessel regeneration,thus providing new insight into the development of clinically effective vascular grafts. | Meng Zheng Jiazhi Guo Qing Li Jian Yang Yi Han Hongcai Yang Mali Yu Lianmei Zhong Di Lu Limei Li Lin Sun | 2021 | Bioactive Materials2021，6，2： | 7 |
| 3 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 4 | Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients显示文摘 | Guo Limei Huang Yonghui Wang Tianli Shi Xueying Chang Hong Yao Wei Huang Xuebiao | 2014 | Chinese Medical Journal2014，，23： | 5 |
| 5 | Research Progress of Active Ingredients and Pharmacological Action of Honeysuckle显示文摘Honeysuckle,the dry flower bud or with open flower of Lonicera japonica in caprifoliaceae,has been touted as a cure-all for heat-clearing and detoxifying effect.Honeysuckle contains abundant components such as volatile oil,flavonoids and organic acids,playing the role of antibiosis,antivirus,antiphlogosis,immunopotentiation and antioxidation.The active ingredients and pharmacological action of honeysuckle are reviewed in the paper,so as to lay the foundation for further application of honeysuckle in veterinary clinic. | Zhang Zhimei Guo Shijin Fu Shijun Xu Qianqian Yang Limei Zhang Ying Wang Yanping Ma Li Wang Jianjun Shen Zhiqiang | 2014 | Animal Husbandry and Feed Science2014，6，1： | 4 |
| 6 | Effects of Shuanghuanglian Propolis Oral Liquid on Growth Performance,Slaughter Performance and Meat Quality of Broilers显示文摘[Objective] The paper was to investigate the effects of adding Shuanghuanglian propolis oral liquid in drinking water on growth performance,slaughter performance and meat quality of broilers. [Method]Ninety one-day-old broilers were randomly divided into three groups( group Ⅰ,group Ⅱ and group Ⅲ) : group Ⅰ was the control group,and groups Ⅱ and Ⅲ were added 0. 5 and 1. 0 mL / L Shuanghuanglian propolis oral liquid in drinking water,respectively.[Result] Compared with broilers in group I,the average daily feed intakes of broilers in group Ⅱ and group Ⅲ were increased by 0. 86%( P > 0. 05) and 1. 10%( P > 0. 05),respectively; the average daily gains were increased by 2. 33%( P < 0. 05) and 4. 43%( P < 0. 05),respectively; the feed gain ratios were decreased by 1. 05%( P >0. 05) and 2. 63%( P <0. 05),respectively; the slaughter rates were increased by 0. 94%( P >0. 05) and 1. 70%( P <0. 05),respectively; the eviscerated rates were increased by 0. 52%( P > 0. 05) and 1. 15%( P > 0. 05),respectively; the semi-eviscerated rates were increased by 1. 51%( P < 0. 05) and 2.23%( P < 0. 05),respectively; the breast muscle rates were increased by 3. 77%( P < 0. 05) and 5. 51%( P < 0. 05),respectively; the leg muscle rates were increased by 1. 96%( P > 0. 05) and 4. 09%( P < 0. 05),respectively; the lightness( L*) were decreased by 0. 96%( P > 0. 05) and 1. 47%( P > 0. 05),respectively; the redness( a*) were increased by 1. 24%( P < 0. 05) and 1. 86%( P < 0. 05),respectively; the yellowness( b*) were decreased by 0. 44%( P >0. 05) and 1. 03%( P <0. 05),respectively; the drip losses were decreased by 1. 22%( P <0. 05) and 1. 56%( P <0. 05),respectively; the cooking losses were decreased by 1. 76%( P > 0. 05) and 2. 89%( P < 0. 05),respectively. [Conclusion]Adding 0. 5 and 1. 0 mL / L Shuanghuanglian propolis oral liquid in drinking water could improve growth performance,slaughter performance,meat quality of broilers,and the dose of 1. 0 mL / L is recommended in clinical application. | Ma Li Yang Limei Shen Zhiqiang Wang Yanping Xu Qianqian Zhang Ying Guo Shijin | 2016 | Animal Husbandry and Feed Science2016，8，4： | 4 |
| 7 | Microwaveassisted direct liquefaction of Ulva prolifera for bio-oil production by acid catalysis显示文摘 | Yingbin Zhuang Jingxue Guo Limei Chen | | 0，，7： | 1 |
| 8 | NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor,RIG-I显示文摘 | Guo Zhu Chen Limei Zeng Hui | 2007 | Am J Respir Cell Mol Biol2007，36，： | 1 |
| 9 | Interaction Between water-soluble rh-odium Complex RhCI (CO) (TPPTS)z and Surfactants Probed by Speetroscop-ic Methods显示文摘 | ZHOU Limei GUO Caihong FU Haiyan | 2012 | Spectrochimica Acta (Part A)2012，93，： | 1 |
| 10 | Advance in Effect of Veterinary Drug Residues on Ecological Environment显示文摘Thousands of tons of pharmaceutically active substances are used in veterinary medicines in intensive livestock and poultry production,but most of the drugs are poorly absorbed by animals and excreted with the animal feces. The veterinary medicines can cause various kinds of harmful impact to the environment.Now the relevant research has been a hot all over the world. With the feces excreted to the environment,the veterinary medicines can be accumulated in the soil and water,and produce all sorts of reaction. Some medicines can cause toxic effect to animals,plants and microorganisms. The article summarized the residue,the environmental impact,the transformation and the development direction of the veterinary medicine in the environment to supply frame of reference for further research. | Zhang Zhimei Fu Shijun Guo Shijin Zhang Ying Ma Li Yang Limei Wang Jianjun Shen Zhiqiang | 2015 | Animal Husbandry and Feed Science2015，7，3： | 1 |
| 11 | A new flavonoid glycoside and other constituents from Dracocephalum moldavica 显示文摘 | Shuang Yang Limei Wang Xiaojiang Guo | 2013 | Natural Product Re- search2013，27，3： | 1 |
| 12 | Permeable reactive barrier of surface hydrophobic granular activated carbon coupled with elemental iron for the removal of 2,4-dichlorophenol in water显示文摘 | Yang Ji Cao Limei Guo Rui | 2010 | J Hazard Mater2010，184，123： | 1 |
| 13 | Permeable reactive barrier of surface hydrophobic granular activated carbon coupled with elemental iron for the removal of 2,4-dichlorophenol in water显示文摘 | YANG Ji CAO Limei GUO Rui | 2010 | J Hazard Mater2010，184，123： | 1 |
| 14 | Dual-spar- sity preserving projeetion显示文摘 | Yan Xuemei Zhang Limei Guo Wenbin | 2012 | Transactions of Nan jing Aeronautics and Astronautics2012，29，3： | 1 |
| 15 | Robust Fuzzy Variable Structure Control of PMLSM Servo System显示文摘 | Guo QingDing Wang Limei Luo Ruifu | 1997 | IEEE International Conference on Intelligent Proceedings Systems1997，，： | 1 |
| 16 | Cancer survival in C hina, 2003–2005: A population‐based study显示文摘 | Hongmei Zeng Rongshou Zheng Yuming Guo Siwei Zhang Xiaonong Zou Ning Wang Limei Zhang Jingao Tang Jianguo Chen Kuangrong Wei Suqin Huang Jian Wang Liang Yu Deli Zhao Guohui Song Jianshun Chen Yongzhou Shen Xiaoping Yang Xiaoping Gu Feng Jin Qilong Li Yanh | 2015 | Int. J. Cancer2015，，8： | 1 |
| 17 | Cancer survival in C hina, 2003–2005: A population‐based study显示文摘 | Hongmei Zeng Rongshou Zheng Yuming Guo Siwei Zhang Xiaonong Zou Ning Wang Limei Zhang Jingao Tang Jianguo Chen Kuangrong Wei Suqin Huang Jian Wang Liang Yu Deli Zhao Guohui Song Jianshun Chen Yongzhou Shen Xiaoping Yang Xiaoping Gu Feng Jin Qilong Li Yanh | 2015 | Cancer2015，，8： | 1 |
| 18 | Advances in Research and Application of gE Gene/Protein in Prevention and Control of Swine Pseudora-bies显示文摘Research and application progresses of gE gene and its encoding gE protein in PR vaccines,diagnostic technique and epidemiological investigation are summarized,which have certain reference value for comprehensive prevention and control of PR and gradual purification of PR in different regions. | Ma Li Yang Limei Zhuang Jinqiu Xu Qianqian Wang Yan Guo Shijin Shen Zhiqiang Wang Yanping Zhang Ying | 2017 | Animal Husbandry and Feed Science2017，9，2： | 0 |
| 19 | Preliminary single-arm study of brain effects during transcutaneous auricular vagus nerve stimulation treatment of recurrent depression by resting-state functional magnetic resonance imaging显示文摘OBJECTIVE:To examine the brain effects of transcutaneous auricular vagus nerve stimulation(ta VNS)treatment of recurrent depression based on the functional brain network by using resting-state functional magnetic resonance imaging(f MRI).METHODS:Twenty-five patients with recurrent depression were enrolled in a single-arm trial of ta VNS treatment for eight weeks.Clinical results were assessed by 17-item Hamilton Depression Rating Scale(HAMD-17),Hamilton Anxiety Scale(HAMA),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),and Ruminative Response Scale(RRS)scales.Resting-state f MRI was conducted to explore the brain effects before and after treatment.For the functional connectivity(FC)analysis,the bilateral nucleus accumbens,globus pallidus,caudate,and putamen were selected as seeds.Finally,the correlations between FC and the clinical scale scores were calculated.RESULTS:After treatment,the patients’scores of HAMD-17,HAMA,SDS,SAS,and RRS were significantly decreased(P<0.05).FC was considerably decreased between the following areas:the left globus pallidus and the right postcentral gyrus,inferior parietal gyrus,the right globus pallidus and the left superior marginal gyrus,postcentral gyrus,superior parietal gyrus,inferior parietal gyrus,precuneus,right postcentral gyrus,superior marginal gyrus,and inferior parietal gyrus,between the right caudate and the right lingual gyrus,calcarine gyrus,and cerebellum.Changes in FC between the right globus pallidus and the left inferior parietal gyrus,between the left globus pallidus and the right postcentral gyrus were negatively correlated with HAMD-17 scores change before and after treatment(before,P=0.003,r=-0.6;after,P=0.009,r=-0.54).The change of FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in SDS(P=0.026,r=-0.474).The difference in FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in SAS(P=0.016,r=-0.513).CONCLUSIONS:Recurrent depression could be effectively treated with ta VNS.The changes in brain FC involving the basal ganglia,default mode,and sensorimotor networks provide insight into the effects of ta VNS treatment on recurrent depression. | CHEN Limei SUN Jifei GUO Chunlei LI Xiaojiao WANG Zhi Hong Yang() FANG Jiliang() | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 20 | Application value of Qisexingtai hand diagnostic method in diagnosis of coronary artery disease显示文摘OBJECTIVE:To evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method in the diagnosis of coronary artery disease(CAD).METHODS:This was an investigator-initiated,prospective,multi-center,cross-sectional study.All the participants from three hospitals in China had been diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.We compared the two diagnostic methods to calculate the sensitivity,the specificity,the omission diagnostic rate,the mistaken diagnostic rate and accuracy in order to evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method for CAD.RESULTS:A total of 326 subjects were enrolled,diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.As a result,there were 166 positive cases according to Qisexingtai hand diagnostic method,and 131 positive cases according to coronary angiography.Compared with the results of coronary angiography,the sensitivity of Qisexingtai hand diagnostic method was 80.2%,the specificity was 68.7%,the omission diagnostic rate was 19.8%,the mistaken diagnostic rate was 31.3%,and the accuracy was 73.3%.Area under the receiver operating characteristic curve was estimated as 0.735 for all,and 0.718,0.735,0.783 for the three sub-centers.CONCLUSION:Qisexingtai hand diagnostic method with high accuracy and sensitivity has certain application value in the diagnosis of CAD. | LIU Qian ZHAO Zhupei GUO Hua WANG Shiheng HAO Mingzhao QIN Peijie WANG Liuqing LIU Xuechun ZHANG Fengxia AN Hong LI Yu SHI Xueqin ZHU Tingyu LIU Jianfeng WANG Liying XU Tao ZHANG Limei ZOU Xu | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
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