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4篇 您的检索式:作者名="Lingjun Rao"
    题名 作者 年代 出处 被引量
1Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao 2008Cell Research2008,18,5:61
2Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming显示文摘Jiangtao Ren Yongjun Pak Lixiazi He Lei Qian Yijun Gu Hui Li Lingjun Rao Jing Liao Chun Cui Xun Xu Jinqiu Zhou Hakchol Ri Lei Xiao 2011Cell Research2011,21,5:10
3Derivation and characterization of human embryonic stem cell lines from the Chinese population显示文摘人的胚胎的干细胞(hESCs ) 无止境地装自我更新并且在人的身体区分进所有房间类型。因此,他们在再生药,人的发展生物学和药发现是珍贵的。很多根 hESC 线从中国人口被导出,但是他们限制了为研究目的是可得到的。这里,我们报导线从中国起源的人的胚囊导出的二 hESC 的推导和描述。这些 hESCs 快车碱的磷酸酶和 hESC 特定的标记,包括的 Oct4, Nanog, SSEA-3, SSEA-4, TRA-1-60 和 TRA-1-81。他们也有 telomerase 活动和正常 karyotypes 的高水平。这些房间能在 vitro 形成胚胎植物或动物身体并且能被 teratoma 形成在 vivo 区分进所有三细菌层。最新确定的 hESCs 将为研究目的被散布。从中国人口的 hESC 线的可获得性将从不同的种族组在 hESCs 在差别上便于研究。Zhao Wu Hui Li Lingjun Rao Lixiaz iHe Lei Bao Jing Liao Chun Cui Zhenyu Zuo Qiao Li Huimin Dai Lei Qian Qing Tian Lei Xiao Xiao junTan 2011Journal of Genetics and Genomics2011,38,1:3
4Generation and application of human iPS cells显示文摘Human embryonic stem (ES) cells are capable of unlimited proliferation and maintenance of pluripo-tency in vitro;these properties may lead to potential applications in regenerative medicine. However,immune rejection hampers the allogenic application of human ES cells. Over-expression of several specific transcription factors has been used to reprogram human adult cells into induced pluripotent stem (iPS) cells,which are similar to hESCs in many aspects. The iPS technique makes it possible to produce patient-specific pluripotent stem cells for transplantation therapy without immune rejection. However,some challenges remain,including viral vector integration into the genome,the existence of exogenous oncogenic factors,and low induction efficiency. Here,we review recent advances in human iPS methodology,as well as remaining challenges and its potential applications.CUI Chun RAO LingJun CHENG LinZhao XIAO Lei 2009Chinese Science Bulletin2009,54,1:1
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