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| 1 | 肝肺综合征显示文摘 | Lin Jusheng WU Jinming 林菊生 吴金明 | 2001 | 临床内科杂志2001，18，2： | 15 |
| 2 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 3 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 4 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 5 | Reduction behaviors of iron ore lump and pellets with H_2 -CO gas显示文摘The differences of reduction behaviors between iron ore lump and pellets were studied by conducting low temperature reduction degradation,static load reduction and droplet tests. These tests simulated the conditions of reduction temperature and hydrogen-containing gas in COREX. Due to its dense structure and low porosity compared with pellets, lump ore possesses poor reduction degradation index ( RDI) and slower reduction rate in early and medium reaction stages,showing signs of lower strength,lower softening and melting temperatures,as well as a wider melting zone and higher ΔP. That provides some basis to explain the phenomena of differential pressure rise,metallization decline and more sticking after the usage of lump ore in COREX plant. | LI Jian ZHU Jinming XIONG Lin ZHAO Xiaoyan LIN Jinjia PENG Xin | 2012 | Baosteel Technical Research2012，6，2： | 3 |
| 6 | The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non-small cell lung cancer patients with epidermal growth factor receptor mutation显示文摘Over the past few years,immune checkpoint inhibitors(ICIs)have greatly improved the survival for patients with non-small cell lung cancer(NSCLC)without driver mutations.Compared with wild-type tumors,tumors with epidermal growth factor receptor(EGFR)mutations show more heterogeneity in the expression level of programmed cell death-ligand 1(PD-L1),tumor mutational burden(TMB),and other immune microenvironment characteristics.Whether ICIs are suitable for NSCLC patients with EGFR mutations is still worth exploring.In previous studies,no significantly improved benefits were observed with immunotherapy monotherapy in NSCLC patients with EGFR mutation.Here,we summarized and analyzed data from the clinical trials of ICIs or combined therapy in NSCLC patients with EGFR mutations.We also focused on the mechanisms affecting the efficacy of ICIs in NSCLC patients with EGFR mutations,the characteristics of potential responders,and provided insights into areas worth further investigations in future studies. | Lin Ma Bowen Diao Zhaoqin Huang Bin Wang Jinming Yu Xiangjiao Meng | 2021 | Cancer Communications2021，41，12： | 3 |
| 7 | Climatology of Cloud-base Height from Long-term Radiosonde Measurements in China显示文摘Clouds are critical to the global radiation budget and hydrological cycle, but knowledge is still poor concerning the observed climatology of cloud-base height(CBH) in China. Based on fine-resolution sounding observations from the China Radiosonde Network(CRN), the method used to estimate CBH was modified, and uncertainty analyses indicated that the CBH is good enough. The accuracy of CBH estimation is verified by the comparison between the sounding-derived CBHs and those estimated from the micro-pulse lidar and millimeter-wave cloud radar. As such, the CBH climatology was compiled for the period 2006–16. Overall, the CBH exhibits large geographic variability across China, at both 0800 Local Standard Time(LST) and 2000 LST, irrespective of season. In addition, the summertime cloud base tends to be elevated to higher altitudes in dry regions [i.e., Inner Mongolia and the North China Plain(NCP)]. By comparison, the Tibetan Plateau(TP),Pearl River Delta(PRD) and Sichuan Basin(SCB) have relatively low CBHs(< 2.4 km above ground level). In terms of seasonality, the CBH reaches its maximum in summer and minimum in winter. A low cloud base tends to occur frequently(> 70%) over the TP, PRD and SCB. In contrast, at most sites over the Yangtze River Delta(YRD) and the NCP, about half the cloud belongs to the high-cloud category. The CBH does not exhibit marked diurnal variation in summer, throughout all CRN sites, probably due to the persistent cloud coverage caused by the East Asia Summer Monsson. To the best of our knowledge, this is the first CBH climatology produced from sounding measurements in China, and provides a useful reference for obtaining observational cloud base information. | Yong ZHANG Lejian ZHANG Jianping GUO Jinming FENG Lijuan CAO Yang WANG Qing ZHOU Liangxu LI Bai LI Hui XU Lin LIU Ning AN Huan LIU | 2018 | Advances in Atmospheric Sciences2018，35，2： | 2 |
| 8 | On-chip solid phase extraction coupled with electrophoresis using modified magnetic microspheres as stationary phase显示文摘A poly(dimethylsiloxane)(PDMS)/glass hybrid microchip for on-line solid phase extraction (SPE) and electrophoresis separation has been developed and evaluated. The SPE microchannel was crossed to the electrophoresis microchannel. All the microfluidic channels were etched on the glass substrate. The magnetic microspheres were coated with hydroxyl-terminated poly-dimethylsiloxane (PDMS-OH) serving as extraction phase,which could be conveniently immobilized into the sample pretreatment channel by magnetic field. The PDMS-OH microspheres were mobilized into and out of the pretreatment channel by injection flow. The 0.1 μmol/L solution of fluorescence isothiocyanate (FITC)-labeled phenylalanine (Phe) was electrically injected into the SPE channel and extracted onto the PDMS-OH microspheres bed. The enriched FITC-labeled Phe was electrically eluted by 9 mmol/L sodium acetate containing 10% acetonitrile and electrically driven into the electrophoresis channel and then separated. The preconcentration factor could reach 87.5 after sufficient extraction. A linear preconcentration curve was obtained with the initial FITC-labeled Phe concentration ranging from 6 nmol/L to 300 nmol/L (R2=0.9922) with 200 s loading time. The detection limit (S/N=3) for the FITC-labeled Phe was 3 nmol/L. | LI Hong LI HaiFang CHEN ZhiFeng LIN JinMing | 2009 | Science China Chemistry2009，52，12： | 2 |
| 9 | A novel sterol from Chinese truffles Tuber indicum 显示文摘 | Jinming G Lin H Jikai L | 2001 | Steroids2001，66，10： | 1 |
| 10 | Lipid profiling of mammalian cells with in situ matrix-assisted laser desorption ionization-mass spectrometry显示文摘The analysis of cellular lipids and phospholipids has been of continuously increasing research interest due to the importance of these molecules in psychological process.In this work,a mass spectrometry-based method for direct,in situ analysis of lipids in cells was reported.Mammalian cells were directly cultured on ITO-coated glass and then analyzed by matrix-assisted laser desorption ionization-mass spectrometry(MALDI-MS).The matrix application process was achieved by electrospray coating,which produced a homogenous layer of matrix crystal on the sample.The detection results and reproducibility are satisfactory.With this method,a profile of abundant membrane lipids is generated,which is characteristic of cell type.In conclusion,this in situ MALDI-MS cellular lipid analysis method provides a platform for sensitive and robust molecular profiling of mammalian cells. | ZHANG YanDong LI HaiFang MA Yuan LIN JinMing | 2014 | Science China Chemistry2014，57，3： | 1 |
| 11 | Rapid detection of peste des petits ruminants virus by a reverse transcription loop-mediated isothermal amplification assay显示文摘 | Lin Li Jingyue Bao Xiaodong Wu Zhiliang Wang Junwei Wang Mingxia Gong Chunju Liu Jinming Li | 2010 | Journal of Virological Methods2010，，1： | 1 |
| 12 | Development of one-step real-time RT-PCR assay for detection and quantitation of peste des petits ruminants virus显示文摘 | Jingyue Bao Lin Li Zhiliang Wang Tom Barrett Longciren Suo Wenji Zhao Yutian Liu Chunju Liu Jinming Li | 2007 | Journal of Virological Methods2007，，1： | 1 |
| 13 | Effect of Low Temperature on Germination Characteristics of Rice Cultivars显示文摘The effects of low temperature on germination characteristics of rice seeds were studied,using three rice varieties as materials.The results showed that the germination rate,germination energy,germination index,vigor index,shoot length and root length all reduced with the decrease of temperature.When the treatment temperature was 10 ℃,whether or not cold-resistant varieties,the values of all parameters showed an extremely significant difference from the control's.When the stress temperature was 15 ℃,compared with the normal condition,the parameter values of the non-tolerant variety( Changbai 9) had an extremely significant difference and the germination rate,germination potential,seedling length and root length of two cold-tolerance varieties( Jisheng 202 and Tongjing 9) had little difference from the control.Therefore,the above four indicators at 15 ℃ can be considered as the evaluation indices of cold tolerance at early stage. | Yadong ZHAO Dianfa ZHOU Xiuyun LIN Qiang SUN Pengzhi Li Ding Zaisong Jinming WANG | 2018 | Agricultural Biotechnology2018，7，6： | 1 |
| 14 | Production of superoxide anion radicals as evidence for carbon nanodots acting as electron donors by the chemiluminescence method显示文摘 | Dou Xiangnan Lin Zhen Lin Jinming | 2013 | Chemical Communications(Camb)2013，49，52： | 1 |
| 15 | Separation and determination of norepinephrine, epinephrine andisoprinaline enantiomers by capillary electrophoresis in pharmaceutical formulation and human serum 显示文摘 | Wei Shoulian Song Guanqun Lin Jinming | 2005 | Journal of Chromatography A2005，1098，： | 1 |
| 16 | Vacuumassisted thermal bonding of plastic capillary electrophoresis microchip imprinted with stainless steel template显示文摘 | CHEN Zhifeng GAO Yunhua LIN Jinming | 2004 | J Chromatogr A2004，1038，12： | 1 |
| 17 | Study of Tea Digitized Chromatographic Fingerprint Spectra Using Mieellar Electrokinetie Chromatography显示文摘 | Song Guanquna LIN Jinming Qu Feng | 2003 | Chinese Journal of Chemistry2003，21，： | 1 |
| 18 | Determination of folic acid by chemiluminescence based on peroxomonosulfate-cobalt(Ⅱ) system显示文摘 | ZHANG Botao ZHAO Lixia LIN Jinming | 2008 | Talanta2008，74，5： | 1 |
| 19 | Vacuum- Assisted Thermal Bonding of Plastic Capillary Electrophoresis Microchip Imprinted with Stainless Steel Template显示文摘 | Chen Zhifeng Gao Yunhua Lin Jinming | 2004 | Journal of Chromatography A2004，1038，12： | 1 |
| 20 | Chemiluminescent flow sensor for H2O2 based on the decomposition of H2O2 catalyzed by cobalt(Ⅱ) -ethanolamine complex immobilized on resin显示文摘 | HANAOKA S LIN Jinming YAMADA M | 2001 | Anal Chim Acta2001，426，： | 1 |
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