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| 1 | A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases--Wuhan,China 2019−2020显示文摘Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of pneumonia cases with an unknown cause occurred in Wuhan starting on December 21,2019.As of January 20,2020,a total of 201 cases of pneumonia in China have been confirmed.A team of professionals from the National Health Commission and China CDC conducted epidemiological and etiological investigations.On January 3,2020,the first complete genome of the novelβgenus coronaviruses(2019-nCoVs)was identified in samples of bronchoalveolar lavage fluid(BALF)from a patient from Wuhan by scientists of the National Institute of Viral Disease Control and Prevention(IVDC)through a combination of Sanger sequencing,Illumina sequencing,and nanopore sequencing.Three distinct strains have been identified,the virus has been designated as 2019-nCoV,and the disease has been subsequently named novel coronavirus-infected pneumonia(NCIP). | Wenjie Tan Xiang Zhao Xuejun Ma Wenling Wang Peihua Niu Wenbo Xu George F.Gao Guizhen Wu | 2020 | China CDC weekly2020，2，4： | 95 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | D(β)-vertex-distinguishing total coloring of graphs显示文摘A new concept of the D(β)-vertex-distinguishing total coloring of graphs, i.e., the proper total coloring such that any two vertices whose distance is not larger than β have different color sets, where the color set of a vertex is the set composed of all colors of the vertex and the edges incident to it, is proposed in this paper. The D(2)-vertex-distinguishing total colorings of some special graphs are discussed, meanwhile, a conjecture and an open problem are presented. | ZHANG Zhongfu,LI Jingwen,CHEN Xiang’en,YAO Bing, WANG Wenjie & QIU Pengxiang Institute of Applied Mathematic, Lanzhou Jiaotong University, Lanzhou 730070, China College of Mathematics and Information Science, Northwest Normal University, Lanzhou 730070, China College of Information and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China | 2006 | Science China Mathematics2006，49，10： | 54 |
| 4 | Numerical Simulation on Climate Effects of Freezing-Thawing Processes Using CCM3显示文摘A parameterization of soil freezing-thawing physics for use in the land-surface model of the National Center for Atmospheric Research(NCAR) Community Climate Model(CCM3) is developed and evaluated.The new parameterization scheme has improved the representation of physical processes in the existing land surface model.Numerical simulations using CCM3 with improved land-surface processes and with the original land-surface processes are compared against the NCEP reanalysis.It is found that the CCM3 version using the improved land surface model shows significant improvements in simulating precipitation in China during the summer season,the general circulation over East Asia,and wind fields over the Tibet Plateau.For the summer season,the improved model was able to better simulate the Indian summer monsoon components,including the mean northerly wind in the upper troposphere and mean southerly wind in the lower troposphere. | Chenghai Wang1,2*,Guodong Cheng3,Aijun Deng4,Wenjie Dong5 1.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 2.State Key Laboratory of Cryosphere Sciences,Cold and Arid Regions Environmental and Engineering Research Insti-tute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 3.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 4.Department of Meteorology,The Pennsylvania State University,University Park,PA 16802 5.State Key Laboratory of Earth Surface Processes and Ecology Resource,Beijing Normal University,Beijing 100875,China Chenghai Wang1,2*,Guodong Cheng3,Aijun Deng4,Wenjie Dong5 1.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 2.State Key Laboratory of Cryosphere Sciences,Cold and Arid Regions Environmental and Engineering Research Insti-tute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 3.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 4.Department of Meteorology,The Pennsylvania State University,University Park,PA 16802 5.State Key Laboratory of Earth Surface Processes and Ecology Resource,Beijing Normal University,Beijing 100875,China | 2008 | Research in Cold and Arid Regions2008，，1： | 44 |
| 5 | A Survey on Terahertz Communications显示文摘With the exponential growth of the data traffic in wireless communication systems, terahertz(THz) frequency band is envisioned as a promising candidate to support ultra-broadband for future beyond fifth generation(5G), bridging the gap between millimeter wave(mmWave) and optical frequency ranges. The purpose of this paper is to provide a comprehensive literature review on the development towards THz communications and presents some key technologies faced in THz wireless communication systems. Firstly, despite the substantial hardware problems that have to be developed in terms of the THz solid state superheterodyne receiver, high speed THz modulators and THz antennas, the practical THz channel model and the efficient THz beamforming are also described to compensate for the severe path attenuation. Moreover, two different kinds of lab-level THz communication systems are introduced minutely, named a solid state THz communication system and a spatial direct modulation THz communication system, respectively. The solid state THz system converts intermediate frequency(IF) modulated signal to THz frequency while the direct modulation THz system allows the high power THz sources to input for approving the relatively long distance communications. Finally, we discuss several potential application scenarios as well as some vital technical challenges that will be encountered in the future THz communications. | Zhi Chen Xinying Ma Bo Zhang Yaxin Zhang Zhongqian Niu Ningyuan Kuang Wenjie Chen Lingxiang Li Shaoqian Li | 2019 | China Communications2019，16，2： | 43 |
| 6 | Analyses on the climate change responses over China under SRES B2 scenario using PRECIS显示文摘The PRECIS,a regional climate model system developed at the UK Met Office Hadley Cen- tre for Climate Prediction and Research,which is nested in one-way mode within the HadAM3P,a higher-resolution version of the atmospheric com- ponent of the Hadley Centre climate model HadCM3,is employed to simulate the baseline (1961—1990) climate for evaluation of model’s capacity of simu- lating present climate and analyze the future climate change responses in the time-slice of 2071—2100 (2080s) under SRES B2 scenario over China relative to baseline average. It is indicated from the com- parison of the simulated baseline climate with in situ observation that PRECIS can simulate the local dis- tribution characteristics of surface air temperature over China quite well; generally speaking,the simu- lation for precipitation in the north of China and in winter is better than in the south of China and in summer,respectively; the simulation of precipitation in summer is sensitive to topography,and the simu- lated precipitation values are lower than observations over southeast coastal areas. It is shown from the analyses on the simulated climate change responses in 2080s under SRES B2 scenario relative to base- line that there would be an obvious surface air tem- perature increase in the north of China relative to that in the south of China,and especially in Northwest China and Northeast China,the amplitude ofsummer mean surface air temperature increments could reach 5℃; there would be an overall increase of the simulated precipitation in 2080s under SRES B2 scenario over most areas of China,while there would be significant precipitation decreases in South China in winter; there would be obvious precipitation decreases in Northeast China and North China in summer with high surface air temperature increase. However,it presents an obvious precipitation in- crease over the middle and lower reaches of the Yangtze River in summer. | XU Yinlong ZHANG Yong LIN Erda LIN Wantao DONG Wenjie Richard Jones David Hassell Simon Wilson | 2006 | Chinese Science Bulletin2006，51，18： | 39 |
| 7 | Identification of gamyb-4 and Analysis of the Regulatory Role of GAMYB in Rice Anther Development显示文摘In higher plants,male reproductive development is a complex biological process that includes cell division and differentiation,cell to cell communication etc.,while the mechanism underlying plant male reproductive development remains less understood.GAMYB encodes a gibberellins acid(GA) inducible transcription factor that is required for the early anther development in rice(Oryza sativa L.).Here,we report the isolation and characterization of a new allele gamyb-4 with a C base deletion in the second exon(+2308),causing a frame shift and premature translational termination.Histological analysis showed that gamyb-4 developed abnormal enlarged tapetum and could not undergo normal meiosis.To understand the regulatory role of GAMYB,we carried out quantitative reverse transcription-polymerase chain reaction analysis and comparison of microarray data.These results revealed that the expression of TDR(TAPETUM DEGENERATION RETARDATION),a tapetal cell death regulator,was downregulated in gamyb-4 and udt1(undeveloped tapetum1).While the GAMYB expression was not obviously changed in tdr and udt1-1,and no apparent expression fold change of UDT1 in tdr and gamyb-4,suggesting that TDR may act downstream of GAMYB and UDT1,and GAMYB and UDT1 work in parallel to regulate rice early anther development.This work is helpful in understanding the regulatory network in rice anther development. | Zhenhua Liu Wenjie Bao Wanqi Liang Jingyuan Yin Dabing Zhang | 2010 | Journal of Integrative Plant Biology2010，52，7： | 35 |
| 8 | Reconstruction of Soil Particle Composition During Freeze-Thaw Cycling: A Review显示文摘在几十年进行的研究证明了结冰融化周期在土壤是精力输入和输出的进程,它帮助驾驶土壤结构的形成,通过由结晶化和由热坡度的水和盐的运动的水扩大。然而,大多数这些研究用俄语或汉语被出版并且对国际研究人员不太可存取。这评论在在土壤结构上结冰并且融化的效果上召集了大量研究。下列调查结果被总结:我) 在结冰融化周期以后的土壤结构更加变化,变化由于粗糙的矿物质粒子和土壤的聚集罚款的土壤的机械破碎粒子;ii ) 土壤的粒子尺寸变得同类,当结冰融化周期的数字增加,在土壤结构的变化变弱;iii ) 在土壤的结冰过程,在土壤粒子结合的变化的一个重要原则表现为:冷凝作用 →
聚集 →
结晶化;iv ) 结冰融化骑车的过程由在土壤以内改变矿物质粒子和结构的 granulometric 作文在土壤结构上有强壮的效果。骑车的过程加强粒子结合的结冰融化,在土壤的总数稳定性引起全面增加,从破坏显示出一个过程到重建。 | ZHANG Ze MA Wei FENG Wenjie XIAO Donghui HOU Xin | 2016 | Pedosphere2016，26，2： | 37 |
| 9 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 10 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 11 | Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways显示文摘Acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) is a severe, lifethreatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide(trade name: Xi-Yan-Ping Injection), on lipopolysaccharide(LPS)-induced ALI and inflammation. Andrographolide sulfonate was administered by intraperitoneal injection to mice with LPS-induced ALI. LPS-induced airway inflammatory cell recruitment and lung histological alterations were significantly ameliorated by andrographolide sulfonate. Protein levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid(BALF) and serum were reduced by andrographolide sulfonate administration. m RNA levels of pro-inflammatory cytokines in lung tissue were also suppressed. Moreover, andrographolide sulfonate markedly suppressed the activation of mitogen-activated protein kinase(MAPK) as well as p65 subunit of nuclear factor-κB(NF-κB). In summary, these results suggest that andrographolide sulfonate ameliorated LPS-induced ALI in mice by inhibiting NF-κB and MAPK-mediated inflammatory responses. Our study shows that water-soluble andrographolide sulfonate may represent a new therapeutic approach for treating inflammatory lung disorders. | Shuang Peng Nan Hang Wen Liu Wenjie Guo Chunhong Jiang Xiaoling Yang Qiang Xu Yang Sun | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 38 |
| 12 | Assessment of the uncertainties in temperature change in China during the last century显示文摘We have used the China Homogenized Historic Temperature dataset and some long-term station series of the neighbor countries from CRUTEM3,a 5°×5° gridded dataset of monthly mean temperature since 1900,to provide a 107-year record of surface temperature trends and variability.We derived a comprehensive set of uncertainty estimates to accompany the data:measurement and sampling errors,uncertainties in temperature bias estimates,and uncertainties arising from limited observational coverage on large-scale averages have all been estimated.We reanalysed the temperature changes during the period of record.The best estimates of trends for 1900-2006 with uncertainties at 95% confidence range are about 0.09±0.017°C/decade for the year as a whole,and 0.14±0.021°C/decade,0.11±0.021°C/decade,0.04±0.017°C/decade,and 0.07±0.017°C/decade for winter,spring,summer and autumn respectively.For 1954-2006,the trends for annual,winter,spring,summer and autumn are:0.26±0.032°C/decade,0.35±0.046°C/decade,0.25±0.051°C/decade,0.16±0.037°C/decade and 0.22±0.055°C/decade.Winter saw the most significant warming trend in both 1900-2006 and 1954-2006,while during the most recent period(the satellite era,1979-2006),all the seasons show similar warming trends:0.45±0.13°C/decade,0.51±0.11°C/decade,0.52±0.16°C/decade,0.37±0.10°C/decade and 0.50±0.16°C/decade for annual,winter,spring,summer and autumn.Trends arising from urbanization have been evaluated as less than 5% of the total warming trend for 1951-2001,so this bias was not removed. | LI QingXiang DONG WenJie LI Wei GAO XiaoRong JONES P KENNEDY J PARKER D | 2010 | Chinese Science Bulletin2010，55，19： | 26 |
| 13 | Quantifying driving forces of urban wetlands change in Beijing City显示文摘决定树和阀值方法被采用了描出从 LANDSAT 图象的水身体的边界和特征。在空间覆盖分析以后并且用在北京的一种遥感技术和沼泽地库存数据,水身体视觉上在 1986 在北京的城市的沼泽地上被分类进城市的沼泽地,和数据的不同类型, 1991 , 1996 , 2000 , 2002 , 2004 和 2007 被获得。影响沼泽地变化的 13 辆开车因素被选择,并且灰色的关联分析被采用计算在每个开车因素和城市的沼泽地的全部的区域之间的关联。然后,六个主要开车因素基于关联系数被选择,并且贡献这六个开车因素评价到各种各样的城市的沼泽地的区域变化基于正规关联分析被计算。在那以后,这研究分析了在主要开车因素和沼泽地的各种各样的类型之间的关系和机制。五个结论能被得出。(1 ) 在北京的表面水身体的全部的区域从 1986 ~ 1996 增加了,并且逐渐地从 1996 ~ 2007 减少了。(2 ) 河沼泽地,水存储区域和水池的区域和文化区域逐渐地减少了,并且它的变化趋势与沼泽地的全部的区域的一致。采矿水区域和废水处理植物的区域稍微增加了。( 3 )驱动力的六个因素是年度降雨,蒸发,流入水的数量,可得到的地下水的体积,都市化率和废水的每天平均的分泌物是在沼泽地区域影响变化的主要因素,并且他们与沼泽地的全部的区域相关很好。(4 ) 象流入水和地下水的体积的数量那样的水资源的 hydrologic 指示物是影响沼泽地区域的变化的最重要、直接的驱动力。这些因素有 43.94% 的联合贡献率。(5 ) 象降雨和蒸发那样的气候因素是在沼泽地区域影响变化的外部因素,并且他们有 36.54% 的贡献率。(6 ) 象都市化率和废水的每天平均的数量那样的人的活动是主要人工的开车因素。他们有 19.52% 的影响率。 | JIANG Weiguo WANG Wenjie CHEN Yunhao LIU Jing TANG Hong HOU Peng | 2012 | Journal of Geographical Sciences2012，22，2： | 25 |
| 14 | An energy-efficient geographic routing based on cooperative transmission in wireless sensor networks显示文摘In this paper, we propose an energy-efficient cooperative geographic routing (ECGR) to reach energy-efficient routing in wireless sensor networks (WSN). ECGR takes full advantage of cooperative diversity and geographic routing. At physical layer, cooperative nodes transmit the same packet in a cooperative way to achieve farther transmission distance of each hop without more energy consumption. While at the network layer, ECGR adaptively selects the appropriate cooperative nodes to form forwarding clusters to forward the packet to the destination when we consider energy consumption and geographic information of the sensor nodes. Meanwhile, in order to fully assess the energy consumption, we take circuit energy consumption of the sensor nodes into consideration. According to the description above, we increase the transmit distance of each hop; and thereby reducing and balancing the overall network energy consumption among nodes to extend the lifetime of the network. | LI Bin WANG WenJie YIN QinYe LI HongXiang YANG Rong | 2013 | Science China(Information Sciences)2013，56，7： | 26 |
| 15 | The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists显示文摘The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to characterize the expression of the structural(S,E,M,N)and accessory(ORF 3,ORF 4a,ORF 4b,ORF 5)proteins of MERS-CoV and to determine whether any of these pro-teins acts as an interferon antagonist.Individual structural and accessory protein-coding plasmids with an N-terminal HA tag were constructed and transiently transfected into cells,and their native expression and subcellular localiza-tion were assessed using Wes tern blotting and indirect immunofl uorescence.While ORF 4b demonstrated majorly nuclear localization,all of the other proteins demonstrated cytoplasmic localization.In addition,for the fi rst time,our experiments revealed that the M,ORF 4a,ORF 4b,and ORF 5 proteins are potent interferon antagonists.Further exami-nation revealed that the ORF 4a protein of MERS-CoV has the most potential to counteract the antiviral effects of IFN via the inhibition of both the interferon production(IFN-βpromoter activity,IRF-3/7 and NF-κB activation)and ISRE promoter element signaling pathways.Together,our re-sults provide new insights into the function and pathogenic role of the structural and accessory proteins of MERS-CoV. | Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan | 2013 | Protein & Cell2013，4，12： | 25 |
| 16 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 17 | Reconstruction of temperature series of China for the last 1000 years显示文摘This paper reports a study on reconstructing temperature series for ten regions of China over the last 1000 years with a time resolution of 10 a. The regions concerned are: Northeast, North, East, South China, Taiwan, Central, Southwest, Northwest China, Xinjiang and Qinghai-Tibet Plateau. A variety of proxy data, such as ice core, tree-rings, stalagmites, peat, lake sediments, pollen and historical records, were validated with instrumental observations made in the last 120 years, and applied in the recon- struction of the temperature series. A temperature series for whole China is then established by aver- aging the ten regional series with a weighting proportional to the area of each region. Finally, tem- perature variations for the last 1000 years are examined, with special focus placed on the characteris- tics of the Medieval Warm Period (MWP), the Little Ice Age (LIA), and Modern Warming (MW). | WANG ShaoWu WEN XinYu LUO Yong DONG WenJie ZHAO ZongCi YANG Bao | 2007 | Chinese Science Bulletin2007，52，23： | 22 |
| 18 | Effect of particle size on the microstructure and thermal conductivity of Al/diamond composites prepared by spark plasma sintering显示文摘Spark plasma sintering (SPS) was used to fabricate Al/diamond composites. The influence of diamond particle size on the microstructure and thermal conductivity (TC) of composites was investigated by combining experimental results with model prediction. The results show that both composites with 40 μm particles and 70 μm particles exhibit high density and good TC, and the composite with 70 μm particles indicates an excellent TC of 325 W·m-1·K-1. Their TCs lay between the theoretical estimated bounds. In contrast, the composite with 100 μm particles demonstrates low density as well as poor TC due to its high porosity and weak interfacial bonding. Its TC is even considerably less than the lower bound of the predicted value. Using larger diamond particles can further enhance thermal conductive performance only based on the premise that highly dense composites of strong interfacial bonding can be obtained. | CHU Ke JIA Chengchang LIANG Xuebing CHEN Hui GAO Wenji | 2009 | Rare Metals2009，28，6： | 22 |
| 19 | Strength reduction and step-loading finite element approaches in geotechnical engineering显示文摘The finite element limit analysis method has the advantages of both numerical and traditional limit equilibrium techniques and it is particularly useful to geotechnical engineering.This method has been developed in China,following well-accepted international procedures,to enhance understanding of stability issues in a number of geotechnical settings.Great advancements have been made in basic theory,the improvement of computational precision,and the broadening of practical applications.This paper presents the results of research on(1) the efficient design of embedded anti-slide piles,(2) the stability analysis of reservoir slopes with strength reduction theory,and(3) the determination of the ultimate bearing capacity of foundations using step-loading FEM(overloading).These three applications are evidence of the design improvements and benefits made possible in geotechnical engineering by finite element modeling. | Yingren Zheng Xiaosong Tang Shangyi Zhao Chujian Deng Wenjie Lei | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 23 |
| 20 | Vegetation effects on mean daily maximum and minimum surface air temperatures over China显示文摘Changes in the daily maximum (Tmax) and minimum (Tmin) surface air temperatures and the associated temperature extremes have severe consequences on human society and the natural environment. In this study, we assess vegetation effects on mean Tmax and Tmin over China by computing a vegetation feedback parameter using the satellite-sensed Normalized Difference Vegetation Index (NDVI) and observed temperatures for the period 1982–2002. In all seasons, vegetation exerts a much stronger forcing on Tmax than on Tmin, and thus has a substantial effect on the diurnal temperature range (DTR) over China. Significant positive feedbacks on Tmax and the DTR occupy many areas of China with the feedback parameters exceeding 1°C (0.1 NDVI)–1, while significant negative effects only appear over the summertime climatic and ecological transition zone of northern China and some other isolated areas. Also, the vegetation feedbacks are found to vary with season. In areas where significant feedbacks occur, vegetation contributes to typically 10%–30% of the total variances in Tmax, Tmin, and the DTR. These findings suggest that vegetation memory offers the potential for improving monthly-to-seasonal forecasting of Tmax and Tmin, and the associated temperature extremes over China. Meanwhile, the limitations and uncertainties of the study should be recognized. | WU LingYun ZHANG JingYong DONG WenJie | 2011 | Chinese Science Bulletin2011，56，9： | 22 |
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