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| 1 | 激光老视逆转术治疗老视的两组临床报告显示文摘目的:了解激光老视逆转手术(LAPR)治疗老视的安全性、有效性及稳定性。方法:来自于阿根廷的35例61眼(A组)、印度的14例26眼(B组)接受手术治疗。年龄40~60岁,近视、远视和散光均小于1.0D,双眼未矫正视力大于或等于20/40,近附加度数大于+1.0D。采用紫外或红外激光于角巩缘外的巩膜区对 称性放射状切开4对(8条)切口,每条切口长度约4.5mm,深度约500μm至600μm,宽度约0.6~0.7mm,观察术后结果。结果:进行LAPR手术的87眼中有64眼术后近视力达到J3或更好。A组平均年龄为53.2岁,随访6m后发现:21眼(34.4%)近视力达J1,16眼(26.2%)近视力达J2,4眼(6.6%)近视力达J3,2眼(3.3%)近视力达J4,2眼(3.3%)近视力达J5,8眼(13.1%)近视力达J6。如果排除6个薄巩膜或切削浅的患者,结果则为:51%的患者近视力达J1或更好,90%的患者近视力达J2或更好,100%的患者近视力达J3以上。术后随访发现近视力无明显回退(最长随访时间为12m)。术前近附加为+1.0至+3.0D(平均+2.27D),术后进附加为0,0至+2.0D(平均+0.31D)。B组平均年龄为46.1岁,最短随访时间为8m,最长随访时间为28m,术前无一患者近视力可达J3,术后87.5%的患者可达到J3或更好。平均调节幅度由术前1.9D提高到术后3.6D(用Kadambi-Ranger调节测量尺测量),近附加由术前+1.7D? | JT Lin Vivek Kadarnbi Oscar Mallo 张亚丽 | 2003 | 眼视光学杂志2003，5，3： | 7 |
| 2 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Cervical squamous dysplasias and carcinoma with immunodetectable p53 frequently contain HPV显示文摘 | Mittal KR Lin Oscar Chan Wai | 1995 | Gynecol Oncol1995，58，： | 1 |
| 5 | Challenges in the Interpretation of Peritoneal Cytologic Specimens显示文摘 | Oscar Lin | 2009 | Arch Pathol Lab Med2009，133，5： | 1 |
| 6 | Electroanatomic Substrate and Ablation Outcome for Suspected Epicardial Ventricular Tachycardia in Left Ventricular Nonischemic Cardiomyopathy显示文摘 | Oscar Cano Mathew Hutchinson David Lin Fermin Garcia Erica Zado Rupa Bala Michael Riley Joshua Cooper Sanjay Dixit Edward Gerstenfeld David Callans Francis E. Marchlinski | 2009 | Journal of the American College of Cardiology2009，，9： | 1 |
| 7 | Embryonic XMab21l2 Expression Is Required for Gastrulation and Subsequent Neural Development显示文摘 | Gene T.C Lau Oscar G.W Wong Priscilla M.Y Chan Kin-Hang Kok Rebecca L.Y Wong King-Tung Chin Marie C.M Lin Hsiang-Fu Kung King L Chow | 2001 | Biochemical and Biophysical Research Communications2001，，5： | 1 |
| 8 | Substantial hepatic necrosis is prognostic in fulminant liver failure显示文摘AIM To evaluate if any association existed between the extent of hepatic necrosis in initial liver biopsies and patient survival.METHODS Thirty-seven patients with fulminant liver failure, whose liver biopsy exhibited substantial necrosis, were identified and included in the study. The histological and clinical data was then analyzed in order to assess the relationship between the extent of necrosis and patient survival, with and without liver transplantation. The patients were grouped based on the etiology of hepatic necrosis. Each of the etiology groups were then further stratified according to whether or not they had received a liver transplant post-index biopsy, and whether or not the patient survived.RESULTS The core tissue length ranged from 5 to 44 mm with an average of 23 mm. Causes of necrosis included 14 autoimmune hepatitis, 10 drug induced liver injury(DILI), 9 hepatitis virus infection, and 4 unknown origin. Among them, 11 showed submassive(26%-75% of the parenchymal volume) and 26 massive(76%-100%) necrosis. Transplant-free survival was worse in patients with a higher extent of necrosis(40%, 71.4% and 100% in groups with necrosis of 76%-100%, 51%-75%and 26%-50%, respectively). Additionally, transplantfree survival rates were 66.7%, 57.1%, and 25.0% in groups of autoimmune hepatitis, DILI, and viral hepatitis, respectively. Even after liver transplantation, the survival rate in patients as a result of viral hepatitis remained the lowest(80%, 100%, and 40% in groups of autoimmune hepatitis, DILI, and viral hepatitis, respectively).CONCLUSION Adequate liver biopsy with more than 75% necrosis is associated with significant transplant-free mortality that is critical in predicting survival. | Paul Ndekwe Marwan S Ghabril Yong Zang Steven A Mann Oscar W Cummings Jingmei Lin | 2017 | World Journal of Gastroenterology2017，23，23： | 1 |
| 9 | Challenges in the Interpretation of Peritoneal Cytologic Specimens 显示文摘 | Oscar Lin | 2009 | Arch Pathol Lab Med2009，133，5： | 1 |
| 10 | Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese显示文摘 | Liang Sun Oscar H. Franco Frank B. Hu Lu Cai Zhijie Yu Huaixing Li Xingwang Ye Qibin Qi Jing Wang An Pan Yong Liu Xu Lin | 2008 | The Journal of Clinical Endocrinology & Metabolism2008，，12： | 1 |
| 11 | Cervical Squamous Dysplasias and Carcinomas with Immunodetectable p53 Frequently Contain HPV显示文摘 | Khush R. Mittal Oscar Lin Wai Chan Sunanda Goswami Rita I. Demopoulos | 1995 | Gynecologic Oncology1995，，3： | 1 |
| 12 | Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics显示文摘Dear Editor,Recent study showed that around 80%of coronavirus disease-19(COVID-19)patients are moderate cases who will recover with or without conventional treatment,while the remaining 20%developed severe disease requiring intensive care.1 Early and accurate screening of new COVID-19 patients to identify those who will develop severe disease will facilitate decision-making on appropriate treatment regimens and reasonable allocation of limited healthcare resources.Therefore,novel predictive factors for disease progress from moderate to severe are urgently needed. | Biao Di Hongling Jia Oscar Junhong Luo Fangqin Lin Kuibiao Li Yuanliang Zhang Huadong Wang Huiying Liang Jun Fan Zhicong Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 13 | Genomes reveal selective sweeps in kiang and donkey for high-altitude adaptation显示文摘Over the last several hundred years,donkeys have adapted to high-altitude conditions on the Tibetan Plateau.Interestingly,the kiang,a closely related equid species,also inhabits this region.Previous reports have demonstrated the importance of specific genes and adaptive introgression in divergent lineages for adaptation to hypoxic conditions on the Tibetan Plateau.Here,we assessed whether donkeys and kiangs adapted to the Tibetan Plateau via the same or different biological pathways and whether adaptive introgression has occurred.We assembled a de novo genome from a kiang individual and analyzed the genomes of five kiangs and 93 donkeys(including 24 from the Tibetan Plateau).Our analyses suggested the existence of a strong hard selective sweep at the EPAS1 locus in kiangs.In Tibetan donkeys,however,another gene,i.e.,EGLN1,was likely involved in their adaptation to high altitude.In addition,admixture analysis found no evidence for interspecific gene flow between kiangs and Tibetan donkeys.Our findings indicate that despite the short evolutionary time scale since the arrival of donkeys on the Tibetan Plateau,as well as the existence of a closely related species already adapted to hypoxia,Tibetan donkeys did not acquire adaptation via admixture but instead evolved adaptations via a different biological pathway. | Lin Zeng He-Qun Liu Xiao-Long Tu Chang-Mian Ji Xiao Gou Ali Esmailizadeh Sheng Wang Ming-Shan Wang Ming-Cheng Wang Xiao-Long Li Hadi Charati Adeniyi CAdeola Rahamon Akinyele Moshood Adedokun Olatunbosun Oladipo Sunday Charles Olaogun Oscar JSanke Mangbon Godwin F Sheila Cecily Ommeh Bernard Agwanda Jacqueline Kasiiti Lichoti Jian-Lin Han Hong-Kun Zheng Chang-Fa Wang Ya-Ping Zhang Laurent A.F.Frantz Dong-Dong Wu | 2021 | Zoological Research2021，42，4： | 0 |
| 14 | ZnS Semiconductive Powder Doped with Transition Metal Ions via Mechanochemical Synthesis Technique显示文摘 | R.F. Louh C.K. Lin Oscar Lin G.S. Chen C.C. Chan | 2004 | 过程工程学报2004，4，z1： | 0 |
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