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| 1 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 2 | Crystallization and Melt Behavior of Magnesium Hydroxide/Polypropylene Composites Modified by Functionalized Polypropylene显示文摘 | Lin Zhidan Qiu Yixin Mai Kanchen | 2004 | Journal of Applied Polymer Science2004，91，： | 1 |
| 3 | Agricultural Development and Implication for Wetlands Sustainability: A Case from Baoqing County, Northeast China显示文摘Historical thematic maps and remote sensing data were applied to address spatiotemporal dynamics of land use/land cover(LULC)changes and its impact on wetlands sustainability based on eight LULC datasets from 1954 to 2015 in Baoqing County,Northeast China.This study demonstrated that LULC drastically changed in the past six decades due to conversion of wetlands,woodland,and grassland into cropland.The cropland was 578.8 km^2 in 1954,accounting for 5.8% of the area in Baoqing County,and it increased to 54.3% in 2015,which was nearly equivalent to 9.4 times of that in 1954.Cropland increased 4843.6 km^2 from 1954 to 2015 with average increased area of 79.4 km^2/yr.The conversion of wetlands was the main reason for cropland increase(49.7%),and woodland(18%)and grassland(16.3%)conversion were other reasons.Results also revealed that 78% of wetlands were lost during the past six decades,of which 91.2% were converted cropland.Population increasing(population across Baoqing in 2015 was 7.8 times of that in 1949),agricultural technology development was the main reason for cropland increase,institutional and economic policies also played important roles for cropland dynamics,particularly paddy field influenced by market price.Agricultural development has caused severe wetlands degradation both in area and functionality,and still being the major threads for wetlands sustainable development.Several suggestions concerning the future land use policy formulation and wetlands sustainability were proposed.They are adjusting the‘food first’agricultural policy,reinforce management for wetlands nature reserves,creating infrastructure for the rational use of surface and groundwater,harnessing the degraded cultivated land. | FANG Chong WEN Zhidan LI Lin DU Jia LIU Ge WANG Xiaodi SONG Kaishan | 2019 | Chinese Geographical Science2019，29，2： | 1 |
| 4 | Mechanical Properties of Mg(OH)2/PP Composites Modified by Functionalized Polypropylene显示文摘 | Kancheng Mai Yuxin Qiu Zhidan Lin | 2003 | J Appl Polym Sci2003，88，： | 1 |
| 5 | Crystallization and Melt Behavior of Magnesium Hydroxide/Polypropylene Composites Modified by Functionalized Polypropylene显示文摘 | Lin Zhidan Qiu Yuxin Mai Kancheng | 2004 | J Appl Polym Sci2004，91，： | 1 |
| 6 | Fracture Morphology of Mg(OH)2/PP Composites Modified by Functionalized Polypropylene显示文摘 | Qiu Yuxin Lin Zhidan Mai Kancheng | 2003 | J Appl Polym Sci2003，88，： | 1 |
| 7 | Nanodiamond as an efficient nucleating agent for polyphenylene sulfide 显示文摘 | Deng Shulin Cao Lin Lin Zhidan | 2014 | Ther- moehim Aeta2014，584，5： | 1 |
| 8 | Microalgae cultivation and culture medium recycling by a two-stage cultivation system显示文摘Nutrients and water play an important role in microalgae cultivation.Using wastewater as a culture medium is a promising alternative to recycle nutrients and water,and for further developing microalgae-based products.In the present study,two species of microalgae,Chlorella sp.(high ammonia nitrogen tolerance)and Spirulinaplatensis (S.platensis,high growth rate),were cultured by using poultry wastewater through a two-stage cultivation system for algal biomass production.Ultrafiltration (UF)or centrifuge was used to harvest Chlorella-sp.from the first cultivation stage and to recycle culture medium for S.platensis growth in the second cultivation stage.Results showed the two-stage cultiyation system produced high microalgae biomass including 0.39g·L^-1 Chlorella sp.and 3.45g·L^-1 S.platensis in the first-stage and second-stage,respectively.In addition,the removal efficiencies of NH4+reached 19% and almost 100% in the first and the second stage,respectively. Total phosphorus (TP)removal reached 17% and 83%,and total organic carbon (TOC)removal reached 55% and 72% in the first and the second stage,respectively.UF and centrifuge can reeycle 96.8% and 100% water,respectively.This study provides a new method for the combined of pure microalgae cultivation and wastewater treatment with eulture medium recycling. | Xinfeng Wang Lu Lin Haifeng Lu Zhidan Liu Na Duan Taili Dong Hua Xiao Baoming Li Pei Xu | 2018 | Frontiers of Environmental Science & Engineering2018，12，6： | 1 |
| 9 | Monetaria moneta as a novel β-nucleating agent for isotactic polypropylene显示文摘 | Guan Zixian Lin Zhidan Mai Kancheng | 2013 | Composites Science and TechnQlogy2013，87，18： | 1 |
| 10 | Isothermal crystallization kinetics, morphology, and thermal conductivity of graphene nanoplatelets/polyphenylene sulfide composites显示文摘 | Deng Shuling Lin Zhidan Xu Baofeng et a l | 2014 | Journal of Thermal Analysis and Calorimetry2014，118，1： | 1 |
| 11 | Crystallization and Meli Behavior of Magnesium Hydroxide/Polypropylene Composites Modified by Functionalized Polypropylene显示文摘 | Lin Zhidan QiuYixin Mai Kanehen | 2004 | Journal of Applied Polymer Science2004，91，： | 1 |
| 12 | Crystallization and melt behavior of magnesium hydroxide/polypropylene composites modified by functionalized polypropylene显示文摘 | Lin Zhidan Qiu Yixin Mai Kancheng | 2004 | Journal of Applied Polymer Science2004，91，6： | 1 |
| 13 | The use of polyethyleneimine-modified reduced graphene oxide as a substrate for silver nanoparticles to produce a material with lower cytotoxicity and long-term antibacterial activity显示文摘 | Xiang Cai Minsong Lin Shaozao Tan Wenjie Mai Yuanming Zhang Zhiwen Liang Zhidan Lin Xiuju Zhang | 2012 | Carbon2012，，10： | 1 |
| 14 | Crystallization and melting behavior of nano-CaCO3/polypropylene composites modified by acrylic acid显示文摘 | Lin Zhidan Huang Zhenzhen Zhang Yu Mai Kancheng Zeng Hanmin | 2004 | Journal of Applied Polymer Science2004，91，： | 1 |
| 15 | The use of polyethyleneimine-modified reduced graphene oxide as a substrate for silver nanoparticles to produce a material with lower cytotoxicity and long-term antibacterial activity显示文摘 | Xiang Cai Minsong Lin Shaozao Tan Wenjie Mai Yuanming Zhang Zhiwen Liang Zhidan Lin Xiuju Zhang | 2012 | Carbon2012，，10： | 1 |
| 16 | The utilization of bamboo charcoal enhances wood plastic composites with excellent mechanical and thermal properties显示文摘 | Li Xiang Lei Bingrong Lin Zhidan | 2014 | Material & Design2014，53，41： | 1 |
| 17 | Monetaria Mo- neta as a Novel 13-nucleating Agent for Isotactic Polypro- pylene显示文摘 | Guan Zixian Lin Zhidan Mai Kancheng | 2013 | Composites Science and Technology2013，87，18： | 1 |
| 18 | Monetaria moneta as a novel β-nucleating agent for isotactic polypropylene显示文摘 | Zixian Guan Zhidan Lin Kancheng Mai | 2013 | Composites Science and Technology2013，，： | 1 |
| 19 | Crystallization and melting behavior of nano-CaCO3/polypropylene composites modified by acrylic acid显示文摘 | Zhidan Lin Zhenzhen Huang Yu Zhang | 2004 | J Appl Polym Sci2004，91，： | 1 |
| 20 | Nanodiamond as an efficient nucleating agent for polyphenylene sulfide显示文摘 | Shuling Deng Lin Cao Zhidan Lin Weiping Qiu Kunyu Liang Wei Li | 2014 | Thermochimica Acta2014，，： | 1 |
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