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| 1 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 2 | Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy显示文摘Berberine chloride(BBR) is a pharmacokinetic profile of drug with poor bioavailability but good therapeutic efficacy,which is closely related to the discovery of BBR intestinal target.The major aim of this paper is to develop BBR intestinal retention type sustained-release pellets and evaluate their in vivo and in vitro behaviors base on the aspect of local action on intestinal tract. Here,wet milling technology is used to improve dissolution and dissolution rate of BBR by decreasing the particle size and increasing the wettability. The pellets are prepared by liquid layer deposition technology,and then the core pellets are coated with Eudragit~?L30 D-55 and Eudragit~?NE30 D aqueous dispersion. The prepared pellets show high drug loading capacity,and the drug loading up to 93%. Meanwhile,it possesses significant sustained drug release effect in purified water which is expected to improve the pharmacokinetic behavior of BBR. The pharmacokinetics results demonstrate that the halflife of BBR was increased significantly from 24 h to 36 h and the inter-and intra-subject variability are decreased compared to commercial BBR tablets. The retention test results indicate that the pellet size and Eudragit~?NE30 D plays an important role in retention time of the pellet,and it is found that the pellets with small particle size and high Eudragit~?NE30 D coating content can stay longer in the intestine than the pellets with large particle size. All in all,BBR intestinal retention type pellets are prepared successfully in this study,and the pellets show satisfactory in vivo and in vitro behaviors. | Guofei Li Mingming Zhao Xianying Su Lin Song Limei Zhao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 5 |
| 3 | Motion-based pH sensing using spindle-like micromotors显示文摘在这研究,我们报导一台像锭子的微电机。这台设备,用一个一步舞 electrospinning 方法被制作,由可被细菌破坏的 polycaprolactone 和 anionic 表面活化剂组成。有趣地,不是仅仅,产生微电机能为时间的一个长时期在水的表面上独立地移动(~ 40 min )由于 Marangoni 效果,但是在表面活化剂的版本在不同 pH 条件下面引起的表面紧张由于变化察觉到行为也展出 pH 。更有趣地,我们表明察觉到性质的基于运动的 pH 是尺寸依赖者,与展出更高的敏感的更小的结构。另外,自从 polycaprolactone 是可被细菌破坏的材料,微电机在这描述了学习能容易在答案被降级。因此,象一步舞制造,运动读出,和 biodegradability 那样的特征显示这台微电机察觉到应用的一个吸引人的候选人。 | Limei Liu Yonggang Dong Yunyu Sun Mei Liu Yajun Su Hui Zhang Bin Dong | 2016 | Nano Research2016，9，5： | 4 |
| 4 | Lead-bismuth-free piezoceramics (Na_(0.5)K_(0.44)Li_(0.06))Nb_(0.95)Sb_(0.05)O_3-Na_(5.6)Cu_(1.2)Sb_(10)O_(29)显示文摘Newly developed sintering aid Na5.6Cu1.2Sb10O29 (NCS) and lead-bismuth-free piezoceramics (Na0.5K0.44Li0.06) Nb0.95Sb0.05O3 (NKLNS) were prepared by the conventional solid state reaction. The effects of sintering aid NCS on the electrical properties of NKLNS were investigated. It was found that the addition of a proper amount of sintering aid NCS to NKLNS is effective not only on improving the density and the piezoelectric activity, but also on reducing the dielectric loss of NKLNS. The NKLNS doped with 0.4 mol% NCS has a piezoelectric constant d33 as high as 261pC/N and an electromechanical coupling factor k33 above 60%. These results show that NCS-doped NKLNS is a promising and practicable candidate for lead-bismuth-free piezoceramics. | ZHENG LiMei WANG JinFeng ZANG GuoZhong ZHAO MingLei QI Peng DU Juan SU WenBin MING BaoQuan | 2007 | Chinese Science Bulletin2007，52，4： | 2 |
| 5 | Study on simulation of dynam- ic meshing force of high speed gear system based on ADAMS显示文摘 | Wu Limei YinTubang Su Fulian | 2011 | Advanced Material Research2011，338，： | 1 |
| 6 | Automated apoptosis identification in fluorescence imaging of nucleus based on histogram of oriented gradients of high-frequency wavelet coefficients显示文摘The automatic and accurate identification of apoptosis facilitates large-scale cell analysis.Most identification approaches using nucleus fluorescence imaging are based on specific morphological parameters.However,these parameters cannot completely describe nuclear morphology,thus limiting the identification accuracy of models.This paper proposes a new feature extraction method to improve the performance of the model for apoptosis identification.The proposed method uses a histogram of oriented gradient(HOG)of high-frequency wavelet coefficients to extract internal and edge texture information.The HOG vectors are classified using support vector machine.The experimental results demonstrate that the proposed feature extraction method well performs apoptosis identification,attaining 95:7% accuracy with low cost in terms of time.We confirmed that our method has potential applications to cell biology research. | Shutong Liu Limei Su Han Sun Tongsheng Chen Min Hu Zhengfei Zhuang | 2023 | Journal of Innovative Optical Health Sciences2023，16，2： | 0 |
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