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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | Fluorescent probe gold nanodots to quick detect Cr(VI) via oxidoreduction quenching process显示文摘A method is described here for the quickly(<30 s) accurate determination of Cr(VI)(Cr_2O_7^(2-)), based on fluorescent probes gold nanodots(AuNDs, excitation/emission peaks at 395/604 nm) coated with glutathione(GSH). The fluorescence of the AuNDs responses linearly to Cr(VI) concentrations, ranging widely from 1 nM to 10 m M with detection limit as low as 0.35 nM. At the same time, the AuNDs is demonstrated highly selective for Cr(VI) detection over other acid group ions and metal ions without any masking reagent. These make probability for practical use. The quenching mechanism is investigated deeply via fluorescent lifetime, XPS and TEM analysis. Different from most reported quenching explanation of aggregation derived from charge attraction, these results verify the redox reaction between Cr_2O_7^(2-)and sulfhydryl(–S) of GSH. The Au(I)–S bonds of AuNDs broke, accompanies with the oxidation of –S to form S–S bonds. As a result, AuNDs cross linked to each other. In the end, the fluorescence quenched. Attractively, the present study provides a new strategy for pollutant detection, such as from harmful Cr(VI) of Cr_2O_7^(2-)to nontoxic Cr(III). | Yueqi Zhao Yuanqing Sun Yingnan Jiang Shanliang Song Tianxin Zhao Yue Zhao Xinyu Wang Baoquan Li Bai Yang Quan Lin | 2019 | Science China Chemistry2019，62，1： | 1 |
| 3 | Recycling the magnesium alloy AZ91D in solid stare显示文摘 | Wang Jianyih Lin Yingnan Chang Tienchan | 2006 | Mater Trans2006，47，： | 1 |
| 4 | A Facile Synthesis of ZnCo2O4 Nanocluster Particles and the Performance as Anode Materials for Lithium Ion Batteries显示文摘ZnCo_2O_4 nanocluster particles(NCPs) were prepared through a designed hydrothermal method, with the assistance of a surfactant, sodium dodecyl benzene sulfonate. The crystalline structure and surface morphology of ZnCo_2O_4 were investigated by XRD, XPS, SEM, TEM, and BET analyses. The results of SEM and TEM suggest a clear nanocluster particle structure of cubic ZnCo_2O_4(*100 nm in diameter), which consists of aggregated primary nanoparticles(*10 nm in diameter), is achieved. The electrochemical behavior of synthesized ZnCo_2O_4 NCPs was investigated by galvanostatic discharge/charge measurements and cyclic voltammetry. The ZnCo_2O_4 NCPs exhibit a high reversible capacity of 700 mAh g^(-1) over 100 cycles under a current density of 100 mA g^(-1) with an excellent coulombic efficiency of 98.9% and a considerable cycling stability. This work demonstrates a facile technique designed to synthesize ZnCo_2O_4 NCPs which show great potential as anode materials for lithium ion batteries. | Yue Pan Weijia Zeng Lin Li Yuzi Zhang Yingnan Dong Dianxue Cao Guiling Wang Brett L.Lucht Ke Ye Kui Cheng | 2017 | Nano-Micro Letters2017，9，2： | 1 |
| 5 | Assembly of Three Scandium-containing Heteropolytungstates Based on a Building-block Synthetic Strategy显示文摘Three novel scandium-containing heteropolytungstates[Sc3(H2O)3NO(PW9O34)2]^10(1a)Scs(H2O)2(GeW6O34)2(GeW6O26)2]^12(2a)and[Sc11(W6O10)2(OH)2(H2O)16(BiW9O33)6]^27(3a)were synthesized by reactions of Sclllions with trilacunary Keggin precursors,[A-a-XW9O34]^n(X=P,Ge,n=9,10)or[B-a-BiW9O33]^9,in NaOAc/HOAc buffer solution under conventional synthetic condition,respectively.All the three compounds were characterized by means of single-crystal X-ray diffraction(XRD),Fourier transform-infrared(FTIR)spectroscopy ultraviolet-visible(UV-Vis)spectroscopy,elemental analysis,and thermogravimetric analysis.The aqueous solutior stability of the sandwich polvanion[Sc3(H2O)3(pw9O34)2]^10-was also verified by electrospray ionization mass Spectrometry(ESI-MS)due to its good solubility in water. | ZHANG Wenqi LIN Zhengguo CHI Yingnan HONG Jie YAN Li HU Changwen | 2020 | Chemical Research in Chinese Universities2020，36，6： | 0 |
| 6 | A robust & weak-nucleophilicity electrocatalyst with an inert response for chlorine ion oxidation in large-current seawater electrolysis显示文摘Seawater splitting into hydrogen,a promising technology,is seriously limited by the durability and tolerance of electrocatalysts for chlorine ions in seawater at large current densities due to chloride oxidation and corrosion.Here,we present a robust and weak-nucleophilicity nickel-iron hydroxide electrocatalyst with excellent selectivity for oxygen evolution and an inert response for chlorine ion oxidation which are key and highly desired for efficient seawater electrolysis.Such a weak-nucleophilicity electrocatalyst can well match with strong-nucleophilicity OH-compared with the weak-nucleophilicity Cl^(-),resultantly,the oxidation of OH-in electrolyte can be more easily achieved relative to chlorine ion oxidation,confirmed by ethylenediaminetetraacetic acid disodium probing test.Further,no strongly corrosive hypochlorite is produced when the operating voltage reaches about 2.1 V vs.RHE,a potential that is far beyond the thermodynamic potential of chlorine ion oxidatio n.This concept and approach to reasonably designing weaknucleophilicity electrocatalysts that can greatly avoid chlorine ion oxidation under alkaline seawater environments can push forward the seawater electrolysis technology and also accelerate the development of green hydrogen technique. | Junting Dong Chang Yu Hui Wang Lin Chen Hongling Huang Yingnan Han Qianbing Wei Jieshan Qiu | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 7 | Controllable surface reconstruction of copper foam for electrooxidation of benzyl alcohol integrated with pure hydrogen production显示文摘Electrocatalytic water splitting that is coupled with electrocatalytic chemical oxidation is considered as one of the promising methods for efficiently obtaining hydrogen energy and fine chemicals.Herein,we focus on an electrochemical redox activation strategy to rationally manipulate the microstructure and surface valence states of copper foam(CF)and boost the corresponding performance towards electrocatalytic benzyl alcohol oxidation(EBA),accompanied by the efficient hydrogen production.Correspondingly,the Cu(II)‐dominated species are gradually formed on the CF surface with the dissolution and redeposition of copper in the suitable potential range.The new species containing Cu2O,CuO,and Cu(OH)2 during surface reconstruction process of the CF were confirmed by multiple characterization techniques.After 220‐cycled activation(CF‐220),the activated CF achieves an increase of current density for EBA in anode from 9.5 for the original CF to 29.3 mmol/cm2,while the pure hydrogen yield increases threefold than that of the original CF at 1.5 VRHE.The produced new species can endow the CF‐220 with abundant acidity sites,which can enhance the adsorption toward Lewis‐basicity benzyl alcohol,confirmed by NH3‐temperature‐programmed desorption.In situ Raman result further reveals that the as‐produced CuO,Cu(OH)2,and Cu(OH)42−are the main active species toward the EBA process. | Yingnan Han Chang Yu Hongling Huang Qianbing Wei Junting Dong Lin Chen Jieshan Qiu | 2024 | SmartMat2024，5，1： | 0 |
| 8 | The Cost Analysis on the Law Regulation for Recycling Economy显示文摘The paper analyzes the external economy of pollution. Two different cost models of enterprises are established. From the point of enterprises and the government, the measures of eliminating the externality are discussed, and the limits to the measures are analyzed. | Zhou Yingnan Yang Lin Wang Xuedong | 2005 | Ecological Economy2005，1，4： | 0 |
| 9 | Enhanced water-induced effects enabled by alkali-stabilized Pd-OH_(x) species for oxidation of benzyl alcohol显示文摘The water promotion effects,where water can provide a solution-mediated reaction pathway in various heterogeneous chemical catalysis,have been presented and attracted wide attention recently,yet,the rational design of catalysts with a certain ability of enhancing water-induced reaction process is full of challenges and difficulties.Here,we show that by incorporating alkali(Na,K)cations as an electronic and/or structural promoter into Pd/rGO-ZnCr_(2)O_(4)(r GO,reduced graphene oxide),the obtained Pd(Na)/rGO-ZnCr_(2)O_(4)as a representative example demonstrates an outstanding benzyl alcohol oxidation activity in the Pickering emulsion system in comparison to the alkali-free counterpart.The response experiments of water injection confirm the enhanced activity,and the Na-modified catalyst can further enhance the promotion effects of water on the reaction.The effects of alkali cations for Pd nanoparticles are identified and deciphered by a series of experimental characterizations(XPS,in situ CO-DRIFTS,and CO-TPR coupled with MS),showing that there is abundant-OH on the surface of the catalyst,which is stabilized by the formation of Pd-OH_(x).The alkali-stabilized Pd-OH_(x)is helpful to enhance the waterinduced reaction process.According to the results of in situ Raman as well as UV-vis absorption spectra,the Na-modulated Pd(Na)/rGO-ZnCr_(2)O_(4)enables the beneficial characteristics for distorting the benzyl alcohol structure and enhancing the adsorption of benzyl alcohol.Further,the mechanism for enhanced water promotion effects is rationally proposed.The strategy of alkali cations-modified catalysts can provide a new direction to effectively enhance the chemical reaction involving small molecule water. | Qianbing Wei Chang Yu Yongwen Ren Lin Ni Dongming Liu Lin Chen Hongling Huang Yingnan Han Junting Dong Jieshan Qiu | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 10 | FGF8 signaling sustains progenitor status and multipotency of cranial neural crest-derived mesenchymal cells in vivo and in vitro显示文摘The cranial neural crest(CNC)cells play a vital role in craniofacial development and regeneration.They are multi-potent progenitors,being able to differentiate into various types of tissues.Both pre-migratory and post-migratory CNC cells are plastic,taking on diverse fates by responding to different inductive signals.However,what sustains the multipotency ofCNCcells andderivatives remains largely unknown.In this study,we present evidence that FGF8 signaling is able to sustain progenitor status and multipotency of CNC-derived mesenchymal cells both in vivo and in vitro.We show that augmented FGF8 signaling in pre-migratory CNC cells prevents cell differentiation and organogenesis in the craniofacial region by maintaining their progenitor status.CNC-derived mesenchymal cells with Fgf8 overexpression or control cells in the presence of exogenous FGF8 exhibit prolonged survival,proliferation,and multi-potent differentiation capability in cell cultures.Remarkably,exogenous FGF8 also sustains the capability of CNC-derived mesenchymal cells to participate in organogenesis such as odontogenesis.Furthermore,FGF8-mediated signaling strongly promotes adipogenesis but inhibits osteogenesis of CNC-derived mesenchymal cells in vitro.Our results reveal a specific role for FGF8 in the maintenance of progenitor status and in fate determination of CNC cells,implicating a potential application in expansion and fate manipulation of CNC-derived cells in stem cell-based craniofacial regeneration. | Meiying Shao Chao Liu Yingnan Song Wenduo Ye Wei He Guohua Yuan Shuping Gu Congxin Lin Liang Ma Yanding Zhang Weidong Tian Tao Hu YiPing Chen | 2015 | Journal of Molecular Cell Biology2015，7，5： | 0 |
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