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| 1 | Perihepatic nodes detected by point-of-care ultrasound in acute hepatitis and acute-on-chronic liver disease显示文摘AIM: To study the manifestations of perihepatic lymph nodes during the episode of acute hepatitis flare by point-of-care ultrasonography.METHODS: One hundred and seventy-six patients with an episode of acute hepatitis flare(ALT value > 5 × upper normal limit) were enrolled retrospectively. Diagnosis of etiology of the acute hepatitis flare was based on chart records and serological and virological assays. The patients were categorized into two groups(viral origin and non-viral origin) and further defined into ten subgroups according to the etiologies. An ultrasonograpy was performed within 2 h to 72 h(median, 8 h). The maximum size of each noticeable lymph node was measured. Correlation between clinical parameters and nodal manifestations was analyzed RESULTS: Enlarged lymph nodes(width ≥ 5mm)were noticeable in 110(62.5%) patients, mostly in acute on chronic hepatitis B(54.5%). The viral group had a higher prevalence rate(89/110 = 80.9%) and larger nodal size(median, 7 mm) than those of the non-viral group(21/66 = 31.8%; median, 0 mm)(P < 0.001 for both). Meanwhile, there were significant differences in the nodal size between acute and chronic viral groups(P < 0.01), and between acute hepatitis A and non-hepatitis A viral groups(P < 0.001). In logistical regression analysis, the nodal width still showed strong significance in multivariate analysis(P < 0.0001) to stratify the two groups. The area under the curve of ROC was 0.805, with a sensitivity of 80.9%, a specificity of 68.2%, positive predictive value of 80.92%, negative predictive value of 68.18%, and an accuracy of 76.14%. CONCLUSION: Point-of-care ultrasonography to detect perihepatic nodal change is valuable for clarifying the etiologies in an episode of acute hepatitis flare. | I Che Feng Szu Jen Wang Ming Jen Sheu Lok-Beng Koay Ching Yih Lin Chung Han Ho Chi Shu Sun Hsing Tao Kuo | 2015 | World Journal of Gastroenterology2015，21，44： | 2 |
| 2 | Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases显示文摘 | Chin‐Jung Yang Ja‐Liang Lin Dan‐Tzu Lin‐Tan Cheng‐Hao Weng Ching‐Wei Hsu Shen‐Yang Lee Shwu‐Hua Lee Chia‐Ming Chang Wey‐Ran Lin Tzung‐Hai Yen | 2012 | Liver Int2012，，9： | 1 |
| 3 | Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-κB signaling显示文摘 | Yu Wen Cheng Ching Yi Chang Kou Lung Lin Chien Ming Hu Cheng Hui Lin Jaw Jou Kang | 2008 | Journal of Ethnopharmacology2008，，2： | 1 |
| 4 | Surface modification of poly(L-lactic acid) membrane via layerby-layer assembly of silver nanoparticle-embedded polyelectrolyte multilayer 显示文摘 | Da Guang Yu Wen Ching Lin Ming Chien Yang | 2007 | Bioconjugate Chem2007，18，： | 1 |
| 5 | Influence of surface modification on the dispersion of nanoscale ct - AI~O3 particles in a thermoplastic polyurethane matrix 显示文摘 | Cheng -Ho Chen Ching - Feng Mao Ming - Shyong Tsai Fu - Su Yen Jian - Min Lin Ching - Hui Tseng Heng - Yi Chen | 2008 | Journal of Applied Polymer Science2008，110，： | 1 |
| 6 | Shrimp antilipopolysacch-aride factor peptide enhances the antitumoractivity of cisplatin in vitro and inhibits HeLa cells growth in nude mice显示文摘 | Lin Ming Ching Lin Shih Bin Chen Jian Chyi | 2010 | Peptides2010，31，： | 1 |
| 7 | Relationship of interleukin‐8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development显示文摘 | Ming‐Hsien Chien Chao‐Bin Yeh Yi‐Ching Li Lin‐Hung Wei Jer‐Hwa Chang Yu‐Ting Peng Shun‐Fa Yang Wu‐Hsien Kuo | 2011 | Oncol2011，，7： | 1 |
| 8 | Hepatitis B virus–DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma显示文摘 | Chau‐Ting Yeh Mary So Jennifer Ng Han‐Wen Yang Ming‐Ling Chang Ming‐Wei Lai Tse‐Ching Chen Chun‐Yen Lin Ta‐Sen Yeh Wei‐Chen Lee | 2010 | Hepatology2010，，6： | 1 |
| 9 | Risk of oral antifungal agent‐induced liver injury in T aiwanese显示文摘 | Wei‐Yu Kao Chien‐Wei Su Yi‐Shin Huang Yueh‐Ching Chou Yi‐Chih Chen Wen‐Hung Chung Ming‐Chih Hou Han‐Chieh Lin Fa‐Yauh Lee Jaw‐Ching Wu | 2014 | Br J Clin Pharmacol2014，，1： | 1 |
| 10 | Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX‐4 adjuvant chemotherapy显示文摘 | Ming‐Yii Huang Hsiang‐Lin Tsai Chih‐Hung Lin Ching‐Wen Huang Cheng‐Jen Ma Chun‐Ming Huang Chee‐Yin Chai Jaw‐Yuan Wang | 2013 | J Surg Oncol2013，，7： | 1 |
| 11 | A multi - technique approach to bridge electronic case report form design and data standard adoption显示文摘 | Ching - Heng Lin Nai - Yuan Wu Der- Ming Liou | 2015 | Journal of Biomedical Informat- ics2015，53，2： | 1 |
| 12 | EGCG ‐rich green tea extract stimulates s RAGE secretion to inhibit S 100 A 12‐ RAGE axis through ADAM 10‐mediated ectodomain shedding of extracellular RAGE in type 2 diabetes显示文摘 | Shang‐Ming Huang Yin‐Hsuan Chang Ya‐Chan Chao Jer‐An Lin Chi‐Hao Wu Ching‐Yi Lai Kung‐Chi Chan Shih‐Ting Tseng Gow‐Chin Yen | 2013 | Mol Nutr Food Res2013，，12： | 1 |
| 13 | Validation and simplification of F ournier’s gangrene severity index显示文摘 | Tsung‐Yen Lin Chien‐Hui Ou Tzong‐Shin Tzai Yat‐Ching Tong Chien‐Chen Chang Hong‐Lin Cheng Wen‐Horng Yang Yung‐Ming Lin | 2014 | Int J Urol2014，，7： | 1 |
| 14 | The Positive Effects of Relationship Learning and Absorptive Capacity on Innovation Performance and Competitive Advantage in In- dustrial Markets 显示文摘 | Yu -Shan Chen Ming - Ji James Lin Ching - Hsun Chang | 2009 | Industrial Marketing Management2009，，38： | 1 |
| 15 | Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution显示文摘Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex chromosomes.We sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and P.vera cv.Bagyolu,the male parent.Two chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were assembled.The ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 Mya.Three inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining region.These W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in pistachio.The W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or differentiation.Demographic history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in Iran.We identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought tolerance.These findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks. | Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan Murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles Coral del Val Muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour Hatice Gozel Nergiz C¸oban Nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming | 2023 | Plant Communications2023，4，3： | 0 |
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